Mutagenetix > Incidental Mutation

Incidental Mutation 'R1794:Mslnl'

202082

Institutional Source

Beutler Lab

Gene Symbol

Mslnl

Ensembl Gene

ENSMUSG00000041062

Gene Name

mesothelin-like

Synonyms

MMRRC Submission

039824-MU

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1794 (G1)

Quality Score

173

Status

Not validated

Chromosome

Chromosomal Location

25736040-25748330 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 25742934 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Methionine at position 128 (V128M)

Ref Sequence

ENSEMBL: ENSMUSP00000049020 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000047098]

AlphaFold

Q8C160

Predicted Effect

probably damaging
Transcript: ENSMUST00000047098
AA Change: V128M

PolyPhen 2 Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000049020
Gene: ENSMUSG00000041062
AA Change: V128M

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Pfam:Mesothelin	29	589	2.8e-70	PFAM
low complexity region	633	653	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000102319

Meta Mutation Damage Score

0.2148

Coding Region Coverage

1x: 97.4%
3x: 96.7%
10x: 94.8%
20x: 91.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 72 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700014D04Rik	T	C	13: 59,742,620	E44G	probably benign	Het
Anxa7	A	G	14: 20,471,467	Y54H	unknown	Het
Arhgef3	A	G	14: 27,397,605	T331A	probably benign	Het
Arhgef40	G	T	14: 51,989,930	C477F	possibly damaging	Het
Arsi	G	A	18: 60,916,651	G202E	probably benign	Het
Atp13a5	C	A	16: 29,321,709	R343L	probably damaging	Het
Brdt	ACAGCAGCAGCAGCAGC	ACAGCAGCAGCAGC	5: 107,359,853		probably benign	Het
Btbd2	G	T	10: 80,643,913	D426E	probably damaging	Het
Cabin1	A	C	10: 75,725,745	I974R	possibly damaging	Het
Cacna1i	G	A	15: 80,389,122	V1670M	probably damaging	Het
Cc2d2a	C	A	5: 43,688,252	Q288K	probably damaging	Het
Ccl20	T	A	1: 83,117,829	I37K	possibly damaging	Het
Cdcp1	A	G	9: 123,190,094	V40A	probably benign	Het
Cdcp1	T	C	9: 123,215,831	T27A	probably benign	Het
Cdh4	C	T	2: 179,886,842	T581I	probably damaging	Het
Cgn	A	G	3: 94,762,557		probably null	Het
Col7a1	G	A	9: 108,965,928	G1493D	unknown	Het
Creb3	A	G	4: 43,563,302	E133G	probably benign	Het
Dchs1	T	C	7: 105,771,720	T498A	probably benign	Het
Dis3l	A	C	9: 64,317,776	V413G	possibly damaging	Het
Dnah6	T	C	6: 73,024,958	E3865G	probably damaging	Het
Fam219b	A	G	9: 57,539,281	Y139C	probably damaging	Het
Fat3	A	T	9: 15,997,136	Y2523*	probably null	Het
Fat3	A	T	9: 15,997,138	Y2523N	probably benign	Het
Fmnl1	T	C	11: 103,197,147	S40P	probably benign	Het
Gm17727	T	A	9: 35,777,122	I56F	probably benign	Het
Gm4792	T	C	10: 94,298,490	D6G	unknown	Het
Hhat	G	T	1: 192,693,906	Y306*	probably null	Het
Hmcn1	A	G	1: 150,598,285	I4802T	probably benign	Het
Hmcn1	G	A	1: 150,627,152	T3908I	probably damaging	Het
Hsph1	A	T	5: 149,630,773	N79K	probably damaging	Het
Ikbke	T	A	1: 131,259,218	Y579F	probably damaging	Het
Jak2	A	G	19: 29,299,557	D838G	probably benign	Het
Klhdc7b	T	C	15: 89,387,020	S702P	probably benign	Het
Lingo3	C	A	10: 80,835,598	R166L	probably benign	Het
Lins1	T	C	7: 66,711,909	F436S	probably damaging	Het
Lman1	T	C	18: 65,991,684	D328G	probably benign	Het
Lox	A	G	18: 52,528,307	C232R	probably damaging	Het
Lrrc59	T	C	11: 94,638,595	V165A	probably benign	Het
Map9	A	G	3: 82,380,221	D50G	probably damaging	Het
March1	T	A	8: 66,386,942	Y126N	possibly damaging	Het
Mcf2l	T	C	8: 12,915,982	F3L	probably benign	Het
Nin	G	A	12: 70,043,795	Q949*	probably null	Het
Nlgn3	A	G	X: 101,320,033	H636R	probably benign	Het
Notch2	A	G	3: 98,099,547	D411G	possibly damaging	Het
Olfr1263	A	G	2: 90,015,020	Y30C	probably damaging	Het
Olfr1449	G	C	19: 12,934,968	A77P	probably damaging	Het
Plekha7	A	G	7: 116,140,681	V579A	probably damaging	Het
Prrc2c	T	C	1: 162,705,959		probably benign	Het
Rab7b	T	C	1: 131,697,068		probably null	Het
Reg3b	G	T	6: 78,372,214		probably null	Het
Rgs20	A	G	1: 4,910,572	Y177H	probably damaging	Het
Ripk3	G	T	14: 55,785,329	N379K	probably benign	Het
Rnf220	G	T	4: 117,307,568	Q7K	probably benign	Het
Ros1	T	A	10: 52,124,103	K1109*	probably null	Het
Slc22a7	T	G	17: 46,433,153	R460S	probably damaging	Het
Slc4a2	A	G	5: 24,439,328	M975V	probably damaging	Het
Slc4a3	A	T	1: 75,557,308	I1100F	probably damaging	Het
Smco1	A	G	16: 32,274,132	E207G	probably benign	Het
Snrnp200	A	G	2: 127,216,736	E369G	probably benign	Het
Tcf4	T	A	18: 69,657,853	M178K	probably benign	Het
Tex2	T	C	11: 106,567,902		probably benign	Het
Tjp1	A	T	7: 65,323,129	I521N	probably damaging	Het
Tmem203	A	G	2: 25,255,994	T109A	probably benign	Het
Tmem50b	T	C	16: 91,578,029	I126V	probably benign	Het
Ugcg	C	T	4: 59,207,798	P46S	probably benign	Het
Ush2a	T	C	1: 188,862,809	F3813L	probably benign	Het
Vmn1r203	C	T	13: 22,524,351	R101W	probably damaging	Het
Vmn2r79	G	A	7: 87,001,413	V136I	probably benign	Het
Wdr38	A	G	2: 39,000,729	Y205C	probably damaging	Het
Zfp248	A	G	6: 118,429,303	F442L	probably damaging	Het
Znrf4	A	G	17: 56,511,599	I236T	probably damaging	Het

Other mutations in Mslnl

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01621:Mslnl	APN	17	25743667	unclassified	probably benign
IGL01629:Mslnl	APN	17	25744775	missense	possibly damaging	0.95
IGL02084:Mslnl	APN	17	25746151	missense	probably benign	0.07
IGL02408:Mslnl	APN	17	25747998	missense	possibly damaging	0.80
IGL02726:Mslnl	APN	17	25744103	critical splice donor site	probably null
IGL03387:Mslnl	APN	17	25744077	missense	probably benign	0.06
R0561:Mslnl	UTSW	17	25743203	nonsense	probably null
R0881:Mslnl	UTSW	17	25742965	missense	possibly damaging	0.82
R1295:Mslnl	UTSW	17	25743240	missense	probably damaging	1.00
R1296:Mslnl	UTSW	17	25743240	missense	probably damaging	1.00
R1582:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1629:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1630:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1631:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1632:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1850:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1866:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1876:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1914:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2166:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2241:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2243:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2247:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2282:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2284:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2852:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2867:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2867:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2877:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2878:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2919:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2920:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3026:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3405:Mslnl	UTSW	17	25746181	missense	probably damaging	1.00
R3406:Mslnl	UTSW	17	25746181	missense	probably damaging	1.00
R3411:Mslnl	UTSW	17	25744517	missense	probably benign	0.05
R3434:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3546:Mslnl	UTSW	17	25744969	missense	probably damaging	0.98
R3612:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3729:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3730:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3802:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3804:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3894:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3895:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4454:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4455:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4456:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4457:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4561:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4562:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4564:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4600:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4601:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4610:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4704:Mslnl	UTSW	17	25738978	missense	possibly damaging	0.73
R5155:Mslnl	UTSW	17	25738968	nonsense	probably null
R5257:Mslnl	UTSW	17	25746165	missense	probably benign	0.00
R5456:Mslnl	UTSW	17	25743159	missense	probably damaging	0.98
R5645:Mslnl	UTSW	17	25737842	missense	possibly damaging	0.95
R6007:Mslnl	UTSW	17	25746775	missense	probably benign	0.00
R6083:Mslnl	UTSW	17	25737902	missense	possibly damaging	0.83
R6142:Mslnl	UTSW	17	25744557	missense	probably damaging	1.00
R6761:Mslnl	UTSW	17	25746073	missense	probably damaging	1.00
R7058:Mslnl	UTSW	17	25743212	missense	probably benign	0.03
R7156:Mslnl	UTSW	17	25743210	missense	probably benign	0.20
R7467:Mslnl	UTSW	17	25736921	start codon destroyed	probably benign	0.33
R7687:Mslnl	UTSW	17	25743183	missense	probably damaging	0.97
R7807:Mslnl	UTSW	17	25746777	missense	probably benign	0.03
R8682:Mslnl	UTSW	17	25746988	missense	probably benign
R8735:Mslnl	UTSW	17	25745088	missense	probably benign	0.09
R8742:Mslnl	UTSW	17	25745073	missense	probably damaging	1.00
R9208:Mslnl	UTSW	17	25742720	missense	possibly damaging	0.94
RF007:Mslnl	UTSW	17	25743228	missense	possibly damaging	0.87

Predicted Primers

PCR Primer
(F):5'- GCCATCAGAAGGGAGGTTTG -3'
(R):5'- ACAGGTCTGAAGCACTGAGC -3'

Sequencing Primer
(F):5'- TTTGAACCCAGGACTGAGGTGAC -3'
(R):5'- GCCCTGCCGAGACAGTAG -3'

Posted On

2014-06-23