Mutagenetix > Incidental Mutation

Incidental Mutation 'R1809:Lrrk2'

203741

Institutional Source

Beutler Lab

Gene Symbol

Lrrk2

Ensembl Gene

ENSMUSG00000036273

Gene Name

leucine-rich repeat kinase 2

Synonyms

9330188B09Rik, 4921513O20Rik, LOC381026, cI-46, D630001M17Rik

MMRRC Submission

039838-MU

Accession Numbers

Genbank: NM_025730; MGI: 1913975

Essential gene?

Possibly essential (E-score: 0.520) question?

Stock #

R1809 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

91673175-91816120 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 91699892 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 285 (F285S)

Ref Sequence

ENSEMBL: ENSMUSP00000052584 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000060642]

AlphaFold

Q5S006

Predicted Effect

possibly damaging
Transcript: ENSMUST00000060642
AA Change: F285S

PolyPhen 2 Score 0.858 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000052584
Gene: ENSMUSG00000036273
AA Change: F285S

Domain	Start	End	E-Value	Type
low complexity region	138	156	N/A	INTRINSIC
low complexity region	332	347	N/A	INTRINSIC
ANK	708	737	3.95e1	SMART
ANK	770	800	4.58e2	SMART
low complexity region	890	901	N/A	INTRINSIC
low complexity region	953	966	N/A	INTRINSIC
low complexity region	971	979	N/A	INTRINSIC
LRR	1010	1033	9.96e-1	SMART
LRR	1034	1057	8.01e0	SMART
LRR	1082	1105	2.45e0	SMART
LRR	1128	1151	9.3e-1	SMART
LRR	1195	1219	3.24e0	SMART
LRR	1244	1266	3.87e1	SMART
LRR	1267	1291	4.98e1	SMART
Pfam:Roc	1336	1456	4.9e-32	PFAM
Pfam:Ras	1336	1489	3.3e-17	PFAM
Pfam:COR	1524	1740	4e-28	PFAM
Pfam:Pkinase	1881	2132	4.7e-40	PFAM
Pfam:Pkinase_Tyr	1882	2132	6.8e-39	PFAM
WD40	2231	2276	3.09e-1	SMART
WD40	2401	2438	1.37e2	SMART

Meta Mutation Damage Score

0.4031

Coding Region Coverage

1x: 97.5%
3x: 96.8%
10x: 94.9%
20x: 91.2%

Validation Efficiency

96% (107/111)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-in allele exhibit impaired response to dopamine, amphetamine, and quinpirole. Mice homozygous for one knock-out allele exhibit increased neurite growth. Mice homozygous for different knock-out alleles exhibit alopecia due to excessive grooming or kdiney atrophy. [provided by MGI curators]

Allele List at MGI

All alleles(7) : Targeted, knock-out(6) Targeted, other(1)

Other mutations in this stock

Total: 104 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930502E18Rik	A	G	X: 53,733,749 (GRCm38)	E99G	probably benign	Het
9130409I23Rik	T	C	1: 181,059,687 (GRCm38)	I279T	probably damaging	Het
Ablim2	A	G	5: 35,843,270 (GRCm38)		probably benign	Het
Adamts20	C	T	15: 94,341,087 (GRCm38)	S750N	probably damaging	Het
Adh6a	G	A	3: 138,330,961 (GRCm38)	R370H	possibly damaging	Het
Akr1b7	A	G	6: 34,419,111 (GRCm38)	N183D	probably damaging	Het
Aktip	A	T	8: 91,129,720 (GRCm38)	I43N	probably damaging	Het
Ankrd26	A	T	6: 118,525,922 (GRCm38)		probably benign	Het
Ano9	G	A	7: 141,108,804 (GRCm38)	T144I	possibly damaging	Het
Anpep	G	T	7: 79,841,823 (GRCm38)	D143E	probably benign	Het
Aox2	C	A	1: 58,294,325 (GRCm38)	Q234K	probably benign	Het
Ap1g1	C	G	8: 109,833,182 (GRCm38)		probably benign	Het
Arhgef4	G	A	1: 34,810,555 (GRCm38)		probably null	Het
Armc4	T	A	18: 7,211,630 (GRCm38)	Y748F	probably benign	Het
Arsj	A	G	3: 126,438,295 (GRCm38)	Y230C	possibly damaging	Het
Asmt	C	T	X: 170,675,745 (GRCm38)		probably benign	Het
Astl	A	T	2: 127,345,485 (GRCm38)	K72N	probably damaging	Het
Atp2b2	G	A	6: 113,803,743 (GRCm38)		probably benign	Het
Baiap2l1	A	C	5: 144,324,555 (GRCm38)		probably null	Het
C7	A	T	15: 5,034,339 (GRCm38)	N193K	probably damaging	Het
Cacna2d4	G	T	6: 119,270,824 (GRCm38)	R362L	probably damaging	Het
Cct4	T	A	11: 22,997,615 (GRCm38)	D189E	probably benign	Het
Cd300lg	G	A	11: 102,043,112 (GRCm38)	G62S	probably benign	Het
Cdk14	T	A	5: 5,010,901 (GRCm38)	M307L	probably damaging	Het
Cfi	G	A	3: 129,873,119 (GRCm38)		probably null	Het
Clec2g	G	T	6: 128,980,310 (GRCm38)		probably null	Het
Cntnap2	T	C	6: 46,988,675 (GRCm38)	S807P	probably damaging	Het
Col6a3	T	A	1: 90,827,949 (GRCm38)	H206L	probably damaging	Het
Cyp2c23	A	T	19: 44,021,558 (GRCm38)		probably benign	Het
Dlec1	T	C	9: 119,136,699 (GRCm38)	V1058A	probably benign	Het
Dpp9	A	G	17: 56,199,038 (GRCm38)	Y454H	probably damaging	Het
Drosha	G	A	15: 12,890,112 (GRCm38)	G920R	probably null	Het
Duox2	A	G	2: 122,283,897 (GRCm38)	S1142P	possibly damaging	Het
Fam13a	C	T	6: 58,965,060 (GRCm38)		probably null	Het
Filip1l	A	G	16: 57,506,660 (GRCm38)	R18G	probably benign	Het
Foxa1	A	G	12: 57,542,741 (GRCm38)	V231A	probably damaging	Het
Gm11756	A	G	4: 73,917,517 (GRCm38)	F237L	probably benign	Het
Gm4787	A	T	12: 81,378,529 (GRCm38)	M285K	possibly damaging	Het
Gm5084	T	A	13: 60,212,506 (GRCm38)		noncoding transcript	Het
Gm6788	G	A	19: 28,763,186 (GRCm38)		noncoding transcript	Het
Gm9922	G	T	14: 101,729,405 (GRCm38)		probably benign	Het
Gtf3c4	A	T	2: 28,833,976 (GRCm38)	Y440*	probably null	Het
Helq	A	G	5: 100,773,954 (GRCm38)	S795P	probably damaging	Het
Helz	T	A	11: 107,599,171 (GRCm38)	S151T	possibly damaging	Het
Irgm1	T	C	11: 48,866,613 (GRCm38)	T124A	probably benign	Het
Itgam	C	T	7: 128,070,937 (GRCm38)	P134S	possibly damaging	Het
Kdm6a	T	C	X: 18,236,684 (GRCm38)	Y217H	probably benign	Het
Kif6	T	C	17: 49,901,784 (GRCm38)	L744P	probably benign	Het
Kmt2c	C	T	5: 25,284,192 (GRCm38)	R1203H	probably damaging	Het
Ksr2	A	G	5: 117,555,470 (GRCm38)	T328A	probably damaging	Het
Lig1	T	C	7: 13,300,355 (GRCm38)		probably benign	Het
Lpar3	G	A	3: 146,240,548 (GRCm38)		probably benign	Het
March7	A	G	2: 60,232,293 (GRCm38)	D148G	probably benign	Het
Mcee	T	C	7: 64,400,301 (GRCm38)	L60S	probably damaging	Het
Mob2	A	G	7: 142,016,374 (GRCm38)	I81T	probably damaging	Het
Mphosph8	T	A	14: 56,672,452 (GRCm38)	D87E	probably damaging	Het
Myo1g	T	C	11: 6,512,283 (GRCm38)	T560A	probably benign	Het
Nagk	C	T	6: 83,797,187 (GRCm38)	T42I	probably benign	Het
Naip1	G	T	13: 100,426,239 (GRCm38)	T806K	probably benign	Het
Ncor2	A	G	5: 125,118,793 (GRCm38)		probably benign	Het
Ocln	G	T	13: 100,511,459 (GRCm38)	Y401*	probably null	Het
Olfr922	G	A	9: 38,816,147 (GRCm38)	V215I	probably benign	Het
Oma1	T	A	4: 103,325,177 (GRCm38)	N292K	probably damaging	Het
Ovch2	T	A	7: 107,790,205 (GRCm38)		probably null	Het
Pcdhb16	T	C	18: 37,478,388 (GRCm38)	F134L	probably damaging	Het
Pipox	A	T	11: 77,881,534 (GRCm38)	Y337N	probably benign	Het
Polr3b	A	G	10: 84,693,001 (GRCm38)	D763G	probably damaging	Het
Pygo1	T	A	9: 72,944,796 (GRCm38)	N88K	probably damaging	Het
Rab3gap1	T	C	1: 127,934,514 (GRCm38)	M674T	probably damaging	Het
Rbm25	T	C	12: 83,672,727 (GRCm38)		probably benign	Het
Rbm26	C	T	14: 105,117,106 (GRCm38)		probably benign	Het
Rbms2	G	A	10: 128,138,186 (GRCm38)	T187I	possibly damaging	Het
Rnase11	T	A	14: 51,049,727 (GRCm38)	R123S	probably benign	Het
Rngtt	A	G	4: 33,443,614 (GRCm38)	N485D	probably benign	Het
Rp1l1	A	T	14: 64,027,966 (GRCm38)	M334L	probably benign	Het
Rps9	T	A	7: 3,704,727 (GRCm38)	L56Q	probably damaging	Het
Saysd1	C	A	14: 20,083,102 (GRCm38)		probably benign	Het
Sema4d	C	T	13: 51,713,691 (GRCm38)		probably null	Het
Shisa5	A	T	9: 109,040,930 (GRCm38)	D34V	probably damaging	Het
Skil	A	G	3: 31,117,506 (GRCm38)	D547G	probably damaging	Het
Slc2a5	T	A	4: 150,143,057 (GRCm38)	F444L	probably damaging	Het
Slc9b2	T	G	3: 135,317,131 (GRCm38)	C10G	possibly damaging	Het
Sorcs2	G	T	5: 36,229,220 (GRCm38)		probably benign	Het
Stk17b	T	G	1: 53,765,981 (GRCm38)	K140N	possibly damaging	Het
Stradb	T	A	1: 58,994,390 (GRCm38)	L404Q	possibly damaging	Het
Synj2	T	C	17: 6,026,551 (GRCm38)	M432T	possibly damaging	Het
Tanc1	G	T	2: 59,800,097 (GRCm38)	R800L	probably damaging	Het
Tenm4	A	G	7: 96,873,780 (GRCm38)	M1473V	probably benign	Het
Tesc	A	G	5: 118,061,602 (GRCm38)	I190V	probably benign	Het
Tex15	T	C	8: 33,574,234 (GRCm38)	F1231L	probably benign	Het
Thrsp	T	C	7: 97,417,125 (GRCm38)	I127V	probably benign	Het
Tlr6	A	T	5: 64,953,712 (GRCm38)	C617*	probably null	Het
Trank1	A	T	9: 111,392,825 (GRCm38)	I2877F	probably benign	Het
Ucp1	T	C	8: 83,297,867 (GRCm38)	S274P	probably damaging	Het
Ucp2	T	A	7: 100,498,399 (GRCm38)	V195E	probably damaging	Het
Vars2	T	C	17: 35,662,216 (GRCm38)	T394A	probably damaging	Het
Vmn1r1	A	G	1: 182,157,806 (GRCm38)	V98A	possibly damaging	Het
Vmn1r225	A	G	17: 20,502,656 (GRCm38)	I120V	probably benign	Het
Vmn2r102	A	T	17: 19,677,619 (GRCm38)	M299L	probably benign	Het
Vmn2r25	A	G	6: 123,825,378 (GRCm38)	V522A	probably benign	Het
Vmn2r70	T	C	7: 85,565,922 (GRCm38)	I135V	probably benign	Het
Vwf	T	C	6: 125,590,175 (GRCm38)		probably benign	Het
Zcchc11	T	A	4: 108,549,355 (GRCm38)	H1373Q	probably damaging	Het
Zfp446	T	C	7: 12,979,121 (GRCm38)	F29L	probably damaging	Het

Other mutations in Lrrk2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00159:Lrrk2	APN	15	91,747,799 (GRCm38)	missense	possibly damaging	0.90
IGL00542:Lrrk2	APN	15	91,699,943 (GRCm38)	missense	probably benign
IGL00770:Lrrk2	APN	15	91,801,833 (GRCm38)	splice site	probably benign
IGL00774:Lrrk2	APN	15	91,801,833 (GRCm38)	splice site	probably benign
IGL00791:Lrrk2	APN	15	91,779,841 (GRCm38)	missense	probably damaging	1.00
IGL00827:Lrrk2	APN	15	91,755,790 (GRCm38)	missense	probably damaging	1.00
IGL00843:Lrrk2	APN	15	91,757,058 (GRCm38)	missense	possibly damaging	0.58
IGL01109:Lrrk2	APN	15	91,738,832 (GRCm38)	missense	probably damaging	1.00
IGL01293:Lrrk2	APN	15	91,726,137 (GRCm38)	missense	probably benign	0.21
IGL01296:Lrrk2	APN	15	91,683,142 (GRCm38)	missense	probably benign
IGL01301:Lrrk2	APN	15	91,767,339 (GRCm38)	missense	probably damaging	1.00
IGL01360:Lrrk2	APN	15	91,700,569 (GRCm38)	splice site	probably null
IGL01465:Lrrk2	APN	15	91,728,925 (GRCm38)	missense	probably benign	0.21
IGL01529:Lrrk2	APN	15	91,812,313 (GRCm38)	missense	possibly damaging	0.92
IGL01557:Lrrk2	APN	15	91,699,989 (GRCm38)	missense	probably damaging	1.00
IGL01560:Lrrk2	APN	15	91,774,988 (GRCm38)	missense	probably benign	0.33
IGL01991:Lrrk2	APN	15	91,779,946 (GRCm38)	missense	probably damaging	0.99
IGL02003:Lrrk2	APN	15	91,731,491 (GRCm38)	missense	probably damaging	0.99
IGL02325:Lrrk2	APN	15	91,726,308 (GRCm38)	critical splice donor site	probably null
IGL02711:Lrrk2	APN	15	91,685,822 (GRCm38)	missense	possibly damaging	0.71
IGL02869:Lrrk2	APN	15	91,750,277 (GRCm38)	missense	probably damaging	1.00
IGL03104:Lrrk2	APN	15	91,747,755 (GRCm38)	missense	possibly damaging	0.68
IGL03179:Lrrk2	APN	15	91,700,578 (GRCm38)	missense	probably damaging	1.00
IGL03395:Lrrk2	APN	15	91,797,414 (GRCm38)	splice site	probably null
horned	UTSW	15	91,772,858 (GRCm38)	missense	probably damaging	1.00
R1312_Lrrk2_980	UTSW	15	91,699,895 (GRCm38)	missense	probably damaging	1.00
R4710_lrrk2_232	UTSW	15	91,699,927 (GRCm38)	missense	possibly damaging	0.88
R5245_Lrrk2_127	UTSW	15	91,796,089 (GRCm38)	missense	probably damaging	1.00
spree	UTSW	15	91,702,247 (GRCm38)	missense	probably benign	0.00
Spur	UTSW	15	91,774,995 (GRCm38)	nonsense	probably null
3-1:Lrrk2	UTSW	15	91,801,934 (GRCm38)	missense	probably benign	0.01
ANU18:Lrrk2	UTSW	15	91,767,339 (GRCm38)	missense	probably damaging	1.00
H8562:Lrrk2	UTSW	15	91,673,358 (GRCm38)	missense	probably benign
H8786:Lrrk2	UTSW	15	91,673,358 (GRCm38)	missense	probably benign
IGL02835:Lrrk2	UTSW	15	91,814,660 (GRCm38)	critical splice acceptor site	probably null
R0014:Lrrk2	UTSW	15	91,802,045 (GRCm38)	splice site	probably benign
R0014:Lrrk2	UTSW	15	91,802,045 (GRCm38)	splice site	probably benign
R0078:Lrrk2	UTSW	15	91,734,009 (GRCm38)	missense	probably benign	0.01
R0100:Lrrk2	UTSW	15	91,745,796 (GRCm38)	missense	probably damaging	1.00
R0282:Lrrk2	UTSW	15	91,778,414 (GRCm38)	splice site	probably benign
R0448:Lrrk2	UTSW	15	91,709,305 (GRCm38)	missense	probably damaging	0.99
R0449:Lrrk2	UTSW	15	91,750,275 (GRCm38)	missense	probably damaging	1.00
R0610:Lrrk2	UTSW	15	91,815,416 (GRCm38)	missense	probably benign
R0617:Lrrk2	UTSW	15	91,752,278 (GRCm38)	missense	probably benign	0.00
R0632:Lrrk2	UTSW	15	91,796,028 (GRCm38)	missense	probably damaging	0.98
R0639:Lrrk2	UTSW	15	91,772,996 (GRCm38)	missense	probably benign	0.03
R0661:Lrrk2	UTSW	15	91,787,016 (GRCm38)	missense	probably damaging	1.00
R0666:Lrrk2	UTSW	15	91,757,070 (GRCm38)	critical splice donor site	probably null
R0764:Lrrk2	UTSW	15	91,775,046 (GRCm38)	splice site	probably null
R0766:Lrrk2	UTSW	15	91,699,895 (GRCm38)	missense	probably damaging	1.00
R0845:Lrrk2	UTSW	15	91,755,962 (GRCm38)	missense	probably benign	0.22
R0940:Lrrk2	UTSW	15	91,729,081 (GRCm38)	missense	possibly damaging	0.83
R0970:Lrrk2	UTSW	15	91,729,169 (GRCm38)	missense	probably benign	0.22
R1080:Lrrk2	UTSW	15	91,673,689 (GRCm38)	missense	probably benign	0.01
R1114:Lrrk2	UTSW	15	91,700,468 (GRCm38)	nonsense	probably null
R1223:Lrrk2	UTSW	15	91,673,635 (GRCm38)	missense	probably benign	0.00
R1289:Lrrk2	UTSW	15	91,812,360 (GRCm38)	missense	probably benign	0.00
R1296:Lrrk2	UTSW	15	91,728,920 (GRCm38)	missense	probably damaging	1.00
R1312:Lrrk2	UTSW	15	91,699,895 (GRCm38)	missense	probably damaging	1.00
R1637:Lrrk2	UTSW	15	91,734,058 (GRCm38)	missense	probably benign
R1773:Lrrk2	UTSW	15	91,779,981 (GRCm38)	missense	possibly damaging	0.96
R1839:Lrrk2	UTSW	15	91,683,134 (GRCm38)	missense	probably benign	0.00
R1946:Lrrk2	UTSW	15	91,736,661 (GRCm38)	splice site	probably null
R2160:Lrrk2	UTSW	15	91,796,060 (GRCm38)	missense	probably damaging	1.00
R2232:Lrrk2	UTSW	15	91,764,716 (GRCm38)	missense	probably benign	0.05
R2419:Lrrk2	UTSW	15	91,797,526 (GRCm38)	splice site	probably benign
R2516:Lrrk2	UTSW	15	91,755,927 (GRCm38)	missense	probably benign
R3110:Lrrk2	UTSW	15	91,814,695 (GRCm38)	missense	probably benign	0.02
R3112:Lrrk2	UTSW	15	91,814,695 (GRCm38)	missense	probably benign	0.02
R3801:Lrrk2	UTSW	15	91,737,111 (GRCm38)	missense	probably benign
R3842:Lrrk2	UTSW	15	91,755,916 (GRCm38)	missense	probably benign	0.01
R3903:Lrrk2	UTSW	15	91,747,701 (GRCm38)	missense	probably damaging	1.00
R3903:Lrrk2	UTSW	15	91,747,700 (GRCm38)	missense	probably damaging	1.00
R3930:Lrrk2	UTSW	15	91,767,461 (GRCm38)	critical splice donor site	probably null
R3937:Lrrk2	UTSW	15	91,778,504 (GRCm38)	missense	probably damaging	0.98
R3938:Lrrk2	UTSW	15	91,778,504 (GRCm38)	missense	probably damaging	0.98
R3938:Lrrk2	UTSW	15	91,712,780 (GRCm38)	missense	possibly damaging	0.69
R3982:Lrrk2	UTSW	15	91,709,284 (GRCm38)	missense	probably benign	0.22
R4125:Lrrk2	UTSW	15	91,815,483 (GRCm38)	missense	probably benign	0.01
R4130:Lrrk2	UTSW	15	91,755,794 (GRCm38)	missense	probably benign	0.19
R4296:Lrrk2	UTSW	15	91,699,895 (GRCm38)	missense	probably damaging	1.00
R4465:Lrrk2	UTSW	15	91,747,820 (GRCm38)	missense	probably damaging	0.96
R4478:Lrrk2	UTSW	15	91,723,188 (GRCm38)	missense	probably damaging	1.00
R4517:Lrrk2	UTSW	15	91,705,120 (GRCm38)	missense	probably benign
R4539:Lrrk2	UTSW	15	91,729,142 (GRCm38)	missense	possibly damaging	0.86
R4654:Lrrk2	UTSW	15	91,765,681 (GRCm38)	missense	probably damaging	0.96
R4710:Lrrk2	UTSW	15	91,699,927 (GRCm38)	missense	possibly damaging	0.88
R4722:Lrrk2	UTSW	15	91,688,901 (GRCm38)	missense	probably damaging	1.00
R4723:Lrrk2	UTSW	15	91,764,759 (GRCm38)	missense	probably damaging	1.00
R4732:Lrrk2	UTSW	15	91,765,747 (GRCm38)	missense	probably damaging	1.00
R4732:Lrrk2	UTSW	15	91,688,849 (GRCm38)	missense	probably damaging	1.00
R4733:Lrrk2	UTSW	15	91,765,747 (GRCm38)	missense	probably damaging	1.00
R4733:Lrrk2	UTSW	15	91,688,849 (GRCm38)	missense	probably damaging	1.00
R4787:Lrrk2	UTSW	15	91,712,828 (GRCm38)	missense	probably benign
R4945:Lrrk2	UTSW	15	91,804,920 (GRCm38)	missense	probably benign	0.02
R4948:Lrrk2	UTSW	15	91,803,389 (GRCm38)	missense	probably benign	0.20
R5000:Lrrk2	UTSW	15	91,749,878 (GRCm38)	missense	probably damaging	1.00
R5031:Lrrk2	UTSW	15	91,700,619 (GRCm38)	missense	possibly damaging	0.50
R5067:Lrrk2	UTSW	15	91,765,790 (GRCm38)	missense	probably benign	0.01
R5245:Lrrk2	UTSW	15	91,796,089 (GRCm38)	missense	probably damaging	1.00
R5341:Lrrk2	UTSW	15	91,772,858 (GRCm38)	missense	probably damaging	1.00
R5460:Lrrk2	UTSW	15	91,814,644 (GRCm38)	splice site	probably null
R5551:Lrrk2	UTSW	15	91,812,350 (GRCm38)	missense	probably benign
R5574:Lrrk2	UTSW	15	91,787,016 (GRCm38)	missense	probably damaging	1.00
R5577:Lrrk2	UTSW	15	91,765,745 (GRCm38)	missense	probably damaging	1.00
R5685:Lrrk2	UTSW	15	91,803,301 (GRCm38)	nonsense	probably null
R5712:Lrrk2	UTSW	15	91,702,222 (GRCm38)	nonsense	probably null
R5728:Lrrk2	UTSW	15	91,774,974 (GRCm38)	missense	probably benign	0.36
R5782:Lrrk2	UTSW	15	91,702,183 (GRCm38)	missense	probably damaging	1.00
R5788:Lrrk2	UTSW	15	91,764,648 (GRCm38)	missense	possibly damaging	0.55
R5821:Lrrk2	UTSW	15	91,709,390 (GRCm38)	critical splice donor site	probably null
R5852:Lrrk2	UTSW	15	91,755,949 (GRCm38)	missense	probably damaging	1.00
R5934:Lrrk2	UTSW	15	91,734,046 (GRCm38)	missense	probably benign	0.00
R5935:Lrrk2	UTSW	15	91,745,831 (GRCm38)	missense	probably benign	0.14
R5979:Lrrk2	UTSW	15	91,772,945 (GRCm38)	missense	possibly damaging	0.47
R6101:Lrrk2	UTSW	15	91,723,135 (GRCm38)	missense	probably benign	0.10
R6114:Lrrk2	UTSW	15	91,747,826 (GRCm38)	missense	probably benign	0.33
R6259:Lrrk2	UTSW	15	91,702,247 (GRCm38)	missense	probably benign	0.00
R6376:Lrrk2	UTSW	15	91,742,266 (GRCm38)	missense	possibly damaging	0.89
R6417:Lrrk2	UTSW	15	91,812,346 (GRCm38)	missense	probably benign	0.03
R6420:Lrrk2	UTSW	15	91,812,346 (GRCm38)	missense	probably benign	0.03
R6737:Lrrk2	UTSW	15	91,723,218 (GRCm38)	missense	possibly damaging	0.50
R7056:Lrrk2	UTSW	15	91,774,995 (GRCm38)	nonsense	probably null
R7072:Lrrk2	UTSW	15	91,801,920 (GRCm38)	missense	probably benign	0.03
R7109:Lrrk2	UTSW	15	91,764,782 (GRCm38)	missense	probably damaging	1.00
R7128:Lrrk2	UTSW	15	91,801,885 (GRCm38)	missense	probably benign
R7144:Lrrk2	UTSW	15	91,734,055 (GRCm38)	missense	possibly damaging	0.54
R7187:Lrrk2	UTSW	15	91,757,001 (GRCm38)	missense	possibly damaging	0.92
R7270:Lrrk2	UTSW	15	91,700,441 (GRCm38)	missense	probably benign	0.01
R7356:Lrrk2	UTSW	15	91,738,744 (GRCm38)	missense	probably benign	0.07
R7360:Lrrk2	UTSW	15	91,731,655 (GRCm38)	critical splice donor site	probably null
R7373:Lrrk2	UTSW	15	91,700,004 (GRCm38)	critical splice donor site	probably null
R7465:Lrrk2	UTSW	15	91,767,340 (GRCm38)	missense	probably damaging	1.00
R7477:Lrrk2	UTSW	15	91,812,325 (GRCm38)	missense	probably damaging	0.98
R7614:Lrrk2	UTSW	15	91,772,858 (GRCm38)	missense	probably damaging	1.00
R7622:Lrrk2	UTSW	15	91,812,323 (GRCm38)	missense	probably damaging	1.00
R7658:Lrrk2	UTSW	15	91,700,358 (GRCm38)	missense	possibly damaging	0.91
R7679:Lrrk2	UTSW	15	91,726,186 (GRCm38)	missense	possibly damaging	0.58
R7737:Lrrk2	UTSW	15	91,815,446 (GRCm38)	missense	probably damaging	0.98
R7739:Lrrk2	UTSW	15	91,700,613 (GRCm38)	missense	probably damaging	1.00
R7740:Lrrk2	UTSW	15	91,767,324 (GRCm38)	missense	probably damaging	1.00
R7908:Lrrk2	UTSW	15	91,726,152 (GRCm38)	missense	probably damaging	1.00
R8299:Lrrk2	UTSW	15	91,673,240 (GRCm38)	start gained	probably benign
R8389:Lrrk2	UTSW	15	91,699,991 (GRCm38)	missense	probably damaging	1.00
R8462:Lrrk2	UTSW	15	91,731,477 (GRCm38)	missense	probably benign
R8698:Lrrk2	UTSW	15	91,752,197 (GRCm38)	missense	probably benign	0.38
R8947:Lrrk2	UTSW	15	91,702,270 (GRCm38)	nonsense	probably null
R9084:Lrrk2	UTSW	15	91,750,266 (GRCm38)	missense
R9086:Lrrk2	UTSW	15	91,755,848 (GRCm38)	missense	probably benign	0.01
R9096:Lrrk2	UTSW	15	91,673,256 (GRCm38)	start gained	probably benign
R9097:Lrrk2	UTSW	15	91,673,256 (GRCm38)	start gained	probably benign
R9267:Lrrk2	UTSW	15	91,700,426 (GRCm38)	missense	probably damaging	0.99
R9285:Lrrk2	UTSW	15	91,778,483 (GRCm38)	missense	probably damaging	1.00
R9341:Lrrk2	UTSW	15	91,700,415 (GRCm38)	missense	probably benign	0.18
R9343:Lrrk2	UTSW	15	91,700,415 (GRCm38)	missense	probably benign	0.18
R9371:Lrrk2	UTSW	15	91,723,204 (GRCm38)	missense	probably damaging	1.00
R9424:Lrrk2	UTSW	15	91,752,185 (GRCm38)	nonsense	probably null
R9489:Lrrk2	UTSW	15	91,737,217 (GRCm38)	missense	probably benign	0.37
R9502:Lrrk2	UTSW	15	91,723,162 (GRCm38)	missense	probably damaging	0.98
R9563:Lrrk2	UTSW	15	91,749,840 (GRCm38)	missense	possibly damaging	0.90
R9576:Lrrk2	UTSW	15	91,752,185 (GRCm38)	nonsense	probably null
R9605:Lrrk2	UTSW	15	91,737,217 (GRCm38)	missense	probably benign	0.37
R9635:Lrrk2	UTSW	15	91,812,324 (GRCm38)	missense	probably benign	0.21
R9641:Lrrk2	UTSW	15	91,787,048 (GRCm38)	missense	possibly damaging	0.94
R9660:Lrrk2	UTSW	15	91,734,025 (GRCm38)	missense	probably benign	0.00
R9673:Lrrk2	UTSW	15	91,765,681 (GRCm38)	missense	probably damaging	1.00
R9708:Lrrk2	UTSW	15	91,750,279 (GRCm38)	nonsense	probably null
R9728:Lrrk2	UTSW	15	91,734,025 (GRCm38)	missense	probably benign	0.00
R9757:Lrrk2	UTSW	15	91,811,026 (GRCm38)	missense	probably benign	0.03
RF001:Lrrk2	UTSW	15	91,736,633 (GRCm38)	missense	probably benign	0.11
X0028:Lrrk2	UTSW	15	91,738,851 (GRCm38)	missense	probably benign	0.00
Z1088:Lrrk2	UTSW	15	91,726,240 (GRCm38)	missense	probably benign	0.12

Predicted Primers

PCR Primer
(F):5'- TCTTACTCAGCCAGCAAAGTC -3'
(R):5'- CTGGAAGAAGGTCCTTTAACCCTC -3'

Sequencing Primer
(F):5'- CCAGAGTTTCAAAAAGTCTCTTGC -3'
(R):5'- TTTAACCCTCAACACTTAAAAGGAG -3'

Posted On

2014-06-23