Incidental Mutation 'R1863:Or4a74'
ID 204088
Institutional Source Beutler Lab
Gene Symbol Or4a74
Ensembl Gene ENSMUSG00000075081
Gene Name olfactory receptor family 4 subfamily A member 74
Synonyms GA_x6K02T2Q125-51051555-51050611, Olfr1247, MOR231-6
MMRRC Submission 039886-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R1863 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 89439433-89440497 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 89440053 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Stop codon at position 131 (L131*)
Ref Sequence ENSEMBL: ENSMUSP00000149408 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099771] [ENSMUST00000111532] [ENSMUST00000216424]
AlphaFold A2AT78
Predicted Effect probably null
Transcript: ENSMUST00000099771
AA Change: L131*
SMART Domains Protein: ENSMUSP00000097359
Gene: ENSMUSG00000075081
AA Change: L131*

DomainStartEndE-ValueType
Pfam:7tm_1 39 285 4.9e-29 PFAM
Pfam:7tm_4 137 278 4.2e-39 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000111532
AA Change: L131*
SMART Domains Protein: ENSMUSP00000107157
Gene: ENSMUSG00000075081
AA Change: L131*

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 1.2e-48 PFAM
Pfam:7tm_1 39 285 1.6e-18 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000216424
AA Change: L131*
Coding Region Coverage
  • 1x: 97.5%
  • 3x: 96.9%
  • 10x: 95.0%
  • 20x: 90.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 85 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 A T 6: 128,527,746 (GRCm39) S1015T probably damaging Het
Adamts10 T A 17: 33,770,406 (GRCm39) probably null Het
Adgrv1 G A 13: 81,711,685 (GRCm39) T1097I probably damaging Het
Apeh T C 9: 107,969,302 (GRCm39) Y274C possibly damaging Het
Apobec3 A G 15: 79,782,068 (GRCm39) D26G possibly damaging Het
Arg2 C T 12: 79,196,794 (GRCm39) Q172* probably null Het
Asb18 C T 1: 89,942,104 (GRCm39) V66I probably benign Het
Cacna1i G A 15: 80,243,132 (GRCm39) G430S probably damaging Het
Cadps A G 14: 12,449,802 (GRCm38) S1136P possibly damaging Het
Cadps A G 14: 12,505,796 (GRCm38) V758A probably benign Het
Calhm3 A G 19: 47,140,539 (GRCm39) W185R probably damaging Het
Car5b T C X: 162,774,369 (GRCm39) D146G probably damaging Het
Card10 G A 15: 78,664,714 (GRCm39) R747W probably damaging Het
Cd300lg T G 11: 101,932,430 (GRCm39) V5G probably damaging Het
Cd46 C A 1: 194,765,931 (GRCm39) G145C probably damaging Het
Chit1 T C 1: 134,078,988 (GRCm39) S433P probably damaging Het
Cntrl G A 2: 35,008,131 (GRCm39) E182K possibly damaging Het
Col6a5 T A 9: 105,817,400 (GRCm39) M304L unknown Het
Cplane1 A G 15: 8,258,077 (GRCm39) I2108V probably benign Het
Cpxm2 C T 7: 131,745,392 (GRCm39) probably null Het
Dbf4 G A 5: 8,447,375 (GRCm39) Q612* probably null Het
Dnah11 G C 12: 118,027,587 (GRCm39) Q1835E possibly damaging Het
Ehbp1l1 A T 19: 5,767,882 (GRCm39) N1140K probably benign Het
Eps8l1 C A 7: 4,468,359 (GRCm39) probably benign Het
Fbxl21 A T 13: 56,674,876 (GRCm39) I76L probably benign Het
Gcnt2 A T 13: 41,014,577 (GRCm39) K249N possibly damaging Het
Gm5819 A G 18: 8,694,179 (GRCm39) T35A probably benign Het
Gm8180 T C 14: 44,021,139 (GRCm39) E23G probably benign Het
Gorab A G 1: 163,231,131 (GRCm39) F8L probably damaging Het
Hlf A G 11: 90,231,652 (GRCm39) L274S probably damaging Het
Il15ra T A 2: 11,728,247 (GRCm39) S137T possibly damaging Het
Krt78 A T 15: 101,855,004 (GRCm39) C936S possibly damaging Het
Lamb2 T C 9: 108,358,583 (GRCm39) S207P probably benign Het
Lce1a1 T C 3: 92,554,118 (GRCm39) S119G unknown Het
Lipo3 A G 19: 33,762,092 (GRCm39) F135S probably damaging Het
Lrp4 T A 2: 91,328,708 (GRCm39) L1536Q probably benign Het
Lrrc25 T C 8: 71,070,596 (GRCm39) S126P possibly damaging Het
Mbd3l2 T C 9: 18,356,217 (GRCm39) S181P possibly damaging Het
Msantd5f6 A T 4: 73,320,037 (GRCm39) Y247* probably null Het
Mss51 C T 14: 20,534,936 (GRCm39) R278H probably damaging Het
Myom3 G A 4: 135,505,348 (GRCm39) M412I probably benign Het
Naa25 T C 5: 121,573,611 (GRCm39) V780A probably benign Het
Naip6 A T 13: 100,437,067 (GRCm39) F485L probably benign Het
Notch1 T C 2: 26,359,962 (GRCm39) Y1251C probably damaging Het
Npas3 A G 12: 54,115,609 (GRCm39) N826D probably damaging Het
Nup155 A T 15: 8,187,244 (GRCm39) H1391L probably damaging Het
Or2t47 T C 11: 58,442,849 (GRCm39) Y72C probably benign Het
Or4c35 A T 2: 89,808,754 (GRCm39) I211F probably benign Het
Or5p57 A C 7: 107,665,932 (GRCm39) Y24* probably null Het
Or6c66 T C 10: 129,461,217 (GRCm39) T238A probably damaging Het
Or8c8 T G 9: 38,165,016 (GRCm39) M101R probably damaging Het
Or8s16 G T 15: 98,211,372 (GRCm39) Q20K probably benign Het
Osbpl6 G A 2: 76,415,402 (GRCm39) R588H probably damaging Het
Pcdhb17 A T 18: 37,619,164 (GRCm39) D318V probably benign Het
Pcnx2 T A 8: 126,545,525 (GRCm39) E1162V probably damaging Het
Pde2a G A 7: 101,160,361 (GRCm39) R845H probably damaging Het
Pkhd1 G T 1: 20,621,244 (GRCm39) R805S probably benign Het
Ppl T C 16: 4,905,844 (GRCm39) K1484E possibly damaging Het
Pramel7 T C 2: 87,321,675 (GRCm39) E120G probably benign Het
Prg4 T A 1: 150,336,420 (GRCm39) D60V probably damaging Het
Prpf6 T A 2: 181,249,967 (GRCm39) D42E possibly damaging Het
Rbm5 C T 9: 107,627,718 (GRCm39) V408I possibly damaging Het
Rsrp1 G T 4: 134,651,388 (GRCm39) D51Y unknown Het
Sec22a A G 16: 35,168,088 (GRCm39) M141T probably damaging Het
Spryd3 A G 15: 102,026,094 (GRCm39) S417P probably benign Het
Sptbn2 A G 19: 4,782,713 (GRCm39) M550V possibly damaging Het
Sugt1 C T 14: 79,846,434 (GRCm39) T157I probably damaging Het
Syne4 T C 7: 30,016,308 (GRCm39) V168A probably benign Het
Tas2r122 A T 6: 132,688,065 (GRCm39) L276* probably null Het
Tbc1d14 G A 5: 36,665,037 (GRCm39) S231F probably damaging Het
Tenm3 T A 8: 48,729,381 (GRCm39) I1526F probably benign Het
Tgm2 C T 2: 157,966,139 (GRCm39) C505Y probably damaging Het
Thop1 T C 10: 80,909,151 (GRCm39) Y61H probably damaging Het
Ticam1 G A 17: 56,578,436 (GRCm39) H220Y probably damaging Het
Tle6 T C 10: 81,427,755 (GRCm39) D500G possibly damaging Het
Tm6sf2 T A 8: 70,532,375 (GRCm39) L345Q probably damaging Het
Tnxb T C 17: 34,889,848 (GRCm39) C114R probably damaging Het
Topors G T 4: 40,262,149 (GRCm39) C378* probably null Het
Ttc6 G A 12: 57,760,881 (GRCm39) G1544R probably benign Het
Vmn2r4 A T 3: 64,314,410 (GRCm39) N190K probably benign Het
Wdr70 C A 15: 7,950,054 (GRCm39) V447F probably benign Het
Xpa A G 4: 46,155,730 (GRCm39) probably benign Het
Xrcc1 T C 7: 24,270,000 (GRCm39) S474P possibly damaging Het
Zfp658 T G 7: 43,223,323 (GRCm39) F533V possibly damaging Het
Zfp799 G A 17: 33,038,374 (GRCm39) H631Y probably damaging Het
Other mutations in Or4a74
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01101:Or4a74 APN 2 89,440,191 (GRCm39) missense probably benign 0.00
IGL01337:Or4a74 APN 2 89,439,720 (GRCm39) missense probably damaging 0.97
IGL02537:Or4a74 APN 2 89,439,739 (GRCm39) missense possibly damaging 0.88
IGL02651:Or4a74 APN 2 89,439,842 (GRCm39) missense possibly damaging 0.67
IGL02734:Or4a74 APN 2 89,440,303 (GRCm39) missense probably benign 0.04
IGL03177:Or4a74 APN 2 89,439,826 (GRCm39) missense probably benign 0.03
IGL03184:Or4a74 APN 2 89,439,912 (GRCm39) missense probably damaging 1.00
R0207:Or4a74 UTSW 2 89,440,207 (GRCm39) missense probably damaging 0.97
R0278:Or4a74 UTSW 2 89,440,108 (GRCm39) missense probably damaging 1.00
R0278:Or4a74 UTSW 2 89,440,107 (GRCm39) missense probably damaging 1.00
R0601:Or4a74 UTSW 2 89,439,564 (GRCm39) missense probably benign 0.00
R0633:Or4a74 UTSW 2 89,439,718 (GRCm39) missense probably benign 0.10
R1824:Or4a74 UTSW 2 89,439,693 (GRCm39) missense probably damaging 1.00
R2073:Or4a74 UTSW 2 89,439,822 (GRCm39) missense probably benign 0.01
R2074:Or4a74 UTSW 2 89,439,822 (GRCm39) missense probably benign 0.01
R2075:Or4a74 UTSW 2 89,439,822 (GRCm39) missense probably benign 0.01
R3921:Or4a74 UTSW 2 89,439,853 (GRCm39) missense probably benign 0.00
R4559:Or4a74 UTSW 2 89,440,043 (GRCm39) missense probably damaging 0.99
R5128:Or4a74 UTSW 2 89,439,647 (GRCm39) missense probably damaging 1.00
R5140:Or4a74 UTSW 2 89,439,627 (GRCm39) missense probably damaging 1.00
R5426:Or4a74 UTSW 2 89,440,083 (GRCm39) missense probably damaging 1.00
R5896:Or4a74 UTSW 2 89,439,667 (GRCm39) missense probably damaging 0.98
R5902:Or4a74 UTSW 2 89,439,595 (GRCm39) missense probably damaging 1.00
R6478:Or4a74 UTSW 2 89,439,790 (GRCm39) missense probably damaging 1.00
R7143:Or4a74 UTSW 2 89,440,363 (GRCm39) missense probably benign 0.00
R7221:Or4a74 UTSW 2 89,440,272 (GRCm39) missense probably damaging 1.00
R7599:Or4a74 UTSW 2 89,439,571 (GRCm39) missense possibly damaging 0.89
R8709:Or4a74 UTSW 2 89,440,366 (GRCm39) missense probably benign 0.00
R8711:Or4a74 UTSW 2 89,440,291 (GRCm39) missense probably benign 0.05
R8721:Or4a74 UTSW 2 89,440,186 (GRCm39) missense probably benign 0.05
R9278:Or4a74 UTSW 2 89,439,948 (GRCm39) missense probably damaging 1.00
R9630:Or4a74 UTSW 2 89,440,349 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TACACATGGCTCCATTATTGGC -3'
(R):5'- ACTGCCATCTTGCCCAAGTTG -3'

Sequencing Primer
(F):5'- CCATTATTGGCAACTACCGTGAG -3'
(R):5'- CTTGCCCAAGTTGCTTAAAGAC -3'
Posted On 2014-06-23