Incidental Mutation 'R1574:Zfp949'
ID 202735
Institutional Source Beutler Lab
Gene Symbol Zfp949
Ensembl Gene ENSMUSG00000032425
Gene Name zinc finger protein 949
Synonyms 4930422I07Rik, Nczf
MMRRC Submission 045014-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R1574 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 88430073-88453114 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 88451830 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 467 (K467*)
Ref Sequence ENSEMBL: ENSMUSP00000125325 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000160652] [ENSMUST00000161458] [ENSMUST00000162827]
AlphaFold E9Q732
Predicted Effect probably benign
Transcript: ENSMUST00000160652
Predicted Effect probably null
Transcript: ENSMUST00000161458
AA Change: K467*
SMART Domains Protein: ENSMUSP00000125017
Gene: ENSMUSG00000032425
AA Change: K467*

DomainStartEndE-ValueType
KRAB 8 68 2.63e-32 SMART
ZnF_C2H2 268 290 5.99e1 SMART
ZnF_C2H2 296 318 5.5e-3 SMART
ZnF_C2H2 324 346 6.42e-4 SMART
ZnF_C2H2 352 374 2.91e-2 SMART
ZnF_C2H2 380 402 4.11e-2 SMART
ZnF_C2H2 408 430 3.63e-3 SMART
ZnF_C2H2 436 458 5.67e-5 SMART
ZnF_C2H2 464 486 7.9e-4 SMART
ZnF_C2H2 492 514 2.43e-4 SMART
ZnF_C2H2 520 542 2.95e-3 SMART
ZnF_C2H2 548 570 1.03e-2 SMART
ZnF_C2H2 576 598 1.4e-4 SMART
Predicted Effect probably null
Transcript: ENSMUST00000162827
AA Change: K467*
SMART Domains Protein: ENSMUSP00000125325
Gene: ENSMUSG00000032425
AA Change: K467*

DomainStartEndE-ValueType
KRAB 8 68 2.63e-32 SMART
ZnF_C2H2 268 290 5.99e1 SMART
ZnF_C2H2 296 318 5.5e-3 SMART
ZnF_C2H2 324 346 6.42e-4 SMART
ZnF_C2H2 352 374 2.91e-2 SMART
ZnF_C2H2 380 402 4.11e-2 SMART
ZnF_C2H2 408 430 3.63e-3 SMART
ZnF_C2H2 436 458 5.67e-5 SMART
ZnF_C2H2 464 486 7.9e-4 SMART
ZnF_C2H2 492 514 2.43e-4 SMART
ZnF_C2H2 520 542 2.95e-3 SMART
ZnF_C2H2 548 570 1.03e-2 SMART
ZnF_C2H2 576 598 1.4e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162985
SMART Domains Protein: ENSMUSP00000124007
Gene: ENSMUSG00000032425

DomainStartEndE-ValueType
KRAB 8 68 2.63e-32 SMART
Coding Region Coverage
  • 1x: 97.5%
  • 3x: 97.0%
  • 10x: 95.5%
  • 20x: 93.0%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality during organogenesis with defects in growth, development, cell proliferation, apoptosis and turning. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrl3 T A 5: 81,935,296 (GRCm39) N1276K probably damaging Het
Als2cl A G 9: 110,713,128 (GRCm39) E6G probably damaging Het
Ankrd12 A T 17: 66,293,269 (GRCm39) D721E probably benign Het
Anpep A G 7: 79,488,155 (GRCm39) probably null Het
Apeh A T 9: 107,969,925 (GRCm39) probably null Het
Apob A T 12: 8,040,839 (GRCm39) I655L possibly damaging Het
Atp2b1 T A 10: 98,832,810 (GRCm39) L437Q probably damaging Het
Cacna2d3 T A 14: 29,073,779 (GRCm39) R222S probably damaging Het
Cdc25b T A 2: 131,033,057 (GRCm39) probably benign Het
Cdon A G 9: 35,364,233 (GRCm39) probably benign Het
Cenpf C T 1: 189,384,910 (GRCm39) D2457N probably damaging Het
Cenpo A T 12: 4,265,433 (GRCm39) probably null Het
Ces2b G T 8: 105,562,521 (GRCm39) A284S probably benign Het
Clock T C 5: 76,390,679 (GRCm39) D311G probably damaging Het
Csmd3 T C 15: 47,559,257 (GRCm39) probably null Het
Dbil5 A G 11: 76,109,308 (GRCm39) M71V probably benign Het
Ddhd1 A C 14: 45,833,004 (GRCm39) L864R probably damaging Het
Ddx19a T C 8: 111,719,743 (GRCm39) probably benign Het
Dnah11 A G 12: 118,024,052 (GRCm39) C1900R probably damaging Het
Dnah2 A G 11: 69,405,514 (GRCm39) V666A probably benign Het
Dnah5 T A 15: 28,252,569 (GRCm39) M754K probably benign Het
Dnajc15 A T 14: 78,063,854 (GRCm39) S145T probably benign Het
Drap1 A G 19: 5,474,285 (GRCm39) F25S probably damaging Het
Drgx A G 14: 32,327,281 (GRCm39) probably benign Het
Fam83e G A 7: 45,376,135 (GRCm39) E283K probably damaging Het
Fbxo48 G T 11: 16,903,368 (GRCm39) probably benign Het
Fndc3a A T 14: 72,793,997 (GRCm39) I892N probably damaging Het
Gcn1 A G 5: 115,753,611 (GRCm39) T2321A probably benign Het
Gm1110 G T 9: 26,792,422 (GRCm39) probably benign Het
Gm5499 T C 17: 87,386,423 (GRCm39) noncoding transcript Het
Gmnc G T 16: 26,782,729 (GRCm39) probably benign Het
Greb1l A G 18: 10,554,997 (GRCm39) D1681G possibly damaging Het
Hc G A 2: 34,890,777 (GRCm39) probably benign Het
Hmcn2 A C 2: 31,294,899 (GRCm39) T2563P probably damaging Het
Iqcd A T 5: 120,738,300 (GRCm39) K39N probably damaging Het
Irag2 T G 6: 145,104,356 (GRCm39) probably benign Het
Kank2 A G 9: 21,685,871 (GRCm39) S668P probably damaging Het
Kcng1 T A 2: 168,110,961 (GRCm39) N68Y probably damaging Het
Kmt5b T A 19: 3,836,633 (GRCm39) probably null Het
Lama2 T A 10: 27,200,750 (GRCm39) I533F possibly damaging Het
Lcmt1 T A 7: 123,002,131 (GRCm39) I132N probably damaging Het
Mad2l2 G T 4: 148,227,429 (GRCm39) probably benign Het
Mcph1 T C 8: 18,851,428 (GRCm39) I807T probably damaging Het
Mdn1 A G 4: 32,722,315 (GRCm39) I2366V probably benign Het
Moxd1 T C 10: 24,176,217 (GRCm39) W558R probably damaging Het
Myh13 T C 11: 67,253,407 (GRCm39) probably benign Het
Myrf T C 19: 10,202,851 (GRCm39) D141G probably damaging Het
Ncoa7 T C 10: 30,570,097 (GRCm39) I249M probably damaging Het
Obox5 T C 7: 15,492,558 (GRCm39) V171A probably damaging Het
Or13e8 A T 4: 43,697,134 (GRCm39) V13D possibly damaging Het
Or2c1 T C 16: 3,657,521 (GRCm39) I228T probably damaging Het
Or5ak20 A T 2: 85,184,243 (GRCm39) V9E probably damaging Het
Or6c219 A G 10: 129,781,379 (GRCm39) L69P probably damaging Het
Or7a36 C A 10: 78,819,820 (GRCm39) N32K probably damaging Het
Parp4 A G 14: 56,839,752 (GRCm39) T487A probably damaging Het
Pclo A G 5: 14,729,845 (GRCm39) probably benign Het
Pcnx2 G A 8: 126,500,669 (GRCm39) R1474C probably damaging Het
Qtrt2 A G 16: 43,692,195 (GRCm39) probably benign Het
Sart1 G A 19: 5,430,287 (GRCm39) P788L probably damaging Het
Sdk1 A G 5: 141,984,634 (GRCm39) T740A probably benign Het
Serpinb1c T C 13: 33,072,979 (GRCm39) D61G possibly damaging Het
Slc24a5 G A 2: 124,922,782 (GRCm39) G152S probably damaging Het
Slc6a4 A T 11: 76,910,022 (GRCm39) I426F possibly damaging Het
Stk33 C T 7: 108,879,027 (GRCm39) V441I probably benign Het
Sult1c2 A G 17: 54,143,927 (GRCm39) probably null Het
Tdpoz4 T A 3: 93,703,835 (GRCm39) V44E probably benign Het
Tmprss13 C A 9: 45,254,529 (GRCm39) T432K probably damaging Het
Traf7 A G 17: 24,729,527 (GRCm39) L428P probably damaging Het
Tubb1 T C 2: 174,299,215 (GRCm39) I299T probably benign Het
Vmn1r158 A T 7: 22,489,772 (GRCm39) W146R probably damaging Het
Vmn1r42 A G 6: 89,822,059 (GRCm39) I170T possibly damaging Het
Vmn2r116 A T 17: 23,606,063 (GRCm39) H325L probably damaging Het
Zfp516 T A 18: 83,011,300 (GRCm39) L1111H possibly damaging Het
Zfp61 C G 7: 23,990,635 (GRCm39) K505N probably damaging Het
Zfp653 C A 9: 21,969,274 (GRCm39) E331* probably null Het
Other mutations in Zfp949
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03201:Zfp949 APN 9 88,450,717 (GRCm39) missense probably benign 0.23
R0034:Zfp949 UTSW 9 88,449,693 (GRCm39) intron probably benign
R0462:Zfp949 UTSW 9 88,450,787 (GRCm39) missense possibly damaging 0.63
R1457:Zfp949 UTSW 9 88,451,891 (GRCm39) missense probably damaging 1.00
R1574:Zfp949 UTSW 9 88,451,830 (GRCm39) nonsense probably null
R1878:Zfp949 UTSW 9 88,451,356 (GRCm39) missense probably damaging 0.99
R1917:Zfp949 UTSW 9 88,452,115 (GRCm39) missense probably damaging 0.98
R4488:Zfp949 UTSW 9 88,452,142 (GRCm39) missense probably damaging 0.98
R4839:Zfp949 UTSW 9 88,452,047 (GRCm39) missense probably damaging 0.97
R5309:Zfp949 UTSW 9 88,449,236 (GRCm39) missense possibly damaging 0.92
R5312:Zfp949 UTSW 9 88,449,236 (GRCm39) missense possibly damaging 0.92
R5461:Zfp949 UTSW 9 88,451,537 (GRCm39) missense probably benign 0.00
R6530:Zfp949 UTSW 9 88,449,340 (GRCm39) critical splice donor site probably null
R6844:Zfp949 UTSW 9 88,451,464 (GRCm39) missense possibly damaging 0.91
R7749:Zfp949 UTSW 9 88,451,923 (GRCm39) missense probably damaging 1.00
R7937:Zfp949 UTSW 9 88,451,323 (GRCm39) missense probably damaging 1.00
R8150:Zfp949 UTSW 9 88,452,053 (GRCm39) missense probably benign
R8290:Zfp949 UTSW 9 88,451,293 (GRCm39) missense probably damaging 0.98
R8349:Zfp949 UTSW 9 88,449,302 (GRCm39) missense possibly damaging 0.84
R8449:Zfp949 UTSW 9 88,449,302 (GRCm39) missense possibly damaging 0.84
R8808:Zfp949 UTSW 9 88,451,417 (GRCm39) missense probably damaging 1.00
R8949:Zfp949 UTSW 9 88,450,771 (GRCm39) missense possibly damaging 0.78
R9219:Zfp949 UTSW 9 88,451,723 (GRCm39) missense probably damaging 1.00
R9396:Zfp949 UTSW 9 88,449,260 (GRCm39) missense probably damaging 0.99
R9486:Zfp949 UTSW 9 88,452,182 (GRCm39) missense probably benign 0.01
R9488:Zfp949 UTSW 9 88,452,182 (GRCm39) missense probably benign 0.01
R9643:Zfp949 UTSW 9 88,436,500 (GRCm39) start gained probably benign
R9727:Zfp949 UTSW 9 88,451,913 (GRCm39) nonsense probably null
R9778:Zfp949 UTSW 9 88,449,340 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- GAAAACCTTTCCCAGTGAATTAGAC -3'
(R):5'- TCCCACATTTATTGCACTCATAGG -3'

Sequencing Primer
(F):5'- TGAGTGTGGTAAAGCCTTCCAAC -3'
(R):5'- ACTCATAGGGCTTTTCACCTGTG -3'
Posted On 2014-06-23