Incidental Mutation 'R1818:Morc3'
ID 204651
Institutional Source Beutler Lab
Gene Symbol Morc3
Ensembl Gene ENSMUSG00000039456
Gene Name microrchidia 3
Synonyms Zcwcc3, D16Jhu32e, 1110051N18Rik, 1110051N18Rik
MMRRC Submission 039846-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R1818 (G1)
Quality Score 225
Status Not validated
Chromosome 16
Chromosomal Location 93629009-93672961 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 93652398 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 367 (Y367C)
Ref Sequence ENSEMBL: ENSMUSP00000144369 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044068] [ENSMUST00000201097] [ENSMUST00000201754] [ENSMUST00000202261]
AlphaFold F7BJB9
Predicted Effect probably damaging
Transcript: ENSMUST00000044068
AA Change: Y367C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000040152
Gene: ENSMUSG00000039456
AA Change: Y367C

DomainStartEndE-ValueType
Pfam:HATPase_c 25 130 8e-8 PFAM
Pfam:HATPase_c_3 26 164 1.1e-18 PFAM
Pfam:zf-CW 409 452 2.7e-19 PFAM
low complexity region 461 472 N/A INTRINSIC
low complexity region 630 639 N/A INTRINSIC
coiled coil region 765 871 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000201097
AA Change: Y296C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000144058
Gene: ENSMUSG00000039456
AA Change: Y296C

DomainStartEndE-ValueType
Blast:HATPase_c 1 70 4e-39 BLAST
Pfam:zf-CW 340 383 1.2e-16 PFAM
low complexity region 392 403 N/A INTRINSIC
low complexity region 557 566 N/A INTRINSIC
coiled coil region 692 798 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201706
Predicted Effect probably benign
Transcript: ENSMUST00000201754
SMART Domains Protein: ENSMUSP00000144357
Gene: ENSMUSG00000039456

DomainStartEndE-ValueType
Pfam:HATPase_c 25 91 1.3e-6 PFAM
Pfam:HATPase_c_3 26 92 1.2e-8 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000202261
AA Change: Y367C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000144369
Gene: ENSMUSG00000039456
AA Change: Y367C

DomainStartEndE-ValueType
Pfam:HATPase_c 25 130 8e-8 PFAM
Pfam:HATPase_c_3 26 164 1.1e-18 PFAM
Pfam:zf-CW 409 452 2.7e-19 PFAM
low complexity region 461 472 N/A INTRINSIC
low complexity region 630 639 N/A INTRINSIC
coiled coil region 765 871 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232425
Coding Region Coverage
  • 1x: 97.3%
  • 3x: 96.6%
  • 10x: 94.5%
  • 20x: 90.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]
PHENOTYPE: Mice homozygous for a null allele die at or within a day of birth. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 93 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aass T A 6: 23,075,857 (GRCm39) probably null Het
Adam6b T A 12: 113,454,876 (GRCm39) N564K probably benign Het
Ahi1 A G 10: 20,864,461 (GRCm39) Y731C probably damaging Het
Ankk1 A G 9: 49,331,725 (GRCm39) Y190H probably benign Het
Ankmy1 T A 1: 92,814,553 (GRCm39) D318V probably benign Het
Ankrd33b G A 15: 31,367,267 (GRCm39) A91V probably damaging Het
Ap3b1 A G 13: 94,608,212 (GRCm39) N561S possibly damaging Het
Apob A G 12: 8,056,834 (GRCm39) N1739S probably damaging Het
Apob A G 12: 8,063,064 (GRCm39) T236A possibly damaging Het
Birc6 G A 17: 74,956,844 (GRCm39) A3593T probably damaging Het
Bnc2 A G 4: 84,210,111 (GRCm39) F778L possibly damaging Het
Capn2 T A 1: 182,300,162 (GRCm39) K609N probably benign Het
Car9 G T 4: 43,512,439 (GRCm39) probably null Het
Card11 A T 5: 140,871,315 (GRCm39) D729E probably benign Het
Ccl20 A G 1: 83,095,529 (GRCm39) Y30C probably damaging Het
Cd209a G A 8: 3,795,576 (GRCm39) T106I probably damaging Het
Cebpz A G 17: 79,242,805 (GRCm39) L283P probably damaging Het
Cecr2 A G 6: 120,708,228 (GRCm39) T77A probably damaging Het
Clec4e T A 6: 123,262,452 (GRCm39) D155V possibly damaging Het
Col25a1 G A 3: 130,379,386 (GRCm39) probably null Het
Cyp2j11 A T 4: 96,185,976 (GRCm39) V403D probably damaging Het
Cyp4v3 G A 8: 45,768,673 (GRCm39) R296C possibly damaging Het
Ddx59 A G 1: 136,360,245 (GRCm39) I420V probably damaging Het
Denr T A 5: 124,055,283 (GRCm39) D49E probably benign Het
Dnaaf3 A T 7: 4,526,568 (GRCm39) probably null Het
Dnaaf3 G T 7: 4,526,569 (GRCm39) L503M probably benign Het
Dnah7a A C 1: 53,598,307 (GRCm39) D1409E probably benign Het
Dnai4 A G 4: 102,929,854 (GRCm39) V56A possibly damaging Het
Efcab3 T A 11: 104,612,333 (GRCm39) L652Q probably benign Het
Ehd4 C T 2: 119,932,885 (GRCm39) W180* probably null Het
Ephb2 A G 4: 136,382,647 (GRCm39) S984P probably benign Het
Eva1a T C 6: 82,048,125 (GRCm39) M1T probably null Het
Fam90a1a C G 8: 22,453,787 (GRCm39) P381A possibly damaging Het
Fam90a1a C A 8: 22,453,788 (GRCm39) P381Q probably damaging Het
Flnc T C 6: 29,457,447 (GRCm39) Y2382H probably damaging Het
Flrt1 A T 19: 7,072,711 (GRCm39) L612Q probably damaging Het
Fubp1 T A 3: 151,927,806 (GRCm39) N419K probably damaging Het
Gin1 A G 1: 97,712,951 (GRCm39) probably null Het
Gm4847 T A 1: 166,465,788 (GRCm39) H267L probably damaging Het
Golga4 T G 9: 118,402,055 (GRCm39) V91G probably damaging Het
Hip1r T C 5: 124,134,018 (GRCm39) probably null Het
Ice2 A G 9: 69,339,383 (GRCm39) S967G probably benign Het
Il18rap A G 1: 40,570,687 (GRCm39) I210V probably benign Het
Impdh2 T G 9: 108,440,411 (GRCm39) probably null Het
Inmt C A 6: 55,150,404 (GRCm39) V78F possibly damaging Het
Inpp5e T C 2: 26,287,886 (GRCm39) S637G probably benign Het
Kansl1 T C 11: 104,233,283 (GRCm39) H748R possibly damaging Het
Kif28 T C 1: 179,533,319 (GRCm39) K541E possibly damaging Het
Kifc1 G A 17: 34,103,685 (GRCm39) R195C probably benign Het
Kifc2 T C 15: 76,550,281 (GRCm39) V480A probably damaging Het
Lrrc74a T C 12: 86,784,484 (GRCm39) Y71H probably damaging Het
Ly75 T G 2: 60,142,121 (GRCm39) T1330P probably damaging Het
Macf1 A G 4: 123,270,210 (GRCm39) V6647A probably damaging Het
Mgat1 T C 11: 49,152,111 (GRCm39) I198T possibly damaging Het
Mtfr1 A G 3: 19,269,837 (GRCm39) T162A probably damaging Het
Myrip C T 9: 120,217,228 (GRCm39) S49L probably damaging Het
Nup153 A T 13: 46,835,113 (GRCm39) N1397K possibly damaging Het
Or5h26 T C 16: 58,988,243 (GRCm39) K88E probably benign Het
Or6x1 T C 9: 40,098,558 (GRCm39) V49A probably benign Het
Or8b36 T C 9: 37,937,803 (GRCm39) S234P probably damaging Het
Or8g21 T C 9: 38,905,902 (GRCm39) I276M possibly damaging Het
Pabpc2 G T 18: 39,907,163 (GRCm39) V143L probably damaging Het
Pals2 T G 6: 50,140,411 (GRCm39) F144V probably benign Het
Panx3 T C 9: 37,575,322 (GRCm39) K180R probably benign Het
Patj G A 4: 98,511,885 (GRCm39) V144M possibly damaging Het
Pde1c T A 6: 56,103,877 (GRCm39) K651* probably null Het
Pde4c A G 8: 71,179,638 (GRCm39) H63R probably benign Het
Pdha2 T A 3: 140,916,960 (GRCm39) K183* probably null Het
Pkd1l3 T A 8: 110,375,038 (GRCm39) C1504S probably benign Het
Plbd2 A T 5: 120,625,574 (GRCm39) probably null Het
Poteg G A 8: 27,940,195 (GRCm39) W121* probably null Het
Prf1 C A 10: 61,138,762 (GRCm39) T240N probably damaging Het
Ptprf A G 4: 118,067,068 (GRCm39) Y1883H probably damaging Het
Puf60 T C 15: 75,943,323 (GRCm39) T322A possibly damaging Het
Rev3l A G 10: 39,704,420 (GRCm39) I281M probably benign Het
Rufy1 T C 11: 50,305,399 (GRCm39) I305V probably benign Het
Shisa9 A C 16: 12,085,426 (GRCm39) Q329P probably damaging Het
Siglech G A 7: 55,418,332 (GRCm39) R100Q probably damaging Het
Slc13a5 T A 11: 72,144,169 (GRCm39) Y303F probably benign Het
Snx6 C T 12: 54,830,259 (GRCm39) V67I possibly damaging Het
Spef2 C T 15: 9,584,194 (GRCm39) E1624K probably damaging Het
Tecpr2 A G 12: 110,892,888 (GRCm39) Y310C probably damaging Het
Top1 T A 2: 160,557,643 (GRCm39) L575Q probably damaging Het
Usp16 C T 16: 87,276,020 (GRCm39) R452* probably null Het
Utrn A G 10: 12,585,708 (GRCm39) probably null Het
Vps13b G A 15: 35,877,723 (GRCm39) G2899E probably benign Het
Wipi2 T A 5: 142,643,963 (GRCm39) L115Q probably damaging Het
Zbtb7c A C 18: 76,270,596 (GRCm39) E228A probably damaging Het
Zfp26 T C 9: 20,353,487 (GRCm39) T101A probably benign Het
Zfp593 A T 4: 133,972,394 (GRCm39) probably null Het
Zfp646 G A 7: 127,482,292 (GRCm39) G1490S probably benign Het
Zfp948 G A 17: 21,805,069 (GRCm39) V20M probably damaging Het
Zranb3 A T 1: 127,945,293 (GRCm39) probably null Het
Other mutations in Morc3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00561:Morc3 APN 16 93,670,283 (GRCm39) critical splice donor site probably null
IGL01015:Morc3 APN 16 93,659,534 (GRCm39) missense probably damaging 1.00
IGL01374:Morc3 APN 16 93,641,101 (GRCm39) missense probably damaging 1.00
IGL01634:Morc3 APN 16 93,670,125 (GRCm39) missense probably benign 0.02
IGL01845:Morc3 APN 16 93,657,455 (GRCm39) missense probably damaging 0.96
IGL02202:Morc3 APN 16 93,667,749 (GRCm39) missense probably benign 0.01
IGL02478:Morc3 APN 16 93,661,844 (GRCm39) splice site probably benign
IGL03026:Morc3 APN 16 93,659,612 (GRCm39) splice site probably benign
IGL03115:Morc3 APN 16 93,667,971 (GRCm39) missense probably damaging 0.99
Ballista UTSW 16 93,638,271 (GRCm39) missense probably damaging 1.00
mindy UTSW 16 93,663,421 (GRCm39) missense probably benign 0.03
Pfaff UTSW 16 93,659,572 (GRCm39) missense probably damaging 0.96
shield UTSW 16 93,671,700 (GRCm39) missense probably damaging 0.98
sparkle UTSW 16 93,667,362 (GRCm39) missense probably damaging 1.00
Stooges UTSW 16 93,638,275 (GRCm39) missense probably damaging 1.00
Sword UTSW 16 93,671,645 (GRCm39) critical splice acceptor site probably null
R0173:Morc3 UTSW 16 93,629,094 (GRCm39) splice site probably null
R0413:Morc3 UTSW 16 93,667,362 (GRCm39) missense probably damaging 1.00
R0639:Morc3 UTSW 16 93,650,738 (GRCm39) missense probably damaging 1.00
R0842:Morc3 UTSW 16 93,670,284 (GRCm39) critical splice donor site probably null
R1134:Morc3 UTSW 16 93,667,557 (GRCm39) missense probably benign
R1162:Morc3 UTSW 16 93,649,996 (GRCm39) missense probably damaging 1.00
R1498:Morc3 UTSW 16 93,650,743 (GRCm39) missense probably damaging 1.00
R1520:Morc3 UTSW 16 93,641,129 (GRCm39) missense probably damaging 0.96
R1603:Morc3 UTSW 16 93,663,391 (GRCm39) missense probably benign
R1622:Morc3 UTSW 16 93,671,694 (GRCm39) missense probably benign 0.28
R1630:Morc3 UTSW 16 93,663,421 (GRCm39) missense probably benign 0.03
R1902:Morc3 UTSW 16 93,667,385 (GRCm39) missense probably damaging 1.00
R2090:Morc3 UTSW 16 93,663,341 (GRCm39) missense probably benign 0.23
R2261:Morc3 UTSW 16 93,650,109 (GRCm39) splice site probably benign
R2360:Morc3 UTSW 16 93,638,275 (GRCm39) missense probably damaging 1.00
R2407:Morc3 UTSW 16 93,641,215 (GRCm39) critical splice donor site probably null
R2519:Morc3 UTSW 16 93,659,427 (GRCm39) splice site probably null
R3736:Morc3 UTSW 16 93,671,700 (GRCm39) missense probably damaging 0.98
R3873:Morc3 UTSW 16 93,659,324 (GRCm39) missense probably damaging 0.99
R4114:Morc3 UTSW 16 93,670,227 (GRCm39) missense probably benign 0.01
R4115:Morc3 UTSW 16 93,670,227 (GRCm39) missense probably benign 0.01
R4116:Morc3 UTSW 16 93,670,227 (GRCm39) missense probably benign 0.01
R4472:Morc3 UTSW 16 93,671,645 (GRCm39) critical splice acceptor site probably null
R4609:Morc3 UTSW 16 93,661,856 (GRCm39) missense probably benign 0.01
R4708:Morc3 UTSW 16 93,670,126 (GRCm39) missense probably benign 0.19
R4883:Morc3 UTSW 16 93,667,250 (GRCm39) critical splice acceptor site probably null
R4945:Morc3 UTSW 16 93,668,082 (GRCm39) missense probably damaging 1.00
R4965:Morc3 UTSW 16 93,657,475 (GRCm39) nonsense probably null
R5399:Morc3 UTSW 16 93,659,427 (GRCm39) splice site probably null
R5481:Morc3 UTSW 16 93,659,543 (GRCm39) missense probably damaging 0.99
R5540:Morc3 UTSW 16 93,644,268 (GRCm39) missense probably benign
R5970:Morc3 UTSW 16 93,663,341 (GRCm39) missense possibly damaging 0.65
R6006:Morc3 UTSW 16 93,663,381 (GRCm39) missense possibly damaging 0.67
R6044:Morc3 UTSW 16 93,663,330 (GRCm39) missense probably benign 0.02
R6045:Morc3 UTSW 16 93,671,733 (GRCm39) missense probably damaging 1.00
R6155:Morc3 UTSW 16 93,659,313 (GRCm39) missense possibly damaging 0.94
R6165:Morc3 UTSW 16 93,638,271 (GRCm39) missense probably damaging 1.00
R6225:Morc3 UTSW 16 93,642,082 (GRCm39) nonsense probably null
R6240:Morc3 UTSW 16 93,659,572 (GRCm39) missense probably damaging 0.96
R6835:Morc3 UTSW 16 93,644,309 (GRCm39) missense probably damaging 1.00
R6918:Morc3 UTSW 16 93,650,023 (GRCm39) missense probably benign 0.36
R6944:Morc3 UTSW 16 93,667,460 (GRCm39) missense probably benign
R7311:Morc3 UTSW 16 93,646,061 (GRCm39) missense probably damaging 1.00
R7398:Morc3 UTSW 16 93,671,748 (GRCm39) missense probably damaging 1.00
R7553:Morc3 UTSW 16 93,667,824 (GRCm39) missense probably damaging 0.98
R8056:Morc3 UTSW 16 93,642,064 (GRCm39) missense probably benign 0.07
R8299:Morc3 UTSW 16 93,650,088 (GRCm39) missense probably damaging 1.00
R8317:Morc3 UTSW 16 93,659,417 (GRCm39) missense probably benign 0.25
R8542:Morc3 UTSW 16 93,644,319 (GRCm39) critical splice donor site probably null
R8697:Morc3 UTSW 16 93,667,908 (GRCm39) missense probably benign 0.00
R8739:Morc3 UTSW 16 93,657,398 (GRCm39) missense probably damaging 1.00
R9072:Morc3 UTSW 16 93,667,482 (GRCm39) missense probably benign 0.00
R9235:Morc3 UTSW 16 93,659,321 (GRCm39) missense probably damaging 1.00
R9305:Morc3 UTSW 16 93,667,302 (GRCm39) missense probably benign 0.00
R9405:Morc3 UTSW 16 93,642,036 (GRCm39) missense probably damaging 1.00
R9431:Morc3 UTSW 16 93,667,771 (GRCm39) nonsense probably null
R9440:Morc3 UTSW 16 93,649,975 (GRCm39) critical splice acceptor site probably null
R9524:Morc3 UTSW 16 93,667,401 (GRCm39) missense probably benign 0.09
R9571:Morc3 UTSW 16 93,641,107 (GRCm39) missense possibly damaging 0.89
X0023:Morc3 UTSW 16 93,644,287 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTTACTCGGAAATTTCATGGGAG -3'
(R):5'- GAGCAAATTCCTGCCTGCATG -3'

Sequencing Primer
(F):5'- CGGAAATTTCATGGGAGTCATATAAG -3'
(R):5'- GGGTACATGTAGTCACAGCACTC -3'
Posted On 2014-06-23