Incidental Mutation 'R0110:Prmt1'
ID 20375
Institutional Source Beutler Lab
Gene Symbol Prmt1
Ensembl Gene ENSMUSG00000109324
Gene Name protein arginine N-methyltransferase 1
Synonyms 6720434D09Rik, Hrmt1l2
MMRRC Submission 038396-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R0110 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 44626179-44635844 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to G at 44628225 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000148815 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045325] [ENSMUST00000063761] [ENSMUST00000107843] [ENSMUST00000207370] [ENSMUST00000207522] [ENSMUST00000208938] [ENSMUST00000209124] [ENSMUST00000208829] [ENSMUST00000207659] [ENSMUST00000212255] [ENSMUST00000208312] [ENSMUST00000212836]
AlphaFold Q9JIF0
Predicted Effect probably benign
Transcript: ENSMUST00000045325
SMART Domains Protein: ENSMUSP00000045365
Gene: ENSMUSG00000109324

DomainStartEndE-ValueType
Pfam:PRMT5 41 343 3.9e-11 PFAM
Pfam:Met_10 72 184 5.4e-7 PFAM
Pfam:MTS 78 162 7e-7 PFAM
Pfam:PrmA 79 182 8.1e-10 PFAM
Pfam:Methyltransf_31 86 226 4.1e-10 PFAM
Pfam:Methyltransf_18 88 195 3.5e-9 PFAM
Pfam:Methyltransf_26 89 189 1.4e-8 PFAM
Pfam:Methyltransf_11 93 192 3.8e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000063761
SMART Domains Protein: ENSMUSP00000069539
Gene: ENSMUSG00000007783

DomainStartEndE-ValueType
Pfam:CPT_N 1 47 2.3e-21 PFAM
transmembrane domain 104 126 N/A INTRINSIC
Pfam:Carn_acyltransf 171 757 7.7e-167 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000107843
SMART Domains Protein: ENSMUSP00000103474
Gene: ENSMUSG00000109324

DomainStartEndE-ValueType
Pfam:PRMT5 41 343 1.9e-8 PFAM
Pfam:MTS 78 162 1.1e-6 PFAM
Pfam:PrmA 79 181 1.3e-9 PFAM
Pfam:Methyltransf_31 86 226 4e-10 PFAM
Pfam:Methyltransf_18 88 192 6.2e-9 PFAM
Pfam:Methyltransf_11 93 192 1e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207370
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207515
Predicted Effect probably benign
Transcript: ENSMUST00000207522
Predicted Effect probably benign
Transcript: ENSMUST00000208938
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207735
Predicted Effect probably benign
Transcript: ENSMUST00000209124
Predicted Effect probably benign
Transcript: ENSMUST00000208829
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207702
Predicted Effect probably benign
Transcript: ENSMUST00000207659
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209089
Predicted Effect probably benign
Transcript: ENSMUST00000212255
Predicted Effect probably benign
Transcript: ENSMUST00000209056
Predicted Effect probably benign
Transcript: ENSMUST00000208312
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208897
Predicted Effect probably benign
Transcript: ENSMUST00000208778
Predicted Effect probably benign
Transcript: ENSMUST00000212836
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.3%
  • 20x: 89.0%
Validation Efficiency 98% (105/107)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]
PHENOTYPE: Embryos homozygous for a null mutation die before E6.5 and exhibit abnormal embryonic tissue morphology. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 99 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930486L24Rik A T 13: 61,001,320 (GRCm39) probably benign Het
Abcg3 A G 5: 105,125,482 (GRCm39) I67T probably damaging Het
Adam10 T A 9: 70,655,530 (GRCm39) W333R probably damaging Het
Ahnak C T 19: 8,995,596 (GRCm39) R5627* probably null Het
AI606181 A C 19: 41,582,170 (GRCm39) K113N unknown Het
Alms1 A T 6: 85,597,351 (GRCm39) R1195* probably null Het
Ankrd11 T C 8: 123,618,914 (GRCm39) D1646G possibly damaging Het
Ap2m1 T A 16: 20,360,990 (GRCm39) I334N possibly damaging Het
Arpc1b T A 5: 145,064,525 (GRCm39) W361R probably damaging Het
Baiap2l1 T C 5: 144,212,701 (GRCm39) Y438C probably damaging Het
Brd8dc A T 18: 34,729,204 (GRCm39) D42E probably damaging Het
Ccdc110 T A 8: 46,388,194 (GRCm39) N50K probably benign Het
Ccdc168 C A 1: 44,098,384 (GRCm39) V905F probably benign Het
Cdhr1 T C 14: 36,802,633 (GRCm39) Y610C probably damaging Het
Celsr3 G A 9: 108,704,204 (GRCm39) C229Y possibly damaging Het
Clca4b A T 3: 144,619,112 (GRCm39) Y676N probably damaging Het
Cntln C T 4: 85,014,994 (GRCm39) T1095I probably damaging Het
Cog2 T C 8: 125,255,797 (GRCm39) probably null Het
Col11a1 A T 3: 113,899,105 (GRCm39) probably benign Het
Cpe T A 8: 65,064,501 (GRCm39) I233F probably damaging Het
Dcaf11 T C 14: 55,806,537 (GRCm39) V446A probably damaging Het
Defa34 A G 8: 22,155,988 (GRCm39) probably null Het
Dnah12 A G 14: 26,520,856 (GRCm39) R1892G probably damaging Het
Dock4 A G 12: 40,671,311 (GRCm39) probably benign Het
Dync1h1 C A 12: 110,606,378 (GRCm39) Q2483K probably benign Het
Enpp3 A T 10: 24,652,679 (GRCm39) D759E probably damaging Het
Epyc A G 10: 97,485,625 (GRCm39) T22A probably benign Het
Fam227b T A 2: 125,942,841 (GRCm39) S319C probably damaging Het
Fam83a C A 15: 57,873,322 (GRCm39) Q384K probably benign Het
Fam83b G T 9: 76,400,108 (GRCm39) L332I possibly damaging Het
Gal3st2c C T 1: 93,937,219 (GRCm39) P388L probably benign Het
Ggn C T 7: 28,870,721 (GRCm39) P47S probably damaging Het
Gli3 T G 13: 15,899,370 (GRCm39) L919R probably damaging Het
Gm5134 C A 10: 75,810,079 (GRCm39) T120N probably benign Het
Gmip C T 8: 70,268,259 (GRCm39) probably benign Het
Gpr39 C T 1: 125,605,237 (GRCm39) T55M probably damaging Het
Grk4 A G 5: 34,873,557 (GRCm39) T208A probably damaging Het
Gsdme C A 6: 50,223,107 (GRCm39) probably benign Het
Gucy2e T C 11: 69,126,402 (GRCm39) D326G probably benign Het
Hadhb T C 5: 30,374,483 (GRCm39) probably benign Het
Hectd4 T A 5: 121,419,959 (GRCm39) Y635N possibly damaging Het
Hectd4 G A 5: 121,443,736 (GRCm39) E1319K possibly damaging Het
Ikbkb A T 8: 23,161,651 (GRCm39) C412* probably null Het
Itpa A T 2: 130,521,338 (GRCm39) probably benign Het
Klhl10 A G 11: 100,347,758 (GRCm39) T605A probably benign Het
Krt74 T C 15: 101,671,751 (GRCm39) noncoding transcript Het
Krt81 C A 15: 101,361,508 (GRCm39) R24L possibly damaging Het
Lap3 T C 5: 45,652,632 (GRCm39) probably benign Het
Lrrc10 T A 10: 116,881,695 (GRCm39) L123Q probably damaging Het
Map3k6 T C 4: 132,971,105 (GRCm39) L273P probably damaging Het
Mbl1 A G 14: 40,880,706 (GRCm39) N198S probably damaging Het
Mcf2l A G 8: 13,047,337 (GRCm39) D233G probably damaging Het
Mdga2 T C 12: 66,517,700 (GRCm39) K45E possibly damaging Het
Mdn1 A G 4: 32,738,619 (GRCm39) N3524S probably benign Het
Mrc1 T A 2: 14,243,353 (GRCm39) probably benign Het
Msto1 A G 3: 88,818,848 (GRCm39) L269P probably benign Het
Mtcl1 C T 17: 66,665,109 (GRCm39) E1149K possibly damaging Het
Naca C T 10: 127,880,659 (GRCm39) A1897V probably benign Het
Ncapg T C 5: 45,850,489 (GRCm39) probably benign Het
Neb A T 2: 52,180,755 (GRCm39) probably benign Het
Or5p5 T C 7: 107,413,895 (GRCm39) Y35H probably damaging Het
Or8b12i T C 9: 20,082,561 (GRCm39) Y102C probably benign Het
Or8g27 G A 9: 39,129,024 (GRCm39) V124I possibly damaging Het
Parp2 T A 14: 51,057,130 (GRCm39) Y361N probably damaging Het
Parp3 A G 9: 106,348,995 (GRCm39) F466L possibly damaging Het
Pcdh15 A T 10: 74,126,808 (GRCm39) N296Y probably damaging Het
Pcf11 G A 7: 92,307,039 (GRCm39) P1043L probably damaging Het
Pdzrn3 A T 6: 101,128,014 (GRCm39) I884N probably damaging Het
Phf24 G T 4: 42,933,761 (GRCm39) V48L possibly damaging Het
Pla2g4a T A 1: 149,716,398 (GRCm39) M688L possibly damaging Het
Plcl2 T C 17: 50,915,010 (GRCm39) L673P probably damaging Het
Ppp1r3c A T 19: 36,711,617 (GRCm39) F51Y possibly damaging Het
Proc G A 18: 32,258,171 (GRCm39) T258I probably benign Het
Prom2 T G 2: 127,373,033 (GRCm39) S679R possibly damaging Het
Psen2 T C 1: 180,066,479 (GRCm39) T153A probably damaging Het
Rem2 T C 14: 54,713,754 (GRCm39) probably benign Het
Rin2 A G 2: 145,702,953 (GRCm39) K550E probably benign Het
Rtn4 T A 11: 29,683,849 (GRCm39) probably benign Het
Semp2l1 T A 1: 32,584,956 (GRCm39) N318I possibly damaging Het
Ssh1 A T 5: 114,084,766 (GRCm39) D448E probably benign Het
Ssmem1 A T 6: 30,519,547 (GRCm39) probably null Het
Stam2 A T 2: 52,609,998 (GRCm39) probably benign Het
Syne1 A G 10: 5,317,600 (GRCm39) L498P probably damaging Het
Syne2 AGAGTGAG AGAGTGAGTGAG 12: 76,144,734 (GRCm39) probably null Het
Taf6l G T 19: 8,755,885 (GRCm39) H254Q probably benign Het
Tas2r123 T C 6: 132,824,295 (GRCm39) V64A probably benign Het
Tnnc1 A G 14: 30,933,365 (GRCm39) D149G probably damaging Het
Tpp2 A G 1: 44,038,853 (GRCm39) D1133G probably damaging Het
Tpp2 T A 1: 44,017,664 (GRCm39) V756E probably benign Het
Traf3ip3 T A 1: 192,860,539 (GRCm39) probably null Het
Tsen15 A G 1: 152,247,548 (GRCm39) V148A probably damaging Het
Ttn T A 2: 76,694,672 (GRCm39) probably benign Het
Ube2u A G 4: 100,343,870 (GRCm39) I90V probably benign Het
Unc79 T A 12: 103,045,329 (GRCm39) probably null Het
Usp47 T C 7: 111,655,787 (GRCm39) S155P possibly damaging Het
Wdr41 T C 13: 95,154,619 (GRCm39) probably benign Het
Zfp217 C T 2: 169,957,382 (GRCm39) A539T probably benign Het
Zfp423 A G 8: 88,508,887 (GRCm39) S486P possibly damaging Het
Zfp628 A T 7: 4,922,732 (GRCm39) Q318L probably benign Het
Other mutations in Prmt1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01344:Prmt1 APN 7 44,627,059 (GRCm39) unclassified probably benign
IGL03195:Prmt1 APN 7 44,626,995 (GRCm39) missense probably damaging 0.98
R0313:Prmt1 UTSW 7 44,628,172 (GRCm39) missense probably benign 0.39
R0326:Prmt1 UTSW 7 44,628,878 (GRCm39) missense probably damaging 1.00
R0522:Prmt1 UTSW 7 44,631,203 (GRCm39) missense probably benign 0.08
R0531:Prmt1 UTSW 7 44,627,048 (GRCm39) missense probably damaging 1.00
R0611:Prmt1 UTSW 7 44,628,225 (GRCm39) splice site probably null
R2002:Prmt1 UTSW 7 44,628,148 (GRCm39) missense probably damaging 1.00
R4712:Prmt1 UTSW 7 44,631,060 (GRCm39) missense probably damaging 1.00
R6032:Prmt1 UTSW 7 44,626,526 (GRCm39) splice site probably null
R6153:Prmt1 UTSW 7 44,631,251 (GRCm39) missense probably damaging 1.00
R7087:Prmt1 UTSW 7 44,631,007 (GRCm39) splice site probably null
R7216:Prmt1 UTSW 7 44,632,997 (GRCm39) missense probably benign
R7655:Prmt1 UTSW 7 44,633,552 (GRCm39) missense probably benign 0.05
R7656:Prmt1 UTSW 7 44,633,552 (GRCm39) missense probably benign 0.05
R7747:Prmt1 UTSW 7 44,633,560 (GRCm39) splice site probably null
R9111:Prmt1 UTSW 7 44,631,169 (GRCm39) missense probably damaging 1.00
Z1177:Prmt1 UTSW 7 44,628,933 (GRCm39) missense possibly damaging 0.83
Predicted Primers PCR Primer
(F):5'- GGCCCTGAAAACTCTGATGTGTGG -3'
(R):5'- ATGGTGGGCTGGACAATTGGAC -3'

Sequencing Primer
(F):5'- AACTCTGATGTGTGGCCCAAC -3'
(R):5'- AATTGGACCACTCAGCTAGG -3'
Posted On 2013-04-11