Incidental Mutation 'R1802:Marchf10'
ID 203230
Institutional Source Beutler Lab
Gene Symbol Marchf10
Ensembl Gene ENSMUSG00000078627
Gene Name membrane associated ring-CH-type finger 10
Synonyms Rnf190, 4933417C16Rik, OTTMUSG00000002847, March10
MMRRC Submission 039832-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R1802 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 105251624-105347561 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 105280741 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Serine at position 515 (A515S)
Ref Sequence ENSEMBL: ENSMUSP00000121919 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049995] [ENSMUST00000138977]
AlphaFold E9PX79
Predicted Effect probably benign
Transcript: ENSMUST00000049995
AA Change: A515S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000063198
Gene: ENSMUSG00000078627
AA Change: A515S

DomainStartEndE-ValueType
low complexity region 36 49 N/A INTRINSIC
low complexity region 56 71 N/A INTRINSIC
low complexity region 114 130 N/A INTRINSIC
low complexity region 292 304 N/A INTRINSIC
RINGv 638 695 7.45e-22 SMART
low complexity region 728 737 N/A INTRINSIC
low complexity region 767 781 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000138977
AA Change: A515S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000121919
Gene: ENSMUSG00000078627
AA Change: A515S

DomainStartEndE-ValueType
low complexity region 36 49 N/A INTRINSIC
low complexity region 56 71 N/A INTRINSIC
low complexity region 114 130 N/A INTRINSIC
low complexity region 292 304 N/A INTRINSIC
RINGv 638 695 7.45e-22 SMART
low complexity region 728 737 N/A INTRINSIC
low complexity region 767 781 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153672
Coding Region Coverage
  • 1x: 97.5%
  • 3x: 96.9%
  • 10x: 95.3%
  • 20x: 92.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] MARCH10 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcd2 G T 15: 91,047,305 (GRCm39) R583S probably benign Het
Ago2 A T 15: 72,993,029 (GRCm39) F492Y probably damaging Het
Ano4 T A 10: 88,816,878 (GRCm39) D610V probably damaging Het
Atp6v0d2 A G 4: 19,922,366 (GRCm39) probably null Het
Atxn7 T G 14: 14,089,419 (GRCm38) S312A probably benign Het
Azgp1 A G 5: 137,983,493 (GRCm39) Y56C probably damaging Het
Bcan A G 3: 87,900,415 (GRCm39) V606A possibly damaging Het
Btnl9 T A 11: 49,066,617 (GRCm39) I335F probably benign Het
Ccdc63 T C 5: 122,267,940 (GRCm39) R9G probably damaging Het
Cdyl T A 13: 36,056,619 (GRCm39) L534* probably null Het
Celf2 T C 2: 6,554,744 (GRCm39) E445G probably damaging Het
Cfap97d1 T A 11: 101,879,302 (GRCm39) Y25N possibly damaging Het
Cimap3 T A 3: 105,921,866 (GRCm39) Q19L possibly damaging Het
Cnot8 T C 11: 58,008,361 (GRCm39) C276R probably benign Het
Dock4 A G 12: 40,844,597 (GRCm39) I1135V possibly damaging Het
Edc3 A G 9: 57,634,598 (GRCm39) D205G probably damaging Het
Emilin1 C T 5: 31,075,082 (GRCm39) P441L possibly damaging Het
Fancl T G 11: 26,409,709 (GRCm39) S188R probably benign Het
Fbn2 T A 18: 58,186,048 (GRCm39) K1767* probably null Het
Glrb A T 3: 80,769,264 (GRCm39) H154Q probably damaging Het
Gm19965 C T 1: 116,748,633 (GRCm39) R105* probably null Het
Grhpr C A 4: 44,988,950 (GRCm39) Y202* probably null Het
Herc2 A G 7: 55,834,080 (GRCm39) E3095G probably damaging Het
Il22ra2 A T 10: 19,502,447 (GRCm39) N89Y probably damaging Het
Itgb6 T C 2: 60,483,625 (GRCm39) D261G probably benign Het
Jmjd7 C T 2: 119,860,589 (GRCm39) L39F probably damaging Het
Kif1a T A 1: 92,993,871 (GRCm39) I360F probably damaging Het
Kmt2d T C 15: 98,760,866 (GRCm39) Q828R unknown Het
Mios T A 6: 8,216,385 (GRCm39) Y436* probably null Het
Mprip C T 11: 59,645,867 (GRCm39) L684F probably damaging Het
Mybpc2 T A 7: 44,161,894 (GRCm39) N519Y possibly damaging Het
Naga C T 15: 82,221,669 (GRCm39) R24Q probably benign Het
Nr2c1 G A 10: 93,999,648 (GRCm39) V103M possibly damaging Het
Oca2 A G 7: 55,904,728 (GRCm39) S65G possibly damaging Het
Or4k49 G T 2: 111,495,099 (GRCm39) S176I probably damaging Het
Or52ab7 A G 7: 102,977,854 (GRCm39) I54V probably benign Het
Phyhipl A T 10: 70,434,855 (GRCm39) I28N probably benign Het
Pik3cb C A 9: 98,983,342 (GRCm39) E89* probably null Het
Plekhm2 A T 4: 141,361,658 (GRCm39) S262T probably benign Het
Ppm1a T A 12: 72,840,481 (GRCm39) probably null Het
Relt T C 7: 100,499,401 (GRCm39) I173V probably damaging Het
Rfx7 T A 9: 72,526,919 (GRCm39) S1370T possibly damaging Het
Rps7 G A 12: 28,684,258 (GRCm39) R81C probably benign Het
Saa3 T C 7: 46,361,550 (GRCm39) *123W probably null Het
Serpina3b C A 12: 104,104,896 (GRCm39) H357Q probably damaging Het
Slc9c1 T A 16: 45,378,644 (GRCm39) N493K probably benign Het
Spata31 T C 13: 65,070,197 (GRCm39) Y782H probably benign Het
Tfap2a T C 13: 40,878,646 (GRCm39) D166G probably damaging Het
Thada A T 17: 84,771,835 (GRCm39) M9K probably benign Het
Tmem269 A T 4: 119,068,070 (GRCm39) probably null Het
Tnxb C A 17: 34,922,863 (GRCm39) P2482Q probably damaging Het
Vit T C 17: 78,912,940 (GRCm39) V291A possibly damaging Het
Zfp930 G T 8: 69,679,046 (GRCm39) A18S possibly damaging Het
Zup1 A T 10: 33,819,714 (GRCm39) V200D probably damaging Het
Other mutations in Marchf10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00434:Marchf10 APN 11 105,293,014 (GRCm39) missense possibly damaging 0.82
IGL01461:Marchf10 APN 11 105,280,431 (GRCm39) missense probably damaging 1.00
IGL01473:Marchf10 APN 11 105,280,431 (GRCm39) missense probably damaging 1.00
Forward UTSW 11 105,273,063 (GRCm39) missense probably damaging 1.00
PIT4142001:Marchf10 UTSW 11 105,281,346 (GRCm39) missense probably benign 0.17
R0195:Marchf10 UTSW 11 105,276,351 (GRCm39) missense probably damaging 1.00
R0520:Marchf10 UTSW 11 105,280,708 (GRCm39) missense probably benign
R0628:Marchf10 UTSW 11 105,280,986 (GRCm39) missense probably benign 0.00
R1087:Marchf10 UTSW 11 105,281,488 (GRCm39) missense probably damaging 1.00
R1440:Marchf10 UTSW 11 105,281,409 (GRCm39) missense probably damaging 1.00
R1855:Marchf10 UTSW 11 105,281,218 (GRCm39) missense probably benign
R1860:Marchf10 UTSW 11 105,287,904 (GRCm39) missense probably damaging 0.99
R2504:Marchf10 UTSW 11 105,276,398 (GRCm39) missense probably damaging 1.00
R3788:Marchf10 UTSW 11 105,287,905 (GRCm39) missense probably damaging 1.00
R4629:Marchf10 UTSW 11 105,280,664 (GRCm39) missense probably benign 0.28
R4755:Marchf10 UTSW 11 105,255,302 (GRCm39) intron probably benign
R4776:Marchf10 UTSW 11 105,280,863 (GRCm39) missense probably benign 0.42
R5067:Marchf10 UTSW 11 105,280,933 (GRCm39) missense possibly damaging 0.51
R5192:Marchf10 UTSW 11 105,262,752 (GRCm39) missense possibly damaging 0.68
R5436:Marchf10 UTSW 11 105,292,991 (GRCm39) missense possibly damaging 0.92
R5541:Marchf10 UTSW 11 105,280,957 (GRCm39) missense probably damaging 1.00
R5888:Marchf10 UTSW 11 105,292,972 (GRCm39) missense possibly damaging 0.92
R5908:Marchf10 UTSW 11 105,281,065 (GRCm39) missense probably benign 0.00
R5914:Marchf10 UTSW 11 105,276,308 (GRCm39) missense probably damaging 1.00
R6038:Marchf10 UTSW 11 105,292,877 (GRCm39) missense probably damaging 0.96
R6178:Marchf10 UTSW 11 105,280,440 (GRCm39) missense probably damaging 1.00
R6300:Marchf10 UTSW 11 105,273,063 (GRCm39) missense probably damaging 1.00
R6612:Marchf10 UTSW 11 105,287,904 (GRCm39) missense probably damaging 0.99
R6894:Marchf10 UTSW 11 105,287,787 (GRCm39) missense possibly damaging 0.94
R6921:Marchf10 UTSW 11 105,280,603 (GRCm39) missense probably benign 0.00
R7134:Marchf10 UTSW 11 105,299,502 (GRCm39) missense probably benign
R7199:Marchf10 UTSW 11 105,281,532 (GRCm39) missense probably damaging 0.99
R7546:Marchf10 UTSW 11 105,280,906 (GRCm39) missense not run
R7792:Marchf10 UTSW 11 105,281,054 (GRCm39) missense probably benign
R8241:Marchf10 UTSW 11 105,280,741 (GRCm39) missense probably benign 0.00
R8467:Marchf10 UTSW 11 105,280,979 (GRCm39) nonsense probably null
R8843:Marchf10 UTSW 11 105,292,802 (GRCm39) missense possibly damaging 0.83
R8962:Marchf10 UTSW 11 105,280,815 (GRCm39) nonsense probably null
R9214:Marchf10 UTSW 11 105,281,100 (GRCm39) missense probably benign 0.02
R9323:Marchf10 UTSW 11 105,280,581 (GRCm39) missense probably damaging 0.98
Z1088:Marchf10 UTSW 11 105,281,185 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATATTTTCCTGCAGGGACCC -3'
(R):5'- GACTGCTTACTTTCTGGGAGGC -3'

Sequencing Primer
(F):5'- CAGGGACCCAGGCATGTAG -3'
(R):5'- ATCATCCATGAATCCACCTTACAGTG -3'
Posted On 2014-06-23