Mutagenetix > Incidental Mutation

Incidental Mutation 'R1834:Vmn2r88'

205098

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r88

Ensembl Gene

ENSMUSG00000000606

Gene Name

vomeronasal 2, receptor 88

Synonyms

V2r3, V2r13

MMRRC Submission

039861-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.163) question?

Stock #

R1834 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

51410819-51419527 bp(+) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to G at 51413030 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000154310 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000022438] [ENSMUST00000159674] [ENSMUST00000162998] [ENSMUST00000228139]

AlphaFold

L7N1W8

Predicted Effect

probably benign
Transcript: ENSMUST00000022438

SMART Domains

Protein: ENSMUSP00000022438
Gene: ENSMUSG00000000606

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
Pfam:ANF_receptor	76	457	8.3e-27	PFAM
Pfam:NCD3G	516	570	1.2e-18	PFAM
Pfam:7tm_3	603	838	1.9e-55	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000159674

SMART Domains

Protein: ENSMUSP00000125126
Gene: ENSMUSG00000000606

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	30	408	3.2e-30	PFAM
Pfam:NCD3G	463	516	1.2e-19	PFAM
Pfam:7tm_3	546	785	3.7e-81	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000161565

Predicted Effect

probably benign
Transcript: ENSMUST00000162998

SMART Domains

Protein: ENSMUSP00000125409
Gene: ENSMUSG00000068399

Domain	Start	End	E-Value	Type
Pfam:Takusan	35	115	2.2e-25	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000163019

SMART Domains

Protein: ENSMUSP00000124837
Gene: ENSMUSG00000000606

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	52	399	3.7e-30	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000228139

Coding Region Coverage

1x: 97.4%
3x: 96.8%
10x: 95.1%
20x: 92.0%

Validation Efficiency

97% (116/119)

Allele List at MGI

Other mutations in this stock

Total: 114 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310033P09Rik	A	G	11: 59,208,487 (GRCm38)	D20G	probably damaging	Het
2310061N02Rik	T	A	16: 88,707,898 (GRCm38)	S4C	unknown	Het
Abca3	A	T	17: 24,376,692 (GRCm38)	N340Y	probably benign	Het
Abcc1	A	G	16: 14,423,117 (GRCm38)	I513V	possibly damaging	Het
Acacb	C	T	5: 114,235,475 (GRCm38)	T1855M	probably damaging	Het
Ace	A	G	11: 105,986,094 (GRCm38)		probably benign	Het
Acss2	T	A	2: 155,558,630 (GRCm38)	Y530N	probably damaging	Het
Adarb1	C	A	10: 77,317,231 (GRCm38)		probably benign	Het
Afm	T	A	5: 90,526,424 (GRCm38)	M265K	probably benign	Het
Agl	A	G	3: 116,788,351 (GRCm38)	F293S	probably benign	Het
Aox2	G	A	1: 58,308,991 (GRCm38)	A623T	probably benign	Het
Arhgap31	C	A	16: 38,603,703 (GRCm38)	S667I	probably benign	Het
Bco1	A	G	8: 117,117,437 (GRCm38)	T297A	probably benign	Het
Bmp1	T	C	14: 70,508,831 (GRCm38)	S123G	possibly damaging	Het
Caps2	G	A	10: 112,195,718 (GRCm38)	D283N	possibly damaging	Het
Ccdc57	A	C	11: 120,861,219 (GRCm38)	S845R	probably benign	Het
Cd209f	A	G	8: 4,104,491 (GRCm38)	S119P	probably damaging	Het
Chrna6	A	G	8: 27,407,214 (GRCm38)	S212P	probably benign	Het
Col10a1	G	C	10: 34,395,015 (GRCm38)	A328P	probably damaging	Het
Col4a2	A	G	8: 11,402,997 (GRCm38)	E188G	probably benign	Het
Creb1	C	T	1: 64,550,950 (GRCm38)	Q32*	probably null	Het
Cttnbp2	C	T	6: 18,501,966 (GRCm38)	V16M	probably damaging	Het
D430041D05Rik	A	G	2: 104,168,101 (GRCm38)	S1102P	probably damaging	Het
Ddx31	C	T	2: 28,892,453 (GRCm38)	H603Y	probably damaging	Het
Ddx52	G	A	11: 83,959,497 (GRCm38)	C568Y	probably benign	Het
Dgki	C	A	6: 37,034,701 (GRCm38)		probably benign	Het
Dmrt1	A	T	19: 25,509,699 (GRCm38)	Q123L	probably damaging	Het
Dnah5	A	T	15: 28,409,124 (GRCm38)	M3563L	probably benign	Het
Dnah7b	A	T	1: 46,233,759 (GRCm38)	N2349I	possibly damaging	Het
Dscaml1	T	G	9: 45,683,632 (GRCm38)	S678A	probably benign	Het
Ece1	A	G	4: 137,958,128 (GRCm38)	N643S	probably damaging	Het
Ece1	C	T	4: 137,958,001 (GRCm38)	R601W	probably damaging	Het
Eno1b	A	G	18: 48,047,463 (GRCm38)	Y236C	probably damaging	Het
Esco1	T	C	18: 10,594,350 (GRCm38)	E312G	probably damaging	Het
Eya3	T	A	4: 132,707,118 (GRCm38)	V276E	probably damaging	Het
Fam161b	A	G	12: 84,348,778 (GRCm38)		probably benign	Het
Fem1c	C	T	18: 46,505,282 (GRCm38)	G551D	probably damaging	Het
Fer1l6	T	C	15: 58,557,869 (GRCm38)	I155T	possibly damaging	Het
Gbp7	A	G	3: 142,534,680 (GRCm38)	Y53C	probably damaging	Het
Gjb3	G	A	4: 127,326,431 (GRCm38)	R103W	probably damaging	Het
Gm10030	C	T	9: 111,004,879 (GRCm38)		noncoding transcript	Het
Gm3443	T	A	19: 21,555,679 (GRCm38)	H2Q	unknown	Het
Gm5800	T	C	14: 51,716,092 (GRCm38)	E22G	possibly damaging	Het
Gsdma2	G	T	11: 98,649,079 (GRCm38)	R9L	probably damaging	Het
Gvin3	A	T	7: 106,603,776 (GRCm38)	V87D	possibly damaging	Het
Ica1l	A	G	1: 60,028,236 (GRCm38)		probably benign	Het
Ice1	G	A	13: 70,615,338 (GRCm38)	T167I	probably damaging	Het
Ifi204	T	A	1: 173,747,606 (GRCm38)	R618S	unknown	Het
Itga2	T	A	13: 114,856,727 (GRCm38)	K784M	probably damaging	Het
Itga2	C	A	13: 114,856,726 (GRCm38)	K784N	probably damaging	Het
Kif3b	A	G	2: 153,317,485 (GRCm38)	E402G	probably benign	Het
Lrp2	T	C	2: 69,466,880 (GRCm38)	I3246V	probably benign	Het
Lrrn3	G	T	12: 41,453,518 (GRCm38)	L267I	probably damaging	Het
Map1s	A	G	8: 70,916,411 (GRCm38)	Y868C	probably damaging	Het
Mcm5	A	G	8: 75,119,273 (GRCm38)	T370A	possibly damaging	Het
Nat8f7	T	C	6: 85,707,811 (GRCm38)	S16G	probably benign	Het
Nav3	T	C	10: 109,720,022 (GRCm38)	T1683A	probably damaging	Het
Nbeal2	T	C	9: 110,627,129 (GRCm38)	N2417S	probably damaging	Het
Neb	T	C	2: 52,236,895 (GRCm38)	N3605S	probably damaging	Het
Net1	A	T	13: 3,912,941 (GRCm38)		probably benign	Het
Nsd1	A	G	13: 55,313,351 (GRCm38)	T2464A	possibly damaging	Het
Nt5e	T	A	9: 88,370,187 (GRCm38)	I534N	probably damaging	Het
Nudt12	T	A	17: 59,011,076 (GRCm38)	H58L	probably damaging	Het
Ocrl	T	A	X: 47,962,116 (GRCm38)	I74N	probably damaging	Het
Or1a1	A	G	11: 74,195,653 (GRCm38)	H50R	probably benign	Het
Or2ag13	A	G	7: 106,874,141 (GRCm38)	Y35H	probably damaging	Het
Or5ae2	A	G	7: 84,856,482 (GRCm38)	T38A	probably damaging	Het
Or9k2b	A	G	10: 130,180,832 (GRCm38)	I16T	probably benign	Het
Pef1	C	A	4: 130,121,173 (GRCm38)	C10*	probably null	Het
Phf21b	A	G	15: 84,797,346 (GRCm38)	Y256H	probably damaging	Het
Phox2a	G	T	7: 101,820,945 (GRCm38)		probably null	Het
Pi16	A	G	17: 29,327,445 (GRCm38)	E399G	possibly damaging	Het
Pipox	A	T	11: 77,882,123 (GRCm38)	Y321N	probably damaging	Het
Plin4	A	G	17: 56,103,522 (GRCm38)	S1170P	probably damaging	Het
Pnma2	C	T	14: 66,917,213 (GRCm38)	S362L	possibly damaging	Het
Ppp1r9a	T	C	6: 5,113,710 (GRCm38)	I738T	probably damaging	Het
Prkcsh	A	T	9: 22,008,338 (GRCm38)	K188M	probably damaging	Het
Rcc1l	A	T	5: 134,163,659 (GRCm38)	Y309N	probably damaging	Het
Ripk1	A	G	13: 34,015,213 (GRCm38)	T123A	probably benign	Het
Robo4	A	G	9: 37,413,059 (GRCm38)	D961G	probably benign	Het
Rps27a	A	G	11: 29,546,299 (GRCm38)	Y105H	probably benign	Het
Scaper	A	G	9: 55,816,734 (GRCm38)	Y641H	possibly damaging	Het
Scn1a	C	A	2: 66,324,616 (GRCm38)	Q666H	probably benign	Het
Scn1a	T	A	2: 66,324,617 (GRCm38)	Q666L	probably benign	Het
Sdhaf4	T	C	1: 24,003,153 (GRCm38)		probably null	Het
Sec14l3	A	G	11: 4,066,510 (GRCm38)		probably benign	Het
Selp	C	A	1: 164,128,160 (GRCm38)		probably null	Het
Sim1	A	G	10: 50,909,828 (GRCm38)	D259G	probably damaging	Het
Sptan1	T	A	2: 29,992,001 (GRCm38)		probably benign	Het
Sptbn4	T	A	7: 27,366,646 (GRCm38)	E679V	probably null	Het
Sytl3	G	A	17: 6,728,327 (GRCm38)	E169K	probably benign	Het
Taar1	T	C	10: 23,921,189 (GRCm38)	C262R	probably benign	Het
Taf7l2	T	C	10: 116,112,665 (GRCm38)	R319G	probably benign	Het
Tbc1d32	A	G	10: 56,017,604 (GRCm38)	I1291T	probably benign	Het
Tet1	G	A	10: 62,813,665 (GRCm38)	P89S	probably damaging	Het
Tgfbrap1	C	A	1: 43,071,635 (GRCm38)	G7W	probably damaging	Het
Thada	A	G	17: 84,226,004 (GRCm38)	V1673A	possibly damaging	Het
Thbs4	A	G	13: 92,761,481 (GRCm38)	V610A	probably benign	Het
Tmem163	A	G	1: 127,677,509 (GRCm38)	S41P	probably benign	Het
Tmem65	A	T	15: 58,787,113 (GRCm38)	H200Q	probably damaging	Het
Trgc3	A	G	13: 19,263,365 (GRCm38)	T163A	possibly damaging	Het
Trim62	T	C	4: 128,909,225 (GRCm38)	V356A	possibly damaging	Het
Ttn	C	T	2: 76,763,260 (GRCm38)	V20679I	probably benign	Het
Ttn	T	C	2: 76,732,158 (GRCm38)	D28781G	probably damaging	Het
Tut7	A	T	13: 59,814,935 (GRCm38)	Y339*	probably null	Het
Unc80	A	T	1: 66,639,248 (GRCm38)	T2063S	possibly damaging	Het
Vav3	A	G	3: 109,506,426 (GRCm38)	T227A	probably benign	Het
Vmn2r118	A	T	17: 55,592,456 (GRCm38)	I816N	probably damaging	Het
Vmn2r26	T	A	6: 124,061,410 (GRCm38)	M648K	possibly damaging	Het
Vwa3a	A	G	7: 120,790,136 (GRCm38)	T66A	probably benign	Het
Xirp2	T	A	2: 67,511,140 (GRCm38)	Y1242N	probably damaging	Het
Ywhag	G	A	5: 135,911,530 (GRCm38)	T70M	probably damaging	Het
Zfp248	T	C	6: 118,428,970 (GRCm38)	T452A	probably damaging	Het
Zfp988	A	T	4: 147,332,887 (GRCm38)	I593F	probably damaging	Het

Other mutations in Vmn2r88

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Vmn2r88	APN	14	51,413,256 (GRCm38)	missense	probably benign	0.00
IGL00990:Vmn2r88	APN	14	51,413,060 (GRCm38)	missense	probably benign	0.00
IGL00990:Vmn2r88	APN	14	51,413,125 (GRCm38)	missense	probably benign	0.00
IGL00990:Vmn2r88	APN	14	51,416,802 (GRCm38)	missense	possibly damaging	0.59
IGL02308:Vmn2r88	APN	14	51,417,980 (GRCm38)	missense	possibly damaging	0.96
IGL02481:Vmn2r88	APN	14	51,414,154 (GRCm38)	missense	probably benign
IGL02483:Vmn2r88	APN	14	51,414,154 (GRCm38)	missense	probably benign
IGL03241:Vmn2r88	APN	14	51,418,373 (GRCm38)	missense	probably benign	0.03
R0052:Vmn2r88	UTSW	14	51,418,700 (GRCm38)	missense	possibly damaging	0.88
R0070:Vmn2r88	UTSW	14	51,414,140 (GRCm38)	missense	probably benign	0.08
R0799:Vmn2r88	UTSW	14	51,414,502 (GRCm38)	missense	possibly damaging	0.61
R0906:Vmn2r88	UTSW	14	51,418,209 (GRCm38)	missense	probably damaging	1.00
R1322:Vmn2r88	UTSW	14	51,414,108 (GRCm38)	missense	probably damaging	1.00
R1352:Vmn2r88	UTSW	14	51,418,550 (GRCm38)	missense	probably damaging	1.00
R1639:Vmn2r88	UTSW	14	51,416,787 (GRCm38)	missense	probably damaging	0.98
R1780:Vmn2r88	UTSW	14	51,418,572 (GRCm38)	missense	probably damaging	1.00
R1911:Vmn2r88	UTSW	14	51,418,214 (GRCm38)	missense	probably damaging	1.00
R2113:Vmn2r88	UTSW	14	51,418,194 (GRCm38)	missense	probably damaging	1.00
R2120:Vmn2r88	UTSW	14	51,413,208 (GRCm38)	missense	probably benign	0.00
R2126:Vmn2r88	UTSW	14	51,413,807 (GRCm38)	missense	probably benign	0.01
R2348:Vmn2r88	UTSW	14	51,414,004 (GRCm38)	missense	probably benign	0.00
R2881:Vmn2r88	UTSW	14	51,418,689 (GRCm38)	missense	probably damaging	0.97
R2884:Vmn2r88	UTSW	14	51,413,934 (GRCm38)	missense	probably damaging	1.00
R3081:Vmn2r88	UTSW	14	51,418,632 (GRCm38)	missense	probably damaging	0.99
R3933:Vmn2r88	UTSW	14	51,413,978 (GRCm38)	missense	probably benign	0.44
R3967:Vmn2r88	UTSW	14	51,413,190 (GRCm38)	missense	probably benign	0.06
R4091:Vmn2r88	UTSW	14	51,415,426 (GRCm38)	missense	probably damaging	1.00
R4378:Vmn2r88	UTSW	14	51,413,289 (GRCm38)	nonsense	probably null
R4397:Vmn2r88	UTSW	14	51,417,978 (GRCm38)	missense	probably damaging	1.00
R4418:Vmn2r88	UTSW	14	51,418,081 (GRCm38)	missense	probably damaging	1.00
R4609:Vmn2r88	UTSW	14	51,418,074 (GRCm38)	missense	probably damaging	0.98
R4647:Vmn2r88	UTSW	14	51,418,793 (GRCm38)	missense	probably benign	0.02
R4672:Vmn2r88	UTSW	14	51,418,155 (GRCm38)	missense	probably damaging	1.00
R4684:Vmn2r88	UTSW	14	51,413,334 (GRCm38)	missense	possibly damaging	0.95
R4686:Vmn2r88	UTSW	14	51,413,339 (GRCm38)	missense	probably benign	0.03
R4720:Vmn2r88	UTSW	14	51,413,245 (GRCm38)	missense	probably benign	0.01
R5046:Vmn2r88	UTSW	14	51,413,181 (GRCm38)	missense	probably benign	0.03
R5063:Vmn2r88	UTSW	14	51,411,146 (GRCm38)	missense	probably damaging	0.96
R5619:Vmn2r88	UTSW	14	51,413,910 (GRCm38)	missense	probably damaging	0.99
R5652:Vmn2r88	UTSW	14	51,418,572 (GRCm38)	missense	probably damaging	0.98
R6020:Vmn2r88	UTSW	14	51,418,149 (GRCm38)	nonsense	probably null
R6103:Vmn2r88	UTSW	14	51,415,369 (GRCm38)	missense	probably benign	0.17
R6674:Vmn2r88	UTSW	14	51,414,338 (GRCm38)	missense	probably benign	0.01
R6799:Vmn2r88	UTSW	14	51,413,969 (GRCm38)	missense	probably benign	0.05
R7089:Vmn2r88	UTSW	14	51,418,643 (GRCm38)	missense
R7104:Vmn2r88	UTSW	14	51,413,796 (GRCm38)	missense
R7265:Vmn2r88	UTSW	14	51,418,319 (GRCm38)	missense
R7316:Vmn2r88	UTSW	14	51,414,255 (GRCm38)	missense
R7552:Vmn2r88	UTSW	14	51,410,858 (GRCm38)	splice site	probably null
R7611:Vmn2r88	UTSW	14	51,413,997 (GRCm38)	missense
R7667:Vmn2r88	UTSW	14	51,417,989 (GRCm38)	missense
R7682:Vmn2r88	UTSW	14	51,418,449 (GRCm38)	missense
R7755:Vmn2r88	UTSW	14	51,413,046 (GRCm38)	missense	probably benign	0.00
R7811:Vmn2r88	UTSW	14	51,418,703 (GRCm38)	missense
R7882:Vmn2r88	UTSW	14	51,413,046 (GRCm38)	missense	probably benign	0.00
R7957:Vmn2r88	UTSW	14	51,413,132 (GRCm38)	missense
R7998:Vmn2r88	UTSW	14	51,414,108 (GRCm38)	missense
R8142:Vmn2r88	UTSW	14	51,414,107 (GRCm38)	missense
R8186:Vmn2r88	UTSW	14	51,418,700 (GRCm38)	missense
R8348:Vmn2r88	UTSW	14	51,418,796 (GRCm38)	missense	probably damaging	0.97
R8448:Vmn2r88	UTSW	14	51,418,796 (GRCm38)	missense	probably damaging	0.97
R8483:Vmn2r88	UTSW	14	51,413,073 (GRCm38)	missense	possibly damaging	0.48
R8783:Vmn2r88	UTSW	14	51,414,066 (GRCm38)	missense
R8859:Vmn2r88	UTSW	14	51,418,806 (GRCm38)	missense	probably damaging	0.97
R8916:Vmn2r88	UTSW	14	51,411,136 (GRCm38)	missense
R8936:Vmn2r88	UTSW	14	51,418,526 (GRCm38)	missense	possibly damaging	0.88
R9004:Vmn2r88	UTSW	14	51,413,167 (GRCm38)	missense
R9038:Vmn2r88	UTSW	14	51,414,033 (GRCm38)	missense
R9063:Vmn2r88	UTSW	14	51,410,872 (GRCm38)	start gained	probably benign
R9311:Vmn2r88	UTSW	14	51,413,046 (GRCm38)	missense	probably benign	0.00
R9382:Vmn2r88	UTSW	14	51,418,740 (GRCm38)	missense
R9483:Vmn2r88	UTSW	14	51,411,184 (GRCm38)	missense
R9602:Vmn2r88	UTSW	14	51,413,732 (GRCm38)	missense
V5622:Vmn2r88	UTSW	14	51,413,127 (GRCm38)	missense	probably benign
X0024:Vmn2r88	UTSW	14	51,413,832 (GRCm38)	missense	possibly damaging	0.79
X0025:Vmn2r88	UTSW	14	51,416,802 (GRCm38)	missense	possibly damaging	0.59
Z1177:Vmn2r88	UTSW	14	51,418,187 (GRCm38)	missense
Z1177:Vmn2r88	UTSW	14	51,418,046 (GRCm38)	frame shift	probably null
Z1190:Vmn2r88	UTSW	14	51,413,201 (GRCm38)	missense

Predicted Primers

PCR Primer
(F):5'- AGATCCCTGTGCTCAGACAAC -3'
(R):5'- GTCCTGTAAGACCTATGGCAC -3'

Sequencing Primer
(F):5'- TGTGCTCAGACAACACTTAAAGG -3'
(R):5'- TGGCACATGAATCATCTAAATAACAG -3'

Posted On

2014-06-23