Incidental Mutation 'R1833:Vmn2r25'
| ID |
204947 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r25
|
| Ensembl Gene |
ENSMUSG00000094672 |
| Gene Name |
vomeronasal 2, receptor 25 |
| Synonyms |
EG545874 |
| MMRRC Submission |
039860-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.140)
|
| Stock # |
R1833 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
123799773-123830149 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 123816643 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Proline to Serine
at position 313
(P313S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124342
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000162046]
|
| AlphaFold |
W4VSP2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000162046
AA Change: P313S
PolyPhen 2
Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000124342
Gene: ENSMUSG00000094672
AA Change: P313S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
473 |
6e-31 |
PFAM |
|
Pfam:NCD3G
|
519 |
572 |
5.8e-25 |
PFAM |
|
Pfam:7tm_3
|
603 |
840 |
4.8e-55 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.1%
- 20x: 91.9%
|
| Validation Efficiency |
99% (83/84) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 79 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700003H04Rik |
T |
A |
3: 124,350,509 (GRCm39) |
D143V |
unknown |
Het |
| 4930438A08Rik |
C |
T |
11: 58,179,214 (GRCm39) |
Q183* |
probably null |
Het |
| 9230009I02Rik |
A |
G |
11: 50,982,293 (GRCm39) |
|
noncoding transcript |
Het |
| Abhd12 |
T |
A |
2: 150,690,338 (GRCm39) |
D119V |
probably damaging |
Het |
| Adam1b |
A |
G |
5: 121,641,000 (GRCm39) |
I15T |
possibly damaging |
Het |
| Agtpbp1 |
A |
T |
13: 59,613,797 (GRCm39) |
|
probably null |
Het |
| Arfgef1 |
G |
C |
1: 10,275,115 (GRCm39) |
I312M |
probably benign |
Het |
| Arid4a |
C |
T |
12: 71,122,240 (GRCm39) |
L874F |
possibly damaging |
Het |
| Bcas3 |
G |
A |
11: 85,474,775 (GRCm39) |
V317I |
probably benign |
Het |
| Ccr1 |
T |
A |
9: 123,764,126 (GRCm39) |
I135F |
probably damaging |
Het |
| Ces2h |
A |
G |
8: 105,747,005 (GRCm39) |
E547G |
possibly damaging |
Het |
| Ces3b |
T |
A |
8: 105,812,271 (GRCm39) |
D173E |
probably damaging |
Het |
| Chd3 |
A |
G |
11: 69,244,949 (GRCm39) |
L1197S |
probably damaging |
Het |
| Cngb1 |
A |
G |
8: 95,968,983 (GRCm39) |
L1175P |
probably damaging |
Het |
| Cyp4f17 |
T |
C |
17: 32,743,184 (GRCm39) |
F286L |
probably benign |
Het |
| Dclre1a |
C |
T |
19: 56,529,932 (GRCm39) |
|
probably null |
Het |
| Dennd6a |
T |
A |
14: 26,328,109 (GRCm39) |
L44H |
probably damaging |
Het |
| Dhx16 |
A |
G |
17: 36,196,511 (GRCm39) |
T560A |
probably benign |
Het |
| Dusp12 |
T |
C |
1: 170,702,022 (GRCm39) |
M326V |
probably benign |
Het |
| Eif3k |
T |
C |
7: 28,670,852 (GRCm39) |
I180V |
probably benign |
Het |
| Erc1 |
A |
G |
6: 119,720,390 (GRCm39) |
I437T |
possibly damaging |
Het |
| Farp2 |
T |
A |
1: 93,504,086 (GRCm39) |
|
probably benign |
Het |
| Foxa3 |
A |
G |
7: 18,748,499 (GRCm39) |
L209P |
probably damaging |
Het |
| Garin2 |
G |
A |
12: 78,762,280 (GRCm39) |
|
probably benign |
Het |
| Gen1 |
A |
T |
12: 11,298,352 (GRCm39) |
|
probably benign |
Het |
| Gm10305 |
A |
G |
4: 99,161,363 (GRCm39) |
T91A |
unknown |
Het |
| Gm14412 |
T |
C |
2: 177,007,583 (GRCm39) |
D104G |
probably benign |
Het |
| Gm6900 |
T |
C |
7: 10,390,515 (GRCm39) |
|
noncoding transcript |
Het |
| Gpx1 |
A |
T |
9: 108,216,555 (GRCm39) |
Y15F |
possibly damaging |
Het |
| H2-M10.3 |
T |
C |
17: 36,678,387 (GRCm39) |
Y146C |
probably damaging |
Het |
| H2-Q7 |
C |
A |
17: 35,658,675 (GRCm39) |
S104R |
probably benign |
Het |
| Hephl1 |
T |
C |
9: 14,988,224 (GRCm39) |
Y628C |
probably damaging |
Het |
| Hspa5 |
T |
A |
2: 34,666,065 (GRCm39) |
Y636* |
probably null |
Het |
| Htt |
A |
G |
5: 35,063,092 (GRCm39) |
|
probably benign |
Het |
| Idh1 |
T |
C |
1: 65,200,273 (GRCm39) |
I364V |
probably benign |
Het |
| Itgae |
G |
T |
11: 73,007,988 (GRCm39) |
A423S |
possibly damaging |
Het |
| Kng2 |
T |
C |
16: 22,830,802 (GRCm39) |
N169S |
possibly damaging |
Het |
| Larp4b |
C |
T |
13: 9,201,235 (GRCm39) |
T369I |
possibly damaging |
Het |
| Lcor |
T |
C |
19: 41,573,387 (GRCm39) |
I714T |
probably benign |
Het |
| Lhfpl7 |
A |
G |
5: 113,382,435 (GRCm39) |
|
probably benign |
Het |
| Lonrf2 |
G |
A |
1: 38,852,357 (GRCm39) |
P165S |
probably benign |
Het |
| Magi2 |
G |
T |
5: 19,432,455 (GRCm39) |
G57C |
probably damaging |
Het |
| Mdn1 |
T |
A |
4: 32,720,761 (GRCm39) |
H2291Q |
probably damaging |
Het |
| Mgam |
T |
C |
6: 40,631,652 (GRCm39) |
|
probably null |
Het |
| Micall2 |
A |
G |
5: 139,702,508 (GRCm39) |
V245A |
probably benign |
Het |
| Mipep |
T |
G |
14: 61,109,512 (GRCm39) |
Y630D |
probably damaging |
Het |
| Msx2 |
A |
T |
13: 53,622,221 (GRCm39) |
M263K |
probably damaging |
Het |
| Nectin2 |
G |
T |
7: 19,451,633 (GRCm39) |
P467H |
probably damaging |
Het |
| Nek10 |
A |
T |
14: 14,842,789 (GRCm38) |
M165L |
probably benign |
Het |
| Nlrp4b |
A |
T |
7: 10,459,863 (GRCm39) |
M455L |
probably benign |
Het |
| Oaz3 |
TGGAGGCAGGAGCACGGGAGGCAGGAGCACGGGAGGCAG |
TGGAGGCAGGAGCACGGGAGGCAG |
3: 94,343,349 (GRCm39) |
|
probably benign |
Het |
| Or10ad1b |
T |
A |
15: 98,124,846 (GRCm39) |
I227F |
probably damaging |
Het |
| Or4c10 |
T |
A |
2: 89,760,645 (GRCm39) |
L164* |
probably null |
Het |
| Pcx |
T |
A |
19: 4,669,132 (GRCm39) |
V710E |
probably damaging |
Het |
| Pkn2 |
C |
T |
3: 142,527,408 (GRCm39) |
R347Q |
probably damaging |
Het |
| Pramel51 |
T |
C |
12: 88,145,218 (GRCm39) |
E44G |
possibly damaging |
Het |
| Qsox1 |
C |
T |
1: 155,666,791 (GRCm39) |
G233S |
probably benign |
Het |
| Rbl1 |
T |
A |
2: 157,037,475 (GRCm39) |
N224I |
probably damaging |
Het |
| Rspry1 |
A |
G |
8: 95,362,116 (GRCm39) |
T132A |
probably damaging |
Het |
| Sclt1 |
A |
G |
3: 41,681,546 (GRCm39) |
V91A |
probably damaging |
Het |
| Sema4f |
A |
T |
6: 82,895,540 (GRCm39) |
L331H |
probably benign |
Het |
| Sf3b3 |
T |
A |
8: 111,544,198 (GRCm39) |
Q814L |
probably benign |
Het |
| Slc19a2 |
T |
G |
1: 164,089,753 (GRCm39) |
Y190D |
probably damaging |
Het |
| Smarcc1 |
T |
A |
9: 109,982,879 (GRCm39) |
H204Q |
possibly damaging |
Het |
| Sox6 |
T |
C |
7: 115,376,328 (GRCm39) |
K135E |
probably damaging |
Het |
| Tecpr1 |
T |
C |
5: 144,145,426 (GRCm39) |
Q607R |
probably damaging |
Het |
| Tgfb1i1 |
A |
G |
7: 127,848,670 (GRCm39) |
|
probably benign |
Het |
| Tirap |
T |
G |
9: 35,099,999 (GRCm39) |
R228S |
probably benign |
Het |
| Trp53bp2 |
T |
A |
1: 182,256,581 (GRCm39) |
H50Q |
probably damaging |
Het |
| Try4 |
A |
G |
6: 41,280,365 (GRCm39) |
H63R |
probably damaging |
Het |
| Vps26a |
A |
C |
10: 62,294,825 (GRCm39) |
L250V |
probably benign |
Het |
| Vwf |
A |
G |
6: 125,619,000 (GRCm39) |
H1226R |
probably benign |
Het |
| Wdtc1 |
TCC |
TC |
4: 133,036,053 (GRCm39) |
|
probably benign |
Het |
| Zc3hav1l |
A |
T |
6: 38,274,881 (GRCm39) |
|
probably benign |
Het |
| Zfp119b |
T |
G |
17: 56,246,271 (GRCm39) |
H305P |
probably damaging |
Het |
| Zfp326 |
C |
T |
5: 106,039,035 (GRCm39) |
Q134* |
probably null |
Het |
| Zfp975 |
C |
T |
7: 42,311,263 (GRCm39) |
R450Q |
probably benign |
Het |
| Zfyve26 |
A |
T |
12: 79,333,032 (GRCm39) |
M313K |
probably benign |
Het |
| Zscan5b |
T |
C |
7: 6,241,965 (GRCm39) |
S395P |
possibly damaging |
Het |
|
| Other mutations in Vmn2r25 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00087:Vmn2r25
|
APN |
6 |
123,830,130 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL01781:Vmn2r25
|
APN |
6 |
123,816,324 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL01843:Vmn2r25
|
APN |
6 |
123,829,962 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL02023:Vmn2r25
|
APN |
6 |
123,816,388 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02502:Vmn2r25
|
APN |
6 |
123,816,392 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02709:Vmn2r25
|
APN |
6 |
123,816,723 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL03053:Vmn2r25
|
APN |
6 |
123,800,077 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4468001:Vmn2r25
|
UTSW |
6 |
123,816,557 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4812001:Vmn2r25
|
UTSW |
6 |
123,800,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0054:Vmn2r25
|
UTSW |
6 |
123,829,984 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0312:Vmn2r25
|
UTSW |
6 |
123,805,539 (GRCm39) |
splice site |
probably benign |
|
|
R0366:Vmn2r25
|
UTSW |
6 |
123,800,581 (GRCm39) |
nonsense |
probably null |
|
|
R0390:Vmn2r25
|
UTSW |
6 |
123,800,140 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0466:Vmn2r25
|
UTSW |
6 |
123,829,008 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0541:Vmn2r25
|
UTSW |
6 |
123,816,786 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0612:Vmn2r25
|
UTSW |
6 |
123,816,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0865:Vmn2r25
|
UTSW |
6 |
123,829,976 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1219:Vmn2r25
|
UTSW |
6 |
123,816,282 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1240:Vmn2r25
|
UTSW |
6 |
123,828,864 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1701:Vmn2r25
|
UTSW |
6 |
123,828,754 (GRCm39) |
splice site |
probably null |
|
|
R1780:Vmn2r25
|
UTSW |
6 |
123,805,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1809:Vmn2r25
|
UTSW |
6 |
123,802,337 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1964:Vmn2r25
|
UTSW |
6 |
123,800,254 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2154:Vmn2r25
|
UTSW |
6 |
123,816,805 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2164:Vmn2r25
|
UTSW |
6 |
123,816,518 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R3799:Vmn2r25
|
UTSW |
6 |
123,830,143 (GRCm39) |
missense |
probably benign |
0.12 |
|
R3836:Vmn2r25
|
UTSW |
6 |
123,830,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3946:Vmn2r25
|
UTSW |
6 |
123,817,057 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4282:Vmn2r25
|
UTSW |
6 |
123,800,606 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4367:Vmn2r25
|
UTSW |
6 |
123,805,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4438:Vmn2r25
|
UTSW |
6 |
123,816,756 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4488:Vmn2r25
|
UTSW |
6 |
123,799,819 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4580:Vmn2r25
|
UTSW |
6 |
123,799,982 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4631:Vmn2r25
|
UTSW |
6 |
123,829,962 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4765:Vmn2r25
|
UTSW |
6 |
123,800,182 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4908:Vmn2r25
|
UTSW |
6 |
123,805,406 (GRCm39) |
missense |
probably benign |
|
|
R5207:Vmn2r25
|
UTSW |
6 |
123,817,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5254:Vmn2r25
|
UTSW |
6 |
123,802,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5444:Vmn2r25
|
UTSW |
6 |
123,805,451 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5586:Vmn2r25
|
UTSW |
6 |
123,802,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5607:Vmn2r25
|
UTSW |
6 |
123,805,318 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R5985:Vmn2r25
|
UTSW |
6 |
123,800,587 (GRCm39) |
missense |
probably benign |
|
|
R6046:Vmn2r25
|
UTSW |
6 |
123,799,876 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6057:Vmn2r25
|
UTSW |
6 |
123,799,900 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6569:Vmn2r25
|
UTSW |
6 |
123,828,941 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6826:Vmn2r25
|
UTSW |
6 |
123,800,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7054:Vmn2r25
|
UTSW |
6 |
123,800,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7120:Vmn2r25
|
UTSW |
6 |
123,805,394 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R7177:Vmn2r25
|
UTSW |
6 |
123,816,882 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7287:Vmn2r25
|
UTSW |
6 |
123,829,040 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7397:Vmn2r25
|
UTSW |
6 |
123,800,498 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7486:Vmn2r25
|
UTSW |
6 |
123,800,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7699:Vmn2r25
|
UTSW |
6 |
123,816,882 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7700:Vmn2r25
|
UTSW |
6 |
123,816,882 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7759:Vmn2r25
|
UTSW |
6 |
123,800,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7802:Vmn2r25
|
UTSW |
6 |
123,828,791 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7850:Vmn2r25
|
UTSW |
6 |
123,805,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8064:Vmn2r25
|
UTSW |
6 |
123,800,581 (GRCm39) |
nonsense |
probably null |
|
|
R8170:Vmn2r25
|
UTSW |
6 |
123,829,976 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8340:Vmn2r25
|
UTSW |
6 |
123,829,972 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8346:Vmn2r25
|
UTSW |
6 |
123,802,350 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8395:Vmn2r25
|
UTSW |
6 |
123,799,982 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8889:Vmn2r25
|
UTSW |
6 |
123,800,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9094:Vmn2r25
|
UTSW |
6 |
123,805,391 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9204:Vmn2r25
|
UTSW |
6 |
123,830,092 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9253:Vmn2r25
|
UTSW |
6 |
123,816,960 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9392:Vmn2r25
|
UTSW |
6 |
123,816,937 (GRCm39) |
missense |
probably benign |
|
|
R9520:Vmn2r25
|
UTSW |
6 |
123,830,066 (GRCm39) |
nonsense |
probably null |
|
|
R9525:Vmn2r25
|
UTSW |
6 |
123,800,164 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9622:Vmn2r25
|
UTSW |
6 |
123,816,579 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0020:Vmn2r25
|
UTSW |
6 |
123,816,359 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
Z1176:Vmn2r25
|
UTSW |
6 |
123,799,856 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATCCCAGAGTCTGTGTTGGTAG -3'
(R):5'- ATCAGCCATGGAATTTGTGTTGC -3'
Sequencing Primer
(F):5'- CCCAGAGTCTGTGTTGGTAGTAATG -3'
(R):5'- CAGCCATGGAATTTGTGTTGCATTTG -3'
|
| Posted On |
2014-06-23 |
Incidental Mutation