Mutagenetix > Incidental Mutation

Incidental Mutation 'R1813:Olfr890'

202562

Institutional Source

Beutler Lab

Gene Symbol

Olfr890

Ensembl Gene

ENSMUSG00000096409

Gene Name

olfactory receptor 890

Synonyms

MOR162-3, MOR162-15_p, GA_x6K02T2PVTD-31822365-31823309

MMRRC Submission

039841-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.058) question?

Stock #

R1813 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

38142517-38148375 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 38143729 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 198 (I198N)

Ref Sequence

ENSEMBL: ENSMUSP00000078733 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079804] [ENSMUST00000213087] [ENSMUST00000213458]

AlphaFold

Q7TRD9

Predicted Effect

possibly damaging
Transcript: ENSMUST00000079804
AA Change: I198N

PolyPhen 2 Score 0.780 (Sensitivity: 0.85; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000078733
Gene: ENSMUSG00000096409
AA Change: I198N

Domain	Start	End	E-Value	Type
Pfam:7tm_4	36	311	2.3e-48	PFAM
Pfam:7tm_1	46	293	9.6e-25	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000213087
AA Change: I193N

Predicted Effect

possibly damaging
Transcript: ENSMUST00000213458
AA Change: I193N

PolyPhen 2 Score 0.587 (Sensitivity: 0.87; Specificity: 0.91)

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 97.5%
3x: 96.8%
10x: 94.8%
20x: 90.3%

Validation Efficiency

96% (79/82)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 74 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2ml1	T	A	6: 128,566,273	N595Y	probably benign	Het
Abca6	A	G	11: 110,233,845		probably benign	Het
Abo	C	A	2: 26,843,597	D199Y	probably damaging	Het
Acvr1c	A	C	2: 58,280,294	V277G	probably damaging	Het
Adam23	G	A	1: 63,545,572	A380T	probably benign	Het
Art2b	A	G	7: 101,580,029	V221A	probably benign	Het
Bcam	A	G	7: 19,766,715	S153P	probably damaging	Het
Brip1	T	C	11: 86,187,080	H174R	possibly damaging	Het
Ccdc186	T	C	19: 56,800,169	D536G	probably benign	Het
Cd109	A	G	9: 78,617,005	N67S	probably benign	Het
Cd8a	G	T	6: 71,373,963	M137I	possibly damaging	Het
Ces2g	T	C	8: 104,966,937	F417L	probably benign	Het
Clec2g	A	G	6: 128,948,697	N23S	unknown	Het
Cntnap2	T	C	6: 46,530,633	Y61C	probably damaging	Het
Cog3	T	A	14: 75,742,344	E182D	probably benign	Het
Dbpht2	A	G	12: 74,295,850		noncoding transcript	Het
Dock4	A	T	12: 40,636,228	N154I	probably damaging	Het
Dysf	T	G	6: 84,151,924	V1422G	possibly damaging	Het
E2f3	T	C	13: 29,920,176	D140G	probably damaging	Het
Epb41l2	T	A	10: 25,441,568		probably null	Het
Epha2	A	G	4: 141,308,546	K98E	possibly damaging	Het
Esyt1	T	C	10: 128,519,618	D444G	probably benign	Het
Fam163a	T	C	1: 156,080,041	T2A	probably damaging	Het
Foxp2	A	T	6: 15,379,768		probably benign	Het
Gcm2	T	C	13: 41,105,891	H34R	probably benign	Het
Gipr	A	G	7: 19,164,071	S79P	probably benign	Het
Gli3	T	C	13: 15,648,691	S333P	probably damaging	Het
Gm10717	T	G	9: 3,026,317	F205C	probably damaging	Het
Gm11639	A	G	11: 104,720,688	K452R	probably benign	Het
Gzmk	A	G	13: 113,172,893	S208P	probably damaging	Het
Htra2	G	T	6: 83,051,602	A318D	probably damaging	Het
Itpkc	T	C	7: 27,208,380	D633G	probably damaging	Het
Lama1	G	A	17: 67,791,223	R1805H	probably benign	Het
Lama4	T	A	10: 39,033,125		probably benign	Het
Lama4	T	C	10: 39,060,186	V619A	probably damaging	Het
Notch3	T	C	17: 32,143,428	T1408A	probably benign	Het
Nwd2	A	G	5: 63,805,410	D779G	probably benign	Het
Nxpe4	A	G	9: 48,393,378	Y255C	possibly damaging	Het
Obox6	A	T	7: 15,834,845	H35Q	possibly damaging	Het
Olfr324	A	G	11: 58,598,307	I304V	probably damaging	Het
Pkig	T	A	2: 163,721,227	I26N	possibly damaging	Het
Plekhm2	C	T	4: 141,642,439	V82M	possibly damaging	Het
Plppr2	G	A	9: 21,947,924	A446T	probably damaging	Het
Psme4	T	A	11: 30,804,353	F203L	probably benign	Het
Sh3bp1	A	G	15: 78,903,680	K137E	probably damaging	Het
Shisa5	T	A	9: 109,056,040	I126N	probably damaging	Het
Slc11a1	T	C	1: 74,375,772	L21P	probably benign	Het
Slc35f1	C	T	10: 52,933,195	P93S	probably damaging	Het
Slc4a4	A	G	5: 89,046,308	T172A	probably damaging	Het
Slc9c1	A	T	16: 45,573,347	Y551F	probably benign	Het
Spata31	T	C	13: 64,921,798	S587P	probably benign	Het
Syna	C	A	5: 134,559,152	M314I	probably benign	Het
Taf5l	A	G	8: 124,003,413	L144P	probably damaging	Het
Tbccd1	T	C	16: 22,822,521	T369A	probably benign	Het
Tnfrsf11b	A	T	15: 54,256,097	C160*	probably null	Het
Trim45	A	G	3: 100,922,967	N19S	probably benign	Het
Uba2	A	G	7: 34,151,030	F364S	probably damaging	Het
Unc50	T	A	1: 37,437,242	L161Q	probably damaging	Het
Uso1	A	T	5: 92,201,133		probably null	Het
Usp25	A	G	16: 77,114,950	I956V	probably benign	Het
Utf1	C	A	7: 139,944,300	L143I	probably damaging	Het
Vmn1r158	C	T	7: 22,790,718	C22Y	probably damaging	Het
Vmn1r36	T	A	6: 66,716,772	M40L	probably benign	Het
Vmn2r43	A	G	7: 8,255,056	V386A	possibly damaging	Het
Vps9d1	C	A	8: 123,247,039	R335L	probably damaging	Het
Wasf1	T	A	10: 40,926,589	V80D	probably damaging	Het
Wdr72	G	A	9: 74,276,016	V1077I	possibly damaging	Het
Wnt8a	A	G	18: 34,542,369	M1V	probably null	Het
Zbtb26	A	G	2: 37,436,335	S230P	possibly damaging	Het
Zfp335	A	G	2: 164,892,605	V1247A	probably damaging	Het
Zfp429	T	C	13: 67,390,386	N313S	possibly damaging	Het
Zfp74	A	T	7: 29,935,144	C380S	probably damaging	Het
Zfyve21	G	A	12: 111,824,894	E134K	probably damaging	Het
Zmynd11	T	C	13: 9,689,580	T474A	possibly damaging	Het

Other mutations in Olfr890

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01505:Olfr890	APN	9	38143871	nonsense	probably null
IGL01861:Olfr890	APN	9	38143750	missense	probably damaging	1.00
IGL02174:Olfr890	APN	9	38143785	missense	possibly damaging	0.90
IGL02723:Olfr890	APN	9	38143411	missense	probably benign	0.02
IGL03085:Olfr890	APN	9	38143183	missense	probably damaging	0.98
FR4449:Olfr890	UTSW	9	38143188	missense	probably benign	0.00
FR4737:Olfr890	UTSW	9	38143188	missense	probably benign	0.00
R0637:Olfr890	UTSW	9	38143882	missense	probably benign	0.00
R1353:Olfr890	UTSW	9	38143728	missense	probably benign	0.03
R5997:Olfr890	UTSW	9	38143801	missense	probably damaging	1.00
R6004:Olfr890	UTSW	9	38143960	missense	probably damaging	1.00
R6417:Olfr890	UTSW	9	38143315	missense	probably damaging	1.00
R6420:Olfr890	UTSW	9	38143315	missense	probably damaging	1.00
R6720:Olfr890	UTSW	9	38143153	start codon destroyed	probably null	1.00
R7223:Olfr890	UTSW	9	38143753	missense	probably benign	0.02
R7601:Olfr890	UTSW	9	38143378	missense	probably benign	0.13
R7671:Olfr890	UTSW	9	38143440	missense	probably benign	0.02
R8034:Olfr890	UTSW	9	38143677	missense	probably damaging	1.00
R8356:Olfr890	UTSW	9	38143685	nonsense	probably null
R8456:Olfr890	UTSW	9	38143685	nonsense	probably null
R8696:Olfr890	UTSW	9	38143137	start codon destroyed	probably null	0.00
R9487:Olfr890	UTSW	9	38143570	missense	probably benign	0.22
R9517:Olfr890	UTSW	9	38143327	missense	probably damaging	1.00
Z1176:Olfr890	UTSW	9	38143431	missense	probably benign	0.02

Predicted Primers

PCR Primer
(F):5'- TGCAATCTGTAAGCCCCTGC -3'
(R):5'- TGAATGCTGAAGCTCCATAGAAAAG -3'

Sequencing Primer
(F):5'- AGGTCACCATGTCCTATCAGG -3'
(R):5'- CTCCATAGAAAAGAGAAACAGCTATG -3'

Posted On

2014-06-23