Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00163:Vsig10'

2021

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vsig10

Ensembl Gene

ENSMUSG00000066894

Gene Name

V-set and immunoglobulin domain containing 10

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.067) question?

Stock #

IGL00163

Quality Score

Status

Chromosome

Chromosomal Location

117457331-117493071 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 117476479 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 311 (N311S)

Ref Sequence

ENSEMBL: ENSMUSP00000107598 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000086464] [ENSMUST00000111967]

AlphaFold

D3YX43

Predicted Effect

probably benign
Transcript: ENSMUST00000086464
AA Change: N284S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000083655
Gene: ENSMUSG00000066894
AA Change: N284S

Domain	Start	End	E-Value	Type
low complexity region	2	16	N/A	INTRINSIC
IG	23	114	4.03e-8	SMART
IG	132	214	9.49e-5	SMART
Pfam:Ig_2	215	300	2.6e-2	PFAM
Pfam:Ig_3	216	284	3.5e-4	PFAM
IGc2	313	384	1.12e-6	SMART
transmembrane domain	403	425	N/A	INTRINSIC
coiled coil region	446	481	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000111967
AA Change: N311S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000107598
Gene: ENSMUSG00000066894
AA Change: N311S

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
IG	50	141	4.03e-8	SMART
IG	159	241	9.49e-5	SMART
Blast:IG_like	248	327	2e-33	BLAST
IGc2	340	411	1.12e-6	SMART
transmembrane domain	430	452	N/A	INTRINSIC
coiled coil region	473	508	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000145052

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000147182

SMART Domains

Protein: ENSMUSP00000125808
Gene: ENSMUSG00000066894

Domain	Start	End	E-Value	Type
Blast:IG_like	1	41	3e-14	BLAST
IGc2	54	125	1.12e-6	SMART
transmembrane domain	144	166	N/A	INTRINSIC
coiled coil region	187	222	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

All alleles(11) : Gene trapped(11)

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930553M12Rik	G	A	4: 88,786,310 (GRCm39)	Q103*	probably null	Het
4933406P04Rik	C	A	10: 20,186,970 (GRCm39)		probably benign	Het
Adgrg6	T	C	10: 14,343,194 (GRCm39)	E251G	probably damaging	Het
Ago2	T	C	15: 72,998,302 (GRCm39)	H292R	probably benign	Het
Akr1c6	T	C	13: 4,498,977 (GRCm39)		probably benign	Het
Arhgap24	T	A	5: 103,008,265 (GRCm39)	M62K	possibly damaging	Het
Bicd1	A	G	6: 149,451,888 (GRCm39)	H834R	possibly damaging	Het
Ccdc77	G	T	6: 120,306,045 (GRCm39)		probably benign	Het
Cdadc1	G	T	14: 59,818,818 (GRCm39)	H337N	probably damaging	Het
Cep192	A	G	18: 68,013,871 (GRCm39)	T2424A	possibly damaging	Het
Cep78	T	C	19: 15,946,504 (GRCm39)	T443A	probably benign	Het
Chrna1	T	A	2: 73,400,986 (GRCm39)	E181D	probably benign	Het
Dmxl1	G	A	18: 49,984,534 (GRCm39)	D177N	probably damaging	Het
Eif3h	T	A	15: 51,650,195 (GRCm39)	I330F	probably damaging	Het
Fam184b	T	C	5: 45,697,091 (GRCm39)	E691G	probably benign	Het
Fastkd1	T	A	2: 69,537,893 (GRCm39)	S230C	probably benign	Het
Gipc2	T	C	3: 151,843,215 (GRCm39)	I141V	probably damaging	Het
Hsd17b2	A	T	8: 118,485,410 (GRCm39)	D291V	probably damaging	Het
Itpr2	G	A	6: 146,292,334 (GRCm39)	A420V	possibly damaging	Het
Jag1	C	T	2: 136,927,952 (GRCm39)		probably null	Het
Minar1	A	T	9: 89,473,150 (GRCm39)		probably benign	Het
Mmp1b	T	A	9: 7,387,946 (GRCm39)	Y16F	probably benign	Het
Muc4	G	T	16: 32,754,090 (GRCm38)	R1322M	probably benign	Het
Myo9b	T	C	8: 71,801,379 (GRCm39)	I1179T	probably benign	Het
Nos1ap	A	G	1: 170,342,175 (GRCm39)		probably benign	Het
Npc1l1	A	T	11: 6,174,199 (GRCm39)	V702E	probably damaging	Het
Or13d1	G	A	4: 52,971,058 (GRCm39)	V146M	possibly damaging	Het
Or1j21	A	G	2: 36,684,012 (GRCm39)	I255V	probably benign	Het
Or2ag17	T	A	7: 106,389,796 (GRCm39)	R137S	probably benign	Het
Or2y10	A	C	11: 49,454,747 (GRCm39)		probably benign	Het
Or4c31	A	T	2: 88,291,696 (GRCm39)	Y4F	probably benign	Het
Or4f7	A	C	2: 111,644,126 (GRCm39)		probably benign	Het
Osmr	A	T	15: 6,873,926 (GRCm39)	L157*	probably null	Het
Pdzph1	T	C	17: 59,281,791 (GRCm39)	T164A	possibly damaging	Het
Ptn	T	C	6: 36,720,424 (GRCm39)	K43E	probably benign	Het
Rbm45	T	C	2: 76,209,051 (GRCm39)	V340A	probably damaging	Het
Rnf5	C	T	17: 34,821,083 (GRCm39)	G83E	probably damaging	Het
Scin	G	T	12: 40,126,971 (GRCm39)	Q459K	probably benign	Het
Serpina5	C	A	12: 104,071,479 (GRCm39)	A362D	probably damaging	Het
Tex47	T	A	5: 7,355,468 (GRCm39)	Y216*	probably null	Het
Tll1	A	T	8: 64,469,170 (GRCm39)	H984Q	probably benign	Het
Tmem259	A	G	10: 79,815,568 (GRCm39)	V81A	probably benign	Het
Tns3	A	T	11: 8,401,066 (GRCm39)	S1077R	probably benign	Het
Trgv3	G	A	13: 19,427,381 (GRCm39)	S88N	probably benign	Het
Ttc17	A	G	2: 94,153,428 (GRCm39)		probably benign	Het
Tubgcp2	T	C	7: 139,610,935 (GRCm39)	T149A	possibly damaging	Het
Ulk1	G	A	5: 110,935,738 (GRCm39)	A25V	probably damaging	Het
Vps13d	T	C	4: 144,895,110 (GRCm39)	E378G	probably damaging	Het
Zfp511	T	C	7: 139,617,429 (GRCm39)	Y144H	possibly damaging	Het

Other mutations in Vsig10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00340:Vsig10	APN	5	117,489,652 (GRCm39)	missense	probably benign	0.03
IGL01082:Vsig10	APN	5	117,472,970 (GRCm39)	missense	probably benign	0.33
IGL01285:Vsig10	APN	5	117,462,954 (GRCm39)	missense	probably benign	0.43
IGL01790:Vsig10	APN	5	117,476,379 (GRCm39)	missense	probably damaging	1.00
IGL03004:Vsig10	APN	5	117,463,140 (GRCm39)	missense	probably damaging	1.00
D3080:Vsig10	UTSW	5	117,481,884 (GRCm39)	missense	probably damaging	1.00
R0101:Vsig10	UTSW	5	117,473,134 (GRCm39)	critical splice donor site	probably null
R0403:Vsig10	UTSW	5	117,476,526 (GRCm39)	missense	probably benign	0.05
R0674:Vsig10	UTSW	5	117,481,911 (GRCm39)	missense	probably damaging	1.00
R1437:Vsig10	UTSW	5	117,489,635 (GRCm39)	missense	probably damaging	0.96
R1689:Vsig10	UTSW	5	117,490,825 (GRCm39)	missense	probably benign	0.00
R1710:Vsig10	UTSW	5	117,489,719 (GRCm39)	missense	probably benign
R1765:Vsig10	UTSW	5	117,456,880 (GRCm39)	unclassified	probably benign
R4422:Vsig10	UTSW	5	117,462,986 (GRCm39)	missense	probably benign	0.00
R4541:Vsig10	UTSW	5	117,490,881 (GRCm39)	utr 3 prime	probably benign
R4909:Vsig10	UTSW	5	117,476,308 (GRCm39)	missense	probably benign	0.31
R4999:Vsig10	UTSW	5	117,482,040 (GRCm39)	missense	probably damaging	1.00
R5855:Vsig10	UTSW	5	117,476,335 (GRCm39)	missense	probably damaging	1.00
R5866:Vsig10	UTSW	5	117,490,814 (GRCm39)	critical splice acceptor site	probably null
R6214:Vsig10	UTSW	5	117,481,989 (GRCm39)	missense	probably damaging	1.00
R6418:Vsig10	UTSW	5	117,486,361 (GRCm39)	missense	probably benign	0.03
R6505:Vsig10	UTSW	5	117,489,824 (GRCm39)	missense	possibly damaging	0.95
R6854:Vsig10	UTSW	5	117,476,472 (GRCm39)	missense	probably benign	0.36
R7121:Vsig10	UTSW	5	117,481,967 (GRCm39)	missense	probably damaging	1.00
R7596:Vsig10	UTSW	5	117,472,848 (GRCm39)	missense	possibly damaging	0.46
R8066:Vsig10	UTSW	5	117,489,849 (GRCm39)	missense	probably benign	0.00
R8335:Vsig10	UTSW	5	117,486,435 (GRCm39)	missense	probably damaging	1.00
R8787:Vsig10	UTSW	5	117,472,981 (GRCm39)	missense	probably benign	0.18
R9026:Vsig10	UTSW	5	117,476,323 (GRCm39)	missense	probably benign	0.00
R9257:Vsig10	UTSW	5	117,463,131 (GRCm39)	missense	probably benign	0.29
R9386:Vsig10	UTSW	5	117,463,140 (GRCm39)	missense	probably damaging	1.00
R9474:Vsig10	UTSW	5	117,463,104 (GRCm39)	missense	probably benign	0.00

Posted On

2011-07-12