Incidental Mutation 'R1806:Vmn2r3'
ID |
203443 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r3
|
Ensembl Gene |
ENSMUSG00000091572 |
Gene Name |
vomeronasal 2, receptor 3 |
Synonyms |
EG637004 |
MMRRC Submission |
039835-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R1806 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
3 |
Chromosomal Location |
64166225-64197130 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 64194810 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Lysine to Arginine
at position 8
(K8R)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000126165
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170244]
[ENSMUST00000176328]
|
AlphaFold |
H3BJ88 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000170244
AA Change: K8R
PolyPhen 2
Score 0.732 (Sensitivity: 0.86; Specificity: 0.92)
|
SMART Domains |
Protein: ENSMUSP00000126165 Gene: ENSMUSG00000091572 AA Change: K8R
Domain | Start | End | E-Value | Type |
Pfam:ANF_receptor
|
64 |
479 |
4e-64 |
PFAM |
Pfam:NCD3G
|
521 |
574 |
1.1e-17 |
PFAM |
Pfam:7tm_3
|
605 |
842 |
2.9e-75 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000176328
AA Change: K36R
PolyPhen 2
Score 0.355 (Sensitivity: 0.90; Specificity: 0.89)
|
SMART Domains |
Protein: ENSMUSP00000134891 Gene: ENSMUSG00000091572 AA Change: K36R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
92 |
507 |
9.5e-66 |
PFAM |
Pfam:NCD3G
|
549 |
602 |
8.8e-17 |
PFAM |
Pfam:7tm_3
|
635 |
869 |
8.5e-48 |
PFAM |
|
Meta Mutation Damage Score |
0.1795 |
Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.8%
- 10x: 94.9%
- 20x: 91.2%
|
Validation Efficiency |
96% (77/80) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 70 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aadacl2fm3 |
T |
C |
3: 59,784,571 (GRCm39) |
L348P |
probably damaging |
Het |
Adamts15 |
C |
A |
9: 30,816,111 (GRCm39) |
C616F |
probably damaging |
Het |
Adarb1 |
T |
C |
10: 77,158,099 (GRCm39) |
N116S |
probably damaging |
Het |
Add2 |
C |
T |
6: 86,095,639 (GRCm39) |
S437L |
probably damaging |
Het |
Adra1d |
T |
A |
2: 131,388,069 (GRCm39) |
R495S |
probably benign |
Het |
Agk |
C |
T |
6: 40,364,429 (GRCm39) |
T309I |
probably damaging |
Het |
Aqr |
T |
C |
2: 113,992,133 (GRCm39) |
Y81C |
probably damaging |
Het |
Bak1 |
G |
A |
17: 27,240,242 (GRCm39) |
Q142* |
probably null |
Het |
Bckdha |
A |
G |
7: 25,330,845 (GRCm39) |
V307A |
probably damaging |
Het |
Camk2n2 |
C |
A |
16: 20,438,948 (GRCm39) |
G72V |
probably benign |
Het |
Cd276 |
A |
T |
9: 58,434,845 (GRCm39) |
|
probably benign |
Het |
Cd2ap |
G |
A |
17: 43,149,649 (GRCm39) |
Q122* |
probably null |
Het |
Cdan1 |
T |
A |
2: 120,561,907 (GRCm39) |
|
probably benign |
Het |
Cdh3 |
T |
C |
8: 107,263,547 (GRCm39) |
S156P |
probably benign |
Het |
Chil4 |
T |
A |
3: 106,117,959 (GRCm39) |
|
probably benign |
Het |
Col11a1 |
C |
T |
3: 113,951,791 (GRCm39) |
R1074C |
probably damaging |
Het |
Depp1 |
G |
A |
6: 116,628,683 (GRCm39) |
V9M |
possibly damaging |
Het |
Fcrlb |
T |
C |
1: 170,735,096 (GRCm39) |
T344A |
probably benign |
Het |
Fras1 |
T |
A |
5: 96,861,829 (GRCm39) |
|
probably benign |
Het |
Fras1 |
G |
T |
5: 96,912,835 (GRCm39) |
V3380F |
possibly damaging |
Het |
Galnt9 |
A |
G |
5: 110,767,119 (GRCm39) |
D530G |
possibly damaging |
Het |
Gja10 |
A |
T |
4: 32,601,135 (GRCm39) |
S416R |
probably benign |
Het |
Gm10549 |
T |
A |
18: 33,603,841 (GRCm39) |
V108E |
unknown |
Het |
Hook3 |
A |
T |
8: 26,558,687 (GRCm39) |
L59Q |
probably damaging |
Het |
Hpf1 |
T |
A |
8: 61,353,154 (GRCm39) |
D178E |
probably benign |
Het |
Hsd17b7 |
T |
C |
1: 169,788,698 (GRCm39) |
N173S |
possibly damaging |
Het |
Hsph1 |
A |
G |
5: 149,553,454 (GRCm39) |
F236L |
probably damaging |
Het |
Kcnk12 |
G |
T |
17: 88,053,537 (GRCm39) |
T375K |
probably benign |
Het |
Klra3 |
A |
T |
6: 130,304,033 (GRCm39) |
S220T |
probably damaging |
Het |
Lhx1 |
A |
T |
11: 84,414,967 (GRCm39) |
L12Q |
probably damaging |
Het |
Lnx1 |
A |
G |
5: 74,766,710 (GRCm39) |
L468P |
probably damaging |
Het |
Ltbp3 |
T |
A |
19: 5,803,970 (GRCm39) |
C827* |
probably null |
Het |
Mical1 |
C |
T |
10: 41,354,210 (GRCm39) |
A53V |
probably damaging |
Het |
Mmp10 |
A |
T |
9: 7,506,502 (GRCm39) |
H326L |
probably benign |
Het |
Mpl |
A |
T |
4: 118,300,729 (GRCm39) |
M600K |
possibly damaging |
Het |
Muc5b |
T |
A |
7: 141,419,230 (GRCm39) |
D4004E |
possibly damaging |
Het |
Myo5b |
A |
T |
18: 74,710,680 (GRCm39) |
H98L |
possibly damaging |
Het |
Nbeal1 |
A |
G |
1: 60,323,251 (GRCm39) |
T2110A |
probably damaging |
Het |
Nedd4l |
C |
A |
18: 65,345,862 (GRCm39) |
R825S |
probably damaging |
Het |
Ntn4 |
C |
T |
10: 93,543,215 (GRCm39) |
R314W |
probably damaging |
Het |
Or4k35 |
A |
T |
2: 111,100,622 (GRCm39) |
I30N |
possibly damaging |
Het |
Or52e19 |
T |
A |
7: 102,959,432 (GRCm39) |
L168Q |
probably damaging |
Het |
Or8k41 |
A |
T |
2: 86,313,483 (GRCm39) |
I201N |
probably damaging |
Het |
Otog |
A |
T |
7: 45,940,361 (GRCm39) |
|
probably null |
Het |
Parp2 |
T |
A |
14: 51,056,836 (GRCm39) |
L320H |
probably damaging |
Het |
Poglut3 |
T |
C |
9: 53,307,150 (GRCm39) |
Y365H |
probably damaging |
Het |
Pola2 |
C |
T |
19: 5,993,250 (GRCm39) |
|
probably null |
Het |
Poln |
A |
T |
5: 34,264,494 (GRCm39) |
|
probably benign |
Het |
Pomt1 |
T |
A |
2: 32,131,680 (GRCm39) |
V123E |
probably damaging |
Het |
Prom2 |
T |
C |
2: 127,374,802 (GRCm39) |
Y578C |
probably damaging |
Het |
Prss23 |
T |
C |
7: 89,159,599 (GRCm39) |
T157A |
probably damaging |
Het |
Sdk1 |
T |
A |
5: 141,598,950 (GRCm39) |
V205E |
probably damaging |
Het |
Sdk1 |
A |
G |
5: 142,147,681 (GRCm39) |
K1771R |
probably benign |
Het |
Sidt1 |
A |
T |
16: 44,102,234 (GRCm39) |
S309T |
possibly damaging |
Het |
Sirpa |
T |
A |
2: 129,457,432 (GRCm39) |
F169I |
probably damaging |
Het |
Slc8a1 |
T |
C |
17: 81,955,916 (GRCm39) |
N374S |
probably damaging |
Het |
Sp110 |
C |
T |
1: 85,523,831 (GRCm39) |
|
probably null |
Het |
Stard9 |
A |
G |
2: 120,509,934 (GRCm39) |
|
probably null |
Het |
Synpr |
A |
G |
14: 13,563,082 (GRCm38) |
N105S |
probably damaging |
Het |
Tbc1d16 |
T |
C |
11: 119,046,927 (GRCm39) |
Y440C |
probably damaging |
Het |
Trabd |
A |
G |
15: 88,969,824 (GRCm39) |
I313V |
possibly damaging |
Het |
Trappc10 |
T |
C |
10: 78,046,610 (GRCm39) |
R430G |
probably damaging |
Het |
Trim50 |
A |
G |
5: 135,387,743 (GRCm39) |
E145G |
probably benign |
Het |
Uba2 |
A |
T |
7: 33,862,624 (GRCm39) |
F105I |
probably damaging |
Het |
Uba3 |
A |
G |
6: 97,176,230 (GRCm39) |
V92A |
possibly damaging |
Het |
Uhmk1 |
T |
C |
1: 170,038,628 (GRCm39) |
K153R |
probably damaging |
Het |
Xpot |
G |
T |
10: 121,443,543 (GRCm39) |
|
probably benign |
Het |
Zfp128 |
A |
G |
7: 12,624,949 (GRCm39) |
Y439C |
probably benign |
Het |
Zfy1 |
T |
A |
Y: 725,620 (GRCm39) |
H715L |
possibly damaging |
Het |
Zmym1 |
A |
C |
4: 126,941,872 (GRCm39) |
L839V |
probably damaging |
Het |
|
Other mutations in Vmn2r3 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01019:Vmn2r3
|
APN |
3 |
64,167,304 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01468:Vmn2r3
|
APN |
3 |
64,182,382 (GRCm39) |
missense |
possibly damaging |
0.57 |
IGL02032:Vmn2r3
|
APN |
3 |
64,182,476 (GRCm39) |
missense |
possibly damaging |
0.95 |
IGL02405:Vmn2r3
|
APN |
3 |
64,178,620 (GRCm39) |
splice site |
probably benign |
|
IGL02640:Vmn2r3
|
APN |
3 |
64,194,816 (GRCm39) |
missense |
probably benign |
|
IGL02719:Vmn2r3
|
APN |
3 |
64,183,031 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02746:Vmn2r3
|
APN |
3 |
64,167,239 (GRCm39) |
missense |
possibly damaging |
0.74 |
IGL02952:Vmn2r3
|
APN |
3 |
64,186,256 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03390:Vmn2r3
|
APN |
3 |
64,182,767 (GRCm39) |
missense |
possibly damaging |
0.55 |
G1citation:Vmn2r3
|
UTSW |
3 |
64,194,876 (GRCm39) |
missense |
probably benign |
0.30 |
R0023:Vmn2r3
|
UTSW |
3 |
64,182,787 (GRCm39) |
missense |
probably damaging |
0.99 |
R0433:Vmn2r3
|
UTSW |
3 |
64,183,054 (GRCm39) |
missense |
possibly damaging |
0.51 |
R0647:Vmn2r3
|
UTSW |
3 |
64,183,046 (GRCm39) |
missense |
probably damaging |
1.00 |
R1071:Vmn2r3
|
UTSW |
3 |
64,182,697 (GRCm39) |
missense |
possibly damaging |
0.79 |
R1536:Vmn2r3
|
UTSW |
3 |
64,182,538 (GRCm39) |
missense |
probably damaging |
1.00 |
R1806:Vmn2r3
|
UTSW |
3 |
64,182,893 (GRCm39) |
missense |
probably benign |
0.03 |
R1852:Vmn2r3
|
UTSW |
3 |
64,166,815 (GRCm39) |
missense |
probably damaging |
1.00 |
R1868:Vmn2r3
|
UTSW |
3 |
64,166,537 (GRCm39) |
missense |
probably damaging |
1.00 |
R2072:Vmn2r3
|
UTSW |
3 |
64,182,493 (GRCm39) |
missense |
possibly damaging |
0.87 |
R2240:Vmn2r3
|
UTSW |
3 |
64,166,483 (GRCm39) |
missense |
probably benign |
0.44 |
R2446:Vmn2r3
|
UTSW |
3 |
64,182,733 (GRCm39) |
missense |
probably damaging |
0.98 |
R4133:Vmn2r3
|
UTSW |
3 |
64,183,138 (GRCm39) |
missense |
probably damaging |
0.99 |
R4159:Vmn2r3
|
UTSW |
3 |
64,194,850 (GRCm39) |
nonsense |
probably null |
|
R4494:Vmn2r3
|
UTSW |
3 |
64,182,692 (GRCm39) |
missense |
probably damaging |
1.00 |
R4860:Vmn2r3
|
UTSW |
3 |
64,183,022 (GRCm39) |
missense |
probably benign |
0.00 |
R4895:Vmn2r3
|
UTSW |
3 |
64,167,182 (GRCm39) |
missense |
probably benign |
0.00 |
R4912:Vmn2r3
|
UTSW |
3 |
64,166,618 (GRCm39) |
missense |
probably damaging |
1.00 |
R5018:Vmn2r3
|
UTSW |
3 |
64,178,774 (GRCm39) |
missense |
probably benign |
|
R5033:Vmn2r3
|
UTSW |
3 |
64,167,220 (GRCm39) |
missense |
probably benign |
0.09 |
R5126:Vmn2r3
|
UTSW |
3 |
64,166,740 (GRCm39) |
missense |
probably damaging |
1.00 |
R5148:Vmn2r3
|
UTSW |
3 |
64,186,247 (GRCm39) |
missense |
probably damaging |
1.00 |
R5414:Vmn2r3
|
UTSW |
3 |
64,166,978 (GRCm39) |
nonsense |
probably null |
|
R5785:Vmn2r3
|
UTSW |
3 |
64,166,444 (GRCm39) |
missense |
possibly damaging |
0.89 |
R5905:Vmn2r3
|
UTSW |
3 |
64,182,698 (GRCm39) |
missense |
probably benign |
0.19 |
R5992:Vmn2r3
|
UTSW |
3 |
64,167,068 (GRCm39) |
missense |
probably damaging |
1.00 |
R6028:Vmn2r3
|
UTSW |
3 |
64,182,698 (GRCm39) |
missense |
probably benign |
0.19 |
R6331:Vmn2r3
|
UTSW |
3 |
64,186,182 (GRCm39) |
missense |
probably damaging |
1.00 |
R6378:Vmn2r3
|
UTSW |
3 |
64,182,517 (GRCm39) |
missense |
probably damaging |
1.00 |
R6775:Vmn2r3
|
UTSW |
3 |
64,183,039 (GRCm39) |
missense |
possibly damaging |
0.88 |
R6822:Vmn2r3
|
UTSW |
3 |
64,194,876 (GRCm39) |
missense |
probably benign |
0.30 |
R6826:Vmn2r3
|
UTSW |
3 |
64,182,327 (GRCm39) |
nonsense |
probably null |
|
R6886:Vmn2r3
|
UTSW |
3 |
64,166,927 (GRCm39) |
missense |
probably damaging |
1.00 |
R6971:Vmn2r3
|
UTSW |
3 |
64,166,668 (GRCm39) |
missense |
probably damaging |
0.99 |
R7154:Vmn2r3
|
UTSW |
3 |
64,194,732 (GRCm39) |
missense |
probably benign |
0.02 |
R7192:Vmn2r3
|
UTSW |
3 |
64,167,364 (GRCm39) |
missense |
probably benign |
0.24 |
R7282:Vmn2r3
|
UTSW |
3 |
64,168,825 (GRCm39) |
missense |
possibly damaging |
0.90 |
R7472:Vmn2r3
|
UTSW |
3 |
64,182,953 (GRCm39) |
missense |
probably benign |
0.00 |
R7563:Vmn2r3
|
UTSW |
3 |
64,182,770 (GRCm39) |
missense |
possibly damaging |
0.60 |
R7726:Vmn2r3
|
UTSW |
3 |
64,182,939 (GRCm39) |
nonsense |
probably null |
|
R7966:Vmn2r3
|
UTSW |
3 |
64,186,235 (GRCm39) |
missense |
probably damaging |
0.99 |
R8025:Vmn2r3
|
UTSW |
3 |
64,182,871 (GRCm39) |
missense |
possibly damaging |
0.91 |
R8050:Vmn2r3
|
UTSW |
3 |
64,178,714 (GRCm39) |
missense |
probably damaging |
0.99 |
R8300:Vmn2r3
|
UTSW |
3 |
64,182,347 (GRCm39) |
missense |
probably benign |
0.00 |
R8402:Vmn2r3
|
UTSW |
3 |
64,178,617 (GRCm39) |
splice site |
probably benign |
|
R8486:Vmn2r3
|
UTSW |
3 |
64,186,370 (GRCm39) |
missense |
probably damaging |
1.00 |
R8523:Vmn2r3
|
UTSW |
3 |
64,182,311 (GRCm39) |
missense |
probably benign |
0.03 |
R8678:Vmn2r3
|
UTSW |
3 |
64,166,896 (GRCm39) |
missense |
possibly damaging |
0.76 |
R8885:Vmn2r3
|
UTSW |
3 |
64,182,383 (GRCm39) |
missense |
probably benign |
0.00 |
R8886:Vmn2r3
|
UTSW |
3 |
64,194,892 (GRCm39) |
missense |
possibly damaging |
0.47 |
R8905:Vmn2r3
|
UTSW |
3 |
64,166,695 (GRCm39) |
missense |
probably damaging |
0.99 |
R8937:Vmn2r3
|
UTSW |
3 |
64,166,673 (GRCm39) |
missense |
probably damaging |
1.00 |
R8955:Vmn2r3
|
UTSW |
3 |
64,168,803 (GRCm39) |
missense |
possibly damaging |
0.56 |
R9172:Vmn2r3
|
UTSW |
3 |
64,186,403 (GRCm39) |
missense |
possibly damaging |
0.79 |
R9485:Vmn2r3
|
UTSW |
3 |
64,183,046 (GRCm39) |
missense |
probably damaging |
1.00 |
R9575:Vmn2r3
|
UTSW |
3 |
64,178,735 (GRCm39) |
missense |
probably benign |
0.01 |
R9618:Vmn2r3
|
UTSW |
3 |
64,178,724 (GRCm39) |
missense |
probably damaging |
0.98 |
X0022:Vmn2r3
|
UTSW |
3 |
64,182,389 (GRCm39) |
missense |
probably damaging |
1.00 |
X0022:Vmn2r3
|
UTSW |
3 |
64,178,669 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
Predicted Primers |
PCR Primer
(F):5'- AGGCTCCAAGGTATCCACTC -3'
(R):5'- AGGTTAGGCACTCACACACTC -3'
Sequencing Primer
(F):5'- AAGGTATCCACTCTTTTCTGGC -3'
(R):5'- ACACTCTAACACTCTATTAAGGTGC -3'
|
Posted On |
2014-06-23 |