Mutagenetix > Incidental Mutation

Incidental Mutation 'R0091:Vmn2r104'

20244

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r104

Ensembl Gene

ENSMUSG00000090315

Gene Name

vomeronasal 2, receptor 104

Synonyms

V2r7

MMRRC Submission

038378-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.124) question?

Stock #

R0091 (G1)

Quality Score

175

Status

Validated (trace)

Chromosome

Chromosomal Location

20029425-20048205 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 20041813 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 352 (I352F)

Ref Sequence

ENSEMBL: ENSMUSP00000129895 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168050]

AlphaFold

E9Q2J5

Predicted Effect

possibly damaging
Transcript: ENSMUST00000168050
AA Change: I352F

PolyPhen 2 Score 0.793 (Sensitivity: 0.85; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000129895
Gene: ENSMUSG00000090315
AA Change: I352F

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	85	457	4e-38	PFAM
Pfam:NCD3G	512	565	2.1e-20	PFAM
Pfam:7tm_3	598	833	1.7e-52	PFAM

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.1%
3x: 97.9%
10x: 94.4%
20x: 84.5%

Validation Efficiency

98% (86/88)

Allele List at MGI

Other mutations in this stock

Total: 70 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca4	T	C	3: 122,138,530	S278P	possibly damaging	Het
Adam11	A	G	11: 102,772,839	Y281C	probably damaging	Het
Adam6a	G	T	12: 113,544,229	R74L	possibly damaging	Het
Adcy5	T	C	16: 35,270,998		probably null	Het
Adrb2	A	G	18: 62,179,019	L245P	probably benign	Het
Aebp2	T	C	6: 140,644,074		probably null	Het
Arhgap23	A	G	11: 97,452,244	T240A	probably benign	Het
Atp10a	T	C	7: 58,774,046		probably benign	Het
Atp13a4	T	A	16: 29,455,395	Y416F	probably damaging	Het
Atp5g2	A	C	15: 102,663,057	L133R	probably damaging	Het
Bicral	A	T	17: 46,825,307	Y326N	probably damaging	Het
Chst4	T	C	8: 110,030,665	S189G	probably damaging	Het
Cnot1	A	T	8: 95,763,144	I477N	probably damaging	Het
Col7a1	G	T	9: 108,967,506		probably benign	Het
Dchs1	A	G	7: 105,766,094		probably benign	Het
Dcn	A	G	10: 97,506,689	N169S	probably benign	Het
Dnajc6	T	C	4: 101,616,777		probably benign	Het
Egln3	A	G	12: 54,181,646	F225L	probably benign	Het
Erap1	G	A	13: 74,668,052	R100Q	possibly damaging	Het
Erc2	A	T	14: 27,776,824		probably null	Het
Fto	G	A	8: 91,441,807		probably null	Het
Gdap1l1	C	T	2: 163,446,091	P80S	probably damaging	Het
Gm1123	T	C	9: 99,023,352	E35G	possibly damaging	Het
Hhipl1	A	G	12: 108,321,897		probably benign	Het
Ift80	A	T	3: 68,914,675	L679Q	probably damaging	Het
Il18	A	G	9: 50,576,713		probably benign	Het
Inhbb	T	C	1: 119,417,395	Y388C	probably damaging	Het
Kmt2d	G	T	15: 98,844,479		probably benign	Het
Krt20	A	G	11: 99,437,814	V95A	probably damaging	Het
Lck	A	T	4: 129,555,681	S274R	possibly damaging	Het
Lrp1	T	A	10: 127,540,979	N4243I	probably damaging	Het
Lrrfip2	G	A	9: 111,214,243	V506I	probably damaging	Het
Ltbp2	A	G	12: 84,793,733	C1000R	probably damaging	Het
Matn3	G	A	12: 8,952,105	D106N	probably damaging	Het
Micalcl	A	G	7: 112,381,296	E49G	probably benign	Het
Mmadhc	A	G	2: 50,292,857	S36P	probably damaging	Het
Morn1	T	C	4: 155,145,172	Y433H	probably damaging	Het
Mpo	A	G	11: 87,801,610	M525V	probably benign	Het
Myo5a	C	T	9: 75,161,492	R659C	probably damaging	Het
Obox6	T	C	7: 15,834,439	S171G	probably benign	Het
Olfr1280	T	A	2: 111,316,173	D231E	probably benign	Het
Olfr347	A	G	2: 36,734,905	N195D	probably damaging	Het
Olfr998	A	T	2: 85,591,352	N271Y	probably benign	Het
P2ry14	A	G	3: 59,115,893	Y49H	probably benign	Het
Papss2	C	T	19: 32,633,902	T17I	possibly damaging	Het
Pcid2	T	C	8: 13,085,392	T206A	probably benign	Het
Pex6	A	G	17: 46,711,918	E140G	probably damaging	Het
Ppp1r3b	A	G	8: 35,384,667	Y220C	probably damaging	Het
Prdx2	T	G	8: 84,971,701		probably benign	Het
Ptbp2	A	T	3: 119,720,661	L471Q	probably damaging	Het
Rbm33	T	A	5: 28,352,606	D232E	possibly damaging	Het
Rnf214	T	A	9: 45,898,493		probably null	Het
Rora	G	A	9: 69,374,048	R314H	probably damaging	Het
Rufy4	T	C	1: 74,128,936		probably benign	Het
Sag	T	C	1: 87,814,680	V58A	probably damaging	Het
Serpina3i	C	T	12: 104,265,164	T20M	probably damaging	Het
Slc4a5	A	G	6: 83,277,555	N578S	probably benign	Het
Soat2	A	G	15: 102,158,139	Y285C	probably damaging	Het
Syk	A	G	13: 52,640,733	Y478C	probably damaging	Het
Syne4	G	A	7: 30,318,919	G362E	probably damaging	Het
Tas2r126	A	T	6: 42,435,102	M190L	probably benign	Het
Tnfrsf21	C	T	17: 43,038,213	H239Y	probably benign	Het
Ttc19	A	G	11: 62,309,084	D218G	probably damaging	Het
Tut1	T	C	19: 8,965,436	V629A	probably damaging	Het
Txndc11	T	C	16: 11,088,104	N521D	probably benign	Het
Ushbp1	T	C	8: 71,388,970	E405G	possibly damaging	Het
Usp46	C	T	5: 74,003,257	R246Q	probably benign	Het
Utrn	T	C	10: 12,735,204	D469G	probably damaging	Het
Wdr4	G	A	17: 31,496,916	T398I	probably benign	Het
Ythdc1	T	A	5: 86,820,701		probably benign	Het

Other mutations in Vmn2r104

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00427:Vmn2r104	APN	17	20038239	missense	probably damaging	0.98
IGL01098:Vmn2r104	APN	17	20048096	missense	probably benign	0.27
IGL01333:Vmn2r104	APN	17	20042793	missense	probably benign	0.17
IGL01527:Vmn2r104	APN	17	20042896	missense	possibly damaging	0.82
IGL01773:Vmn2r104	APN	17	20040668	missense	probably benign	0.10
IGL01939:Vmn2r104	APN	17	20029925	missense	probably damaging	0.99
IGL02121:Vmn2r104	APN	17	20041794	nonsense	probably null
IGL02305:Vmn2r104	APN	17	20042856	missense	probably benign	0.09
IGL02374:Vmn2r104	APN	17	20042786	missense	probably benign	0.34
IGL03260:Vmn2r104	APN	17	20042821	missense	probably benign	0.05
IGL03366:Vmn2r104	APN	17	20029604	missense	probably damaging	1.00
R0125:Vmn2r104	UTSW	17	20029807	missense	probably damaging	0.98
R0257:Vmn2r104	UTSW	17	20029627	missense	probably damaging	1.00
R0381:Vmn2r104	UTSW	17	20048002	nonsense	probably null
R0709:Vmn2r104	UTSW	17	20042904	missense	probably damaging	1.00
R0786:Vmn2r104	UTSW	17	20042725	missense	probably benign
R1575:Vmn2r104	UTSW	17	20042215	missense	probably damaging	1.00
R1827:Vmn2r104	UTSW	17	20042235	missense	probably damaging	0.97
R1932:Vmn2r104	UTSW	17	20040769	missense	probably damaging	1.00
R1956:Vmn2r104	UTSW	17	20042051	missense	probably damaging	0.98
R2203:Vmn2r104	UTSW	17	20029821	missense	probably benign	0.05
R2205:Vmn2r104	UTSW	17	20029821	missense	probably benign	0.05
R2859:Vmn2r104	UTSW	17	20048193	missense	possibly damaging	0.82
R3701:Vmn2r104	UTSW	17	20029556	missense	probably damaging	1.00
R3834:Vmn2r104	UTSW	17	20029921	missense	probably benign	0.02
R4151:Vmn2r104	UTSW	17	20029885	missense	probably damaging	1.00
R4470:Vmn2r104	UTSW	17	20042241	missense	probably damaging	1.00
R4625:Vmn2r104	UTSW	17	20048181	missense	probably benign	0.00
R4754:Vmn2r104	UTSW	17	20040768	nonsense	probably null
R4911:Vmn2r104	UTSW	17	20030026	missense	probably benign	0.00
R5270:Vmn2r104	UTSW	17	20038266	missense	probably damaging	1.00
R5279:Vmn2r104	UTSW	17	20041884	missense	probably benign	0.07
R5311:Vmn2r104	UTSW	17	20029901	missense	probably damaging	1.00
R5370:Vmn2r104	UTSW	17	20030188	missense	probably damaging	0.97
R5461:Vmn2r104	UTSW	17	20030081	missense	probably damaging	1.00
R5683:Vmn2r104	UTSW	17	20040719	nonsense	probably null
R5795:Vmn2r104	UTSW	17	20030110	missense	probably benign	0.02
R5795:Vmn2r104	UTSW	17	20030282	missense	possibly damaging	0.89
R5970:Vmn2r104	UTSW	17	20029471	missense	probably benign	0.01
R5983:Vmn2r104	UTSW	17	20041708	missense	probably damaging	1.00
R5992:Vmn2r104	UTSW	17	20029485	missense	probably damaging	1.00
R6066:Vmn2r104	UTSW	17	20038311	missense	possibly damaging	0.69
R6156:Vmn2r104	UTSW	17	20041647	missense	probably damaging	1.00
R6182:Vmn2r104	UTSW	17	20030245	missense	probably benign	0.16
R6245:Vmn2r104	UTSW	17	20041567	missense	possibly damaging	0.69
R6333:Vmn2r104	UTSW	17	20029586	missense	probably benign	0.30
R6573:Vmn2r104	UTSW	17	20042225	missense	probably damaging	1.00
R7101:Vmn2r104	UTSW	17	20030096	missense	possibly damaging	0.65
R7123:Vmn2r104	UTSW	17	20040826	missense	probably benign	0.12
R7485:Vmn2r104	UTSW	17	20029475	missense	probably benign	0.01
R7514:Vmn2r104	UTSW	17	20029529	missense	probably damaging	1.00
R7634:Vmn2r104	UTSW	17	20041709	missense	possibly damaging	0.48
R7958:Vmn2r104	UTSW	17	20042726	missense	probably benign
R8031:Vmn2r104	UTSW	17	20042786	missense	probably benign	0.34
R8094:Vmn2r104	UTSW	17	20030221	missense	possibly damaging	0.77
R8191:Vmn2r104	UTSW	17	20030203	missense	possibly damaging	0.89
R8308:Vmn2r104	UTSW	17	20040778	missense	possibly damaging	0.55
R8691:Vmn2r104	UTSW	17	20041848	missense	probably damaging	0.98
R8795:Vmn2r104	UTSW	17	20042726	missense	probably benign
R8900:Vmn2r104	UTSW	17	20041662	missense	probably damaging	0.99
R8913:Vmn2r104	UTSW	17	20029706	missense	probably damaging	1.00
R9180:Vmn2r104	UTSW	17	20042825	missense	probably benign	0.00
R9199:Vmn2r104	UTSW	17	20041835	missense	probably damaging	0.99
R9282:Vmn2r104	UTSW	17	20040836	missense	probably damaging	1.00
R9303:Vmn2r104	UTSW	17	20048177	missense	possibly damaging	0.90
R9305:Vmn2r104	UTSW	17	20048177	missense	possibly damaging	0.90
R9322:Vmn2r104	UTSW	17	20042825	missense	probably benign	0.00
R9325:Vmn2r104	UTSW	17	20048171	missense	possibly damaging	0.95
R9414:Vmn2r104	UTSW	17	20029988	missense	probably damaging	0.99
R9785:Vmn2r104	UTSW	17	20048147	missense	probably benign
RF007:Vmn2r104	UTSW	17	20048040	missense	probably benign	0.36
Z1177:Vmn2r104	UTSW	17	20029789	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GCTGTGAGCCAGAGCATATACACC -3'
(R):5'- GATTGGCCTCATCATCCCCGATAAC -3'

Sequencing Primer
(F):5'- GTGCTCTCTTCACTCATGACA -3'
(R):5'- AGCCACATGGACCTCATATTTTAC -3'

Posted On

2013-04-11