Mutagenetix > Incidental Mutation

Incidental Mutation 'R1813:Lama1'

202594

Institutional Source

Beutler Lab

Gene Symbol

Lama1

Ensembl Gene

ENSMUSG00000032796

Gene Name

laminin, alpha 1

Synonyms

Lama

MMRRC Submission

039841-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R1813 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

67697265-67822645 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 67791223 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Histidine at position 1805 (R1805H)

Ref Sequence

ENSEMBL: ENSMUSP00000043957 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000035471]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000035471
AA Change: R1805H

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000043957
Gene: ENSMUSG00000032796
AA Change: R1805H

Domain	Start	End	E-Value	Type
low complexity region	3	22	N/A	INTRINSIC
LamNT	23	275	1.2e-131	SMART
EGF_Lam	277	331	1e-5	SMART
EGF_Lam	334	401	6.6e-6	SMART
EGF_Lam	404	458	9.11e-9	SMART
EGF_Lam	461	507	8.12e-6	SMART
LamB	570	702	2.09e-57	SMART
EGF_like	715	746	3.36e0	SMART
EGF_Lam	749	795	7.01e-10	SMART
EGF_Lam	798	853	3.59e-7	SMART
EGF_Lam	856	906	1.53e-10	SMART
EGF_Lam	909	955	1.13e-13	SMART
EGF_Lam	958	1002	1.36e-7	SMART
EGF_Lam	1005	1048	7.29e-8	SMART
EGF_like	1034	1082	4.83e1	SMART
EGF_Lam	1051	1094	1.67e-7	SMART
EGF_Lam	1097	1154	1.32e-5	SMART
LamB	1220	1352	8.7e-46	SMART
Pfam:Laminin_EGF	1367	1397	1.7e-6	PFAM
EGF_Lam	1410	1456	7.12e-11	SMART
EGF_Lam	1459	1513	3.25e-5	SMART
EGF_like	1497	1547	6.41e1	SMART
EGF_Lam	1516	1560	1.71e-13	SMART
Pfam:Laminin_I	1574	1838	1.7e-91	PFAM
low complexity region	2012	2031	N/A	INTRINSIC
low complexity region	2087	2098	N/A	INTRINSIC
LamG	2145	2287	3.66e-30	SMART
LamG	2332	2473	5.98e-35	SMART
LamG	2513	2661	1.11e-29	SMART
low complexity region	2695	2708	N/A	INTRINSIC
LamG	2743	2877	9.72e-35	SMART
LamG	2920	3056	4.63e-41	SMART

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 97.5%
3x: 96.8%
10x: 94.8%
20x: 90.3%

Validation Efficiency

96% (79/82)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. [provided by RefSeq, Sep 2014]
PHENOTYPE: Homozygous null mice display embryonic lethality before somite formation with impaired formation of Reichert's membrane. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 74 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2ml1	T	A	6: 128,566,273 (GRCm38)	N595Y	probably benign	Het
Abca6	A	G	11: 110,233,845 (GRCm38)		probably benign	Het
Abo	C	A	2: 26,843,597 (GRCm38)	D199Y	probably damaging	Het
Acvr1c	A	C	2: 58,280,294 (GRCm38)	V277G	probably damaging	Het
Adam23	G	A	1: 63,545,572 (GRCm38)	A380T	probably benign	Het
Art2b	A	G	7: 101,580,029 (GRCm38)	V221A	probably benign	Het
Bcam	A	G	7: 19,766,715 (GRCm38)	S153P	probably damaging	Het
Brip1	T	C	11: 86,187,080 (GRCm38)	H174R	possibly damaging	Het
Ccdc186	T	C	19: 56,800,169 (GRCm38)	D536G	probably benign	Het
Cd109	A	G	9: 78,617,005 (GRCm38)	N67S	probably benign	Het
Cd8a	G	T	6: 71,373,963 (GRCm38)	M137I	possibly damaging	Het
Ces2g	T	C	8: 104,966,937 (GRCm38)	F417L	probably benign	Het
Clec2g	A	G	6: 128,948,697 (GRCm38)	N23S	unknown	Het
Cntnap2	T	C	6: 46,530,633 (GRCm38)	Y61C	probably damaging	Het
Cog3	T	A	14: 75,742,344 (GRCm38)	E182D	probably benign	Het
Dbpht2	A	G	12: 74,295,850 (GRCm38)		noncoding transcript	Het
Dock4	A	T	12: 40,636,228 (GRCm38)	N154I	probably damaging	Het
Dysf	T	G	6: 84,151,924 (GRCm38)	V1422G	possibly damaging	Het
E2f3	T	C	13: 29,920,176 (GRCm38)	D140G	probably damaging	Het
Epb41l2	T	A	10: 25,441,568 (GRCm38)		probably null	Het
Epha2	A	G	4: 141,308,546 (GRCm38)	K98E	possibly damaging	Het
Esyt1	T	C	10: 128,519,618 (GRCm38)	D444G	probably benign	Het
Fam163a	T	C	1: 156,080,041 (GRCm38)	T2A	probably damaging	Het
Foxp2	A	T	6: 15,379,768 (GRCm38)		probably benign	Het
Gcm2	T	C	13: 41,105,891 (GRCm38)	H34R	probably benign	Het
Gipr	A	G	7: 19,164,071 (GRCm38)	S79P	probably benign	Het
Gli3	T	C	13: 15,648,691 (GRCm38)	S333P	probably damaging	Het
Gm10717	T	G	9: 3,026,317 (GRCm38)	F205C	probably damaging	Het
Gm11639	A	G	11: 104,720,688 (GRCm38)	K452R	probably benign	Het
Gzmk	A	G	13: 113,172,893 (GRCm38)	S208P	probably damaging	Het
Htra2	G	T	6: 83,051,602 (GRCm38)	A318D	probably damaging	Het
Itpkc	T	C	7: 27,208,380 (GRCm38)	D633G	probably damaging	Het
Lama4	T	A	10: 39,033,125 (GRCm38)		probably benign	Het
Lama4	T	C	10: 39,060,186 (GRCm38)	V619A	probably damaging	Het
Notch3	T	C	17: 32,143,428 (GRCm38)	T1408A	probably benign	Het
Nwd2	A	G	5: 63,805,410 (GRCm38)	D779G	probably benign	Het
Nxpe4	A	G	9: 48,393,378 (GRCm38)	Y255C	possibly damaging	Het
Obox6	A	T	7: 15,834,845 (GRCm38)	H35Q	possibly damaging	Het
Olfr324	A	G	11: 58,598,307 (GRCm38)	I304V	probably damaging	Het
Olfr890	T	A	9: 38,143,729 (GRCm38)	I198N	possibly damaging	Het
Pkig	T	A	2: 163,721,227 (GRCm38)	I26N	possibly damaging	Het
Plekhm2	C	T	4: 141,642,439 (GRCm38)	V82M	possibly damaging	Het
Plppr2	G	A	9: 21,947,924 (GRCm38)	A446T	probably damaging	Het
Psme4	T	A	11: 30,804,353 (GRCm38)	F203L	probably benign	Het
Sh3bp1	A	G	15: 78,903,680 (GRCm38)	K137E	probably damaging	Het
Shisa5	T	A	9: 109,056,040 (GRCm38)	I126N	probably damaging	Het
Slc11a1	T	C	1: 74,375,772 (GRCm38)	L21P	probably benign	Het
Slc35f1	C	T	10: 52,933,195 (GRCm38)	P93S	probably damaging	Het
Slc4a4	A	G	5: 89,046,308 (GRCm38)	T172A	probably damaging	Het
Slc9c1	A	T	16: 45,573,347 (GRCm38)	Y551F	probably benign	Het
Spata31	T	C	13: 64,921,798 (GRCm38)	S587P	probably benign	Het
Syna	C	A	5: 134,559,152 (GRCm38)	M314I	probably benign	Het
Taf5l	A	G	8: 124,003,413 (GRCm38)	L144P	probably damaging	Het
Tbccd1	T	C	16: 22,822,521 (GRCm38)	T369A	probably benign	Het
Tnfrsf11b	A	T	15: 54,256,097 (GRCm38)	C160*	probably null	Het
Trim45	A	G	3: 100,922,967 (GRCm38)	N19S	probably benign	Het
Uba2	A	G	7: 34,151,030 (GRCm38)	F364S	probably damaging	Het
Unc50	T	A	1: 37,437,242 (GRCm38)	L161Q	probably damaging	Het
Uso1	A	T	5: 92,201,133 (GRCm38)		probably null	Het
Usp25	A	G	16: 77,114,950 (GRCm38)	I956V	probably benign	Het
Utf1	C	A	7: 139,944,300 (GRCm38)	L143I	probably damaging	Het
Vmn1r158	C	T	7: 22,790,718 (GRCm38)	C22Y	probably damaging	Het
Vmn1r36	T	A	6: 66,716,772 (GRCm38)	M40L	probably benign	Het
Vmn2r43	A	G	7: 8,255,056 (GRCm38)	V386A	possibly damaging	Het
Vps9d1	C	A	8: 123,247,039 (GRCm38)	R335L	probably damaging	Het
Wasf1	T	A	10: 40,926,589 (GRCm38)	V80D	probably damaging	Het
Wdr72	G	A	9: 74,276,016 (GRCm38)	V1077I	possibly damaging	Het
Wnt8a	A	G	18: 34,542,369 (GRCm38)	M1V	probably null	Het
Zbtb26	A	G	2: 37,436,335 (GRCm38)	S230P	possibly damaging	Het
Zfp335	A	G	2: 164,892,605 (GRCm38)	V1247A	probably damaging	Het
Zfp429	T	C	13: 67,390,386 (GRCm38)	N313S	possibly damaging	Het
Zfp74	A	T	7: 29,935,144 (GRCm38)	C380S	probably damaging	Het
Zfyve21	G	A	12: 111,824,894 (GRCm38)	E134K	probably damaging	Het
Zmynd11	T	C	13: 9,689,580 (GRCm38)	T474A	possibly damaging	Het

Other mutations in Lama1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00157:Lama1	APN	17	67,815,928 (GRCm38)	missense	probably benign
IGL00336:Lama1	APN	17	67,813,948 (GRCm38)	missense	probably benign	0.07
IGL01066:Lama1	APN	17	67,743,326 (GRCm38)	missense	probably damaging	1.00
IGL01140:Lama1	APN	17	67,802,933 (GRCm38)	missense	probably benign	0.14
IGL01291:Lama1	APN	17	67,738,870 (GRCm38)	missense	probably damaging	1.00
IGL01296:Lama1	APN	17	67,745,051 (GRCm38)	missense	probably benign	0.27
IGL01317:Lama1	APN	17	67,818,701 (GRCm38)	missense	probably damaging	1.00
IGL01490:Lama1	APN	17	67,750,584 (GRCm38)	missense	possibly damaging	0.54
IGL01506:Lama1	APN	17	67,785,070 (GRCm38)	missense	probably benign	0.01
IGL01508:Lama1	APN	17	67,809,361 (GRCm38)	splice site	probably benign
IGL01522:Lama1	APN	17	67,752,774 (GRCm38)	splice site	probably benign
IGL01530:Lama1	APN	17	67,796,790 (GRCm38)	missense	probably benign	0.02
IGL01541:Lama1	APN	17	67,785,070 (GRCm38)	missense	probably benign	0.01
IGL01677:Lama1	APN	17	67,779,148 (GRCm38)	missense	probably benign	0.15
IGL01886:Lama1	APN	17	67,807,797 (GRCm38)	missense	probably benign	0.36
IGL01994:Lama1	APN	17	67,752,439 (GRCm38)	missense	probably benign	0.05
IGL02017:Lama1	APN	17	67,764,725 (GRCm38)	missense	probably benign	0.00
IGL02021:Lama1	APN	17	67,821,626 (GRCm38)	missense	probably damaging	1.00
IGL02026:Lama1	APN	17	67,809,292 (GRCm38)	missense	possibly damaging	0.82
IGL02044:Lama1	APN	17	67,811,490 (GRCm38)	missense	probably benign	0.01
IGL02120:Lama1	APN	17	67,716,789 (GRCm38)	missense	probably damaging	1.00
IGL02425:Lama1	APN	17	67,811,485 (GRCm38)	missense	probably benign	0.45
IGL02549:Lama1	APN	17	67,790,835 (GRCm38)	missense	possibly damaging	0.93
IGL02642:Lama1	APN	17	67,812,366 (GRCm38)	missense	probably benign	0.00
IGL02795:Lama1	APN	17	67,738,894 (GRCm38)	splice site	probably null
IGL02798:Lama1	APN	17	67,795,191 (GRCm38)	splice site	probably benign
IGL02863:Lama1	APN	17	67,804,536 (GRCm38)	missense	probably damaging	0.99
IGL02870:Lama1	APN	17	67,804,536 (GRCm38)	missense	probably damaging	0.99
IGL02876:Lama1	APN	17	67,750,692 (GRCm38)	critical splice donor site	probably null
IGL02885:Lama1	APN	17	67,804,536 (GRCm38)	missense	probably damaging	0.99
IGL02891:Lama1	APN	17	67,804,536 (GRCm38)	missense	probably damaging	0.99
IGL02978:Lama1	APN	17	67,786,081 (GRCm38)	nonsense	probably null
IGL03064:Lama1	APN	17	67,779,104 (GRCm38)	missense	probably benign	0.01
IGL03076:Lama1	APN	17	67,716,799 (GRCm38)	missense	possibly damaging	0.95
IGL03110:Lama1	APN	17	67,798,986 (GRCm38)	missense	probably benign	0.04
IGL03143:Lama1	APN	17	67,804,536 (GRCm38)	missense	probably damaging	0.99
IGL03159:Lama1	APN	17	67,804,536 (GRCm38)	missense	probably damaging	0.99
IGL03268:Lama1	APN	17	67,804,536 (GRCm38)	missense	probably damaging	0.99
ANU05:Lama1	UTSW	17	67,738,870 (GRCm38)	missense	probably damaging	1.00
PIT4472001:Lama1	UTSW	17	67,764,704 (GRCm38)	missense
R0047:Lama1	UTSW	17	67,795,186 (GRCm38)	splice site	probably benign
R0047:Lama1	UTSW	17	67,795,186 (GRCm38)	splice site	probably benign
R0050:Lama1	UTSW	17	67,782,056 (GRCm38)	missense	possibly damaging	0.66
R0096:Lama1	UTSW	17	67,805,413 (GRCm38)	missense	probably benign	0.12
R0096:Lama1	UTSW	17	67,805,413 (GRCm38)	missense	probably benign	0.12
R0111:Lama1	UTSW	17	67,737,498 (GRCm38)	missense	probably damaging	0.98
R0116:Lama1	UTSW	17	67,776,923 (GRCm38)	missense	probably benign	0.10
R0121:Lama1	UTSW	17	67,798,513 (GRCm38)	splice site	probably benign
R0278:Lama1	UTSW	17	67,810,183 (GRCm38)	missense	probably null	0.98
R0281:Lama1	UTSW	17	67,817,569 (GRCm38)	missense	probably damaging	1.00
R0312:Lama1	UTSW	17	67,775,851 (GRCm38)	missense	possibly damaging	0.45
R0419:Lama1	UTSW	17	67,791,610 (GRCm38)	critical splice donor site	probably null
R0512:Lama1	UTSW	17	67,779,134 (GRCm38)	missense	possibly damaging	0.67
R0514:Lama1	UTSW	17	67,764,698 (GRCm38)	missense	probably benign	0.40
R0562:Lama1	UTSW	17	67,815,959 (GRCm38)	missense	probably damaging	1.00
R0632:Lama1	UTSW	17	67,752,368 (GRCm38)	splice site	probably benign
R0645:Lama1	UTSW	17	67,773,712 (GRCm38)	missense	probably benign	0.01
R0712:Lama1	UTSW	17	67,779,042 (GRCm38)	splice site	probably null
R0763:Lama1	UTSW	17	67,772,818 (GRCm38)	missense	probably damaging	0.97
R0941:Lama1	UTSW	17	67,775,865 (GRCm38)	missense	probably benign	0.10
R1025:Lama1	UTSW	17	67,752,898 (GRCm38)	missense	probably benign	0.00
R1084:Lama1	UTSW	17	67,804,469 (GRCm38)	missense	probably benign	0.12
R1103:Lama1	UTSW	17	67,790,947 (GRCm38)	missense	probably damaging	0.98
R1420:Lama1	UTSW	17	67,790,947 (GRCm38)	missense	probably damaging	0.98
R1430:Lama1	UTSW	17	67,782,155 (GRCm38)	missense	possibly damaging	0.95
R1569:Lama1	UTSW	17	67,780,618 (GRCm38)	splice site	probably null
R1575:Lama1	UTSW	17	67,810,409 (GRCm38)	missense	possibly damaging	0.96
R1613:Lama1	UTSW	17	67,807,923 (GRCm38)	missense	probably benign	0.42
R1620:Lama1	UTSW	17	67,767,033 (GRCm38)	missense	probably benign	0.01
R1629:Lama1	UTSW	17	67,805,428 (GRCm38)	missense	probably benign	0.00
R1645:Lama1	UTSW	17	67,737,682 (GRCm38)	missense	probably benign	0.14
R1652:Lama1	UTSW	17	67,807,846 (GRCm38)	missense	probably damaging	0.97
R1674:Lama1	UTSW	17	67,791,244 (GRCm38)	missense	probably benign
R1678:Lama1	UTSW	17	67,810,155 (GRCm38)	missense	possibly damaging	0.56
R1710:Lama1	UTSW	17	67,753,791 (GRCm38)	missense	probably benign	0.00
R1712:Lama1	UTSW	17	67,717,186 (GRCm38)	missense	possibly damaging	0.95
R1737:Lama1	UTSW	17	67,802,921 (GRCm38)	missense	probably benign	0.36
R1757:Lama1	UTSW	17	67,697,383 (GRCm38)	missense	unknown
R1757:Lama1	UTSW	17	67,763,836 (GRCm38)	missense	probably benign	0.40
R1896:Lama1	UTSW	17	67,791,223 (GRCm38)	missense	probably benign
R1945:Lama1	UTSW	17	67,745,853 (GRCm38)	missense	probably benign	0.14
R2086:Lama1	UTSW	17	67,817,623 (GRCm38)	missense	probably damaging	1.00
R2149:Lama1	UTSW	17	67,773,865 (GRCm38)	missense	possibly damaging	0.95
R2178:Lama1	UTSW	17	67,769,515 (GRCm38)	missense	probably benign	0.07
R2183:Lama1	UTSW	17	67,791,009 (GRCm38)	missense	probably damaging	0.98
R2197:Lama1	UTSW	17	67,752,941 (GRCm38)	missense	probably benign	0.02
R2213:Lama1	UTSW	17	67,777,034 (GRCm38)	nonsense	probably null
R2260:Lama1	UTSW	17	67,737,507 (GRCm38)	missense	probably damaging	0.96
R2356:Lama1	UTSW	17	67,810,114 (GRCm38)	missense	probably damaging	1.00
R2420:Lama1	UTSW	17	67,750,553 (GRCm38)	missense	probably benign	0.00
R2421:Lama1	UTSW	17	67,750,553 (GRCm38)	missense	probably benign	0.00
R2422:Lama1	UTSW	17	67,750,553 (GRCm38)	missense	probably benign	0.00
R2424:Lama1	UTSW	17	67,798,665 (GRCm38)	missense	probably benign	0.09
R2442:Lama1	UTSW	17	67,768,317 (GRCm38)	missense	probably benign	0.04
R3147:Lama1	UTSW	17	67,737,658 (GRCm38)	missense	probably damaging	0.98
R3414:Lama1	UTSW	17	67,737,603 (GRCm38)	missense	probably damaging	1.00
R3683:Lama1	UTSW	17	67,768,333 (GRCm38)	missense	probably benign	0.40
R3820:Lama1	UTSW	17	67,779,046 (GRCm38)	splice site	probably null
R3821:Lama1	UTSW	17	67,779,046 (GRCm38)	splice site	probably null
R3822:Lama1	UTSW	17	67,779,046 (GRCm38)	splice site	probably null
R4012:Lama1	UTSW	17	67,812,373 (GRCm38)	nonsense	probably null
R4113:Lama1	UTSW	17	67,764,703 (GRCm38)	missense	probably benign	0.01
R4133:Lama1	UTSW	17	67,812,486 (GRCm38)	missense	probably damaging	1.00
R4133:Lama1	UTSW	17	67,750,655 (GRCm38)	missense	probably damaging	0.98
R4259:Lama1	UTSW	17	67,752,418 (GRCm38)	missense	possibly damaging	0.95
R4278:Lama1	UTSW	17	67,791,517 (GRCm38)	missense	probably null	0.00
R4321:Lama1	UTSW	17	67,771,083 (GRCm38)	missense	probably benign	0.03
R4374:Lama1	UTSW	17	67,804,518 (GRCm38)	missense	probably benign	0.00
R4386:Lama1	UTSW	17	67,773,712 (GRCm38)	missense	probably benign	0.01
R4463:Lama1	UTSW	17	67,761,700 (GRCm38)	missense	probably damaging	1.00
R4629:Lama1	UTSW	17	67,805,360 (GRCm38)	critical splice acceptor site	probably null
R4630:Lama1	UTSW	17	67,794,300 (GRCm38)	missense	probably benign	0.00
R4633:Lama1	UTSW	17	67,798,584 (GRCm38)	missense	probably damaging	0.96
R4668:Lama1	UTSW	17	67,752,434 (GRCm38)	missense	probably benign	0.27
R4684:Lama1	UTSW	17	67,773,778 (GRCm38)	missense	possibly damaging	0.88
R4745:Lama1	UTSW	17	67,738,780 (GRCm38)	missense	probably damaging	1.00
R4786:Lama1	UTSW	17	67,773,859 (GRCm38)	missense	possibly damaging	0.77
R4797:Lama1	UTSW	17	67,716,775 (GRCm38)	missense	probably benign	0.04
R4803:Lama1	UTSW	17	67,809,271 (GRCm38)	missense	probably damaging	1.00
R4925:Lama1	UTSW	17	67,794,314 (GRCm38)	missense	probably benign	0.02
R4939:Lama1	UTSW	17	67,737,475 (GRCm38)	missense	possibly damaging	0.91
R4952:Lama1	UTSW	17	67,767,566 (GRCm38)	critical splice donor site	probably null
R4975:Lama1	UTSW	17	67,738,834 (GRCm38)	missense	possibly damaging	0.95
R4977:Lama1	UTSW	17	67,737,682 (GRCm38)	missense	probably damaging	1.00
R5039:Lama1	UTSW	17	67,745,893 (GRCm38)	missense	possibly damaging	0.66
R5047:Lama1	UTSW	17	67,743,281 (GRCm38)	nonsense	probably null
R5195:Lama1	UTSW	17	67,764,800 (GRCm38)	missense	probably benign	0.13
R5230:Lama1	UTSW	17	67,745,083 (GRCm38)	nonsense	probably null
R5236:Lama1	UTSW	17	67,804,492 (GRCm38)	missense	probably benign	0.24
R5254:Lama1	UTSW	17	67,756,716 (GRCm38)	missense	probably benign	0.01
R5345:Lama1	UTSW	17	67,817,563 (GRCm38)	missense	probably benign
R5438:Lama1	UTSW	17	67,800,774 (GRCm38)	missense	possibly damaging	0.92
R5521:Lama1	UTSW	17	67,780,894 (GRCm38)	nonsense	probably null
R5568:Lama1	UTSW	17	67,768,298 (GRCm38)	critical splice acceptor site	probably null
R5645:Lama1	UTSW	17	67,802,948 (GRCm38)	missense	probably damaging	1.00
R5665:Lama1	UTSW	17	67,770,987 (GRCm38)	missense	probably damaging	1.00
R5727:Lama1	UTSW	17	67,815,224 (GRCm38)	missense	possibly damaging	0.81
R5757:Lama1	UTSW	17	67,738,787 (GRCm38)	missense	possibly damaging	0.59
R5795:Lama1	UTSW	17	67,796,727 (GRCm38)	missense	probably benign	0.02
R5857:Lama1	UTSW	17	67,807,843 (GRCm38)	missense	probably damaging	0.99
R5894:Lama1	UTSW	17	67,779,047 (GRCm38)	critical splice acceptor site	probably null
R5974:Lama1	UTSW	17	67,773,727 (GRCm38)	missense	probably benign	0.31
R6032:Lama1	UTSW	17	67,750,643 (GRCm38)	missense	probably benign	0.01
R6032:Lama1	UTSW	17	67,750,643 (GRCm38)	missense	probably benign	0.01
R6120:Lama1	UTSW	17	67,780,617 (GRCm38)	critical splice donor site	probably null
R6219:Lama1	UTSW	17	67,790,856 (GRCm38)	missense	probably benign	0.08
R6224:Lama1	UTSW	17	67,802,987 (GRCm38)	missense	possibly damaging	0.56
R6249:Lama1	UTSW	17	67,798,604 (GRCm38)	missense	probably benign
R6265:Lama1	UTSW	17	67,750,655 (GRCm38)	missense	probably damaging	0.98
R6276:Lama1	UTSW	17	67,784,088 (GRCm38)	splice site	probably null
R6284:Lama1	UTSW	17	67,810,096 (GRCm38)	missense	probably damaging	0.99
R6337:Lama1	UTSW	17	67,786,019 (GRCm38)	missense	probably benign	0.27
R6414:Lama1	UTSW	17	67,746,910 (GRCm38)	critical splice donor site	probably null
R6631:Lama1	UTSW	17	67,774,482 (GRCm38)	missense	probably benign	0.21
R6659:Lama1	UTSW	17	67,818,635 (GRCm38)	missense	probably damaging	1.00
R6660:Lama1	UTSW	17	67,804,500 (GRCm38)	missense	probably benign	0.05
R6677:Lama1	UTSW	17	67,795,233 (GRCm38)	missense	probably benign	0.14
R6763:Lama1	UTSW	17	67,746,873 (GRCm38)	missense	unknown
R6787:Lama1	UTSW	17	67,784,025 (GRCm38)	missense	unknown
R6831:Lama1	UTSW	17	67,756,754 (GRCm38)	missense	possibly damaging	0.89
R6855:Lama1	UTSW	17	67,782,155 (GRCm38)	missense	possibly damaging	0.95
R6910:Lama1	UTSW	17	67,791,464 (GRCm38)	missense	possibly damaging	0.60
R6934:Lama1	UTSW	17	67,774,543 (GRCm38)	missense	probably benign	0.04
R6945:Lama1	UTSW	17	67,813,866 (GRCm38)	missense
R6984:Lama1	UTSW	17	67,779,112 (GRCm38)	missense
R6989:Lama1	UTSW	17	67,753,758 (GRCm38)	missense
R6994:Lama1	UTSW	17	67,753,825 (GRCm38)	missense
R6995:Lama1	UTSW	17	67,753,825 (GRCm38)	missense
R7035:Lama1	UTSW	17	67,781,049 (GRCm38)	missense
R7133:Lama1	UTSW	17	67,782,146 (GRCm38)	missense
R7172:Lama1	UTSW	17	67,804,545 (GRCm38)	missense
R7197:Lama1	UTSW	17	67,737,705 (GRCm38)	nonsense	probably null
R7217:Lama1	UTSW	17	67,764,673 (GRCm38)	missense
R7229:Lama1	UTSW	17	67,752,446 (GRCm38)	missense
R7264:Lama1	UTSW	17	67,743,297 (GRCm38)	missense
R7311:Lama1	UTSW	17	67,767,385 (GRCm38)	missense
R7394:Lama1	UTSW	17	67,717,261 (GRCm38)	missense
R7419:Lama1	UTSW	17	67,717,174 (GRCm38)	missense
R7460:Lama1	UTSW	17	67,767,018 (GRCm38)	missense
R7492:Lama1	UTSW	17	67,817,651 (GRCm38)	missense
R7494:Lama1	UTSW	17	67,811,446 (GRCm38)	missense
R7552:Lama1	UTSW	17	67,737,667 (GRCm38)	missense
R7576:Lama1	UTSW	17	67,782,041 (GRCm38)	missense
R7583:Lama1	UTSW	17	67,761,621 (GRCm38)	missense
R7649:Lama1	UTSW	17	67,737,554 (GRCm38)	missense
R7663:Lama1	UTSW	17	67,780,880 (GRCm38)	missense
R7667:Lama1	UTSW	17	67,780,597 (GRCm38)	missense
R7688:Lama1	UTSW	17	67,761,628 (GRCm38)	missense
R7693:Lama1	UTSW	17	67,817,031 (GRCm38)	missense
R7748:Lama1	UTSW	17	67,750,590 (GRCm38)	missense
R7778:Lama1	UTSW	17	67,804,473 (GRCm38)	missense
R7824:Lama1	UTSW	17	67,804,473 (GRCm38)	missense
R7861:Lama1	UTSW	17	67,809,221 (GRCm38)	missense
R7884:Lama1	UTSW	17	67,769,435 (GRCm38)	missense
R8029:Lama1	UTSW	17	67,817,594 (GRCm38)	missense
R8078:Lama1	UTSW	17	67,791,294 (GRCm38)	missense
R8101:Lama1	UTSW	17	67,745,922 (GRCm38)	missense
R8313:Lama1	UTSW	17	67,750,520 (GRCm38)	missense
R8356:Lama1	UTSW	17	67,737,496 (GRCm38)	missense
R8366:Lama1	UTSW	17	67,818,704 (GRCm38)	missense
R8403:Lama1	UTSW	17	67,745,923 (GRCm38)	missense
R8456:Lama1	UTSW	17	67,737,496 (GRCm38)	missense
R8466:Lama1	UTSW	17	67,813,953 (GRCm38)	missense
R8678:Lama1	UTSW	17	67,817,103 (GRCm38)	missense
R8728:Lama1	UTSW	17	67,818,668 (GRCm38)	missense
R8796:Lama1	UTSW	17	67,810,151 (GRCm38)	missense
R8885:Lama1	UTSW	17	67,773,784 (GRCm38)	missense
R8893:Lama1	UTSW	17	67,805,372 (GRCm38)	missense
R8898:Lama1	UTSW	17	67,821,615 (GRCm38)	missense
R8909:Lama1	UTSW	17	67,772,741 (GRCm38)	missense
R9025:Lama1	UTSW	17	67,812,496 (GRCm38)	missense
R9045:Lama1	UTSW	17	67,753,843 (GRCm38)	missense
R9098:Lama1	UTSW	17	67,804,513 (GRCm38)	missense
R9114:Lama1	UTSW	17	67,821,674 (GRCm38)	missense
R9173:Lama1	UTSW	17	67,769,602 (GRCm38)	missense
R9190:Lama1	UTSW	17	67,804,519 (GRCm38)	missense
R9381:Lama1	UTSW	17	67,737,484 (GRCm38)	missense
R9429:Lama1	UTSW	17	67,811,454 (GRCm38)	missense
R9504:Lama1	UTSW	17	67,821,666 (GRCm38)	missense
R9558:Lama1	UTSW	17	67,817,009 (GRCm38)	missense
R9647:Lama1	UTSW	17	67,717,175 (GRCm38)	missense
R9651:Lama1	UTSW	17	67,794,220 (GRCm38)	missense
R9654:Lama1	UTSW	17	67,794,271 (GRCm38)	missense
R9710:Lama1	UTSW	17	67,822,409 (GRCm38)	missense
R9733:Lama1	UTSW	17	67,809,945 (GRCm38)	missense
RF001:Lama1	UTSW	17	67,752,902 (GRCm38)	missense
RF013:Lama1	UTSW	17	67,781,062 (GRCm38)	missense
V8831:Lama1	UTSW	17	67,752,883 (GRCm38)	missense	probably benign	0.00
X0024:Lama1	UTSW	17	67,738,888 (GRCm38)	missense	probably damaging	1.00
X0028:Lama1	UTSW	17	67,794,310 (GRCm38)	missense	probably benign	0.06
X0028:Lama1	UTSW	17	67,767,422 (GRCm38)	missense	probably benign	0.00
X0066:Lama1	UTSW	17	67,811,566 (GRCm38)	missense	probably damaging	1.00
Z1088:Lama1	UTSW	17	67,810,171 (GRCm38)	missense	probably damaging	1.00
Z1088:Lama1	UTSW	17	67,771,082 (GRCm38)	missense	probably benign	0.25
Z1088:Lama1	UTSW	17	67,752,883 (GRCm38)	missense	probably benign	0.00
Z1176:Lama1	UTSW	17	67,752,883 (GRCm38)	missense	probably benign	0.00
Z1177:Lama1	UTSW	17	67,752,883 (GRCm38)	missense	probably benign	0.00
Z1191:Lama1	UTSW	17	67,798,644 (GRCm38)	missense

Predicted Primers

PCR Primer
(F):5'- TGAAAGAATTCCAGGTGAGTCTC -3'
(R):5'- CTGTTTAGCTACAAGTGTGCGC -3'

Sequencing Primer
(F):5'- AAGAATTCCAGGTGAGTCTCAGTGTC -3'
(R):5'- TACAAGTGTGCGCGCACC -3'

Posted On

2014-06-23