Incidental Mutation 'R1835:Myo10'
| ID |
205217 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myo10
|
| Ensembl Gene |
ENSMUSG00000022272 |
| Gene Name |
myosin X |
| Synonyms |
D15Ertd600e, myosin-X |
| MMRRC Submission |
039862-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1835 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
15 |
| Chromosomal Location |
25622525-25813673 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 25805587 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Arginine
at position 1685
(C1685R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000106087
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000022882]
[ENSMUST00000110457]
|
| AlphaFold |
F8VQB6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000022882
AA Change: C939R
PolyPhen 2
Score 0.264 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000022882
Gene: ENSMUSG00000022272
AA Change: C939R
| Domain | Start | End | E-Value | Type |
|---|
|
IQ
|
1 |
17 |
7.83e1 |
SMART |
|
IQ
|
18 |
40 |
1.06e0 |
SMART |
|
IQ
|
41 |
63 |
7.07e-2 |
SMART |
|
PDB:2LW9|B
|
136 |
171 |
7e-13 |
PDB |
|
low complexity region
|
172 |
186 |
N/A |
INTRINSIC |
|
low complexity region
|
213 |
235 |
N/A |
INTRINSIC |
|
low complexity region
|
344 |
356 |
N/A |
INTRINSIC |
|
low complexity region
|
401 |
419 |
N/A |
INTRINSIC |
|
PH
|
471 |
570 |
1.39e-21 |
SMART |
|
SCOP:d1faoa_
|
588 |
639 |
3e-6 |
SMART |
|
PH
|
651 |
757 |
6.76e-11 |
SMART |
|
MyTH4
|
805 |
953 |
4.12e-37 |
SMART |
|
B41
|
954 |
1216 |
1.72e-44 |
SMART |
|
Blast:B41
|
1218 |
1303 |
3e-45 |
BLAST |
|
low complexity region
|
1304 |
1316 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000110457
AA Change: C1685R
PolyPhen 2
Score 0.529 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000106087
Gene: ENSMUSG00000022272
AA Change: C1685R
| Domain | Start | End | E-Value | Type |
|---|
|
MYSc
|
57 |
740 |
N/A |
SMART |
|
IQ
|
741 |
763 |
1.27e-3 |
SMART |
|
IQ
|
764 |
786 |
1.06e0 |
SMART |
|
IQ
|
787 |
809 |
7.07e-2 |
SMART |
|
Pfam:MYO10_CC
|
881 |
932 |
4.2e-22 |
PFAM |
|
low complexity region
|
959 |
981 |
N/A |
INTRINSIC |
|
low complexity region
|
1090 |
1102 |
N/A |
INTRINSIC |
|
low complexity region
|
1147 |
1165 |
N/A |
INTRINSIC |
|
PH
|
1217 |
1316 |
1.39e-21 |
SMART |
|
PH
|
1397 |
1503 |
6.76e-11 |
SMART |
|
MyTH4
|
1551 |
1699 |
4.12e-37 |
SMART |
|
B41
|
1700 |
1962 |
1.72e-44 |
SMART |
|
low complexity region
|
2050 |
2062 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 94.9%
- 20x: 91.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011]
PHENOTYPE: Homozygous null mutations are semi-lethal with over half of homozygous embryos exhibiting exencephaly. Surviving mutants show decreased body weight, white spotting, syndactyly, persistence of hyaloid vascular system and other eye defects. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 97 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acss2 |
T |
A |
2: 155,558,630 (GRCm38) |
Y530N |
probably damaging |
Het |
| Adam4 |
T |
C |
12: 81,419,559 (GRCm38) |
I763V |
probably benign |
Het |
| Aipl1 |
T |
G |
11: 72,030,499 (GRCm38) |
K190T |
possibly damaging |
Het |
| Alms1 |
T |
A |
6: 85,678,503 (GRCm38) |
S3344T |
possibly damaging |
Het |
| Alpi |
A |
G |
1: 87,099,414 (GRCm38) |
V381A |
possibly damaging |
Het |
| Ankfn1 |
A |
T |
11: 89,447,618 (GRCm38) |
S365R |
probably benign |
Het |
| Aox2 |
G |
A |
1: 58,308,991 (GRCm38) |
A623T |
probably benign |
Het |
| Apc |
T |
A |
18: 34,317,077 (GRCm38) |
L2308Q |
probably damaging |
Het |
| Atp9b |
C |
T |
18: 80,778,883 (GRCm38) |
V501I |
probably benign |
Het |
| Baz2b |
T |
C |
2: 59,901,819 (GRCm38) |
E1994G |
probably benign |
Het |
| Bltp2 |
G |
T |
11: 78,287,750 (GRCm38) |
V1993F |
probably damaging |
Het |
| Cacna1a |
T |
C |
8: 84,581,357 (GRCm38) |
|
probably null |
Het |
| Cacna1h |
C |
A |
17: 25,392,076 (GRCm38) |
V583L |
probably benign |
Het |
| Cd55 |
T |
C |
1: 130,447,609 (GRCm38) |
|
probably benign |
Het |
| Cep192 |
T |
A |
18: 67,804,424 (GRCm38) |
S75T |
possibly damaging |
Het |
| Cfap54 |
T |
A |
10: 92,962,375 (GRCm38) |
D1674V |
probably benign |
Het |
| Churc1 |
T |
C |
12: 76,773,297 (GRCm38) |
F27L |
possibly damaging |
Het |
| Coro1c |
A |
G |
5: 113,848,543 (GRCm38) |
I280T |
probably benign |
Het |
| Creb1 |
C |
T |
1: 64,550,950 (GRCm38) |
Q32* |
probably null |
Het |
| Cyp2b9 |
A |
G |
7: 26,200,783 (GRCm38) |
T339A |
probably benign |
Het |
| Dctn3 |
T |
C |
4: 41,720,813 (GRCm38) |
R51G |
probably damaging |
Het |
| Ddb1 |
T |
C |
19: 10,626,593 (GRCm38) |
V888A |
probably damaging |
Het |
| Disp1 |
A |
G |
1: 183,089,000 (GRCm38) |
Y619H |
probably damaging |
Het |
| Dnajc9 |
T |
C |
14: 20,388,334 (GRCm38) |
D96G |
possibly damaging |
Het |
| Eepd1 |
A |
G |
9: 25,482,868 (GRCm38) |
T143A |
possibly damaging |
Het |
| Eps8 |
T |
A |
6: 137,522,279 (GRCm38) |
K204* |
probably null |
Het |
| Ercc5 |
T |
A |
1: 44,180,875 (GRCm38) |
S1102R |
probably benign |
Het |
| Ergic2 |
T |
A |
6: 148,189,581 (GRCm38) |
Y211F |
possibly damaging |
Het |
| Fam135b |
G |
T |
15: 71,490,711 (GRCm38) |
L274M |
probably damaging |
Het |
| Fat3 |
G |
A |
9: 15,998,088 (GRCm38) |
T2206I |
probably damaging |
Het |
| Fat4 |
A |
G |
3: 38,983,571 (GRCm38) |
I3791V |
probably benign |
Het |
| Gemin4 |
A |
G |
11: 76,213,296 (GRCm38) |
M213T |
possibly damaging |
Het |
| Gnai3 |
T |
C |
3: 108,118,407 (GRCm38) |
M119V |
probably benign |
Het |
| Heatr5b |
A |
T |
17: 78,773,563 (GRCm38) |
L1420Q |
probably damaging |
Het |
| Herc2 |
G |
T |
7: 56,206,765 (GRCm38) |
G3918* |
probably null |
Het |
| Ints9 |
A |
G |
14: 65,032,256 (GRCm38) |
Y465C |
probably damaging |
Het |
| Ist1 |
A |
G |
8: 109,678,883 (GRCm38) |
V175A |
probably damaging |
Het |
| Kcnj12 |
T |
C |
11: 61,069,557 (GRCm38) |
L227P |
possibly damaging |
Het |
| Kcnq5 |
T |
C |
1: 21,466,387 (GRCm38) |
S416G |
probably benign |
Het |
| Kdm3a |
T |
A |
6: 71,613,956 (GRCm38) |
T295S |
probably benign |
Het |
| Kif1c |
T |
A |
11: 70,708,971 (GRCm38) |
M479K |
probably damaging |
Het |
| Kif20b |
T |
C |
19: 34,956,038 (GRCm38) |
L83P |
probably damaging |
Het |
| Kndc1 |
A |
G |
7: 139,927,711 (GRCm38) |
E1194G |
probably damaging |
Het |
| Llgl1 |
A |
G |
11: 60,704,730 (GRCm38) |
M81V |
probably benign |
Het |
| Map4k5 |
C |
A |
12: 69,824,662 (GRCm38) |
M495I |
probably damaging |
Het |
| Mest |
C |
T |
6: 30,742,791 (GRCm38) |
R146C |
probably benign |
Het |
| Mettl24 |
T |
A |
10: 40,737,816 (GRCm38) |
|
probably null |
Het |
| Mical1 |
T |
C |
10: 41,483,535 (GRCm38) |
S586P |
probably benign |
Het |
| Mrgpra3 |
G |
T |
7: 47,589,946 (GRCm38) |
Y77* |
probably null |
Het |
| Mss51 |
A |
T |
14: 20,483,178 (GRCm38) |
C408* |
probably null |
Het |
| Myh6 |
T |
C |
14: 54,957,401 (GRCm38) |
T666A |
probably benign |
Het |
| Naip5 |
A |
T |
13: 100,223,218 (GRCm38) |
Y503* |
probably null |
Het |
| Neil1 |
A |
C |
9: 57,146,604 (GRCm38) |
F144C |
probably damaging |
Het |
| Nipbl |
T |
A |
15: 8,343,517 (GRCm38) |
I1082F |
possibly damaging |
Het |
| Nkiras1 |
T |
C |
14: 18,276,732 (GRCm38) |
V7A |
probably damaging |
Het |
| Nt5el |
C |
A |
13: 105,082,194 (GRCm38) |
A12E |
unknown |
Het |
| Ntng2 |
G |
A |
2: 29,197,057 (GRCm38) |
Q384* |
probably null |
Het |
| Ocrl |
T |
A |
X: 47,962,116 (GRCm38) |
I74N |
probably damaging |
Het |
| Or10j27 |
A |
G |
1: 173,130,815 (GRCm38) |
V134A |
probably benign |
Het |
| Or13a22 |
A |
G |
7: 140,492,709 (GRCm38) |
S24G |
probably benign |
Het |
| Or14j8 |
C |
T |
17: 37,952,385 (GRCm38) |
G213E |
possibly damaging |
Het |
| Or1e22 |
A |
C |
11: 73,486,374 (GRCm38) |
V150G |
probably benign |
Het |
| Or2j3 |
A |
T |
17: 38,305,312 (GRCm38) |
S50T |
probably benign |
Het |
| Or2y1 |
A |
T |
11: 49,494,670 (GRCm38) |
I46F |
probably damaging |
Het |
| Patj |
A |
G |
4: 98,491,590 (GRCm38) |
D151G |
probably benign |
Het |
| Plpbp |
T |
C |
8: 27,049,231 (GRCm38) |
V126A |
probably damaging |
Het |
| Pold2 |
A |
G |
11: 5,873,454 (GRCm38) |
L325P |
possibly damaging |
Het |
| Ppp1r12c |
A |
C |
7: 4,483,651 (GRCm38) |
S480A |
probably damaging |
Het |
| Pum1 |
T |
C |
4: 130,701,048 (GRCm38) |
S124P |
possibly damaging |
Het |
| Pwp2 |
C |
G |
10: 78,179,091 (GRCm38) |
G353A |
probably damaging |
Het |
| Reln |
C |
A |
5: 21,979,002 (GRCm38) |
Q1666H |
probably damaging |
Het |
| Rnf19a |
T |
C |
15: 36,265,925 (GRCm38) |
I9V |
probably benign |
Het |
| Ryr2 |
T |
C |
13: 11,769,878 (GRCm38) |
H1063R |
probably benign |
Het |
| Samd14 |
C |
G |
11: 95,023,600 (GRCm38) |
D361E |
probably damaging |
Het |
| Samd15 |
A |
T |
12: 87,201,843 (GRCm38) |
N365I |
probably damaging |
Het |
| Sec16b |
A |
G |
1: 157,531,312 (GRCm38) |
H105R |
probably benign |
Het |
| Sez6 |
T |
C |
11: 77,953,503 (GRCm38) |
S51P |
probably benign |
Het |
| Sh3bp1 |
T |
A |
15: 78,905,150 (GRCm38) |
L236Q |
probably damaging |
Het |
| Sspo |
C |
T |
6: 48,457,340 (GRCm38) |
T991I |
probably damaging |
Het |
| Suco |
A |
T |
1: 161,859,500 (GRCm38) |
L97* |
probably null |
Het |
| Tab1 |
C |
A |
15: 80,148,296 (GRCm38) |
R35S |
probably benign |
Het |
| Tet3 |
C |
A |
6: 83,404,163 (GRCm38) |
S341I |
possibly damaging |
Het |
| Tlr1 |
A |
T |
5: 64,925,700 (GRCm38) |
D511E |
probably benign |
Het |
| Tmem132b |
A |
C |
5: 125,785,899 (GRCm38) |
D656A |
probably damaging |
Het |
| Tmtc4 |
T |
A |
14: 122,941,988 (GRCm38) |
|
probably null |
Het |
| Trmo |
T |
C |
4: 46,380,158 (GRCm38) |
T404A |
probably damaging |
Het |
| Trpm1 |
A |
G |
7: 64,230,268 (GRCm38) |
K790E |
probably damaging |
Het |
| Ulk4 |
C |
A |
9: 121,168,184 (GRCm38) |
R774M |
probably null |
Het |
| Ush2a |
C |
T |
1: 188,451,818 (GRCm38) |
L1440F |
probably benign |
Het |
| Usp16 |
A |
G |
16: 87,480,907 (GRCm38) |
K682E |
probably damaging |
Het |
| Virma |
T |
C |
4: 11,540,511 (GRCm38) |
S1471P |
probably benign |
Het |
| Vmn1r177 |
A |
T |
7: 23,865,686 (GRCm38) |
I255N |
probably damaging |
Het |
| Vmn2r61 |
A |
T |
7: 42,266,652 (GRCm38) |
R230* |
probably null |
Het |
| Vps13c |
T |
A |
9: 67,993,013 (GRCm38) |
F3671L |
probably benign |
Het |
| Washc5 |
T |
C |
15: 59,359,340 (GRCm38) |
N358S |
possibly damaging |
Het |
| Wdr72 |
A |
G |
9: 74,151,617 (GRCm38) |
K331E |
probably damaging |
Het |
| Zfp986 |
A |
T |
4: 145,899,235 (GRCm38) |
K155I |
probably benign |
Het |
|
| Other mutations in Myo10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00557:Myo10
|
APN |
15 |
25,776,380 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01068:Myo10
|
APN |
15 |
25,739,309 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
IGL01352:Myo10
|
APN |
15 |
25,701,697 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01388:Myo10
|
APN |
15 |
25,736,617 (GRCm38) |
missense |
possibly damaging |
0.55 |
|
IGL01460:Myo10
|
APN |
15 |
25,714,108 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01553:Myo10
|
APN |
15 |
25,776,329 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01732:Myo10
|
APN |
15 |
25,732,063 (GRCm38) |
missense |
probably benign |
0.10 |
|
IGL01992:Myo10
|
APN |
15 |
25,799,548 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
IGL02000:Myo10
|
APN |
15 |
25,808,066 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02045:Myo10
|
APN |
15 |
25,726,488 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL02307:Myo10
|
APN |
15 |
25,776,315 (GRCm38) |
splice site |
probably benign |
|
|
IGL02511:Myo10
|
APN |
15 |
25,723,889 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL03240:Myo10
|
APN |
15 |
25,701,602 (GRCm38) |
missense |
probably damaging |
1.00 |
|
least
|
UTSW |
15 |
25,726,475 (GRCm38) |
nonsense |
probably null |
|
|
R0037:Myo10
|
UTSW |
15 |
25,666,532 (GRCm38) |
intron |
probably benign |
|
|
R0153:Myo10
|
UTSW |
15 |
25,781,238 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R0282:Myo10
|
UTSW |
15 |
25,793,167 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0360:Myo10
|
UTSW |
15 |
25,804,368 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0585:Myo10
|
UTSW |
15 |
25,736,455 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0617:Myo10
|
UTSW |
15 |
25,738,005 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0729:Myo10
|
UTSW |
15 |
25,722,157 (GRCm38) |
splice site |
probably benign |
|
|
R0771:Myo10
|
UTSW |
15 |
25,778,178 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0960:Myo10
|
UTSW |
15 |
25,801,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1562:Myo10
|
UTSW |
15 |
25,780,411 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R1651:Myo10
|
UTSW |
15 |
25,742,369 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1789:Myo10
|
UTSW |
15 |
25,726,525 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1816:Myo10
|
UTSW |
15 |
25,800,200 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1908:Myo10
|
UTSW |
15 |
25,801,222 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2082:Myo10
|
UTSW |
15 |
25,785,993 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2101:Myo10
|
UTSW |
15 |
25,722,259 (GRCm38) |
missense |
probably benign |
0.26 |
|
R2129:Myo10
|
UTSW |
15 |
25,781,799 (GRCm38) |
missense |
probably benign |
0.09 |
|
R2141:Myo10
|
UTSW |
15 |
25,714,108 (GRCm38) |
missense |
probably benign |
|
|
R2142:Myo10
|
UTSW |
15 |
25,714,108 (GRCm38) |
missense |
probably benign |
|
|
R2920:Myo10
|
UTSW |
15 |
25,801,140 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2938:Myo10
|
UTSW |
15 |
25,795,717 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R3723:Myo10
|
UTSW |
15 |
25,803,288 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3852:Myo10
|
UTSW |
15 |
25,779,626 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4162:Myo10
|
UTSW |
15 |
25,726,415 (GRCm38) |
splice site |
probably null |
|
|
R4163:Myo10
|
UTSW |
15 |
25,726,415 (GRCm38) |
splice site |
probably null |
|
|
R4164:Myo10
|
UTSW |
15 |
25,726,415 (GRCm38) |
splice site |
probably null |
|
|
R4177:Myo10
|
UTSW |
15 |
25,734,051 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R4409:Myo10
|
UTSW |
15 |
25,807,869 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4667:Myo10
|
UTSW |
15 |
25,793,153 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R4905:Myo10
|
UTSW |
15 |
25,800,212 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4933:Myo10
|
UTSW |
15 |
25,781,118 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R4968:Myo10
|
UTSW |
15 |
25,808,184 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5081:Myo10
|
UTSW |
15 |
25,785,940 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5123:Myo10
|
UTSW |
15 |
25,726,483 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R5310:Myo10
|
UTSW |
15 |
25,778,078 (GRCm38) |
splice site |
probably null |
|
|
R6073:Myo10
|
UTSW |
15 |
25,736,642 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6117:Myo10
|
UTSW |
15 |
25,805,659 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6185:Myo10
|
UTSW |
15 |
25,726,510 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6749:Myo10
|
UTSW |
15 |
25,714,110 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6819:Myo10
|
UTSW |
15 |
25,781,410 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
R6875:Myo10
|
UTSW |
15 |
25,805,659 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6908:Myo10
|
UTSW |
15 |
25,804,383 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6963:Myo10
|
UTSW |
15 |
25,734,063 (GRCm38) |
missense |
probably benign |
0.31 |
|
R7144:Myo10
|
UTSW |
15 |
25,723,925 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7266:Myo10
|
UTSW |
15 |
25,782,981 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7380:Myo10
|
UTSW |
15 |
25,779,620 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7460:Myo10
|
UTSW |
15 |
25,807,827 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7614:Myo10
|
UTSW |
15 |
25,701,623 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7618:Myo10
|
UTSW |
15 |
25,726,475 (GRCm38) |
nonsense |
probably null |
|
|
R7717:Myo10
|
UTSW |
15 |
25,731,970 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7811:Myo10
|
UTSW |
15 |
25,804,524 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7830:Myo10
|
UTSW |
15 |
25,737,971 (GRCm38) |
nonsense |
probably null |
|
|
R7862:Myo10
|
UTSW |
15 |
25,666,436 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8232:Myo10
|
UTSW |
15 |
25,804,314 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R8264:Myo10
|
UTSW |
15 |
25,800,109 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8377:Myo10
|
UTSW |
15 |
25,804,395 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R8385:Myo10
|
UTSW |
15 |
25,804,398 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8426:Myo10
|
UTSW |
15 |
25,799,490 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8439:Myo10
|
UTSW |
15 |
25,725,072 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8696:Myo10
|
UTSW |
15 |
25,799,486 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8775:Myo10
|
UTSW |
15 |
25,800,059 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R8775-TAIL:Myo10
|
UTSW |
15 |
25,800,059 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R8970:Myo10
|
UTSW |
15 |
25,803,381 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R9024:Myo10
|
UTSW |
15 |
25,793,209 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R9196:Myo10
|
UTSW |
15 |
25,805,630 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R9224:Myo10
|
UTSW |
15 |
25,807,995 (GRCm38) |
missense |
probably benign |
0.33 |
|
R9308:Myo10
|
UTSW |
15 |
25,781,776 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9358:Myo10
|
UTSW |
15 |
25,781,434 (GRCm38) |
missense |
possibly damaging |
0.69 |
|
R9606:Myo10
|
UTSW |
15 |
25,776,315 (GRCm38) |
frame shift |
probably null |
|
|
R9722:Myo10
|
UTSW |
15 |
25,801,141 (GRCm38) |
missense |
probably damaging |
1.00 |
|
RF013:Myo10
|
UTSW |
15 |
25,799,479 (GRCm38) |
missense |
probably damaging |
0.99 |
|
Z1177:Myo10
|
UTSW |
15 |
25,799,554 (GRCm38) |
critical splice donor site |
probably null |
|
|
Z1177:Myo10
|
UTSW |
15 |
25,781,401 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCACTCCTGTCACCACAAGG -3'
(R):5'- ACATTCAGGTACCACAGGC -3'
Sequencing Primer
(F):5'- TCACCACAAGGGGGCAG -3'
(R):5'- CATTCAGGTACCACAGGCGTATG -3'
|
| Posted On |
2014-06-23 |
Incidental Mutation