Incidental Mutation 'R1795:Plxnb1'
| ID |
202142 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Plxnb1
|
| Ensembl Gene |
ENSMUSG00000053646 |
| Gene Name |
plexin B1 |
| Synonyms |
2900002G15Rik |
| MMRRC Submission |
039825-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1795 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
9 |
| Chromosomal Location |
108924457-108948985 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 108929813 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 223
(V223A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000071966
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000072093]
[ENSMUST00000130366]
[ENSMUST00000131462]
|
| AlphaFold |
Q8CJH3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000072093
AA Change: V223A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000071966
Gene: ENSMUSG00000053646
AA Change: V223A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Sema
|
35 |
463 |
5.84e-101 |
SMART |
|
PSI
|
481 |
534 |
1.17e-13 |
SMART |
|
PSI
|
628 |
678 |
6.97e-3 |
SMART |
|
low complexity region
|
691 |
706 |
N/A |
INTRINSIC |
|
low complexity region
|
752 |
771 |
N/A |
INTRINSIC |
|
PSI
|
1019 |
1066 |
2.06e-5 |
SMART |
|
IPT
|
1067 |
1158 |
7.48e-18 |
SMART |
|
IPT
|
1159 |
1247 |
3.97e-22 |
SMART |
|
IPT
|
1249 |
1359 |
6.09e-9 |
SMART |
|
low complexity region
|
1483 |
1494 |
N/A |
INTRINSIC |
|
Pfam:Plexin_cytopl
|
1546 |
2086 |
6.5e-230 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000130366
|
| SMART Domains |
Protein: ENSMUSP00000114358
Gene: ENSMUSG00000053646
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:Sema
|
35 |
138 |
7.5e-11 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000131462
|
| SMART Domains |
Protein: ENSMUSP00000115265
Gene: ENSMUSG00000053646
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:Sema
|
35 |
138 |
7.5e-11 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000134690
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000192988
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000195364
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.9%
- 10x: 95.4%
- 20x: 92.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Homozygous null mutants are viable and fertile and show no apparent defects in development, adult histology or basic functional parameters. However, a transitory renal phenotype, characterized by increased ureteric branching and enlarged kidneys, is noted over early stages of renal development. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca8a |
A |
G |
11: 109,941,792 (GRCm39) |
I1159T |
probably benign |
Het |
| Abcc1 |
T |
C |
16: 14,283,001 (GRCm39) |
V1159A |
possibly damaging |
Het |
| Abcg5 |
A |
G |
17: 84,981,007 (GRCm39) |
I194T |
probably damaging |
Het |
| Abtb2 |
A |
G |
2: 103,397,369 (GRCm39) |
T100A |
probably benign |
Het |
| Adam4 |
C |
T |
12: 81,468,068 (GRCm39) |
M184I |
probably benign |
Het |
| Afap1l2 |
T |
C |
19: 56,916,841 (GRCm39) |
D155G |
probably damaging |
Het |
| Ahnak |
T |
C |
19: 8,979,802 (GRCm39) |
V362A |
possibly damaging |
Het |
| Ak7 |
C |
T |
12: 105,692,482 (GRCm39) |
R179* |
probably null |
Het |
| Akap8 |
C |
A |
17: 32,534,451 (GRCm39) |
G332C |
probably damaging |
Het |
| Akr1e1 |
T |
A |
13: 4,645,071 (GRCm39) |
Q204L |
probably damaging |
Het |
| Ankrd12 |
T |
C |
17: 66,293,222 (GRCm39) |
E737G |
possibly damaging |
Het |
| Atrn |
A |
G |
2: 130,814,208 (GRCm39) |
D718G |
probably benign |
Het |
| Bco2 |
A |
G |
9: 50,452,469 (GRCm39) |
S200P |
possibly damaging |
Het |
| C030005K15Rik |
A |
T |
10: 97,561,648 (GRCm39) |
S28T |
unknown |
Het |
| Cdc14a |
T |
A |
3: 116,092,122 (GRCm39) |
Q356L |
possibly damaging |
Het |
| Cdk5rap3 |
A |
G |
11: 96,799,654 (GRCm39) |
L387P |
probably damaging |
Het |
| Celsr1 |
A |
T |
15: 85,914,524 (GRCm39) |
S1150T |
probably damaging |
Het |
| Cntfr |
A |
G |
4: 41,670,841 (GRCm39) |
|
probably null |
Het |
| Cramp1 |
T |
C |
17: 25,183,884 (GRCm39) |
N1244D |
probably damaging |
Het |
| Csmd3 |
G |
T |
15: 47,721,316 (GRCm39) |
D1542E |
possibly damaging |
Het |
| Cyp4f17 |
A |
T |
17: 32,736,943 (GRCm39) |
I92F |
probably benign |
Het |
| Dhx30 |
A |
T |
9: 109,937,051 (GRCm39) |
|
probably null |
Het |
| Dlg1 |
T |
A |
16: 31,561,965 (GRCm39) |
H120Q |
probably benign |
Het |
| Dmgdh |
A |
T |
13: 93,843,207 (GRCm39) |
M348L |
probably benign |
Het |
| Dnmt3b |
G |
A |
2: 153,525,559 (GRCm39) |
E741K |
possibly damaging |
Het |
| Dock3 |
T |
G |
9: 106,902,534 (GRCm39) |
H292P |
probably damaging |
Het |
| Ercc6 |
T |
A |
14: 32,238,985 (GRCm39) |
N24K |
probably benign |
Het |
| Esco2 |
T |
C |
14: 66,064,726 (GRCm39) |
Q338R |
probably benign |
Het |
| Etl4 |
T |
C |
2: 20,812,837 (GRCm39) |
|
probably null |
Het |
| Exoc7 |
A |
T |
11: 116,183,347 (GRCm39) |
I498N |
probably damaging |
Het |
| Fap |
G |
A |
2: 62,378,933 (GRCm39) |
S123L |
probably damaging |
Het |
| Foxn1 |
T |
C |
11: 78,262,051 (GRCm39) |
E106G |
probably benign |
Het |
| Fscb |
T |
A |
12: 64,521,175 (GRCm39) |
D97V |
probably damaging |
Het |
| Gabrg1 |
T |
C |
5: 70,939,596 (GRCm39) |
T174A |
possibly damaging |
Het |
| Gan |
C |
T |
8: 117,923,199 (GRCm39) |
A461V |
possibly damaging |
Het |
| Gbp2 |
T |
A |
3: 142,336,284 (GRCm39) |
D211E |
possibly damaging |
Het |
| Gm10271 |
A |
T |
10: 116,792,746 (GRCm39) |
Y47N |
unknown |
Het |
| Gm17333 |
G |
T |
16: 77,649,711 (GRCm39) |
|
noncoding transcript |
Het |
| Gm1758 |
T |
A |
16: 14,320,142 (GRCm39) |
|
noncoding transcript |
Het |
| Golga3 |
A |
G |
5: 110,355,493 (GRCm39) |
K989R |
possibly damaging |
Het |
| Gucy2g |
C |
A |
19: 55,187,973 (GRCm39) |
V1041F |
probably damaging |
Het |
| Guk1 |
A |
T |
11: 59,077,639 (GRCm39) |
F25I |
probably benign |
Het |
| H2al1o |
C |
T |
X: 9,438,329 (GRCm39) |
E87K |
possibly damaging |
Het |
| Hemgn |
C |
A |
4: 46,395,958 (GRCm39) |
C426F |
probably damaging |
Het |
| Hps3 |
A |
G |
3: 20,066,859 (GRCm39) |
|
probably null |
Het |
| Il2rb |
A |
T |
15: 78,368,187 (GRCm39) |
D287E |
probably damaging |
Het |
| Ino80 |
A |
T |
2: 119,237,340 (GRCm39) |
V1123D |
probably damaging |
Het |
| Kdm2b |
A |
G |
5: 123,122,523 (GRCm39) |
|
probably null |
Het |
| Kif21a |
A |
T |
15: 90,856,930 (GRCm39) |
|
probably null |
Het |
| Klhl33 |
A |
T |
14: 51,129,583 (GRCm39) |
N347K |
probably damaging |
Het |
| Krt1c |
A |
G |
15: 101,724,861 (GRCm39) |
F250L |
possibly damaging |
Het |
| Krt82 |
T |
A |
15: 101,451,819 (GRCm39) |
N332I |
possibly damaging |
Het |
| Lgi1 |
A |
G |
19: 38,294,631 (GRCm39) |
I444V |
probably benign |
Het |
| Lmod1 |
G |
A |
1: 135,252,862 (GRCm39) |
V39M |
probably damaging |
Het |
| Lonrf2 |
G |
A |
1: 38,852,357 (GRCm39) |
P165S |
probably benign |
Het |
| Mex3d |
T |
C |
10: 80,217,376 (GRCm39) |
T149A |
probably benign |
Het |
| Mideas |
A |
G |
12: 84,205,748 (GRCm39) |
|
probably null |
Het |
| Mlxipl |
A |
C |
5: 135,136,024 (GRCm39) |
D83A |
probably damaging |
Het |
| Mroh8 |
T |
A |
2: 157,111,471 (GRCm39) |
E161V |
probably benign |
Het |
| Mroh9 |
G |
A |
1: 162,884,347 (GRCm39) |
T397I |
probably damaging |
Het |
| Mtss1 |
T |
C |
15: 58,930,249 (GRCm39) |
D32G |
possibly damaging |
Het |
| Mus81 |
T |
C |
19: 5,533,504 (GRCm39) |
D495G |
probably benign |
Het |
| Neurod1 |
A |
C |
2: 79,284,673 (GRCm39) |
S237A |
probably benign |
Het |
| Npas1 |
G |
A |
7: 16,208,725 (GRCm39) |
R51C |
probably damaging |
Het |
| Or11g27 |
T |
C |
14: 50,771,159 (GRCm39) |
S97P |
possibly damaging |
Het |
| P2ry14 |
T |
C |
3: 59,023,274 (GRCm39) |
N62S |
probably damaging |
Het |
| Pcdh15 |
A |
G |
10: 74,460,087 (GRCm39) |
Y1308C |
probably damaging |
Het |
| Pcdhb14 |
A |
T |
18: 37,582,588 (GRCm39) |
M565L |
probably benign |
Het |
| Pde6a |
A |
G |
18: 61,390,283 (GRCm39) |
E502G |
probably damaging |
Het |
| Pde8b |
A |
G |
13: 95,178,527 (GRCm39) |
V566A |
probably benign |
Het |
| Phf11b |
G |
T |
14: 59,565,554 (GRCm39) |
Q108K |
probably benign |
Het |
| Pikfyve |
T |
C |
1: 65,291,716 (GRCm39) |
Y1312H |
probably damaging |
Het |
| Plcb3 |
T |
C |
19: 6,933,381 (GRCm39) |
|
probably benign |
Het |
| Plxna2 |
G |
A |
1: 194,488,611 (GRCm39) |
G1629D |
probably damaging |
Het |
| Prkca |
A |
T |
11: 107,903,518 (GRCm39) |
Y285N |
possibly damaging |
Het |
| Prl2a1 |
A |
T |
13: 27,992,554 (GRCm39) |
N226I |
probably damaging |
Het |
| Pus7 |
A |
C |
5: 23,946,914 (GRCm39) |
M636R |
probably damaging |
Het |
| Samd9l |
G |
A |
6: 3,375,264 (GRCm39) |
Q666* |
probably null |
Het |
| Sema3d |
A |
G |
5: 12,634,854 (GRCm39) |
D640G |
probably benign |
Het |
| Slc6a15 |
A |
G |
10: 103,236,121 (GRCm39) |
I279V |
probably benign |
Het |
| Slk |
T |
C |
19: 47,608,973 (GRCm39) |
V642A |
possibly damaging |
Het |
| Spata31e2 |
C |
A |
1: 26,722,070 (GRCm39) |
G1037* |
probably null |
Het |
| Spta1 |
T |
A |
1: 174,073,296 (GRCm39) |
M2305K |
probably damaging |
Het |
| Srrt |
T |
C |
5: 137,301,274 (GRCm39) |
|
probably benign |
Het |
| Stfa2l1 |
A |
T |
16: 35,977,228 (GRCm39) |
I8L |
probably benign |
Het |
| Tap1 |
T |
C |
17: 34,413,899 (GRCm39) |
L638P |
probably benign |
Het |
| Tbccd1 |
A |
T |
16: 22,640,995 (GRCm39) |
L461M |
probably benign |
Het |
| Tecta |
T |
C |
9: 42,289,345 (GRCm39) |
T407A |
probably benign |
Het |
| Tmbim7 |
T |
C |
5: 3,707,493 (GRCm39) |
|
probably null |
Het |
| Tnrc18 |
C |
A |
5: 142,800,869 (GRCm39) |
V30L |
probably benign |
Het |
| Tomm7 |
A |
G |
5: 24,049,025 (GRCm39) |
F16S |
probably damaging |
Het |
| Ugt2a2 |
A |
G |
5: 87,622,315 (GRCm39) |
S428P |
probably benign |
Het |
| Vmn1r189 |
T |
C |
13: 22,286,324 (GRCm39) |
E171G |
probably benign |
Het |
| Vmn1r61 |
T |
C |
7: 5,614,324 (GRCm39) |
|
probably benign |
Het |
| Vmn2r120 |
A |
T |
17: 57,832,038 (GRCm39) |
S250R |
probably benign |
Het |
| Vmn2r8 |
T |
C |
5: 108,950,972 (GRCm39) |
R158G |
probably benign |
Het |
| Vmn2r98 |
A |
T |
17: 19,286,702 (GRCm39) |
Y400F |
probably damaging |
Het |
| Vps13c |
C |
A |
9: 67,801,267 (GRCm39) |
Y582* |
probably null |
Het |
| Zfp518a |
T |
A |
19: 40,904,000 (GRCm39) |
F1310I |
probably benign |
Het |
| Zswim1 |
A |
G |
2: 164,667,320 (GRCm39) |
I191V |
probably benign |
Het |
|
| Other mutations in Plxnb1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00593:Plxnb1
|
APN |
9 |
108,942,936 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01014:Plxnb1
|
APN |
9 |
108,935,102 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01142:Plxnb1
|
APN |
9 |
108,931,765 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01454:Plxnb1
|
APN |
9 |
108,942,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01469:Plxnb1
|
APN |
9 |
108,934,483 (GRCm39) |
intron |
probably benign |
|
|
IGL01530:Plxnb1
|
APN |
9 |
108,939,473 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01599:Plxnb1
|
APN |
9 |
108,939,672 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01968:Plxnb1
|
APN |
9 |
108,930,052 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02175:Plxnb1
|
APN |
9 |
108,929,914 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL02216:Plxnb1
|
APN |
9 |
108,929,918 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02277:Plxnb1
|
APN |
9 |
108,941,201 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02311:Plxnb1
|
APN |
9 |
108,930,190 (GRCm39) |
missense |
probably benign |
|
|
IGL02645:Plxnb1
|
APN |
9 |
108,943,311 (GRCm39) |
splice site |
probably benign |
|
|
IGL03076:Plxnb1
|
APN |
9 |
108,935,970 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03107:Plxnb1
|
APN |
9 |
108,934,054 (GRCm39) |
missense |
probably benign |
|
|
IGL03343:Plxnb1
|
APN |
9 |
108,943,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4431001:Plxnb1
|
UTSW |
9 |
108,929,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0117:Plxnb1
|
UTSW |
9 |
108,934,286 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0211:Plxnb1
|
UTSW |
9 |
108,932,731 (GRCm39) |
nonsense |
probably null |
|
|
R0211:Plxnb1
|
UTSW |
9 |
108,932,731 (GRCm39) |
nonsense |
probably null |
|
|
R0843:Plxnb1
|
UTSW |
9 |
108,942,769 (GRCm39) |
missense |
probably benign |
0.20 |
|
R0970:Plxnb1
|
UTSW |
9 |
108,932,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0973:Plxnb1
|
UTSW |
9 |
108,931,210 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R1342:Plxnb1
|
UTSW |
9 |
108,929,720 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1386:Plxnb1
|
UTSW |
9 |
108,930,091 (GRCm39) |
missense |
probably benign |
0.27 |
|
R1419:Plxnb1
|
UTSW |
9 |
108,943,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1445:Plxnb1
|
UTSW |
9 |
108,937,989 (GRCm39) |
missense |
probably null |
|
|
R1548:Plxnb1
|
UTSW |
9 |
108,929,968 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1621:Plxnb1
|
UTSW |
9 |
108,935,873 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1658:Plxnb1
|
UTSW |
9 |
108,931,939 (GRCm39) |
nonsense |
probably null |
|
|
R1727:Plxnb1
|
UTSW |
9 |
108,930,125 (GRCm39) |
splice site |
probably null |
|
|
R1750:Plxnb1
|
UTSW |
9 |
108,940,836 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1929:Plxnb1
|
UTSW |
9 |
108,931,776 (GRCm39) |
splice site |
probably null |
|
|
R1935:Plxnb1
|
UTSW |
9 |
108,924,715 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1936:Plxnb1
|
UTSW |
9 |
108,924,715 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2014:Plxnb1
|
UTSW |
9 |
108,935,687 (GRCm39) |
splice site |
probably benign |
|
|
R2057:Plxnb1
|
UTSW |
9 |
108,938,294 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R2102:Plxnb1
|
UTSW |
9 |
108,944,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2271:Plxnb1
|
UTSW |
9 |
108,931,776 (GRCm39) |
splice site |
probably null |
|
|
R2422:Plxnb1
|
UTSW |
9 |
108,937,506 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2881:Plxnb1
|
UTSW |
9 |
108,943,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3409:Plxnb1
|
UTSW |
9 |
108,935,681 (GRCm39) |
splice site |
probably null |
|
|
R3417:Plxnb1
|
UTSW |
9 |
108,929,828 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3756:Plxnb1
|
UTSW |
9 |
108,942,526 (GRCm39) |
unclassified |
probably benign |
|
|
R3788:Plxnb1
|
UTSW |
9 |
108,938,355 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R3789:Plxnb1
|
UTSW |
9 |
108,938,355 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4042:Plxnb1
|
UTSW |
9 |
108,934,241 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4289:Plxnb1
|
UTSW |
9 |
108,943,420 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4396:Plxnb1
|
UTSW |
9 |
108,929,291 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R4564:Plxnb1
|
UTSW |
9 |
108,942,488 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4676:Plxnb1
|
UTSW |
9 |
108,939,503 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R4706:Plxnb1
|
UTSW |
9 |
108,941,096 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4792:Plxnb1
|
UTSW |
9 |
108,939,716 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4796:Plxnb1
|
UTSW |
9 |
108,943,663 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4835:Plxnb1
|
UTSW |
9 |
108,934,442 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4901:Plxnb1
|
UTSW |
9 |
108,934,027 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4952:Plxnb1
|
UTSW |
9 |
108,943,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5005:Plxnb1
|
UTSW |
9 |
108,935,647 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5015:Plxnb1
|
UTSW |
9 |
108,929,498 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5029:Plxnb1
|
UTSW |
9 |
108,943,723 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5180:Plxnb1
|
UTSW |
9 |
108,940,761 (GRCm39) |
splice site |
probably null |
|
|
R5256:Plxnb1
|
UTSW |
9 |
108,943,661 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5285:Plxnb1
|
UTSW |
9 |
108,937,527 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5431:Plxnb1
|
UTSW |
9 |
108,929,840 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5444:Plxnb1
|
UTSW |
9 |
108,935,521 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5546:Plxnb1
|
UTSW |
9 |
108,929,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5852:Plxnb1
|
UTSW |
9 |
108,935,518 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5892:Plxnb1
|
UTSW |
9 |
108,940,775 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6020:Plxnb1
|
UTSW |
9 |
108,945,679 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6053:Plxnb1
|
UTSW |
9 |
108,940,775 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6177:Plxnb1
|
UTSW |
9 |
108,931,993 (GRCm39) |
splice site |
probably null |
|
|
R6193:Plxnb1
|
UTSW |
9 |
108,933,971 (GRCm39) |
missense |
probably benign |
|
|
R6274:Plxnb1
|
UTSW |
9 |
108,941,209 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6310:Plxnb1
|
UTSW |
9 |
108,938,796 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6404:Plxnb1
|
UTSW |
9 |
108,945,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6422:Plxnb1
|
UTSW |
9 |
108,937,992 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6479:Plxnb1
|
UTSW |
9 |
108,940,733 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6555:Plxnb1
|
UTSW |
9 |
108,937,473 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6646:Plxnb1
|
UTSW |
9 |
108,937,895 (GRCm39) |
missense |
probably benign |
|
|
R6648:Plxnb1
|
UTSW |
9 |
108,933,398 (GRCm39) |
missense |
probably benign |
0.14 |
|
R6661:Plxnb1
|
UTSW |
9 |
108,933,367 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6674:Plxnb1
|
UTSW |
9 |
108,937,214 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6734:Plxnb1
|
UTSW |
9 |
108,937,988 (GRCm39) |
nonsense |
probably null |
|
|
R6859:Plxnb1
|
UTSW |
9 |
108,935,838 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6948:Plxnb1
|
UTSW |
9 |
108,945,702 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7030:Plxnb1
|
UTSW |
9 |
108,941,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7038:Plxnb1
|
UTSW |
9 |
108,929,453 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7204:Plxnb1
|
UTSW |
9 |
108,929,243 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7427:Plxnb1
|
UTSW |
9 |
108,937,236 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7428:Plxnb1
|
UTSW |
9 |
108,937,236 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7443:Plxnb1
|
UTSW |
9 |
108,943,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7527:Plxnb1
|
UTSW |
9 |
108,929,929 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7645:Plxnb1
|
UTSW |
9 |
108,943,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7680:Plxnb1
|
UTSW |
9 |
108,929,571 (GRCm39) |
nonsense |
probably null |
|
|
R7866:Plxnb1
|
UTSW |
9 |
108,929,525 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7898:Plxnb1
|
UTSW |
9 |
108,943,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7905:Plxnb1
|
UTSW |
9 |
108,938,300 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8092:Plxnb1
|
UTSW |
9 |
108,929,573 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8150:Plxnb1
|
UTSW |
9 |
108,941,146 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8286:Plxnb1
|
UTSW |
9 |
108,935,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8290:Plxnb1
|
UTSW |
9 |
108,938,687 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8987:Plxnb1
|
UTSW |
9 |
108,937,178 (GRCm39) |
splice site |
probably benign |
|
|
R9176:Plxnb1
|
UTSW |
9 |
108,941,651 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9231:Plxnb1
|
UTSW |
9 |
108,934,286 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R9698:Plxnb1
|
UTSW |
9 |
108,925,251 (GRCm39) |
start gained |
probably benign |
|
|
Z1177:Plxnb1
|
UTSW |
9 |
108,937,989 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACCCTGCAGTCAGTACAGTG -3'
(R):5'- ACAGCTGCAGCCTGGATAAG -3'
Sequencing Primer
(F):5'- GAGCCCCTCCTGTTTGTGG -3'
(R):5'- TGCAGCCTGGATAAGACCGTAAC -3'
|
| Posted On |
2014-06-23 |
Incidental Mutation