Incidental Mutation 'R1820:Or8g28'
ID 204792
Institutional Source Beutler Lab
Gene Symbol Or8g28
Ensembl Gene ENSMUSG00000063380
Gene Name olfactory receptor family 8 subfamily G member 28
Synonyms MOR171-20, Olfr945, GA_x6K02T2PVTD-32955932-32954982
MMRRC Submission 039848-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R1820 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 39169016-39169975 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 39169695 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 91 (I91T)
Ref Sequence ENSEMBL: ENSMUSP00000151086 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076903] [ENSMUST00000216698]
AlphaFold Q9EQB5
Predicted Effect probably benign
Transcript: ENSMUST00000076903
AA Change: I94T

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000076169
Gene: ENSMUSG00000063380
AA Change: I94T

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 1.2e-50 PFAM
Pfam:7tm_1 44 293 2.3e-23 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000216698
AA Change: I91T

PolyPhen 2 Score 0.740 (Sensitivity: 0.85; Specificity: 0.92)
Coding Region Coverage
  • 1x: 97.4%
  • 3x: 96.8%
  • 10x: 95.0%
  • 20x: 91.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik T C 12: 71,197,018 (GRCm39) V197A possibly damaging Het
9230109A22Rik T C 15: 25,139,176 (GRCm39) noncoding transcript Het
Acbd3 A G 1: 180,572,703 (GRCm39) N321S probably benign Het
Actr3b T C 5: 26,054,156 (GRCm39) probably null Het
Aldh5a1 T C 13: 25,111,555 (GRCm39) D124G probably benign Het
Arhgap35 G A 7: 16,295,874 (GRCm39) R1064W possibly damaging Het
Arhgef9 T A X: 94,125,142 (GRCm39) I225F probably damaging Het
Arl16 T C 11: 120,357,587 (GRCm39) T43A probably damaging Het
Camsap3 T C 8: 3,653,485 (GRCm39) W409R probably damaging Het
Cfap43 T A 19: 47,885,655 (GRCm39) H320L probably damaging Het
Chac2 T A 11: 30,927,496 (GRCm39) N141I probably damaging Het
Chtf18 C A 17: 25,944,913 (GRCm39) G211C probably damaging Het
Cplane1 A G 15: 8,299,129 (GRCm39) K3106E unknown Het
Cwf19l1 T A 19: 44,115,826 (GRCm39) Y201F probably benign Het
Dcun1d1 A T 3: 35,973,153 (GRCm39) L114* probably null Het
Fdps A T 3: 89,002,350 (GRCm39) H249Q probably benign Het
Fhip1a T A 3: 85,573,136 (GRCm39) T938S probably damaging Het
Gabrg1 T A 5: 70,931,756 (GRCm39) Y329F probably damaging Het
Kctd8 T A 5: 69,497,684 (GRCm39) I321F probably damaging Het
Kdm5b G T 1: 134,525,408 (GRCm39) R299L possibly damaging Het
Kif23 T C 9: 61,833,720 (GRCm39) T494A possibly damaging Het
Kmt2e A G 5: 23,678,545 (GRCm39) H208R probably damaging Het
Lipo5 A T 19: 33,441,995 (GRCm39) probably null Het
Lrrc28 G T 7: 67,290,859 (GRCm39) T54K probably damaging Het
Luc7l2 G A 6: 38,575,754 (GRCm39) probably null Het
Man2a2 A G 7: 80,008,681 (GRCm39) F899L probably benign Het
Myo9b T C 8: 71,786,002 (GRCm39) I633T probably damaging Het
Nynrin A T 14: 56,107,835 (GRCm39) I981F possibly damaging Het
Or5an1c A T 19: 12,218,612 (GRCm39) S138T probably damaging Het
Pank1 A G 19: 34,855,084 (GRCm39) probably null Het
Phc2 C T 4: 128,637,336 (GRCm39) A47V probably damaging Het
Plekhs1 A G 19: 56,466,954 (GRCm39) R262G possibly damaging Het
Pnp2 C A 14: 51,201,914 (GRCm39) P300Q possibly damaging Het
Polq T A 16: 36,849,780 (GRCm39) S345T possibly damaging Het
Prag1 A G 8: 36,570,958 (GRCm39) T514A probably benign Het
Psmd5 T C 2: 34,760,758 (GRCm39) probably null Het
Rfx6 T G 10: 51,599,221 (GRCm39) probably null Het
Rhbdd2 G A 5: 135,664,903 (GRCm39) C78Y probably damaging Het
Rnf157 G T 11: 116,245,477 (GRCm39) P313T probably damaging Het
Ryr2 A G 13: 11,602,202 (GRCm39) L4560P probably damaging Het
Scai A T 2: 38,996,990 (GRCm39) M268K possibly damaging Het
Scd3 A T 19: 44,230,245 (GRCm39) T343S probably benign Het
Scimp A T 11: 70,682,423 (GRCm39) S98T probably benign Het
Sfrp2 A G 3: 83,680,461 (GRCm39) N207S probably benign Het
Shf G A 2: 122,199,163 (GRCm39) P51S probably damaging Het
Sis T C 3: 72,828,475 (GRCm39) Y1200C probably damaging Het
Sp1 T A 15: 102,317,511 (GRCm39) S343R possibly damaging Het
Spata31d1a A T 13: 59,849,069 (GRCm39) C1020S possibly damaging Het
Spink5 A G 18: 44,122,486 (GRCm39) N317S possibly damaging Het
Sptbn2 A G 19: 4,776,624 (GRCm39) D224G probably damaging Het
St8sia3 T C 18: 64,402,703 (GRCm39) I114T probably damaging Het
Zscan5b C A 7: 6,242,162 (GRCm39) H460Q probably damaging Het
Other mutations in Or8g28
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01640:Or8g28 APN 9 39,169,559 (GRCm39) missense probably damaging 1.00
IGL01773:Or8g28 APN 9 39,169,830 (GRCm39) missense probably damaging 0.96
IGL02869:Or8g28 APN 9 39,169,520 (GRCm39) nonsense probably null
IGL03245:Or8g28 APN 9 39,169,294 (GRCm39) missense probably damaging 0.99
K3955:Or8g28 UTSW 9 39,169,926 (GRCm39) missense probably damaging 1.00
R1710:Or8g28 UTSW 9 39,169,867 (GRCm39) missense probably benign 0.07
R1746:Or8g28 UTSW 9 39,169,498 (GRCm39) missense probably damaging 1.00
R3410:Or8g28 UTSW 9 39,169,897 (GRCm39) missense possibly damaging 0.75
R4091:Or8g28 UTSW 9 39,169,330 (GRCm39) missense possibly damaging 0.76
R4625:Or8g28 UTSW 9 39,169,614 (GRCm39) missense probably damaging 1.00
R6475:Or8g28 UTSW 9 39,169,378 (GRCm39) missense probably benign 0.00
R7114:Or8g28 UTSW 9 39,169,897 (GRCm39) missense possibly damaging 0.75
R7500:Or8g28 UTSW 9 39,169,762 (GRCm39) missense probably benign 0.03
R7545:Or8g28 UTSW 9 39,169,984 (GRCm39) critical splice acceptor site probably null
R7850:Or8g28 UTSW 9 39,169,518 (GRCm39) missense possibly damaging 0.94
R8263:Or8g28 UTSW 9 39,169,899 (GRCm39) missense probably damaging 1.00
R8477:Or8g28 UTSW 9 39,169,099 (GRCm39) missense probably damaging 1.00
R9466:Or8g28 UTSW 9 39,169,491 (GRCm39) missense possibly damaging 0.57
R9554:Or8g28 UTSW 9 39,169,756 (GRCm39) missense possibly damaging 0.81
R9577:Or8g28 UTSW 9 39,169,737 (GRCm39) missense possibly damaging 0.81
Z1088:Or8g28 UTSW 9 39,169,167 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- TACACTCCTGAAATCAAGGAACTG -3'
(R):5'- AATTCTTCTTGGCTGGGCTC -3'

Sequencing Primer
(F):5'- CTGTAAACCTGATAGGACATGACTAC -3'
(R):5'- TCTCAGAGGAGCCAGAACTC -3'
Posted On 2014-06-23