Mutagenetix > Incidental Mutation

Incidental Mutation 'R0110:Celsr3'

20392

Institutional Source

Beutler Lab

Gene Symbol

Celsr3

Ensembl Gene

ENSMUSG00000023473

Gene Name

cadherin, EGF LAG seven-pass G-type receptor 3

Synonyms

Fmi1, flamingo

MMRRC Submission

038396-MU

Accession Numbers

Genbank: NM_080437; MGI: 1858236

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R0110 (G1)

Quality Score

225

Status

Validated (trace)

Chromosome

Chromosomal Location

108826320-108852969 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 108827005 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Tyrosine at position 229 (C229Y)

Ref Sequence

ENSEMBL: ENSMUSP00000150759 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000024238] [ENSMUST00000192235] [ENSMUST00000213524]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000024238
AA Change: C229Y

PolyPhen 2 Score 0.482 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000024238
Gene: ENSMUSG00000023473
AA Change: C229Y

Domain	Start	End	E-Value	Type
signal peptide	1	31	N/A	INTRINSIC
low complexity region	264	293	N/A	INTRINSIC
CA	338	422	2.25e-27	SMART
CA	446	534	5.05e-30	SMART
CA	558	640	7.6e-25	SMART
CA	664	745	7.36e-32	SMART
CA	769	847	5.95e-18	SMART
CA	871	950	5.25e-28	SMART
CA	974	1056	2.67e-29	SMART
CA	1080	1158	1.18e-21	SMART
CA	1186	1262	3.2e-1	SMART
low complexity region	1328	1335	N/A	INTRINSIC
low complexity region	1350	1360	N/A	INTRINSIC
EGF	1369	1424	1.02e-2	SMART
EGF	1429	1464	3.23e0	SMART
EGF	1467	1503	8.78e-2	SMART
LamG	1524	1691	2.27e-35	SMART
EGF	1714	1747	4.22e-4	SMART
LamG	1774	1913	9.02e-21	SMART
EGF	1938	1971	2.43e-4	SMART
EGF	1973	2009	1.3e-4	SMART
EGF_Lam	2066	2111	5.08e-7	SMART
HormR	2114	2176	3.42e-21	SMART
Pfam:GAIN	2188	2441	1.1e-57	PFAM
GPS	2467	2520	7.92e-20	SMART
Pfam:7tm_2	2527	2758	1.5e-56	PFAM
low complexity region	2813	2829	N/A	INTRINSIC
low complexity region	2882	2906	N/A	INTRINSIC
low complexity region	3058	3072	N/A	INTRINSIC
low complexity region	3149	3189	N/A	INTRINSIC
low complexity region	3239	3261	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000192235

SMART Domains

Protein: ENSMUSP00000141429
Gene: ENSMUSG00000023473

Domain	Start	End	E-Value	Type
low complexity region	67	74	N/A	INTRINSIC
low complexity region	89	99	N/A	INTRINSIC
EGF	108	163	4.9e-5	SMART
EGF	168	201	2.6e-6	SMART
EGF_like	208	239	1.6e-1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000192885

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000193114

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000193519

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000194742

Predicted Effect

possibly damaging
Transcript: ENSMUST00000213524
AA Change: C229Y

PolyPhen 2 Score 0.616 (Sensitivity: 0.87; Specificity: 0.91)

Meta Mutation Damage Score

0.0910

Coding Region Coverage

1x: 98.9%
3x: 98.0%
10x: 95.3%
20x: 89.0%

Validation Efficiency

98% (105/107)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]
PHENOTYPE: Mice homozygous for a null allele exhibit neonatal lethality, abnormal neurvous system development, and abnormal respiratory system development. [provided by MGI curators]

Allele List at MGI

All alleles(4) : Targeted, knock-out(2) Targeted, other(2)

Other mutations in this stock

Total: 99 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930486L24Rik	A	T	13: 60,853,506 (GRCm38)		probably benign	Het
4933408B17Rik	A	T	18: 34,596,151 (GRCm38)	D42E	probably damaging	Het
Abcg3	A	G	5: 104,977,616 (GRCm38)	I67T	probably damaging	Het
Adam10	T	A	9: 70,748,248 (GRCm38)	W333R	probably damaging	Het
Ahnak	C	T	19: 9,018,232 (GRCm38)	R5627*	probably null	Het
AI606181	A	C	19: 41,593,731 (GRCm38)	K113N	unknown	Het
Alms1	A	T	6: 85,620,369 (GRCm38)	R1195*	probably null	Het
Ankrd11	T	C	8: 122,892,175 (GRCm38)	D1646G	possibly damaging	Het
Ap2m1	T	A	16: 20,542,240 (GRCm38)	I334N	possibly damaging	Het
Arpc1b	T	A	5: 145,127,715 (GRCm38)	W361R	probably damaging	Het
Baiap2l1	T	C	5: 144,275,891 (GRCm38)	Y438C	probably damaging	Het
Ccdc110	T	A	8: 45,935,157 (GRCm38)	N50K	probably benign	Het
Cdhr1	T	C	14: 37,080,676 (GRCm38)	Y610C	probably damaging	Het
Clca4b	A	T	3: 144,913,351 (GRCm38)	Y676N	probably damaging	Het
Cntln	C	T	4: 85,096,757 (GRCm38)	T1095I	probably damaging	Het
Cog2	T	C	8: 124,529,058 (GRCm38)		probably null	Het
Col11a1	A	T	3: 114,105,456 (GRCm38)		probably benign	Het
Cpe	T	A	8: 64,611,467 (GRCm38)	I233F	probably damaging	Het
Dcaf11	T	C	14: 55,569,080 (GRCm38)	V446A	probably damaging	Het
Defa34	A	G	8: 21,665,972 (GRCm38)		probably null	Het
Dnah12	A	G	14: 26,798,899 (GRCm38)	R1892G	probably damaging	Het
Dock4	A	G	12: 40,621,312 (GRCm38)		probably benign	Het
Dync1h1	C	A	12: 110,639,944 (GRCm38)	Q2483K	probably benign	Het
Enpp3	A	T	10: 24,776,781 (GRCm38)	D759E	probably damaging	Het
Epyc	A	G	10: 97,649,763 (GRCm38)	T22A	probably benign	Het
Fam227b	T	A	2: 126,100,921 (GRCm38)	S319C	probably damaging	Het
Fam83a	C	A	15: 58,009,926 (GRCm38)	Q384K	probably benign	Het
Fam83b	G	T	9: 76,492,826 (GRCm38)	L332I	possibly damaging	Het
Gal3st2c	C	T	1: 94,009,497 (GRCm38)	P388L	probably benign	Het
Ggn	C	T	7: 29,171,296 (GRCm38)	P47S	probably damaging	Het
Gli3	T	G	13: 15,724,785 (GRCm38)	L919R	probably damaging	Het
Gm5134	C	A	10: 75,974,245 (GRCm38)	T120N	probably benign	Het
Gm5415	T	A	1: 32,545,875 (GRCm38)	N318I	possibly damaging	Het
Gm8251	C	A	1: 44,059,224 (GRCm38)	V905F	probably benign	Het
Gmip	C	T	8: 69,815,609 (GRCm38)		probably benign	Het
Gpr39	C	T	1: 125,677,500 (GRCm38)	T55M	probably damaging	Het
Grk4	A	G	5: 34,716,213 (GRCm38)	T208A	probably damaging	Het
Gsdme	C	A	6: 50,246,127 (GRCm38)		probably benign	Het
Gucy2e	T	C	11: 69,235,576 (GRCm38)	D326G	probably benign	Het
Hadhb	T	C	5: 30,169,485 (GRCm38)		probably benign	Het
Hectd4	T	A	5: 121,281,896 (GRCm38)	Y635N	possibly damaging	Het
Hectd4	G	A	5: 121,305,673 (GRCm38)	E1319K	possibly damaging	Het
Ikbkb	A	T	8: 22,671,635 (GRCm38)	C412*	probably null	Het
Itpa	A	T	2: 130,679,418 (GRCm38)		probably benign	Het
Klhl10	A	G	11: 100,456,932 (GRCm38)	T605A	probably benign	Het
Krt74	T	C	15: 101,763,316 (GRCm38)		noncoding transcript	Het
Krt81	C	A	15: 101,463,627 (GRCm38)	R24L	possibly damaging	Het
Lap3	T	C	5: 45,495,290 (GRCm38)		probably benign	Het
Lrrc10	T	A	10: 117,045,790 (GRCm38)	L123Q	probably damaging	Het
Map3k6	T	C	4: 133,243,794 (GRCm38)	L273P	probably damaging	Het
Mbl1	A	G	14: 41,158,749 (GRCm38)	N198S	probably damaging	Het
Mcf2l	A	G	8: 12,997,337 (GRCm38)	D233G	probably damaging	Het
Mdga2	T	C	12: 66,470,926 (GRCm38)	K45E	possibly damaging	Het
Mdn1	A	G	4: 32,738,619 (GRCm38)	N3524S	probably benign	Het
Mrc1	T	A	2: 14,238,542 (GRCm38)		probably benign	Het
Msto1	A	G	3: 88,911,541 (GRCm38)	L269P	probably benign	Het
Mtcl1	C	T	17: 66,358,114 (GRCm38)	E1149K	possibly damaging	Het
Naca	C	T	10: 128,044,790 (GRCm38)	A1897V	probably benign	Het
Ncapg	T	C	5: 45,693,147 (GRCm38)		probably benign	Het
Neb	A	T	2: 52,290,743 (GRCm38)		probably benign	Het
Olfr467	T	C	7: 107,814,688 (GRCm38)	Y35H	probably damaging	Het
Olfr870	T	C	9: 20,171,265 (GRCm38)	Y102C	probably benign	Het
Olfr944	G	A	9: 39,217,728 (GRCm38)	V124I	possibly damaging	Het
Parp2	T	A	14: 50,819,673 (GRCm38)	Y361N	probably damaging	Het
Parp3	A	G	9: 106,471,796 (GRCm38)	F466L	possibly damaging	Het
Pcdh15	A	T	10: 74,290,976 (GRCm38)	N296Y	probably damaging	Het
Pcf11	G	A	7: 92,657,831 (GRCm38)	P1043L	probably damaging	Het
Pdzrn3	A	T	6: 101,151,053 (GRCm38)	I884N	probably damaging	Het
Phf24	G	T	4: 42,933,761 (GRCm38)	V48L	possibly damaging	Het
Pla2g4a	T	A	1: 149,840,647 (GRCm38)	M688L	possibly damaging	Het
Plcl2	T	C	17: 50,607,982 (GRCm38)	L673P	probably damaging	Het
Ppp1r3c	A	T	19: 36,734,217 (GRCm38)	F51Y	possibly damaging	Het
Prmt1	A	G	7: 44,978,801 (GRCm38)		probably benign	Het
Proc	G	A	18: 32,125,118 (GRCm38)	T258I	probably benign	Het
Prom2	T	G	2: 127,531,113 (GRCm38)	S679R	possibly damaging	Het
Psen2	T	C	1: 180,238,914 (GRCm38)	T153A	probably damaging	Het
Rem2	T	C	14: 54,476,297 (GRCm38)		probably benign	Het
Rin2	A	G	2: 145,861,033 (GRCm38)	K550E	probably benign	Het
Rtn4	T	A	11: 29,733,849 (GRCm38)		probably benign	Het
Ssh1	A	T	5: 113,946,705 (GRCm38)	D448E	probably benign	Het
Ssmem1	A	T	6: 30,519,548 (GRCm38)		probably null	Het
Stam2	A	T	2: 52,719,986 (GRCm38)		probably benign	Het
Syne1	A	G	10: 5,367,600 (GRCm38)	L498P	probably damaging	Het
Syne2	AGAGTGAG	AGAGTGAGTGAG	12: 76,097,960 (GRCm38)		probably null	Het
Taf6l	G	T	19: 8,778,521 (GRCm38)	H254Q	probably benign	Het
Tas2r123	T	C	6: 132,847,332 (GRCm38)	V64A	probably benign	Het
Tnnc1	A	G	14: 31,211,408 (GRCm38)	D149G	probably damaging	Het
Tpp2	T	A	1: 43,978,504 (GRCm38)	V756E	probably benign	Het
Tpp2	A	G	1: 43,999,693 (GRCm38)	D1133G	probably damaging	Het
Traf3ip3	T	A	1: 193,178,231 (GRCm38)		probably null	Het
Tsen15	A	G	1: 152,371,797 (GRCm38)	V148A	probably damaging	Het
Ttn	T	A	2: 76,864,328 (GRCm38)		probably benign	Het
Ube2u	A	G	4: 100,486,673 (GRCm38)	I90V	probably benign	Het
Unc79	T	A	12: 103,079,070 (GRCm38)		probably null	Het
Usp47	T	C	7: 112,056,580 (GRCm38)	S155P	possibly damaging	Het
Wdr41	T	C	13: 95,018,111 (GRCm38)		probably benign	Het
Zfp217	C	T	2: 170,115,462 (GRCm38)	A539T	probably benign	Het
Zfp423	A	G	8: 87,782,259 (GRCm38)	S486P	possibly damaging	Het
Zfp628	A	T	7: 4,919,733 (GRCm38)	Q318L	probably benign	Het

Other mutations in Celsr3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00233:Celsr3	APN	9	108,848,925 (GRCm38)	missense	probably damaging	1.00
IGL00536:Celsr3	APN	9	108,829,192 (GRCm38)	missense	probably benign	0.33
IGL00552:Celsr3	APN	9	108,841,263 (GRCm38)	missense	possibly damaging	0.88
IGL00801:Celsr3	APN	9	108,842,576 (GRCm38)	missense	probably benign
IGL01420:Celsr3	APN	9	108,841,190 (GRCm38)	critical splice acceptor site	probably null
IGL01541:Celsr3	APN	9	108,831,708 (GRCm38)	missense	probably damaging	1.00
IGL01619:Celsr3	APN	9	108,834,557 (GRCm38)	missense	probably damaging	1.00
IGL01619:Celsr3	APN	9	108,837,404 (GRCm38)	missense	probably benign	0.00
IGL01631:Celsr3	APN	9	108,837,404 (GRCm38)	missense	probably benign	0.00
IGL01777:Celsr3	APN	9	108,835,942 (GRCm38)	missense	probably benign	0.08
IGL01938:Celsr3	APN	9	108,828,415 (GRCm38)	missense	probably benign	0.34
IGL02135:Celsr3	APN	9	108,827,556 (GRCm38)	missense	probably benign	0.11
IGL02231:Celsr3	APN	9	108,842,510 (GRCm38)	missense	probably damaging	1.00
IGL02234:Celsr3	APN	9	108,829,960 (GRCm38)	missense	probably benign
IGL02392:Celsr3	APN	9	108,834,721 (GRCm38)	splice site	probably benign
IGL02416:Celsr3	APN	9	108,832,119 (GRCm38)	missense	probably damaging	1.00
IGL02421:Celsr3	APN	9	108,840,463 (GRCm38)	missense	probably damaging	1.00
IGL02455:Celsr3	APN	9	108,842,893 (GRCm38)	missense	probably benign	0.15
IGL02798:Celsr3	APN	9	108,843,575 (GRCm38)	missense	probably damaging	1.00
IGL02939:Celsr3	APN	9	108,849,453 (GRCm38)	missense	probably damaging	1.00
IGL02947:Celsr3	APN	9	108,845,935 (GRCm38)	missense	probably benign	0.12
IGL02986:Celsr3	APN	9	108,841,255 (GRCm38)	splice site	probably null
IGL03089:Celsr3	APN	9	108,826,607 (GRCm38)	missense	probably benign	0.04
IGL03162:Celsr3	APN	9	108,842,558 (GRCm38)	missense	probably damaging	1.00
IGL03267:Celsr3	APN	9	108,836,525 (GRCm38)	splice site	probably benign
Diminishment	UTSW	9	108,842,708 (GRCm38)	intron	probably benign
little_d	UTSW	9	108,827,692 (GRCm38)	missense	probably damaging	0.98
nogal	UTSW	9	108,835,838 (GRCm38)	missense	probably benign
F6893:Celsr3	UTSW	9	108,835,067 (GRCm38)	missense	probably benign	0.00
PIT4243001:Celsr3	UTSW	9	108,832,308 (GRCm38)	missense	probably benign	0.13
PIT4810001:Celsr3	UTSW	9	108,845,733 (GRCm38)	missense	probably damaging	1.00
R0243:Celsr3	UTSW	9	108,843,724 (GRCm38)	splice site	probably benign
R0382:Celsr3	UTSW	9	108,829,218 (GRCm38)	missense	probably damaging	1.00
R0482:Celsr3	UTSW	9	108,829,073 (GRCm38)	nonsense	probably null
R0510:Celsr3	UTSW	9	108,827,005 (GRCm38)	missense	possibly damaging	0.62
R0630:Celsr3	UTSW	9	108,827,692 (GRCm38)	missense	probably damaging	0.98
R0656:Celsr3	UTSW	9	108,834,655 (GRCm38)	missense	possibly damaging	0.89
R0764:Celsr3	UTSW	9	108,827,818 (GRCm38)	missense	probably damaging	1.00
R0883:Celsr3	UTSW	9	108,842,633 (GRCm38)	missense	probably damaging	1.00
R0924:Celsr3	UTSW	9	108,846,025 (GRCm38)	missense	possibly damaging	0.78
R1015:Celsr3	UTSW	9	108,833,176 (GRCm38)	missense	probably benign	0.17
R1321:Celsr3	UTSW	9	108,835,870 (GRCm38)	missense	probably damaging	1.00
R1423:Celsr3	UTSW	9	108,826,905 (GRCm38)	missense	probably benign	0.00
R1497:Celsr3	UTSW	9	108,848,865 (GRCm38)	missense	probably benign	0.14
R1520:Celsr3	UTSW	9	108,848,658 (GRCm38)	missense	probably damaging	1.00
R1534:Celsr3	UTSW	9	108,848,884 (GRCm38)	missense	probably damaging	0.99
R1569:Celsr3	UTSW	9	108,829,068 (GRCm38)	missense	probably damaging	1.00
R1657:Celsr3	UTSW	9	108,842,952 (GRCm38)	nonsense	probably null
R1753:Celsr3	UTSW	9	108,831,857 (GRCm38)	missense	probably damaging	0.99
R1764:Celsr3	UTSW	9	108,828,958 (GRCm38)	missense	probably damaging	1.00
R1801:Celsr3	UTSW	9	108,834,626 (GRCm38)	missense	possibly damaging	0.88
R1838:Celsr3	UTSW	9	108,829,906 (GRCm38)	missense	probably benign
R1839:Celsr3	UTSW	9	108,829,906 (GRCm38)	missense	probably benign
R1874:Celsr3	UTSW	9	108,835,838 (GRCm38)	missense	probably benign
R1875:Celsr3	UTSW	9	108,835,838 (GRCm38)	missense	probably benign
R1953:Celsr3	UTSW	9	108,843,182 (GRCm38)	missense	probably benign	0.19
R1960:Celsr3	UTSW	9	108,845,817 (GRCm38)	missense	probably benign
R2113:Celsr3	UTSW	9	108,838,470 (GRCm38)	missense	probably damaging	1.00
R2290:Celsr3	UTSW	9	108,843,224 (GRCm38)	missense	probably damaging	1.00
R2369:Celsr3	UTSW	9	108,842,552 (GRCm38)	missense	probably benign
R2373:Celsr3	UTSW	9	108,842,552 (GRCm38)	missense	probably benign
R2374:Celsr3	UTSW	9	108,842,552 (GRCm38)	missense	probably benign
R2375:Celsr3	UTSW	9	108,842,552 (GRCm38)	missense	probably benign
R2844:Celsr3	UTSW	9	108,829,308 (GRCm38)	missense	probably damaging	1.00
R2968:Celsr3	UTSW	9	108,832,191 (GRCm38)	missense	probably damaging	1.00
R3103:Celsr3	UTSW	9	108,837,139 (GRCm38)	missense	probably benign	0.31
R3159:Celsr3	UTSW	9	108,827,710 (GRCm38)	missense	possibly damaging	0.94
R3791:Celsr3	UTSW	9	108,842,552 (GRCm38)	missense	probably benign
R4194:Celsr3	UTSW	9	108,843,302 (GRCm38)	critical splice donor site	probably null
R4329:Celsr3	UTSW	9	108,846,049 (GRCm38)	missense	probably benign	0.00
R4365:Celsr3	UTSW	9	108,829,847 (GRCm38)	missense	possibly damaging	0.47
R4419:Celsr3	UTSW	9	108,843,244 (GRCm38)	missense	possibly damaging	0.84
R4484:Celsr3	UTSW	9	108,846,063 (GRCm38)	critical splice donor site	probably null
R4582:Celsr3	UTSW	9	108,845,723 (GRCm38)	missense	probably damaging	1.00
R4681:Celsr3	UTSW	9	108,827,754 (GRCm38)	missense	possibly damaging	0.58
R4729:Celsr3	UTSW	9	108,847,652 (GRCm38)	missense	probably benign	0.05
R4881:Celsr3	UTSW	9	108,843,941 (GRCm38)	missense	probably damaging	1.00
R4893:Celsr3	UTSW	9	108,849,421 (GRCm38)	missense	probably damaging	1.00
R5183:Celsr3	UTSW	9	108,837,560 (GRCm38)	missense	probably damaging	0.99
R5207:Celsr3	UTSW	9	108,832,759 (GRCm38)	missense	probably benign	0.01
R5290:Celsr3	UTSW	9	108,843,158 (GRCm38)	missense	probably benign	0.01
R5327:Celsr3	UTSW	9	108,842,708 (GRCm38)	intron	probably benign
R5345:Celsr3	UTSW	9	108,832,124 (GRCm38)	missense	probably damaging	1.00
R5358:Celsr3	UTSW	9	108,832,025 (GRCm38)	missense	possibly damaging	0.96
R5396:Celsr3	UTSW	9	108,828,582 (GRCm38)	missense	probably damaging	1.00
R5414:Celsr3	UTSW	9	108,840,042 (GRCm38)	missense	possibly damaging	0.88
R5452:Celsr3	UTSW	9	108,844,034 (GRCm38)	missense	possibly damaging	0.68
R5467:Celsr3	UTSW	9	108,828,637 (GRCm38)	missense	probably damaging	1.00
R5479:Celsr3	UTSW	9	108,844,544 (GRCm38)	critical splice donor site	probably null
R5629:Celsr3	UTSW	9	108,849,067 (GRCm38)	missense	probably benign	0.41
R5637:Celsr3	UTSW	9	108,837,133 (GRCm38)	missense	probably damaging	1.00
R5652:Celsr3	UTSW	9	108,838,472 (GRCm38)	missense	probably benign	0.03
R5739:Celsr3	UTSW	9	108,827,158 (GRCm38)	missense	probably benign
R5785:Celsr3	UTSW	9	108,827,797 (GRCm38)	missense	probably damaging	1.00
R5877:Celsr3	UTSW	9	108,845,727 (GRCm38)	missense	probably damaging	0.98
R5961:Celsr3	UTSW	9	108,831,794 (GRCm38)	missense	probably damaging	1.00
R6046:Celsr3	UTSW	9	108,837,151 (GRCm38)	missense	probably benign	0.01
R6176:Celsr3	UTSW	9	108,828,355 (GRCm38)	missense	probably damaging	1.00
R6291:Celsr3	UTSW	9	108,828,842 (GRCm38)	missense	probably damaging	1.00
R6468:Celsr3	UTSW	9	108,835,790 (GRCm38)	missense	probably benign	0.08
R6481:Celsr3	UTSW	9	108,837,084 (GRCm38)	missense	possibly damaging	0.92
R6547:Celsr3	UTSW	9	108,829,128 (GRCm38)	missense	probably damaging	1.00
R6763:Celsr3	UTSW	9	108,827,350 (GRCm38)	missense	probably damaging	1.00
R6870:Celsr3	UTSW	9	108,829,191 (GRCm38)	missense	probably benign	0.02
R6977:Celsr3	UTSW	9	108,827,715 (GRCm38)	missense	probably benign
R7061:Celsr3	UTSW	9	108,847,594 (GRCm38)	nonsense	probably null
R7122:Celsr3	UTSW	9	108,828,567 (GRCm38)	missense	possibly damaging	0.90
R7156:Celsr3	UTSW	9	108,838,004 (GRCm38)	missense	possibly damaging	0.95
R7166:Celsr3	UTSW	9	108,842,951 (GRCm38)	missense	probably damaging	1.00
R7176:Celsr3	UTSW	9	108,845,762 (GRCm38)	missense	probably benign
R7213:Celsr3	UTSW	9	108,849,040 (GRCm38)	missense	probably damaging	0.98
R7314:Celsr3	UTSW	9	108,829,144 (GRCm38)	missense	probably damaging	1.00
R7478:Celsr3	UTSW	9	108,843,578 (GRCm38)	missense	probably benign	0.37
R7508:Celsr3	UTSW	9	108,836,622 (GRCm38)	missense	probably benign
R7554:Celsr3	UTSW	9	108,841,209 (GRCm38)	missense	probably benign
R7615:Celsr3	UTSW	9	108,837,652 (GRCm38)	missense	possibly damaging	0.75
R7653:Celsr3	UTSW	9	108,835,070 (GRCm38)	nonsense	probably null
R7747:Celsr3	UTSW	9	108,829,978 (GRCm38)	missense	possibly damaging	0.61
R7881:Celsr3	UTSW	9	108,828,072 (GRCm38)	missense	probably benign	0.28
R7935:Celsr3	UTSW	9	108,829,641 (GRCm38)	missense	probably benign	0.01
R7995:Celsr3	UTSW	9	108,845,083 (GRCm38)	missense	probably damaging	0.99
R8006:Celsr3	UTSW	9	108,829,107 (GRCm38)	missense	probably damaging	1.00
R8077:Celsr3	UTSW	9	108,828,331 (GRCm38)	missense	probably benign	0.15
R8284:Celsr3	UTSW	9	108,846,413 (GRCm38)	missense	probably damaging	0.99
R8291:Celsr3	UTSW	9	108,837,970 (GRCm38)	missense	probably damaging	1.00
R8322:Celsr3	UTSW	9	108,848,794 (GRCm38)	missense	probably damaging	1.00
R8334:Celsr3	UTSW	9	108,841,272 (GRCm38)	frame shift	probably null
R8337:Celsr3	UTSW	9	108,841,272 (GRCm38)	frame shift	probably null
R8338:Celsr3	UTSW	9	108,827,340 (GRCm38)	nonsense	probably null
R8353:Celsr3	UTSW	9	108,826,535 (GRCm38)	missense	probably benign	0.00
R8407:Celsr3	UTSW	9	108,829,057 (GRCm38)	missense	probably damaging	1.00
R8408:Celsr3	UTSW	9	108,831,789 (GRCm38)	missense	probably damaging	1.00
R8459:Celsr3	UTSW	9	108,829,630 (GRCm38)	missense	probably damaging	1.00
R8510:Celsr3	UTSW	9	108,838,120 (GRCm38)	missense	possibly damaging	0.93
R8713:Celsr3	UTSW	9	108,829,863 (GRCm38)	missense	probably benign
R8728:Celsr3	UTSW	9	108,846,741 (GRCm38)	missense	probably benign	0.24
R8829:Celsr3	UTSW	9	108,840,383 (GRCm38)	missense	probably benign
R8877:Celsr3	UTSW	9	108,829,678 (GRCm38)	missense	probably damaging	1.00
R8905:Celsr3	UTSW	9	108,841,302 (GRCm38)	missense	probably damaging	1.00
R9008:Celsr3	UTSW	9	108,828,952 (GRCm38)	missense	possibly damaging	0.94
R9072:Celsr3	UTSW	9	108,827,094 (GRCm38)	missense	probably benign
R9157:Celsr3	UTSW	9	108,829,986 (GRCm38)	missense	probably damaging	1.00
R9183:Celsr3	UTSW	9	108,829,396 (GRCm38)	missense	probably damaging	1.00
R9275:Celsr3	UTSW	9	108,838,490 (GRCm38)	missense	probably benign	0.27
R9361:Celsr3	UTSW	9	108,849,322 (GRCm38)	missense	probably damaging	1.00
R9382:Celsr3	UTSW	9	108,829,762 (GRCm38)	missense	possibly damaging	0.60
R9407:Celsr3	UTSW	9	108,846,397 (GRCm38)	missense	probably damaging	1.00
R9432:Celsr3	UTSW	9	108,848,833 (GRCm38)	missense	probably benign	0.00
R9607:Celsr3	UTSW	9	108,840,502 (GRCm38)	critical splice donor site	probably null
R9626:Celsr3	UTSW	9	108,849,322 (GRCm38)	missense	probably damaging	1.00
R9628:Celsr3	UTSW	9	108,826,360 (GRCm38)	nonsense	probably null
R9630:Celsr3	UTSW	9	108,827,097 (GRCm38)	missense	probably benign
R9645:Celsr3	UTSW	9	108,827,492 (GRCm38)	nonsense	probably null
R9683:Celsr3	UTSW	9	108,827,323 (GRCm38)	missense	probably damaging	1.00
R9794:Celsr3	UTSW	9	108,851,303 (GRCm38)	missense	probably benign	0.00
R9798:Celsr3	UTSW	9	108,828,595 (GRCm38)	missense	probably damaging	1.00
RF020:Celsr3	UTSW	9	108,849,057 (GRCm38)	missense	probably benign
X0018:Celsr3	UTSW	9	108,840,412 (GRCm38)	missense	probably benign	0.01
X0018:Celsr3	UTSW	9	108,827,778 (GRCm38)	missense	possibly damaging	0.65
X0026:Celsr3	UTSW	9	108,828,930 (GRCm38)	missense	probably damaging	0.99
Z1177:Celsr3	UTSW	9	108,826,477 (GRCm38)	missense	probably benign	0.34

Predicted Primers

PCR Primer
(F):5'- CTTTACGAAGAGGTAGCCTGCCAC -3'
(R):5'- TTGGCTTCAGGACCAGTCGGAAAC -3'

Sequencing Primer
(F):5'- GATTCTGATCTGAGGAACAGCTC -3'
(R):5'- GAGACTCGCGAGGTGCT -3'

Posted On

2013-04-11