Mutagenetix > Incidental Mutation

Incidental Mutation 'R1862:Lrba'

204000

Institutional Source

Beutler Lab

Gene Symbol

Lrba

Ensembl Gene

ENSMUSG00000028080

Gene Name

LPS-responsive beige-like anchor

Synonyms

Lba, D3Ertd775e

MMRRC Submission

039885-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1862 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

86224680-86782692 bp(+) (GRCm38)

Type of Mutation

critical splice donor site (2 bp from exon)

DNA Base Change (assembly)

T to C at 86773203 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000141734 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000107635] [ENSMUST00000194759] [ENSMUST00000195524]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000107635

SMART Domains

Protein: ENSMUSP00000103261
Gene: ENSMUSG00000028080

Domain	Start	End	E-Value	Type
low complexity region	12	31	N/A	INTRINSIC
Pfam:Laminin_G_3	211	377	4.6e-13	PFAM
Pfam:DUF4704	446	717	2.5e-109	PFAM
coiled coil region	1019	1037	N/A	INTRINSIC
low complexity region	1073	1089	N/A	INTRINSIC
low complexity region	1100	1113	N/A	INTRINSIC
low complexity region	1585	1600	N/A	INTRINSIC
low complexity region	1614	1630	N/A	INTRINSIC
low complexity region	1698	1713	N/A	INTRINSIC
low complexity region	1738	1757	N/A	INTRINSIC
low complexity region	1848	1861	N/A	INTRINSIC
Pfam:DUF1088	1882	2049	7e-88	PFAM
Pfam:PH_BEACH	2075	2172	9.1e-31	PFAM
Beach	2203	2480	2.87e-207	SMART
WD40	2578	2615	7.4e0	SMART
WD40	2618	2661	1.72e0	SMART
WD40	2677	2716	3.99e-1	SMART
WD40	2760	2798	1.79e-1	SMART
WD40	2801	2840	4.28e0	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000194490

Predicted Effect

probably null
Transcript: ENSMUST00000194759

SMART Domains

Protein: ENSMUSP00000142043
Gene: ENSMUSG00000028080

Domain	Start	End	E-Value	Type
low complexity region	12	31	N/A	INTRINSIC
Pfam:Laminin_G_3	205	377	8.1e-18	PFAM
coiled coil region	1019	1037	N/A	INTRINSIC
low complexity region	1073	1089	N/A	INTRINSIC
low complexity region	1100	1113	N/A	INTRINSIC
low complexity region	1585	1600	N/A	INTRINSIC
low complexity region	1614	1630	N/A	INTRINSIC
low complexity region	1698	1713	N/A	INTRINSIC
low complexity region	1738	1757	N/A	INTRINSIC
low complexity region	1848	1861	N/A	INTRINSIC
Pfam:DUF1088	1882	2050	1.6e-92	PFAM
Pfam:PH_BEACH	2068	2172	8.3e-32	PFAM
Beach	2203	2480	2.87e-207	SMART
WD40	2578	2615	7.4e0	SMART
WD40	2618	2661	1.72e0	SMART
WD40	2677	2716	3.99e-1	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000195524

SMART Domains

Protein: ENSMUSP00000141734
Gene: ENSMUSG00000028080

Domain	Start	End	E-Value	Type
Pfam:PH_BEACH	3	76	3.6e-20	PFAM
Beach	107	384	2.87e-207	SMART
WD40	482	519	7.4e0	SMART
WD40	522	565	1.72e0	SMART
WD40	581	620	3.99e-1	SMART
WD40	664	702	1.79e-1	SMART
WD40	705	744	4.28e0	SMART

Coding Region Coverage

1x: 97.5%
3x: 96.8%
10x: 94.9%
20x: 90.5%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased numbers of myeloid-derived suppressor cells and regulatory T cells, abnormal NK cell physiology, impaired rejection of allogeneic, xenogeneic and missing self bone-marrow grafts, and resistance to acute graft vs host disease. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 82 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acox2	T	A	14: 8,241,416 (GRCm38)	E565D	probably benign	Het
Adam30	A	T	3: 98,162,113 (GRCm38)	K421*	probably null	Het
Atp6v1b1	A	G	6: 83,749,852 (GRCm38)		probably null	Het
Cacna1a	A	T	8: 84,415,930 (GRCm38)	I96F	possibly damaging	Het
Card10	G	A	15: 78,780,514 (GRCm38)	R747W	probably damaging	Het
Cdh8	T	A	8: 99,190,394 (GRCm38)	D363V	probably damaging	Het
Cecr2	T	C	6: 120,757,941 (GRCm38)	Y685H	probably damaging	Het
Cmklr1	T	C	5: 113,614,407 (GRCm38)	T178A	probably damaging	Het
Col16a1	G	A	4: 130,092,782 (GRCm38)		probably null	Het
Col4a1	C	T	8: 11,226,439 (GRCm38)		probably benign	Het
Coro2a	T	A	4: 46,548,797 (GRCm38)	I166F	possibly damaging	Het
Cry2	T	C	2: 92,424,566 (GRCm38)	H148R	probably damaging	Het
Crygd	T	C	1: 65,061,974 (GRCm38)	Y154C	probably benign	Het
Cubn	T	C	2: 13,308,561 (GRCm38)	Y3066C	probably damaging	Het
Defb15	C	T	8: 21,929,986 (GRCm38)	E42K	possibly damaging	Het
Dnah12	A	G	14: 26,697,398 (GRCm38)	D147G	probably benign	Het
Dnah12	A	T	14: 26,709,257 (GRCm38)	Y340F	probably benign	Het
Dot1l	G	T	10: 80,783,539 (GRCm38)	R193L	probably damaging	Het
Dupd1	A	G	14: 21,686,689 (GRCm38)	V115A	probably benign	Het
Esd	A	C	14: 74,742,074 (GRCm38)	Y119S	probably damaging	Het
Esp36	A	G	17: 38,419,439 (GRCm38)		probably benign	Het
Etfbkmt	T	A	6: 149,144,151 (GRCm38)	M1K	probably null	Het
Exph5	A	G	9: 53,376,248 (GRCm38)	H1543R	probably benign	Het
Fam92a	C	T	4: 12,155,717 (GRCm38)	V306I	possibly damaging	Het
Fbxo16	A	G	14: 65,270,803 (GRCm38)	T23A	probably damaging	Het
Gm11492	A	G	11: 87,567,235 (GRCm38)	H145R	possibly damaging	Het
Gm6614	T	C	6: 142,003,423 (GRCm38)	M76V	possibly damaging	Het
Gorasp2	C	A	2: 70,679,464 (GRCm38)	H136Q	probably damaging	Het
Hdc	T	A	2: 126,597,933 (GRCm38)	I367F	probably benign	Het
Hmcn1	C	T	1: 150,638,900 (GRCm38)	V3574M	probably benign	Het
Ilvbl	A	G	10: 78,584,124 (GRCm38)	D592G	probably benign	Het
Inmt	G	A	6: 55,174,883 (GRCm38)	A34V	probably damaging	Het
Ints9	A	C	14: 65,026,413 (GRCm38)	H378P	probably benign	Het
Kcnh7	T	A	2: 62,787,754 (GRCm38)	I464L	possibly damaging	Het
Kcnt2	T	A	1: 140,425,330 (GRCm38)	V259D	probably damaging	Het
Lipo1	A	G	19: 33,784,692 (GRCm38)	F135S	probably damaging	Het
Mapk1	T	A	16: 17,026,429 (GRCm38)	S22T	probably benign	Het
Mbd3l2	T	C	9: 18,444,921 (GRCm38)	S181P	possibly damaging	Het
Mgat5	C	T	1: 127,459,969 (GRCm38)	P554L	probably damaging	Het
Mki67	T	C	7: 135,699,361 (GRCm38)	T1315A	probably benign	Het
Mprip	C	T	11: 59,758,221 (GRCm38)	T917M	possibly damaging	Het
Mroh3	T	A	1: 136,185,988 (GRCm38)	I688F	probably benign	Het
Myo1d	A	T	11: 80,663,048 (GRCm38)	Y536N	probably damaging	Het
Neb	C	T	2: 52,162,187 (GRCm38)		probably null	Het
Noc2l	A	G	4: 156,237,708 (GRCm38)	R161G	probably benign	Het
Nup54	T	A	5: 92,419,567 (GRCm38)	I375L	possibly damaging	Het
Nup93	T	C	8: 94,306,102 (GRCm38)	F539L	probably damaging	Het
Olfr138	A	G	17: 38,275,344 (GRCm38)	E191G	probably damaging	Het
Olfr417	T	A	1: 174,369,452 (GRCm38)	H178Q	probably damaging	Het
Olfr480	A	C	7: 108,066,725 (GRCm38)	Y24*	probably null	Het
Olfr874	T	A	9: 37,746,968 (GRCm38)	M278K	probably benign	Het
Panx1	A	T	9: 15,007,428 (GRCm38)	D378E	probably damaging	Het
Papss1	T	A	3: 131,583,184 (GRCm38)	V170D	possibly damaging	Het
Pcnx	T	C	12: 81,918,732 (GRCm38)	S558P	probably damaging	Het
Pde3a	T	A	6: 141,250,353 (GRCm38)	I255N	probably damaging	Het
Pde3a	G	T	6: 141,487,513 (GRCm38)	A757S	probably damaging	Het
Pdzph1	A	G	17: 58,922,583 (GRCm38)	Y1027H	probably damaging	Het
Pkhd1	G	T	1: 20,551,020 (GRCm38)	R805S	probably benign	Het
Polr1a	G	A	6: 71,909,203 (GRCm38)	G14D	probably damaging	Het
Prg4	T	A	1: 150,460,669 (GRCm38)	D60V	probably damaging	Het
Ptprc	T	C	1: 138,112,227 (GRCm38)	S311G	probably benign	Het
Rapgefl1	G	A	11: 98,842,209 (GRCm38)	R205K	probably benign	Het
Rcan2	A	T	17: 44,037,089 (GRCm38)		probably null	Het
Rock1	A	G	18: 10,079,207 (GRCm38)	I1087T	probably damaging	Het
Sectm1b	A	G	11: 121,054,942 (GRCm38)	I191T	possibly damaging	Het
Setd1b	T	C	5: 123,147,613 (GRCm38)	S241P	unknown	Het
Srpk2	T	C	5: 23,524,150 (GRCm38)	K497R	probably benign	Het
Sspo	T	C	6: 48,491,006 (GRCm38)	S4296P	probably damaging	Het
Syne4	T	C	7: 30,316,883 (GRCm38)	V168A	probably benign	Het
Tank	T	C	2: 61,649,912 (GRCm38)	F264S	probably damaging	Het
Ticrr	T	C	7: 79,695,207 (GRCm38)	S1607P	probably damaging	Het
Trim30a	A	G	7: 104,411,198 (GRCm38)	V457A	probably damaging	Het
Trim43b	T	A	9: 89,085,571 (GRCm38)	K336N	probably damaging	Het
Trim47	T	C	11: 116,106,137 (GRCm38)	Q598R	probably damaging	Het
Tspan12	T	C	6: 21,851,023 (GRCm38)	N18S	probably damaging	Het
Ubap2	A	G	4: 41,221,607 (GRCm38)	S231P	probably benign	Het
Vit	A	G	17: 78,622,746 (GRCm38)	D380G	probably damaging	Het
Vmn2r2	T	C	3: 64,134,521 (GRCm38)	N258D	possibly damaging	Het
Vmn2r52	C	T	7: 10,173,406 (GRCm38)	C131Y	possibly damaging	Het
Zadh2	T	C	18: 84,095,318 (GRCm38)	V373A	possibly damaging	Het
Zfp58	A	T	13: 67,491,188 (GRCm38)	F395I	probably damaging	Het
Zfp940	C	A	7: 29,845,010 (GRCm38)	G491C	probably damaging	Het

Other mutations in Lrba

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00420:Lrba	APN	3	86,359,782 (GRCm38)	missense	probably benign	0.00
IGL00788:Lrba	APN	3	86,327,685 (GRCm38)	missense	probably damaging	0.97
IGL01139:Lrba	APN	3	86,642,662 (GRCm38)	missense	possibly damaging	0.88
IGL01302:Lrba	APN	3	86,295,400 (GRCm38)	missense	probably damaging	1.00
IGL01612:Lrba	APN	3	86,776,177 (GRCm38)	missense	possibly damaging	0.89
IGL01718:Lrba	APN	3	86,351,248 (GRCm38)	missense	probably damaging	1.00
IGL01719:Lrba	APN	3	86,327,596 (GRCm38)	splice site	probably benign
IGL01730:Lrba	APN	3	86,741,424 (GRCm38)	missense	possibly damaging	0.89
IGL01735:Lrba	APN	3	86,327,661 (GRCm38)	missense	probably benign	0.28
IGL01875:Lrba	APN	3	86,310,047 (GRCm38)	missense	probably damaging	1.00
IGL01884:Lrba	APN	3	86,310,412 (GRCm38)	missense	possibly damaging	0.86
IGL02264:Lrba	APN	3	86,780,262 (GRCm38)	missense	probably damaging	0.99
IGL02638:Lrba	APN	3	86,325,073 (GRCm38)	missense	probably damaging	0.97
IGL02647:Lrba	APN	3	86,359,731 (GRCm38)	missense	probably benign	0.00
IGL02664:Lrba	APN	3	86,325,731 (GRCm38)	missense	possibly damaging	0.84
IGL02728:Lrba	APN	3	86,776,049 (GRCm38)	missense	probably damaging	0.99
IGL02730:Lrba	APN	3	86,328,199 (GRCm38)	missense	probably damaging	1.00
IGL02883:Lrba	APN	3	86,445,413 (GRCm38)	missense	probably damaging	0.99
IGL02883:Lrba	APN	3	86,354,206 (GRCm38)	missense	probably damaging	1.00
IGL02948:Lrba	APN	3	86,310,384 (GRCm38)	splice site	probably null
IGL03090:Lrba	APN	3	86,773,141 (GRCm38)	missense	probably benign	0.01
molasses	UTSW	3	86,354,307 (GRCm38)	critical splice donor site	probably null
oscar	UTSW	3	86,350,304 (GRCm38)	nonsense	probably null
oscar2	UTSW	3	86,664,458 (GRCm38)	nonsense	probably null
P0023:Lrba	UTSW	3	86,417,935 (GRCm38)	missense	probably damaging	1.00
PIT4802001:Lrba	UTSW	3	86,664,494 (GRCm38)	nonsense	probably null
R0077:Lrba	UTSW	3	86,542,688 (GRCm38)	missense	probably damaging	0.99
R0189:Lrba	UTSW	3	86,368,509 (GRCm38)	missense	probably damaging	1.00
R0217:Lrba	UTSW	3	86,642,722 (GRCm38)	missense	probably damaging	1.00
R0349:Lrba	UTSW	3	86,540,005 (GRCm38)	missense	probably damaging	1.00
R0396:Lrba	UTSW	3	86,295,179 (GRCm38)	missense	probably damaging	1.00
R0417:Lrba	UTSW	3	86,715,654 (GRCm38)	missense	probably damaging	1.00
R0536:Lrba	UTSW	3	86,715,532 (GRCm38)	missense	probably damaging	1.00
R0712:Lrba	UTSW	3	86,297,990 (GRCm38)	nonsense	probably null
R0722:Lrba	UTSW	3	86,605,989 (GRCm38)	critical splice donor site	probably null
R0828:Lrba	UTSW	3	86,608,370 (GRCm38)	splice site	probably null
R0927:Lrba	UTSW	3	86,780,233 (GRCm38)	missense	probably damaging	1.00
R1120:Lrba	UTSW	3	86,295,192 (GRCm38)	missense	probably damaging	1.00
R1141:Lrba	UTSW	3	86,619,558 (GRCm38)	missense	probably damaging	1.00
R1276:Lrba	UTSW	3	86,664,526 (GRCm38)	missense	probably damaging	1.00
R1449:Lrba	UTSW	3	86,354,278 (GRCm38)	missense	probably damaging	1.00
R1470:Lrba	UTSW	3	86,737,142 (GRCm38)	missense	probably damaging	1.00
R1470:Lrba	UTSW	3	86,737,142 (GRCm38)	missense	probably damaging	1.00
R1474:Lrba	UTSW	3	86,780,266 (GRCm38)	splice site	probably benign
R1558:Lrba	UTSW	3	86,351,315 (GRCm38)	missense	probably damaging	1.00
R1596:Lrba	UTSW	3	86,350,304 (GRCm38)	nonsense	probably null
R1652:Lrba	UTSW	3	86,539,938 (GRCm38)	missense	probably damaging	1.00
R1800:Lrba	UTSW	3	86,351,868 (GRCm38)	missense	probably benign	0.00
R1819:Lrba	UTSW	3	86,542,634 (GRCm38)	missense	possibly damaging	0.80
R1917:Lrba	UTSW	3	86,664,501 (GRCm38)	missense	probably damaging	1.00
R1965:Lrba	UTSW	3	86,605,868 (GRCm38)	critical splice acceptor site	probably null
R1966:Lrba	UTSW	3	86,605,868 (GRCm38)	critical splice acceptor site	probably null
R1969:Lrba	UTSW	3	86,608,389 (GRCm38)	missense	probably damaging	0.99
R2011:Lrba	UTSW	3	86,310,017 (GRCm38)	missense	probably damaging	0.99
R2179:Lrba	UTSW	3	86,354,281 (GRCm38)	missense	probably damaging	1.00
R2186:Lrba	UTSW	3	86,304,336 (GRCm38)	missense	probably damaging	1.00
R2281:Lrba	UTSW	3	86,776,103 (GRCm38)	missense	possibly damaging	0.46
R2359:Lrba	UTSW	3	86,348,750 (GRCm38)	missense	probably benign	0.01
R2412:Lrba	UTSW	3	86,327,700 (GRCm38)	missense	probably damaging	1.00
R2496:Lrba	UTSW	3	86,532,087 (GRCm38)	missense	probably damaging	1.00
R3153:Lrba	UTSW	3	86,285,219 (GRCm38)	missense	probably damaging	0.99
R3708:Lrba	UTSW	3	86,285,024 (GRCm38)	missense	possibly damaging	0.80
R3746:Lrba	UTSW	3	86,375,953 (GRCm38)	missense	probably damaging	1.00
R3747:Lrba	UTSW	3	86,375,953 (GRCm38)	missense	probably damaging	1.00
R3748:Lrba	UTSW	3	86,375,953 (GRCm38)	missense	probably damaging	1.00
R3749:Lrba	UTSW	3	86,375,953 (GRCm38)	missense	probably damaging	1.00
R3750:Lrba	UTSW	3	86,375,953 (GRCm38)	missense	probably damaging	1.00
R3758:Lrba	UTSW	3	86,776,049 (GRCm38)	missense	probably damaging	0.99
R3975:Lrba	UTSW	3	86,351,255 (GRCm38)	missense	probably damaging	1.00
R4210:Lrba	UTSW	3	86,360,126 (GRCm38)	missense	probably damaging	1.00
R4258:Lrba	UTSW	3	86,445,349 (GRCm38)	missense	probably damaging	1.00
R4657:Lrba	UTSW	3	86,737,164 (GRCm38)	missense	probably damaging	1.00
R4713:Lrba	UTSW	3	86,359,868 (GRCm38)	missense	probably benign	0.13
R4716:Lrba	UTSW	3	86,642,714 (GRCm38)	missense	probably damaging	0.99
R4811:Lrba	UTSW	3	86,776,141 (GRCm38)	missense	probably damaging	1.00
R4827:Lrba	UTSW	3	86,360,150 (GRCm38)	missense	possibly damaging	0.85
R4840:Lrba	UTSW	3	86,619,509 (GRCm38)	critical splice acceptor site	probably null
R4920:Lrba	UTSW	3	86,664,458 (GRCm38)	nonsense	probably null
R4948:Lrba	UTSW	3	86,285,028 (GRCm38)	missense	probably damaging	1.00
R4970:Lrba	UTSW	3	86,225,371 (GRCm38)	missense	probably benign	0.23
R4985:Lrba	UTSW	3	86,327,436 (GRCm38)	splice site	probably null
R4993:Lrba	UTSW	3	86,360,037 (GRCm38)	missense	probably damaging	1.00
R5107:Lrba	UTSW	3	86,359,779 (GRCm38)	missense	possibly damaging	0.47
R5112:Lrba	UTSW	3	86,225,371 (GRCm38)	missense	probably benign	0.23
R5122:Lrba	UTSW	3	86,349,154 (GRCm38)	nonsense	probably null
R5155:Lrba	UTSW	3	86,351,300 (GRCm38)	missense	probably benign	0.25
R5194:Lrba	UTSW	3	86,328,219 (GRCm38)	missense	probably damaging	1.00
R5280:Lrba	UTSW	3	86,325,022 (GRCm38)	missense	possibly damaging	0.94
R5445:Lrba	UTSW	3	86,368,595 (GRCm38)	missense	probably benign
R5469:Lrba	UTSW	3	86,542,641 (GRCm38)	missense	probably damaging	1.00
R5513:Lrba	UTSW	3	86,542,641 (GRCm38)	missense	probably damaging	1.00
R5578:Lrba	UTSW	3	86,757,507 (GRCm38)	missense	probably benign	0.27
R5740:Lrba	UTSW	3	86,328,342 (GRCm38)	missense	probably damaging	1.00
R5868:Lrba	UTSW	3	86,319,604 (GRCm38)	missense	probably damaging	1.00
R6104:Lrba	UTSW	3	86,353,792 (GRCm38)	missense	probably damaging	1.00
R6166:Lrba	UTSW	3	86,354,307 (GRCm38)	critical splice donor site	probably null
R6279:Lrba	UTSW	3	86,348,864 (GRCm38)	missense	probably benign	0.26
R6330:Lrba	UTSW	3	86,348,357 (GRCm38)	missense	probably benign	0.07
R6367:Lrba	UTSW	3	86,368,562 (GRCm38)	missense	probably benign	0.42
R6571:Lrba	UTSW	3	86,360,060 (GRCm38)	missense	probably damaging	1.00
R6584:Lrba	UTSW	3	86,664,576 (GRCm38)	missense	probably damaging	1.00
R6698:Lrba	UTSW	3	86,304,425 (GRCm38)	missense	probably damaging	0.99
R6763:Lrba	UTSW	3	86,354,263 (GRCm38)	missense	probably damaging	1.00
R6834:Lrba	UTSW	3	86,350,286 (GRCm38)	missense	probably benign	0.00
R6951:Lrba	UTSW	3	86,745,873 (GRCm38)	missense	probably benign	0.01
R6969:Lrba	UTSW	3	86,619,590 (GRCm38)	missense	probably benign	0.21
R7045:Lrba	UTSW	3	86,285,091 (GRCm38)	missense	probably benign	0.03
R7133:Lrba	UTSW	3	86,394,931 (GRCm38)	splice site	probably null
R7182:Lrba	UTSW	3	86,741,458 (GRCm38)	frame shift	probably null
R7214:Lrba	UTSW	3	86,328,326 (GRCm38)	missense	probably damaging	1.00
R7224:Lrba	UTSW	3	86,395,246 (GRCm38)	missense	probably damaging	1.00
R7243:Lrba	UTSW	3	86,751,516 (GRCm38)	splice site	probably null
R7350:Lrba	UTSW	3	86,351,902 (GRCm38)	missense	probably damaging	0.96
R7380:Lrba	UTSW	3	86,325,074 (GRCm38)	missense	probably damaging	1.00
R7492:Lrba	UTSW	3	86,664,528 (GRCm38)	missense	probably damaging	1.00
R7651:Lrba	UTSW	3	86,741,466 (GRCm38)	nonsense	probably null
R7729:Lrba	UTSW	3	86,318,167 (GRCm38)	missense	probably damaging	1.00
R7754:Lrba	UTSW	3	86,445,397 (GRCm38)	missense	probably damaging	1.00
R7762:Lrba	UTSW	3	86,532,201 (GRCm38)	missense	probably damaging	0.99
R7855:Lrba	UTSW	3	86,315,430 (GRCm38)	missense	possibly damaging	0.94
R7867:Lrba	UTSW	3	86,368,589 (GRCm38)	missense	probably damaging	1.00
R7912:Lrba	UTSW	3	86,715,565 (GRCm38)	missense	probably damaging	1.00
R7995:Lrba	UTSW	3	86,619,551 (GRCm38)	missense	probably damaging	1.00
R8013:Lrba	UTSW	3	86,417,971 (GRCm38)	missense	probably damaging	1.00
R8014:Lrba	UTSW	3	86,417,971 (GRCm38)	missense	probably damaging	1.00
R8024:Lrba	UTSW	3	86,295,401 (GRCm38)	nonsense	probably null
R8027:Lrba	UTSW	3	86,417,912 (GRCm38)	missense	probably benign	0.05
R8090:Lrba	UTSW	3	86,348,489 (GRCm38)	missense	probably benign
R8111:Lrba	UTSW	3	86,327,705 (GRCm38)	missense	probably damaging	1.00
R8118:Lrba	UTSW	3	86,354,226 (GRCm38)	missense	probably benign
R8204:Lrba	UTSW	3	86,315,403 (GRCm38)	missense	possibly damaging	0.95
R8239:Lrba	UTSW	3	86,542,575 (GRCm38)	missense	probably damaging	1.00
R8509:Lrba	UTSW	3	86,348,176 (GRCm38)	missense	probably benign	0.04
R8532:Lrba	UTSW	3	86,757,483 (GRCm38)	missense	probably damaging	1.00
R8726:Lrba	UTSW	3	86,353,755 (GRCm38)	missense	probably benign
R8744:Lrba	UTSW	3	86,304,333 (GRCm38)	missense	probably benign	0.08
R8782:Lrba	UTSW	3	86,642,669 (GRCm38)	missense	probably benign	0.00
R8784:Lrba	UTSW	3	86,375,928 (GRCm38)	missense	probably damaging	1.00
R8922:Lrba	UTSW	3	86,356,666 (GRCm38)	missense	probably damaging	1.00
R8964:Lrba	UTSW	3	86,351,245 (GRCm38)	missense	probably benign	0.22
R8971:Lrba	UTSW	3	86,615,081 (GRCm38)	missense	probably benign	0.00
R9046:Lrba	UTSW	3	86,395,236 (GRCm38)	missense	possibly damaging	0.94
R9155:Lrba	UTSW	3	86,295,201 (GRCm38)	missense	probably damaging	1.00
R9236:Lrba	UTSW	3	86,353,759 (GRCm38)	missense	probably benign	0.05
R9266:Lrba	UTSW	3	86,291,467 (GRCm38)	missense	probably benign	0.08
R9297:Lrba	UTSW	3	86,373,566 (GRCm38)	missense	probably damaging	1.00
R9404:Lrba	UTSW	3	86,297,917 (GRCm38)	missense	probably damaging	0.99
R9617:Lrba	UTSW	3	86,359,862 (GRCm38)	missense	probably benign
R9640:Lrba	UTSW	3	86,619,568 (GRCm38)	nonsense	probably null
R9779:Lrba	UTSW	3	86,325,771 (GRCm38)	missense	probably damaging	1.00
X0065:Lrba	UTSW	3	86,325,089 (GRCm38)	missense	possibly damaging	0.95
X0065:Lrba	UTSW	3	86,297,899 (GRCm38)	missense	probably damaging	1.00
Z1176:Lrba	UTSW	3	86,751,532 (GRCm38)	missense	possibly damaging	0.85
Z1176:Lrba	UTSW	3	86,715,538 (GRCm38)	missense	probably benign	0.31
Z1177:Lrba	UTSW	3	86,540,049 (GRCm38)	missense	probably null	1.00

Predicted Primers

PCR Primer
(F):5'- GTGGCAAAATGTGGACTCCTAAG -3'
(R):5'- CCAGGCTTTTGGTCCTTATGAG -3'

Sequencing Primer
(F):5'- GTGGACTCCTAAGATCAAAATTGGC -3'
(R):5'- GAGAATATTCTATCTCCAAGTGTAGC -3'

Posted On

2014-06-23