Incidental Mutation 'R1835:Mrgpra3'
ID 205168
Institutional Source Beutler Lab
Gene Symbol Mrgpra3
Ensembl Gene ENSMUSG00000078698
Gene Name MAS-related GPR, member A3
Synonyms G protein-coupled receptor, MrgA3
MMRRC Submission 039862-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R1835 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 47588950-47601372 bp(-) (GRCm38)
Type of Mutation nonsense
DNA Base Change (assembly) G to T at 47589946 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 77 (Y77*)
Ref Sequence ENSEMBL: ENSMUSP00000135437 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000176369]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000176369
AA Change: Y77*
SMART Domains Protein: ENSMUSP00000135437
Gene: ENSMUSG00000078698
AA Change: Y77*

DomainStartEndE-ValueType
low complexity region 14 31 N/A INTRINSIC
Pfam:7TM_GPCR_Srx 48 234 6.3e-7 PFAM
Pfam:7tm_1 57 286 2.7e-9 PFAM
Coding Region Coverage
  • 1x: 97.4%
  • 3x: 96.8%
  • 10x: 94.9%
  • 20x: 91.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 97 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610507B11Rik G T 11: 78,287,750 (GRCm38) V1993F probably damaging Het
4933425L06Rik C A 13: 105,082,194 (GRCm38) A12E unknown Het
Acss2 T A 2: 155,558,630 (GRCm38) Y530N probably damaging Het
Adam4 T C 12: 81,419,559 (GRCm38) I763V probably benign Het
Aipl1 T G 11: 72,030,499 (GRCm38) K190T possibly damaging Het
Alms1 T A 6: 85,678,503 (GRCm38) S3344T possibly damaging Het
Alpi A G 1: 87,099,414 (GRCm38) V381A possibly damaging Het
Ankfn1 A T 11: 89,447,618 (GRCm38) S365R probably benign Het
Aox2 G A 1: 58,308,991 (GRCm38) A623T probably benign Het
Apc T A 18: 34,317,077 (GRCm38) L2308Q probably damaging Het
Atp9b C T 18: 80,778,883 (GRCm38) V501I probably benign Het
Baz2b T C 2: 59,901,819 (GRCm38) E1994G probably benign Het
Cacna1a T C 8: 84,581,357 (GRCm38) probably null Het
Cacna1h C A 17: 25,392,076 (GRCm38) V583L probably benign Het
Cd55 T C 1: 130,447,609 (GRCm38) probably benign Het
Cep192 T A 18: 67,804,424 (GRCm38) S75T possibly damaging Het
Cfap54 T A 10: 92,962,375 (GRCm38) D1674V probably benign Het
Churc1 T C 12: 76,773,297 (GRCm38) F27L possibly damaging Het
Coro1c A G 5: 113,848,543 (GRCm38) I280T probably benign Het
Creb1 C T 1: 64,550,950 (GRCm38) Q32* probably null Het
Cyp2b9 A G 7: 26,200,783 (GRCm38) T339A probably benign Het
Dctn3 T C 4: 41,720,813 (GRCm38) R51G probably damaging Het
Ddb1 T C 19: 10,626,593 (GRCm38) V888A probably damaging Het
Disp1 A G 1: 183,089,000 (GRCm38) Y619H probably damaging Het
Dnajc9 T C 14: 20,388,334 (GRCm38) D96G possibly damaging Het
Eepd1 A G 9: 25,482,868 (GRCm38) T143A possibly damaging Het
Eps8 T A 6: 137,522,279 (GRCm38) K204* probably null Het
Ercc5 T A 1: 44,180,875 (GRCm38) S1102R probably benign Het
Ergic2 T A 6: 148,189,581 (GRCm38) Y211F possibly damaging Het
Fam135b G T 15: 71,490,711 (GRCm38) L274M probably damaging Het
Fat3 G A 9: 15,998,088 (GRCm38) T2206I probably damaging Het
Fat4 A G 3: 38,983,571 (GRCm38) I3791V probably benign Het
Gemin4 A G 11: 76,213,296 (GRCm38) M213T possibly damaging Het
Gnai3 T C 3: 108,118,407 (GRCm38) M119V probably benign Het
Heatr5b A T 17: 78,773,563 (GRCm38) L1420Q probably damaging Het
Herc2 G T 7: 56,206,765 (GRCm38) G3918* probably null Het
Ints9 A G 14: 65,032,256 (GRCm38) Y465C probably damaging Het
Ist1 A G 8: 109,678,883 (GRCm38) V175A probably damaging Het
Kcnj12 T C 11: 61,069,557 (GRCm38) L227P possibly damaging Het
Kcnq5 T C 1: 21,466,387 (GRCm38) S416G probably benign Het
Kdm3a T A 6: 71,613,956 (GRCm38) T295S probably benign Het
Kif1c T A 11: 70,708,971 (GRCm38) M479K probably damaging Het
Kif20b T C 19: 34,956,038 (GRCm38) L83P probably damaging Het
Kndc1 A G 7: 139,927,711 (GRCm38) E1194G probably damaging Het
Llgl1 A G 11: 60,704,730 (GRCm38) M81V probably benign Het
Map4k5 C A 12: 69,824,662 (GRCm38) M495I probably damaging Het
Mest C T 6: 30,742,791 (GRCm38) R146C probably benign Het
Mettl24 T A 10: 40,737,816 (GRCm38) probably null Het
Mical1 T C 10: 41,483,535 (GRCm38) S586P probably benign Het
Mss51 A T 14: 20,483,178 (GRCm38) C408* probably null Het
Myh6 T C 14: 54,957,401 (GRCm38) T666A probably benign Het
Myo10 T C 15: 25,805,587 (GRCm38) C1685R possibly damaging Het
Naip5 A T 13: 100,223,218 (GRCm38) Y503* probably null Het
Neil1 A C 9: 57,146,604 (GRCm38) F144C probably damaging Het
Nipbl T A 15: 8,343,517 (GRCm38) I1082F possibly damaging Het
Nkiras1 T C 14: 18,276,732 (GRCm38) V7A probably damaging Het
Ntng2 G A 2: 29,197,057 (GRCm38) Q384* probably null Het
Ocrl T A X: 47,962,116 (GRCm38) I74N probably damaging Het
Olfr137 A T 17: 38,305,312 (GRCm38) S50T probably benign Het
Olfr1385 A T 11: 49,494,670 (GRCm38) I46F probably damaging Het
Olfr1408 A G 1: 173,130,815 (GRCm38) V134A probably benign Het
Olfr381 A C 11: 73,486,374 (GRCm38) V150G probably benign Het
Olfr535 A G 7: 140,492,709 (GRCm38) S24G probably benign Het
Olfr761 C T 17: 37,952,385 (GRCm38) G213E possibly damaging Het
Patj A G 4: 98,491,590 (GRCm38) D151G probably benign Het
Plpbp T C 8: 27,049,231 (GRCm38) V126A probably damaging Het
Pold2 A G 11: 5,873,454 (GRCm38) L325P possibly damaging Het
Ppp1r12c A C 7: 4,483,651 (GRCm38) S480A probably damaging Het
Pum1 T C 4: 130,701,048 (GRCm38) S124P possibly damaging Het
Pwp2 C G 10: 78,179,091 (GRCm38) G353A probably damaging Het
Reln C A 5: 21,979,002 (GRCm38) Q1666H probably damaging Het
Rnf19a T C 15: 36,265,925 (GRCm38) I9V probably benign Het
Ryr2 T C 13: 11,769,878 (GRCm38) H1063R probably benign Het
Samd14 C G 11: 95,023,600 (GRCm38) D361E probably damaging Het
Samd15 A T 12: 87,201,843 (GRCm38) N365I probably damaging Het
Sec16b A G 1: 157,531,312 (GRCm38) H105R probably benign Het
Sez6 T C 11: 77,953,503 (GRCm38) S51P probably benign Het
Sh3bp1 T A 15: 78,905,150 (GRCm38) L236Q probably damaging Het
Sspo C T 6: 48,457,340 (GRCm38) T991I probably damaging Het
Suco A T 1: 161,859,500 (GRCm38) L97* probably null Het
Tab1 C A 15: 80,148,296 (GRCm38) R35S probably benign Het
Tet3 C A 6: 83,404,163 (GRCm38) S341I possibly damaging Het
Tlr1 A T 5: 64,925,700 (GRCm38) D511E probably benign Het
Tmem132b A C 5: 125,785,899 (GRCm38) D656A probably damaging Het
Tmtc4 T A 14: 122,941,988 (GRCm38) probably null Het
Trmo T C 4: 46,380,158 (GRCm38) T404A probably damaging Het
Trpm1 A G 7: 64,230,268 (GRCm38) K790E probably damaging Het
Ulk4 C A 9: 121,168,184 (GRCm38) R774M probably null Het
Ush2a C T 1: 188,451,818 (GRCm38) L1440F probably benign Het
Usp16 A G 16: 87,480,907 (GRCm38) K682E probably damaging Het
Virma T C 4: 11,540,511 (GRCm38) S1471P probably benign Het
Vmn1r177 A T 7: 23,865,686 (GRCm38) I255N probably damaging Het
Vmn2r61 A T 7: 42,266,652 (GRCm38) R230* probably null Het
Vps13c T A 9: 67,993,013 (GRCm38) F3671L probably benign Het
Washc5 T C 15: 59,359,340 (GRCm38) N358S possibly damaging Het
Wdr72 A G 9: 74,151,617 (GRCm38) K331E probably damaging Het
Zfp986 A T 4: 145,899,235 (GRCm38) K155I probably benign Het
Other mutations in Mrgpra3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00162:Mrgpra3 APN 7 47,589,519 (GRCm38) missense probably benign 0.00
IGL02097:Mrgpra3 APN 7 47,589,456 (GRCm38) missense possibly damaging 0.94
IGL02101:Mrgpra3 APN 7 47,589,552 (GRCm38) missense probably damaging 0.99
IGL03071:Mrgpra3 APN 7 47,589,181 (GRCm38) utr 3 prime probably benign
PIT4445001:Mrgpra3 UTSW 7 47,590,160 (GRCm38) missense possibly damaging 0.88
R0828:Mrgpra3 UTSW 7 47,590,136 (GRCm38) missense probably benign 0.12
R1118:Mrgpra3 UTSW 7 47,589,291 (GRCm38) missense possibly damaging 0.83
R2258:Mrgpra3 UTSW 7 47,590,094 (GRCm38) missense probably benign 0.35
R2393:Mrgpra3 UTSW 7 47,589,617 (GRCm38) missense possibly damaging 0.92
R3437:Mrgpra3 UTSW 7 47,589,566 (GRCm38) missense probably damaging 1.00
R3973:Mrgpra3 UTSW 7 47,589,666 (GRCm38) missense probably benign 0.22
R4273:Mrgpra3 UTSW 7 47,589,432 (GRCm38) missense probably benign 0.01
R4495:Mrgpra3 UTSW 7 47,590,065 (GRCm38) missense probably benign 0.00
R4768:Mrgpra3 UTSW 7 47,589,728 (GRCm38) missense possibly damaging 0.94
R4822:Mrgpra3 UTSW 7 47,589,968 (GRCm38) missense possibly damaging 0.69
R4967:Mrgpra3 UTSW 7 47,589,519 (GRCm38) missense probably benign 0.33
R5207:Mrgpra3 UTSW 7 47,590,161 (GRCm38) missense probably benign 0.06
R5569:Mrgpra3 UTSW 7 47,590,011 (GRCm38) missense probably benign 0.00
R5763:Mrgpra3 UTSW 7 47,589,607 (GRCm38) nonsense probably null
R6102:Mrgpra3 UTSW 7 47,590,149 (GRCm38) missense possibly damaging 0.92
R6612:Mrgpra3 UTSW 7 47,590,035 (GRCm38) missense probably benign 0.00
R6718:Mrgpra3 UTSW 7 47,589,696 (GRCm38) missense probably benign 0.25
R6859:Mrgpra3 UTSW 7 47,590,033 (GRCm38) missense probably benign 0.04
R7029:Mrgpra3 UTSW 7 47,589,542 (GRCm38) missense probably benign 0.00
R7034:Mrgpra3 UTSW 7 47,590,090 (GRCm38) missense possibly damaging 0.49
R7036:Mrgpra3 UTSW 7 47,590,090 (GRCm38) missense possibly damaging 0.49
R7097:Mrgpra3 UTSW 7 47,589,641 (GRCm38) missense probably benign
R7475:Mrgpra3 UTSW 7 47,589,947 (GRCm38) missense probably damaging 1.00
R8289:Mrgpra3 UTSW 7 47,589,720 (GRCm38) missense possibly damaging 0.76
R8315:Mrgpra3 UTSW 7 47,601,303 (GRCm38) start codon destroyed probably null 0.93
R9500:Mrgpra3 UTSW 7 47,589,652 (GRCm38) nonsense probably null
Z1177:Mrgpra3 UTSW 7 47,601,301 (GRCm38) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AGTGATACCAGATGGGGCAC -3'
(R):5'- AACACCAGTGCAGGGTTTC -3'

Sequencing Primer
(F):5'- AGACAGGCAGCGCTCAGTG -3'
(R):5'- GGTTTCTGGCCCGAAACAC -3'
Posted On 2014-06-23