Incidental Mutation 'R1812:Wdr70'
ID 202506
Institutional Source Beutler Lab
Gene Symbol Wdr70
Ensembl Gene ENSMUSG00000039828
Gene Name WD repeat domain 70
Synonyms 4833422F06Rik
MMRRC Submission 039840-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.966) question?
Stock # R1812 (G1)
Quality Score 225
Status Not validated
Chromosome 15
Chromosomal Location 7873055-8099209 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 8079179 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 161 (D161G)
Ref Sequence ENSEMBL: ENSMUSP00000037340 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045766]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000045766
AA Change: D161G

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000037340
Gene: ENSMUSG00000039828
AA Change: D161G

DomainStartEndE-ValueType
coiled coil region 51 81 N/A INTRINSIC
low complexity region 137 167 N/A INTRINSIC
WD40 174 213 1.61e-3 SMART
WD40 220 260 3.2e0 SMART
WD40 272 315 1.03e0 SMART
WD40 324 363 1.7e-2 SMART
WD40 367 409 1.38e-2 SMART
Blast:WD40 413 460 5e-16 BLAST
WD40 463 502 3.44e0 SMART
low complexity region 570 586 N/A INTRINSIC
Coding Region Coverage
  • 1x: 97.3%
  • 3x: 96.3%
  • 10x: 93.2%
  • 20x: 85.7%
Validation Efficiency 100% (1/1)
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017B05Rik G A 9: 57,257,457 (GRCm38) Q545* probably null Het
Aadacl2 T C 3: 60,025,077 (GRCm38) C338R probably damaging Het
Abcb4 G A 5: 8,928,578 (GRCm38) probably null Het
Adam17 T C 12: 21,361,767 (GRCm38) D41G probably damaging Het
Angptl7 T A 4: 148,498,083 (GRCm38) I119F probably damaging Het
Arid1b T A 17: 5,337,029 (GRCm38) S1586T probably benign Het
Arid4b C T 13: 14,195,429 (GRCm38) A1170V probably damaging Het
Atad5 A G 11: 80,133,047 (GRCm38) T1659A probably damaging Het
Bub1b T G 2: 118,632,421 (GRCm38) D754E probably benign Het
Cdkn1a T C 17: 29,098,565 (GRCm38) V53A probably benign Het
Chsy1 T G 7: 66,171,817 (GRCm38) V600G probably benign Het
Cntrl G A 2: 35,149,469 (GRCm38) V561M probably damaging Het
Col6a5 A G 9: 105,928,054 (GRCm38) C1218R unknown Het
Crhr1 T C 11: 104,169,147 (GRCm38) L140P probably damaging Het
Cyb5b CAGAG CAG 8: 107,170,388 (GRCm38) probably null Het
Cyp3a59 A T 5: 146,102,811 (GRCm38) Q298L probably damaging Het
Dctn1 A G 6: 83,192,518 (GRCm38) E638G possibly damaging Het
Ddx41 A G 13: 55,535,954 (GRCm38) I88T probably benign Het
Dennd11 A G 6: 40,409,431 (GRCm38) I288T probably benign Het
Diaph1 G T 18: 37,891,018 (GRCm38) P589Q unknown Het
Dip2b C A 15: 100,198,938 (GRCm38) probably null Het
Dscaml1 G A 9: 45,751,286 (GRCm38) probably null Het
Dync1h1 C T 12: 110,662,900 (GRCm38) A4246V possibly damaging Het
Epb41l1 T C 2: 156,496,511 (GRCm38) I158T probably damaging Het
Fat1 A G 8: 45,036,803 (GRCm38) Y3584C probably damaging Het
Fxyd5 T A 7: 31,037,930 (GRCm38) probably null Het
Gapvd1 T A 2: 34,725,064 (GRCm38) K336* probably null Het
Gm9637 G A 14: 19,402,395 (GRCm38) noncoding transcript Het
Gpr65 C T 12: 98,275,742 (GRCm38) T218M probably damaging Het
Gsdma3 T C 11: 98,632,393 (GRCm38) V203A probably damaging Het
Helb T A 10: 120,089,566 (GRCm38) K969* probably null Het
Hipk2 G A 6: 38,698,163 (GRCm38) A1188V probably benign Het
Itpk1 T A 12: 102,574,058 (GRCm38) E255D probably benign Het
Kif21a T C 15: 90,971,766 (GRCm38) D596G possibly damaging Het
Kif5a A T 10: 127,242,010 (GRCm38) I405N probably benign Het
Klk11 T A 7: 43,777,755 (GRCm38) probably null Het
Luzp1 T A 4: 136,542,331 (GRCm38) L622M probably benign Het
Macf1 T A 4: 123,432,024 (GRCm38) I5227F probably damaging Het
Mapk10 A C 5: 102,913,262 (GRCm38) S470A probably damaging Het
Morc2a C T 11: 3,685,831 (GRCm38) T897I probably damaging Het
Nmbr A G 10: 14,760,539 (GRCm38) probably null Het
Nosip T A 7: 45,076,574 (GRCm38) M214K probably damaging Het
Or13c7d G T 4: 43,770,230 (GRCm38) Y260* probably null Het
Or52m2 A T 7: 102,614,370 (GRCm38) N206K possibly damaging Het
Or52r1 T C 7: 102,888,078 (GRCm38) Y25C probably benign Het
Or5w13 A G 2: 87,693,103 (GRCm38) F260L probably benign Het
Pik3c2a A T 7: 116,417,664 (GRCm38) V286E probably damaging Het
Ppfia4 T A 1: 134,324,573 (GRCm38) I388F probably benign Het
Ppm1f A G 16: 16,917,787 (GRCm38) H289R probably damaging Het
Ptprz1 T A 6: 22,959,712 (GRCm38) D69E probably benign Het
Rad54b A T 4: 11,612,770 (GRCm38) T801S probably damaging Het
Ramp1 A T 1: 91,196,857 (GRCm38) N47Y probably damaging Het
Rnf32 T A 5: 29,206,260 (GRCm38) H181Q possibly damaging Het
Rpa2 T C 4: 132,768,685 (GRCm38) F6L probably benign Het
Ryr2 C A 13: 11,560,586 (GRCm38) R4842L probably damaging Het
Scn11a G T 9: 119,780,865 (GRCm38) C972* probably null Het
Setd2 C T 9: 110,550,102 (GRCm38) T995I probably damaging Het
Slc39a7 A G 17: 34,028,815 (GRCm38) L471P probably damaging Het
Slc6a21 C G 7: 45,282,947 (GRCm38) S350R probably damaging Het
Slx4ip A G 2: 137,068,195 (GRCm38) N300S probably benign Het
Spef2 G A 15: 9,679,349 (GRCm38) P634L probably damaging Het
Stk32b G A 5: 37,466,758 (GRCm38) A215V probably damaging Het
Svil A T 18: 5,097,545 (GRCm38) Y1676F probably damaging Het
Tanc1 G A 2: 59,791,679 (GRCm38) V381M probably damaging Het
Tanc2 T C 11: 105,886,386 (GRCm38) F797L probably benign Het
Tas2r120 T G 6: 132,657,601 (GRCm38) C215W probably benign Het
Tenm4 G A 7: 96,895,940 (GRCm38) D2388N probably damaging Het
Thsd4 C T 9: 60,056,937 (GRCm38) S64N probably damaging Het
Thsd7b C T 1: 129,758,610 (GRCm38) R630C probably damaging Het
Top3a A G 11: 60,759,362 (GRCm38) I145T probably damaging Het
Vmn2r78 A G 7: 86,920,787 (GRCm38) D171G probably benign Het
Vmn2r82 A G 10: 79,379,212 (GRCm38) E343G probably benign Het
Other mutations in Wdr70
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00777:Wdr70 APN 15 8,019,607 (GRCm38) missense probably benign 0.07
IGL01121:Wdr70 APN 15 7,873,174 (GRCm38) missense possibly damaging 0.53
IGL01508:Wdr70 APN 15 8,079,263 (GRCm38) missense probably benign 0.33
IGL01801:Wdr70 APN 15 7,887,324 (GRCm38) splice site probably null
IGL01815:Wdr70 APN 15 7,887,324 (GRCm38) splice site probably null
IGL01929:Wdr70 APN 15 7,920,634 (GRCm38) splice site probably null
IGL02150:Wdr70 APN 15 8,082,546 (GRCm38) missense possibly damaging 0.72
IGL02245:Wdr70 APN 15 8,046,482 (GRCm38) missense possibly damaging 0.86
IGL02541:Wdr70 APN 15 7,884,302 (GRCm38) nonsense probably null
IGL02800:Wdr70 APN 15 8,082,496 (GRCm38) missense probably benign 0.25
IGL02829:Wdr70 APN 15 7,976,982 (GRCm38) missense possibly damaging 0.92
IGL02831:Wdr70 APN 15 7,884,306 (GRCm38) missense possibly damaging 0.86
IGL03169:Wdr70 APN 15 7,884,340 (GRCm38) missense possibly damaging 0.73
IGL03405:Wdr70 APN 15 8,035,871 (GRCm38) missense possibly damaging 0.73
R0106:Wdr70 UTSW 15 8,019,587 (GRCm38) critical splice donor site probably null
R0106:Wdr70 UTSW 15 8,019,587 (GRCm38) critical splice donor site probably null
R0462:Wdr70 UTSW 15 8,079,161 (GRCm38) missense probably benign 0.00
R0539:Wdr70 UTSW 15 7,885,637 (GRCm38) missense possibly damaging 0.96
R1398:Wdr70 UTSW 15 8,035,844 (GRCm38) missense probably benign 0.01
R1863:Wdr70 UTSW 15 7,920,573 (GRCm38) missense probably benign 0.25
R1913:Wdr70 UTSW 15 7,884,410 (GRCm38) missense possibly damaging 0.72
R2425:Wdr70 UTSW 15 7,887,359 (GRCm38) nonsense probably null
R4013:Wdr70 UTSW 15 8,079,214 (GRCm38) nonsense probably null
R4015:Wdr70 UTSW 15 8,079,214 (GRCm38) nonsense probably null
R4017:Wdr70 UTSW 15 8,079,214 (GRCm38) nonsense probably null
R4111:Wdr70 UTSW 15 7,976,991 (GRCm38) missense probably benign 0.32
R5241:Wdr70 UTSW 15 8,079,216 (GRCm38) missense probably benign
R5277:Wdr70 UTSW 15 7,976,984 (GRCm38) nonsense probably null
R5306:Wdr70 UTSW 15 7,924,273 (GRCm38) missense probably benign 0.04
R5426:Wdr70 UTSW 15 7,922,105 (GRCm38) missense possibly damaging 0.59
R5586:Wdr70 UTSW 15 7,884,288 (GRCm38) missense possibly damaging 0.86
R6010:Wdr70 UTSW 15 7,887,419 (GRCm38) splice site probably null
R6035:Wdr70 UTSW 15 7,887,349 (GRCm38) missense possibly damaging 0.86
R6035:Wdr70 UTSW 15 7,887,349 (GRCm38) missense possibly damaging 0.86
R6109:Wdr70 UTSW 15 8,079,154 (GRCm38) splice site probably null
R6139:Wdr70 UTSW 15 8,079,251 (GRCm38) missense probably benign 0.04
R6400:Wdr70 UTSW 15 8,042,841 (GRCm38) missense probably benign 0.32
R6456:Wdr70 UTSW 15 7,885,637 (GRCm38) missense possibly damaging 0.96
R6518:Wdr70 UTSW 15 8,079,337 (GRCm38) missense unknown
R7036:Wdr70 UTSW 15 7,884,374 (GRCm38) missense possibly damaging 0.85
R7056:Wdr70 UTSW 15 7,884,396 (GRCm38) missense possibly damaging 0.53
R7341:Wdr70 UTSW 15 7,924,244 (GRCm38) missense possibly damaging 0.71
R7484:Wdr70 UTSW 15 7,922,081 (GRCm38) missense probably benign 0.23
R7572:Wdr70 UTSW 15 8,035,846 (GRCm38) missense possibly damaging 0.85
R7652:Wdr70 UTSW 15 8,079,216 (GRCm38) missense probably benign
R7886:Wdr70 UTSW 15 8,079,249 (GRCm38) missense probably benign 0.02
R8103:Wdr70 UTSW 15 7,977,131 (GRCm38) missense possibly damaging 0.70
R8214:Wdr70 UTSW 15 7,887,370 (GRCm38) missense probably benign 0.03
R8252:Wdr70 UTSW 15 8,042,856 (GRCm38) splice site probably benign
R8869:Wdr70 UTSW 15 8,093,726 (GRCm38) missense probably benign 0.02
R9203:Wdr70 UTSW 15 7,873,203 (GRCm38) missense probably benign
Predicted Primers PCR Primer
(F):5'- TAAACGACACGGTAGGATGC -3'
(R):5'- CAGTGAGAGTGACGACAGTTC -3'

Sequencing Primer
(F):5'- AACACTGTGGGTTCAAGCTC -3'
(R):5'- GACGACAGTTCTGATTCATCTGACG -3'
Posted On 2014-06-23