Incidental Mutation 'R1816:Or5p80'
ID 204426
Institutional Source Beutler Lab
Gene Symbol Or5p80
Ensembl Gene ENSMUSG00000063764
Gene Name olfactory receptor family 5 subfamily P member 80
Synonyms MOR204-6, GA_x6K02T2PBJ9-10959726-10960658, Olfr508
MMRRC Submission 039844-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # R1816 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 108229201-108230133 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 108229364 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 55 (L55P)
Ref Sequence ENSEMBL: ENSMUSP00000072686 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072914]
AlphaFold Q8VG42
Predicted Effect probably damaging
Transcript: ENSMUST00000072914
AA Change: L55P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000072686
Gene: ENSMUSG00000063764
AA Change: L55P

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.8e-50 PFAM
Pfam:7tm_1 41 290 3.8e-20 PFAM
Meta Mutation Damage Score 0.6104 question?
Coding Region Coverage
  • 1x: 97.4%
  • 3x: 96.8%
  • 10x: 95.0%
  • 20x: 91.9%
Validation Efficiency 99% (72/73)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930433I11Rik T A 7: 40,644,222 (GRCm39) Y721* probably null Het
4933405L10Rik T A 8: 106,436,491 (GRCm39) V220E possibly damaging Het
4933434E20Rik T C 3: 89,960,398 (GRCm39) V13A possibly damaging Het
Adam1b T G 5: 121,639,788 (GRCm39) Q419P probably damaging Het
Ankib1 A G 5: 3,784,028 (GRCm39) V316A probably benign Het
Anks1 T A 17: 28,205,547 (GRCm39) D294E probably damaging Het
Atr T C 9: 95,748,747 (GRCm39) S431P probably benign Het
Bfsp1 C T 2: 143,683,599 (GRCm39) A242T probably benign Het
Bptf A T 11: 106,951,405 (GRCm39) V279E probably damaging Het
Camkk2 A G 5: 122,872,243 (GRCm39) L540P probably damaging Het
Cd84 A G 1: 171,700,317 (GRCm39) T145A possibly damaging Het
Ceacam12 T A 7: 17,805,690 (GRCm39) probably null Het
Cntnap5a G T 1: 116,356,618 (GRCm39) A823S probably benign Het
Cp T C 3: 20,022,384 (GRCm39) probably benign Het
Dhx58 A G 11: 100,593,978 (GRCm39) V163A probably damaging Het
Dicer1 T C 12: 104,688,410 (GRCm39) E389G probably damaging Het
Disp1 T A 1: 182,880,139 (GRCm39) D288V probably damaging Het
Dnah7a A G 1: 53,670,901 (GRCm39) probably benign Het
Eaf2 T G 16: 36,628,371 (GRCm39) probably benign Het
Efna1 T C 3: 89,183,694 (GRCm39) N44S possibly damaging Het
Etnppl T C 3: 130,428,211 (GRCm39) I462T probably benign Het
Fam83d G T 2: 158,610,070 (GRCm39) A13S possibly damaging Het
Fer1l4 C T 2: 155,877,119 (GRCm39) V1139M probably damaging Het
Fstl1 A G 16: 37,647,086 (GRCm39) probably null Het
Gm14226 A T 2: 154,867,549 (GRCm39) D502V probably damaging Het
Gm5117 T A 8: 32,228,986 (GRCm39) noncoding transcript Het
Gm973 A G 1: 59,621,558 (GRCm39) N566S probably damaging Het
Grm7 A T 6: 111,472,752 (GRCm39) K16* probably null Het
Hbb-bh2 G A 7: 103,489,585 (GRCm39) T17I possibly damaging Het
Htt C T 5: 34,961,084 (GRCm39) A237V probably benign Het
Itga6 T C 2: 71,671,153 (GRCm39) V665A probably benign Het
Klf4 G T 4: 55,530,977 (GRCm39) R45S probably benign Het
Mki67 T C 7: 135,309,116 (GRCm39) D445G possibly damaging Het
Myo10 T C 15: 25,800,286 (GRCm39) V1454A probably damaging Het
Nrbp1 T A 5: 31,403,157 (GRCm39) I210N probably damaging Het
Nudt12 G A 17: 59,317,131 (GRCm39) P172L probably damaging Het
Odam A G 5: 88,037,329 (GRCm39) probably null Het
Or1e33 T C 11: 73,738,025 (GRCm39) K309E probably benign Het
Or2ag13 A T 7: 106,472,695 (GRCm39) Y252* probably null Het
Or4p18 T G 2: 88,232,943 (GRCm39) I112L possibly damaging Het
Or5g29 G T 2: 85,421,269 (GRCm39) K128N probably benign Het
Or8k33 A T 2: 86,384,011 (GRCm39) C152* probably null Het
Pcm1 T A 8: 41,762,574 (GRCm39) S1412T probably damaging Het
Pgap1 A G 1: 54,531,216 (GRCm39) L753P probably damaging Het
Pi4k2b T C 5: 52,908,088 (GRCm39) S153P probably damaging Het
Pik3c2b C T 1: 133,029,108 (GRCm39) A1398V probably benign Het
Pkhd1l1 T C 15: 44,391,635 (GRCm39) I1567T possibly damaging Het
Rapgef6 G A 11: 54,585,314 (GRCm39) V1571I probably benign Het
Rfx2 C A 17: 57,115,305 (GRCm39) E5* probably null Het
Sh3tc1 C A 5: 35,857,928 (GRCm39) probably null Het
Slc22a12 G A 19: 6,592,683 (GRCm39) Q20* probably null Het
Slc4a1 A G 11: 102,242,056 (GRCm39) C861R probably damaging Het
Snrnp25 G A 11: 32,157,565 (GRCm39) V48I probably damaging Het
Spata1 G T 3: 146,186,962 (GRCm39) P211Q probably damaging Het
Srgap1 G A 10: 121,761,876 (GRCm39) Q91* probably null Het
Stab1 T C 14: 30,879,422 (GRCm39) D686G probably benign Het
Stx8 T A 11: 67,902,152 (GRCm39) M112K possibly damaging Het
Tfap2b A T 1: 19,279,436 (GRCm39) K15N probably damaging Het
Thbs2 C A 17: 14,890,975 (GRCm39) D1052Y probably benign Het
Thbs2 T A 17: 14,890,976 (GRCm39) E1051D probably benign Het
Thoc2l A G 5: 104,665,700 (GRCm39) D74G probably benign Het
Tlr2 T C 3: 83,745,516 (GRCm39) Y189C probably damaging Het
Tmem268 C A 4: 63,483,947 (GRCm39) P55T possibly damaging Het
Tnpo3 T C 6: 29,557,016 (GRCm39) H745R probably benign Het
Trappc14 A G 5: 138,258,603 (GRCm39) V548A possibly damaging Het
Ube2s T C 7: 4,814,554 (GRCm39) N2S probably damaging Het
Ulk1 A G 5: 110,935,697 (GRCm39) Y39H probably damaging Het
Vmn1r49 G T 6: 90,049,785 (GRCm39) D72E possibly damaging Het
Vmn2r27 C A 6: 124,207,330 (GRCm39) G104* probably null Het
Vmn2r92 A G 17: 18,386,939 (GRCm39) I93V probably damaging Het
Zdhhc20 A T 14: 58,127,600 (GRCm39) V13E probably benign Het
Zfp958 A T 8: 4,679,147 (GRCm39) I391F possibly damaging Het
Other mutations in Or5p80
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01392:Or5p80 APN 7 108,229,885 (GRCm39) missense probably benign 0.01
IGL02045:Or5p80 APN 7 108,229,739 (GRCm39) missense probably damaging 1.00
IGL03354:Or5p80 APN 7 108,229,735 (GRCm39) missense possibly damaging 0.75
R0047:Or5p80 UTSW 7 108,229,759 (GRCm39) missense probably benign 0.00
R1162:Or5p80 UTSW 7 108,230,120 (GRCm39) missense probably benign 0.00
R1828:Or5p80 UTSW 7 108,229,855 (GRCm39) missense possibly damaging 0.88
R1924:Or5p80 UTSW 7 108,229,562 (GRCm39) missense probably damaging 1.00
R1938:Or5p80 UTSW 7 108,230,045 (GRCm39) missense probably benign 0.42
R2155:Or5p80 UTSW 7 108,229,984 (GRCm39) missense probably damaging 1.00
R3416:Or5p80 UTSW 7 108,229,225 (GRCm39) missense possibly damaging 0.75
R4078:Or5p80 UTSW 7 108,230,114 (GRCm39) missense probably benign 0.31
R4271:Or5p80 UTSW 7 108,229,560 (GRCm39) nonsense probably null
R4884:Or5p80 UTSW 7 108,229,819 (GRCm39) missense probably damaging 0.98
R5842:Or5p80 UTSW 7 108,229,859 (GRCm39) missense probably benign 0.06
R6281:Or5p80 UTSW 7 108,229,609 (GRCm39) missense probably benign 0.24
R6558:Or5p80 UTSW 7 108,229,395 (GRCm39) missense probably damaging 0.99
R6828:Or5p80 UTSW 7 108,229,500 (GRCm39) missense possibly damaging 0.48
R7498:Or5p80 UTSW 7 108,229,623 (GRCm39) nonsense probably null
R7708:Or5p80 UTSW 7 108,230,048 (GRCm39) missense probably damaging 1.00
R7766:Or5p80 UTSW 7 108,229,583 (GRCm39) missense probably benign 0.04
R8955:Or5p80 UTSW 7 108,229,506 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ATTCCTATCATAGATGGAACCTGG -3'
(R):5'- ACATCTGCGTGGCATAGAG -3'

Sequencing Primer
(F):5'- TCATAGATGGAACCTGGAAACTAC -3'
(R):5'- CTACATAGCGATCATAGGCCATGG -3'
Posted On 2014-06-23