Mutagenetix > Incidental Mutation

Incidental Mutation 'R1775:Nlrp1b'

204347

Institutional Source

Beutler Lab

Gene Symbol

Nlrp1b

Ensembl Gene

ENSMUSG00000070390

Gene Name

NLR family, pyrin domain containing 1B

Synonyms

Nalp1b

MMRRC Submission

039806-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.061) question?

Stock #

R1775 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

71153102-71230733 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 71161821 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 927 (F927S)

Ref Sequence

ENSEMBL: ENSMUSP00000104155 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094046] [ENSMUST00000108514] [ENSMUST00000108515] [ENSMUST00000108516] [ENSMUST00000136493]

AlphaFold

A1Z198

Predicted Effect

probably damaging
Transcript: ENSMUST00000094046
AA Change: F924S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000091588
Gene: ENSMUSG00000070390
AA Change: F924S

Domain	Start	End	E-Value	Type
Pfam:NACHT	131	300	6.7e-43	PFAM
LRR	627	654	2.24e0	SMART
LRR	656	683	8.82e0	SMART
LRR	684	711	3.49e-5	SMART
Pfam:FIIND	812	1064	8.2e-104	PFAM
Pfam:CARD	1083	1166	3.1e-22	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000108514
AA Change: F927S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000104154
Gene: ENSMUSG00000070390
AA Change: F927S

Domain	Start	End	E-Value	Type
Pfam:NACHT	131	300	2.1e-40	PFAM
LRR	630	657	2.24e0	SMART
LRR	659	686	8.82e0	SMART
LRR	687	714	3.49e-5	SMART
Pfam:FIIND	814	1068	2.4e-136	PFAM
Pfam:CARD	1086	1169	3.7e-22	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000108515
AA Change: F927S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000104155
Gene: ENSMUSG00000070390
AA Change: F927S

Domain	Start	End	E-Value	Type
Pfam:NACHT	131	300	6.9e-41	PFAM
LRR	630	657	2.24e0	SMART
LRR	659	686	8.82e0	SMART
LRR	687	714	3.49e-5	SMART
Pfam:FIIND	815	1067	5e-104	PFAM
Pfam:CARD	1086	1169	1e-22	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000108516
AA Change: F924S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000104156
Gene: ENSMUSG00000070390
AA Change: F924S

Domain	Start	End	E-Value	Type
Pfam:NACHT	131	300	2.2e-42	PFAM
LRR	627	654	2.24e0	SMART
LRR	656	683	8.82e0	SMART
LRR	684	711	3.49e-5	SMART
Pfam:FIIND	811	1065	3.9e-136	PFAM
Pfam:CARD	1083	1166	1.1e-21	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000136493

SMART Domains

Protein: ENSMUSP00000121155
Gene: ENSMUSG00000070390

Domain	Start	End	E-Value	Type
Pfam:NACHT	131	300	8.9e-43	PFAM
PDB:4IM6\|A	610	662	6e-10	PDB
Blast:LRR	627	654	3e-11	BLAST

Meta Mutation Damage Score

0.6178

Coding Region Coverage

1x: 97.5%
3x: 97.0%
10x: 95.5%
20x: 92.9%

Validation Efficiency

98% (95/97)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit protection from anthrax lethal toxin-induced lung injury and pyroptosis of macrophages. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 93 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700034J04Rik	A	G	12: 11,222,142 (GRCm38)	S20P	unknown	Het
4921528I07Rik	G	A	9: 114,279,318 (GRCm38)		noncoding transcript	Het
4930562C15Rik	G	A	16: 4,851,558 (GRCm38)		probably null	Het
4933427I04Rik	A	G	4: 123,860,493 (GRCm38)	T67A	possibly damaging	Het
Abcc2	A	T	19: 43,798,419 (GRCm38)	N160Y	possibly damaging	Het
Acaca	A	G	11: 84,300,422 (GRCm38)	D155G	possibly damaging	Het
Afg3l1	G	A	8: 123,492,900 (GRCm38)	R389Q	possibly damaging	Het
Ank2	G	A	3: 126,934,547 (GRCm38)	T799M	probably benign	Het
Anxa2	T	C	9: 69,488,081 (GRCm38)	Y202H	possibly damaging	Het
Arhgef33	A	G	17: 80,373,743 (GRCm38)	T771A	probably benign	Het
Atp12a	T	C	14: 56,372,589 (GRCm38)	V182A	probably benign	Het
Birc6	T	C	17: 74,612,286 (GRCm38)	L210S	probably damaging	Het
Car3	A	G	3: 14,864,432 (GRCm38)	T73A	probably benign	Het
Cd5l	T	C	3: 87,368,659 (GRCm38)	L312P	probably damaging	Het
Celf5	A	G	10: 81,467,304 (GRCm38)		probably benign	Het
Cep290	T	A	10: 100,496,810 (GRCm38)	V257E	probably damaging	Het
Cntrob	T	C	11: 69,320,867 (GRCm38)	D177G	possibly damaging	Het
Copg2	A	T	6: 30,810,336 (GRCm38)	F658I	probably damaging	Het
Csmd3	T	C	15: 47,899,739 (GRCm38)	T1234A	probably damaging	Het
Dhx35	A	G	2: 158,806,437 (GRCm38)	T72A	probably damaging	Het
Dmrtc2	A	T	7: 24,874,367 (GRCm38)	H209L	possibly damaging	Het
Eml5	G	T	12: 98,852,704 (GRCm38)		probably null	Het
Evpl	T	C	11: 116,223,660 (GRCm38)	E1068G	possibly damaging	Het
Ezh2	A	G	6: 47,576,660 (GRCm38)	M41T	probably damaging	Het
Fmo3	A	G	1: 162,968,725 (GRCm38)	S93P	possibly damaging	Het
Gdi2	A	G	13: 3,560,018 (GRCm38)	Y213C	possibly damaging	Het
Gpr15	A	T	16: 58,718,558 (GRCm38)	I56K	probably benign	Het
Gria2	G	T	3: 80,691,338 (GRCm38)	S796R	probably benign	Het
Hectd4	T	A	5: 121,291,191 (GRCm38)		probably benign	Het
Hgfac	T	C	5: 35,042,850 (GRCm38)		probably benign	Het
Hspg2	C	T	4: 137,520,156 (GRCm38)	R1200W	probably damaging	Het
Ift52	G	A	2: 163,025,355 (GRCm38)	D78N	possibly damaging	Het
Iqca	C	A	1: 90,081,416 (GRCm38)	W415L	probably damaging	Het
Ism1	A	T	2: 139,746,043 (GRCm38)	K236N	probably damaging	Het
Itgb6	C	T	2: 60,672,644 (GRCm38)	W43*	probably null	Het
Kcnk18	T	A	19: 59,235,341 (GRCm38)	I306N	probably damaging	Het
Kctd8	T	C	5: 69,340,560 (GRCm38)	K248E	probably damaging	Het
Layn	T	A	9: 51,059,533 (GRCm38)	I237F	probably benign	Het
Lce3f	C	T	3: 92,992,941 (GRCm38)	P23L	unknown	Het
Lct	A	G	1: 128,300,301 (GRCm38)	F1152L	probably damaging	Het
Mxra8	T	C	4: 155,843,074 (GRCm38)	I413T	probably damaging	Het
Nedd9	A	G	13: 41,317,962 (GRCm38)	V187A	probably benign	Het
Net1	A	G	13: 3,887,642 (GRCm38)	L207P	probably damaging	Het
Neurod1	G	T	2: 79,454,437 (GRCm38)	P201T	probably benign	Het
Ntrk3	T	A	7: 78,356,041 (GRCm38)	H524L	possibly damaging	Het
Nup98	A	C	7: 102,134,937 (GRCm38)	S1063A	probably benign	Het
Olfr1036	G	A	2: 86,074,760 (GRCm38)	V7I	possibly damaging	Het
Olfr1333	T	A	4: 118,829,868 (GRCm38)	M191L	probably benign	Het
Olfr1447	C	A	19: 12,901,235 (GRCm38)	V182F	probably benign	Het
Olfr215	T	C	6: 116,582,964 (GRCm38)		probably benign	Het
Olfr657	G	A	7: 104,636,159 (GRCm38)	V162I	probably benign	Het
Olfr747	G	T	14: 50,681,166 (GRCm38)	P156Q	possibly damaging	Het
Pdzd2	G	A	15: 12,592,460 (GRCm38)	R33W	probably damaging	Het
Phf21a	G	A	2: 92,330,515 (GRCm38)	V243I	probably damaging	Het
Ppp1r12b	A	G	1: 134,893,348 (GRCm38)		probably null	Het
Rexo5	T	C	7: 119,845,411 (GRCm38)	V703A	probably benign	Het
Rgs4	A	G	1: 169,745,278 (GRCm38)	S30P	probably benign	Het
Rrnad1	A	G	3: 87,923,817 (GRCm38)	S404P	probably damaging	Het
Rxra	C	A	2: 27,756,244 (GRCm38)	D340E	probably damaging	Het
Samhd1	A	G	2: 157,107,547 (GRCm38)	V473A	probably benign	Het
Scn3a	T	A	2: 65,472,342 (GRCm38)	K1253N	probably damaging	Het
Scn7a	T	C	2: 66,680,955 (GRCm38)	N1207S	probably benign	Het
Sec24d	T	A	3: 123,336,517 (GRCm38)	I443N	probably damaging	Het
Sema4g	T	A	19: 44,999,242 (GRCm38)		probably null	Het
Sema5b	A	G	16: 35,660,324 (GRCm38)	K787R	probably benign	Het
Serpinc1	A	G	1: 160,989,647 (GRCm38)	N104D	probably benign	Het
Sfn	T	C	4: 133,601,231 (GRCm38)	H180R	probably damaging	Het
Slc22a6	G	T	19: 8,619,107 (GRCm38)		probably null	Het
Slc9a8	T	C	2: 167,457,358 (GRCm38)	S217P	probably benign	Het
Smc6	A	G	12: 11,309,269 (GRCm38)	N965D	probably benign	Het
Sod2	T	A	17: 13,015,032 (GRCm38)	I177N	probably damaging	Het
Sp4	A	T	12: 118,299,600 (GRCm38)	I237K	probably damaging	Het
Sulf2	T	C	2: 166,079,612 (GRCm38)	K697R	probably benign	Het
Svs4	A	T	2: 164,277,085 (GRCm38)	D110E	unknown	Het
Tas1r1	T	A	4: 152,038,218 (GRCm38)	R57*	probably null	Het
Tlr5	T	C	1: 182,973,722 (GRCm38)	I197T	probably damaging	Het
Tmc3	T	C	7: 83,612,532 (GRCm38)	V606A	probably benign	Het
Tmem241	T	A	18: 12,118,412 (GRCm38)	L37F	probably damaging	Het
Tmem59l	A	T	8: 70,486,253 (GRCm38)	N90K	probably damaging	Het
Tram1	A	C	1: 13,576,456 (GRCm38)		probably benign	Het
Trim15	T	A	17: 36,865,169 (GRCm38)	H162L	probably benign	Het
Ttc28	T	A	5: 111,276,811 (GRCm38)	Y1501N	probably benign	Het
Ttc34	T	C	4: 154,862,214 (GRCm38)	V857A	probably benign	Het
Tulp4	A	G	17: 6,139,046 (GRCm38)	T48A	probably damaging	Het
Usp9y	T	C	Y: 1,368,089 (GRCm38)	E939G	probably damaging	Het
Utp20	A	G	10: 88,770,808 (GRCm38)	I1634T	probably benign	Het
Vmn2r72	T	C	7: 85,738,170 (GRCm38)	M729V	probably benign	Het
Vps13c	C	T	9: 67,881,447 (GRCm38)	T334M	probably damaging	Het
Wnk4	C	G	11: 101,276,340 (GRCm38)		probably benign	Het
Xpo1	A	G	11: 23,271,193 (GRCm38)	N97D	probably benign	Het
Xpo4	A	T	14: 57,603,672 (GRCm38)	F518Y	probably benign	Het
Zfp668	C	T	7: 127,866,606 (GRCm38)	V469I	possibly damaging	Het
Zfp85	C	A	13: 67,749,704 (GRCm38)	C83F	probably damaging	Het

Other mutations in Nlrp1b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00161:Nlrp1b	APN	11	71,181,181 (GRCm38)	intron	probably benign
IGL00571:Nlrp1b	APN	11	71,163,973 (GRCm38)	missense	probably null	0.48
IGL01358:Nlrp1b	APN	11	71,181,856 (GRCm38)	missense	possibly damaging	0.91
IGL01937:Nlrp1b	APN	11	71,181,407 (GRCm38)	missense	probably damaging	0.98
IGL01945:Nlrp1b	APN	11	71,181,407 (GRCm38)	missense	probably damaging	0.98
IGL02375:Nlrp1b	APN	11	71,161,680 (GRCm38)	missense	probably damaging	1.00
IGL02552:Nlrp1b	APN	11	71,172,231 (GRCm38)	missense	possibly damaging	0.96
IGL02552:Nlrp1b	APN	11	71,182,052 (GRCm38)	missense	possibly damaging	0.57
IGL02588:Nlrp1b	APN	11	71,182,279 (GRCm38)	nonsense	probably null
IGL02833:Nlrp1b	APN	11	71,161,172 (GRCm38)	missense	probably benign
IGL02955:Nlrp1b	APN	11	71,169,811 (GRCm38)	missense	possibly damaging	0.73
IGL03002:Nlrp1b	APN	11	71,168,859 (GRCm38)	missense	probably benign	0.00
IGL03033:Nlrp1b	APN	11	71,161,839 (GRCm38)	missense	probably benign	0.22
IGL03122:Nlrp1b	APN	11	71,181,833 (GRCm38)	missense	probably benign	0.00
IGL03131:Nlrp1b	APN	11	71,161,915 (GRCm38)	missense	possibly damaging	0.82
androcles	UTSW	11	71,172,075 (GRCm38)	nonsense	probably null
Fangled	UTSW	11	71,172,171 (GRCm38)	missense	possibly damaging	0.94
glitz	UTSW	11	71,181,550 (GRCm38)	missense	possibly damaging	0.89
honeydew	UTSW	11	71,217,884 (GRCm38)	missense	possibly damaging	0.93
Mush	UTSW	11	71,156,079 (GRCm38)	missense	probably damaging	1.00
Thorn	UTSW	11	71,156,300 (GRCm38)	splice site	probably benign
R0001:Nlrp1b	UTSW	11	71,161,759 (GRCm38)	missense	probably damaging	1.00
R0022:Nlrp1b	UTSW	11	71,161,929 (GRCm38)	missense	possibly damaging	0.61
R0022:Nlrp1b	UTSW	11	71,161,929 (GRCm38)	missense	possibly damaging	0.61
R0038:Nlrp1b	UTSW	11	71,172,171 (GRCm38)	missense	possibly damaging	0.94
R0038:Nlrp1b	UTSW	11	71,172,171 (GRCm38)	missense	possibly damaging	0.94
R0164:Nlrp1b	UTSW	11	71,164,099 (GRCm38)	missense	probably damaging	1.00
R0164:Nlrp1b	UTSW	11	71,164,099 (GRCm38)	missense	probably damaging	1.00
R0271:Nlrp1b	UTSW	11	71,161,765 (GRCm38)	missense	possibly damaging	0.51
R0464:Nlrp1b	UTSW	11	71,218,244 (GRCm38)	missense	probably damaging	1.00
R0504:Nlrp1b	UTSW	11	71,182,415 (GRCm38)	missense	probably damaging	0.99
R0605:Nlrp1b	UTSW	11	71,156,179 (GRCm38)	missense	possibly damaging	0.88
R0863:Nlrp1b	UTSW	11	71,181,347 (GRCm38)	missense	probably benign	0.00
R1075:Nlrp1b	UTSW	11	71,181,686 (GRCm38)	missense	probably benign	0.35
R1221:Nlrp1b	UTSW	11	71,181,464 (GRCm38)	missense	probably benign	0.07
R1501:Nlrp1b	UTSW	11	71,156,059 (GRCm38)	missense	probably damaging	1.00
R1654:Nlrp1b	UTSW	11	71,181,298 (GRCm38)	missense	probably damaging	0.99
R1671:Nlrp1b	UTSW	11	71,201,259 (GRCm38)	missense	probably benign	0.45
R1676:Nlrp1b	UTSW	11	71,182,811 (GRCm38)	missense	probably benign	0.13
R1694:Nlrp1b	UTSW	11	71,216,855 (GRCm38)	critical splice donor site	probably null
R1709:Nlrp1b	UTSW	11	71,201,273 (GRCm38)	missense	probably benign	0.11
R1770:Nlrp1b	UTSW	11	71,160,153 (GRCm38)	missense	probably benign	0.22
R1851:Nlrp1b	UTSW	11	71,182,616 (GRCm38)	missense	possibly damaging	0.96
R1932:Nlrp1b	UTSW	11	71,182,138 (GRCm38)	missense	probably damaging	0.96
R2063:Nlrp1b	UTSW	11	71,161,086 (GRCm38)	missense	probably benign	0.09
R2189:Nlrp1b	UTSW	11	71,169,795 (GRCm38)	missense	probably damaging	1.00
R2223:Nlrp1b	UTSW	11	71,155,989 (GRCm38)	splice site	probably benign
R2284:Nlrp1b	UTSW	11	71,156,284 (GRCm38)	missense	probably benign	0.00
R2434:Nlrp1b	UTSW	11	71,156,726 (GRCm38)	splice site	probably null
R3079:Nlrp1b	UTSW	11	71,217,968 (GRCm38)	missense	probably benign	0.27
R3775:Nlrp1b	UTSW	11	71,156,300 (GRCm38)	splice site	probably benign
R3980:Nlrp1b	UTSW	11	71,181,611 (GRCm38)	missense	possibly damaging	0.56
R4016:Nlrp1b	UTSW	11	71,173,085 (GRCm38)	missense	probably damaging	1.00
R4085:Nlrp1b	UTSW	11	71,161,762 (GRCm38)	missense	probably damaging	0.98
R4542:Nlrp1b	UTSW	11	71,228,325 (GRCm38)	missense	probably damaging	1.00
R4623:Nlrp1b	UTSW	11	71,161,843 (GRCm38)	missense	probably benign	0.00
R4726:Nlrp1b	UTSW	11	71,181,406 (GRCm38)	missense	probably benign	0.10
R4764:Nlrp1b	UTSW	11	71,182,663 (GRCm38)	missense	probably damaging	1.00
R4885:Nlrp1b	UTSW	11	71,217,884 (GRCm38)	missense	possibly damaging	0.93
R4910:Nlrp1b	UTSW	11	71,217,277 (GRCm38)	missense	probably benign	0.09
R4997:Nlrp1b	UTSW	11	71,218,334 (GRCm38)	missense	probably damaging	1.00
R5046:Nlrp1b	UTSW	11	71,160,072 (GRCm38)	missense	possibly damaging	0.95
R5126:Nlrp1b	UTSW	11	71,181,533 (GRCm38)	missense	possibly damaging	0.67
R5369:Nlrp1b	UTSW	11	71,181,799 (GRCm38)	missense	probably benign
R5388:Nlrp1b	UTSW	11	71,172,141 (GRCm38)	missense	probably damaging	1.00
R5445:Nlrp1b	UTSW	11	71,217,875 (GRCm38)	missense	probably benign	0.21
R5546:Nlrp1b	UTSW	11	71,217,276 (GRCm38)	missense	probably benign	0.04
R5567:Nlrp1b	UTSW	11	71,181,403 (GRCm38)	missense	probably benign
R5826:Nlrp1b	UTSW	11	71,181,196 (GRCm38)	missense	probably benign	0.17
R5955:Nlrp1b	UTSW	11	71,217,865 (GRCm38)	missense	probably damaging	1.00
R5995:Nlrp1b	UTSW	11	71,181,746 (GRCm38)	missense	probably damaging	1.00
R6059:Nlrp1b	UTSW	11	71,217,010 (GRCm38)	missense	possibly damaging	0.53
R6170:Nlrp1b	UTSW	11	71,156,079 (GRCm38)	missense	probably damaging	1.00
R6191:Nlrp1b	UTSW	11	71,218,457 (GRCm38)	nonsense	probably null
R6250:Nlrp1b	UTSW	11	71,181,799 (GRCm38)	missense	probably benign	0.11
R6312:Nlrp1b	UTSW	11	71,228,397 (GRCm38)	missense	probably benign	0.38
R6352:Nlrp1b	UTSW	11	71,181,701 (GRCm38)	missense	probably damaging	0.99
R6807:Nlrp1b	UTSW	11	71,217,704 (GRCm38)	missense	probably damaging	1.00
R6854:Nlrp1b	UTSW	11	71,228,433 (GRCm38)	missense	possibly damaging	0.93
R6908:Nlrp1b	UTSW	11	71,217,296 (GRCm38)	missense	probably benign
R6938:Nlrp1b	UTSW	11	71,218,216 (GRCm38)	missense	probably damaging	1.00
R7098:Nlrp1b	UTSW	11	71,218,274 (GRCm38)	missense	possibly damaging	0.89
R7142:Nlrp1b	UTSW	11	71,172,075 (GRCm38)	nonsense	probably null
R7149:Nlrp1b	UTSW	11	71,181,656 (GRCm38)	nonsense	probably null
R7349:Nlrp1b	UTSW	11	71,182,117 (GRCm38)	missense	probably benign	0.36
R7354:Nlrp1b	UTSW	11	71,181,550 (GRCm38)	missense	possibly damaging	0.89
R7750:Nlrp1b	UTSW	11	71,168,839 (GRCm38)	missense	probably benign	0.11
R7913:Nlrp1b	UTSW	11	71,217,711 (GRCm38)	missense	possibly damaging	0.93
R8031:Nlrp1b	UTSW	11	71,216,921 (GRCm38)	missense	probably benign	0.15
R8087:Nlrp1b	UTSW	11	71,172,071 (GRCm38)	missense	probably benign	0.04
R8164:Nlrp1b	UTSW	11	71,228,417 (GRCm38)	missense	possibly damaging	0.78
R8378:Nlrp1b	UTSW	11	71,161,719 (GRCm38)	missense	possibly damaging	0.95
R8405:Nlrp1b	UTSW	11	71,182,530 (GRCm38)	missense	possibly damaging	0.66
R8441:Nlrp1b	UTSW	11	71,182,378 (GRCm38)	missense	probably damaging	1.00
R8792:Nlrp1b	UTSW	11	71,160,093 (GRCm38)	missense	probably benign	0.02
R8898:Nlrp1b	UTSW	11	71,182,462 (GRCm38)	missense	probably damaging	1.00
R8953:Nlrp1b	UTSW	11	71,161,806 (GRCm38)	missense	probably damaging	0.96
R8963:Nlrp1b	UTSW	11	71,217,832 (GRCm38)	missense	probably damaging	1.00
R9145:Nlrp1b	UTSW	11	71,218,367 (GRCm38)	missense	probably benign
R9184:Nlrp1b	UTSW	11	71,181,241 (GRCm38)	missense	probably damaging	1.00
R9286:Nlrp1b	UTSW	11	71,169,747 (GRCm38)	missense	probably benign
R9322:Nlrp1b	UTSW	11	71,217,292 (GRCm38)	missense	probably benign	0.12
R9453:Nlrp1b	UTSW	11	71,182,087 (GRCm38)	missense	probably damaging	0.98
R9533:Nlrp1b	UTSW	11	71,218,269 (GRCm38)	missense	probably benign	0.12
R9659:Nlrp1b	UTSW	11	71,182,306 (GRCm38)	missense	possibly damaging	0.77
Z1176:Nlrp1b	UTSW	11	71,182,270 (GRCm38)	missense	probably damaging	1.00
Z1177:Nlrp1b	UTSW	11	71,217,224 (GRCm38)	missense	probably benign	0.03
Z1177:Nlrp1b	UTSW	11	71,181,299 (GRCm38)	nonsense	probably null
Z1186:Nlrp1b	UTSW	11	71,182,544 (GRCm38)	missense	probably benign	0.00
Z1186:Nlrp1b	UTSW	11	71,182,454 (GRCm38)	missense	probably benign	0.00
Z1186:Nlrp1b	UTSW	11	71,182,440 (GRCm38)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,182,322 (GRCm38)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,182,309 (GRCm38)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,181,799 (GRCm38)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,181,713 (GRCm38)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,181,708 (GRCm38)	missense	probably benign	0.02
Z1186:Nlrp1b	UTSW	11	71,182,677 (GRCm38)	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71,182,570 (GRCm38)	missense	probably benign	0.02
Z1186:Nlrp1b	UTSW	11	71,182,552 (GRCm38)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,182,544 (GRCm38)	missense	probably benign	0.00
Z1187:Nlrp1b	UTSW	11	71,182,454 (GRCm38)	missense	probably benign	0.00
Z1187:Nlrp1b	UTSW	11	71,182,440 (GRCm38)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,182,322 (GRCm38)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,181,799 (GRCm38)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,181,713 (GRCm38)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,181,708 (GRCm38)	missense	probably benign	0.02
Z1187:Nlrp1b	UTSW	11	71,182,677 (GRCm38)	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71,182,570 (GRCm38)	missense	probably benign	0.02
Z1187:Nlrp1b	UTSW	11	71,182,552 (GRCm38)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,182,552 (GRCm38)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,182,570 (GRCm38)	missense	probably benign	0.02
Z1188:Nlrp1b	UTSW	11	71,182,677 (GRCm38)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,181,708 (GRCm38)	missense	probably benign	0.02
Z1188:Nlrp1b	UTSW	11	71,181,713 (GRCm38)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,181,799 (GRCm38)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,182,309 (GRCm38)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,182,322 (GRCm38)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,182,440 (GRCm38)	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71,182,454 (GRCm38)	missense	probably benign	0.00
Z1188:Nlrp1b	UTSW	11	71,182,544 (GRCm38)	missense	probably benign	0.00
Z1189:Nlrp1b	UTSW	11	71,182,544 (GRCm38)	missense	probably benign	0.00
Z1189:Nlrp1b	UTSW	11	71,182,454 (GRCm38)	missense	probably benign	0.00
Z1189:Nlrp1b	UTSW	11	71,182,440 (GRCm38)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,182,322 (GRCm38)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,182,309 (GRCm38)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,181,799 (GRCm38)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,181,713 (GRCm38)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,181,708 (GRCm38)	missense	probably benign	0.02
Z1189:Nlrp1b	UTSW	11	71,182,677 (GRCm38)	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71,182,570 (GRCm38)	missense	probably benign	0.02
Z1189:Nlrp1b	UTSW	11	71,182,552 (GRCm38)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,182,544 (GRCm38)	missense	probably benign	0.00
Z1190:Nlrp1b	UTSW	11	71,182,552 (GRCm38)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,182,570 (GRCm38)	missense	probably benign	0.02
Z1190:Nlrp1b	UTSW	11	71,182,677 (GRCm38)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,181,708 (GRCm38)	missense	probably benign	0.02
Z1190:Nlrp1b	UTSW	11	71,181,713 (GRCm38)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,181,799 (GRCm38)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,182,309 (GRCm38)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,182,322 (GRCm38)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,182,440 (GRCm38)	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71,182,454 (GRCm38)	missense	probably benign	0.00
Z1191:Nlrp1b	UTSW	11	71,182,454 (GRCm38)	missense	probably benign	0.00
Z1191:Nlrp1b	UTSW	11	71,182,440 (GRCm38)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,182,322 (GRCm38)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,182,309 (GRCm38)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,181,799 (GRCm38)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,181,713 (GRCm38)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,181,708 (GRCm38)	missense	probably benign	0.02
Z1191:Nlrp1b	UTSW	11	71,182,677 (GRCm38)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,182,570 (GRCm38)	missense	probably benign	0.02
Z1191:Nlrp1b	UTSW	11	71,182,552 (GRCm38)	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71,182,544 (GRCm38)	missense	probably benign	0.00
Z1192:Nlrp1b	UTSW	11	71,182,570 (GRCm38)	missense	probably benign	0.02
Z1192:Nlrp1b	UTSW	11	71,182,552 (GRCm38)	missense	probably benign
Z1192:Nlrp1b	UTSW	11	71,182,544 (GRCm38)	missense	probably benign	0.00
Z1192:Nlrp1b	UTSW	11	71,182,454 (GRCm38)	missense	probably benign	0.00
Z1192:Nlrp1b	UTSW	11	71,182,440 (GRCm38)	missense	probably benign
Z1192:Nlrp1b	UTSW	11	71,182,322 (GRCm38)	missense	probably benign
Z1192:Nlrp1b	UTSW	11	71,181,799 (GRCm38)	missense	probably benign
Z1192:Nlrp1b	UTSW	11	71,181,708 (GRCm38)	missense	probably benign	0.02
Z1192:Nlrp1b	UTSW	11	71,182,677 (GRCm38)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- GCTCAGTAGCTGCATCTTGC -3'
(R):5'- GGTCACAGTTGCAGTCATTAATATC -3'

Sequencing Primer
(F):5'- ACCCTGGCCCCACATTTGG -3'
(R):5'- CAGTCATTCTGAATCCTAGGATGC -3'

Posted On

2014-06-23