Incidental Mutation 'R1835:Myo10'
ID 205217
Institutional Source Beutler Lab
Gene Symbol Myo10
Ensembl Gene ENSMUSG00000022272
Gene Name myosin X
Synonyms D15Ertd600e, myosin-X
MMRRC Submission 039862-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1835 (G1)
Quality Score 225
Status Not validated
Chromosome 15
Chromosomal Location 25622525-25813673 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 25805587 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Cysteine to Arginine at position 1685 (C1685R)
Ref Sequence ENSEMBL: ENSMUSP00000106087 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022882] [ENSMUST00000110457]
AlphaFold F8VQB6
Predicted Effect probably benign
Transcript: ENSMUST00000022882
AA Change: C939R

PolyPhen 2 Score 0.264 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000022882
Gene: ENSMUSG00000022272
AA Change: C939R

DomainStartEndE-ValueType
IQ 1 17 7.83e1 SMART
IQ 18 40 1.06e0 SMART
IQ 41 63 7.07e-2 SMART
PDB:2LW9|B 136 171 7e-13 PDB
low complexity region 172 186 N/A INTRINSIC
low complexity region 213 235 N/A INTRINSIC
low complexity region 344 356 N/A INTRINSIC
low complexity region 401 419 N/A INTRINSIC
PH 471 570 1.39e-21 SMART
SCOP:d1faoa_ 588 639 3e-6 SMART
PH 651 757 6.76e-11 SMART
MyTH4 805 953 4.12e-37 SMART
B41 954 1216 1.72e-44 SMART
Blast:B41 1218 1303 3e-45 BLAST
low complexity region 1304 1316 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000110457
AA Change: C1685R

PolyPhen 2 Score 0.529 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000106087
Gene: ENSMUSG00000022272
AA Change: C1685R

DomainStartEndE-ValueType
MYSc 57 740 N/A SMART
IQ 741 763 1.27e-3 SMART
IQ 764 786 1.06e0 SMART
IQ 787 809 7.07e-2 SMART
Pfam:MYO10_CC 881 932 4.2e-22 PFAM
low complexity region 959 981 N/A INTRINSIC
low complexity region 1090 1102 N/A INTRINSIC
low complexity region 1147 1165 N/A INTRINSIC
PH 1217 1316 1.39e-21 SMART
PH 1397 1503 6.76e-11 SMART
MyTH4 1551 1699 4.12e-37 SMART
B41 1700 1962 1.72e-44 SMART
low complexity region 2050 2062 N/A INTRINSIC
Coding Region Coverage
  • 1x: 97.4%
  • 3x: 96.8%
  • 10x: 94.9%
  • 20x: 91.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011]
PHENOTYPE: Homozygous null mutations are semi-lethal with over half of homozygous embryos exhibiting exencephaly. Surviving mutants show decreased body weight, white spotting, syndactyly, persistence of hyaloid vascular system and other eye defects. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 97 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acss2 T A 2: 155,558,630 (GRCm38) Y530N probably damaging Het
Adam4 T C 12: 81,419,559 (GRCm38) I763V probably benign Het
Aipl1 T G 11: 72,030,499 (GRCm38) K190T possibly damaging Het
Alms1 T A 6: 85,678,503 (GRCm38) S3344T possibly damaging Het
Alpi A G 1: 87,099,414 (GRCm38) V381A possibly damaging Het
Ankfn1 A T 11: 89,447,618 (GRCm38) S365R probably benign Het
Aox2 G A 1: 58,308,991 (GRCm38) A623T probably benign Het
Apc T A 18: 34,317,077 (GRCm38) L2308Q probably damaging Het
Atp9b C T 18: 80,778,883 (GRCm38) V501I probably benign Het
Baz2b T C 2: 59,901,819 (GRCm38) E1994G probably benign Het
Bltp2 G T 11: 78,287,750 (GRCm38) V1993F probably damaging Het
Cacna1a T C 8: 84,581,357 (GRCm38) probably null Het
Cacna1h C A 17: 25,392,076 (GRCm38) V583L probably benign Het
Cd55 T C 1: 130,447,609 (GRCm38) probably benign Het
Cep192 T A 18: 67,804,424 (GRCm38) S75T possibly damaging Het
Cfap54 T A 10: 92,962,375 (GRCm38) D1674V probably benign Het
Churc1 T C 12: 76,773,297 (GRCm38) F27L possibly damaging Het
Coro1c A G 5: 113,848,543 (GRCm38) I280T probably benign Het
Creb1 C T 1: 64,550,950 (GRCm38) Q32* probably null Het
Cyp2b9 A G 7: 26,200,783 (GRCm38) T339A probably benign Het
Dctn3 T C 4: 41,720,813 (GRCm38) R51G probably damaging Het
Ddb1 T C 19: 10,626,593 (GRCm38) V888A probably damaging Het
Disp1 A G 1: 183,089,000 (GRCm38) Y619H probably damaging Het
Dnajc9 T C 14: 20,388,334 (GRCm38) D96G possibly damaging Het
Eepd1 A G 9: 25,482,868 (GRCm38) T143A possibly damaging Het
Eps8 T A 6: 137,522,279 (GRCm38) K204* probably null Het
Ercc5 T A 1: 44,180,875 (GRCm38) S1102R probably benign Het
Ergic2 T A 6: 148,189,581 (GRCm38) Y211F possibly damaging Het
Fam135b G T 15: 71,490,711 (GRCm38) L274M probably damaging Het
Fat3 G A 9: 15,998,088 (GRCm38) T2206I probably damaging Het
Fat4 A G 3: 38,983,571 (GRCm38) I3791V probably benign Het
Gemin4 A G 11: 76,213,296 (GRCm38) M213T possibly damaging Het
Gnai3 T C 3: 108,118,407 (GRCm38) M119V probably benign Het
Heatr5b A T 17: 78,773,563 (GRCm38) L1420Q probably damaging Het
Herc2 G T 7: 56,206,765 (GRCm38) G3918* probably null Het
Ints9 A G 14: 65,032,256 (GRCm38) Y465C probably damaging Het
Ist1 A G 8: 109,678,883 (GRCm38) V175A probably damaging Het
Kcnj12 T C 11: 61,069,557 (GRCm38) L227P possibly damaging Het
Kcnq5 T C 1: 21,466,387 (GRCm38) S416G probably benign Het
Kdm3a T A 6: 71,613,956 (GRCm38) T295S probably benign Het
Kif1c T A 11: 70,708,971 (GRCm38) M479K probably damaging Het
Kif20b T C 19: 34,956,038 (GRCm38) L83P probably damaging Het
Kndc1 A G 7: 139,927,711 (GRCm38) E1194G probably damaging Het
Llgl1 A G 11: 60,704,730 (GRCm38) M81V probably benign Het
Map4k5 C A 12: 69,824,662 (GRCm38) M495I probably damaging Het
Mest C T 6: 30,742,791 (GRCm38) R146C probably benign Het
Mettl24 T A 10: 40,737,816 (GRCm38) probably null Het
Mical1 T C 10: 41,483,535 (GRCm38) S586P probably benign Het
Mrgpra3 G T 7: 47,589,946 (GRCm38) Y77* probably null Het
Mss51 A T 14: 20,483,178 (GRCm38) C408* probably null Het
Myh6 T C 14: 54,957,401 (GRCm38) T666A probably benign Het
Naip5 A T 13: 100,223,218 (GRCm38) Y503* probably null Het
Neil1 A C 9: 57,146,604 (GRCm38) F144C probably damaging Het
Nipbl T A 15: 8,343,517 (GRCm38) I1082F possibly damaging Het
Nkiras1 T C 14: 18,276,732 (GRCm38) V7A probably damaging Het
Nt5el C A 13: 105,082,194 (GRCm38) A12E unknown Het
Ntng2 G A 2: 29,197,057 (GRCm38) Q384* probably null Het
Ocrl T A X: 47,962,116 (GRCm38) I74N probably damaging Het
Or10j27 A G 1: 173,130,815 (GRCm38) V134A probably benign Het
Or13a22 A G 7: 140,492,709 (GRCm38) S24G probably benign Het
Or14j8 C T 17: 37,952,385 (GRCm38) G213E possibly damaging Het
Or1e22 A C 11: 73,486,374 (GRCm38) V150G probably benign Het
Or2j3 A T 17: 38,305,312 (GRCm38) S50T probably benign Het
Or2y1 A T 11: 49,494,670 (GRCm38) I46F probably damaging Het
Patj A G 4: 98,491,590 (GRCm38) D151G probably benign Het
Plpbp T C 8: 27,049,231 (GRCm38) V126A probably damaging Het
Pold2 A G 11: 5,873,454 (GRCm38) L325P possibly damaging Het
Ppp1r12c A C 7: 4,483,651 (GRCm38) S480A probably damaging Het
Pum1 T C 4: 130,701,048 (GRCm38) S124P possibly damaging Het
Pwp2 C G 10: 78,179,091 (GRCm38) G353A probably damaging Het
Reln C A 5: 21,979,002 (GRCm38) Q1666H probably damaging Het
Rnf19a T C 15: 36,265,925 (GRCm38) I9V probably benign Het
Ryr2 T C 13: 11,769,878 (GRCm38) H1063R probably benign Het
Samd14 C G 11: 95,023,600 (GRCm38) D361E probably damaging Het
Samd15 A T 12: 87,201,843 (GRCm38) N365I probably damaging Het
Sec16b A G 1: 157,531,312 (GRCm38) H105R probably benign Het
Sez6 T C 11: 77,953,503 (GRCm38) S51P probably benign Het
Sh3bp1 T A 15: 78,905,150 (GRCm38) L236Q probably damaging Het
Sspo C T 6: 48,457,340 (GRCm38) T991I probably damaging Het
Suco A T 1: 161,859,500 (GRCm38) L97* probably null Het
Tab1 C A 15: 80,148,296 (GRCm38) R35S probably benign Het
Tet3 C A 6: 83,404,163 (GRCm38) S341I possibly damaging Het
Tlr1 A T 5: 64,925,700 (GRCm38) D511E probably benign Het
Tmem132b A C 5: 125,785,899 (GRCm38) D656A probably damaging Het
Tmtc4 T A 14: 122,941,988 (GRCm38) probably null Het
Trmo T C 4: 46,380,158 (GRCm38) T404A probably damaging Het
Trpm1 A G 7: 64,230,268 (GRCm38) K790E probably damaging Het
Ulk4 C A 9: 121,168,184 (GRCm38) R774M probably null Het
Ush2a C T 1: 188,451,818 (GRCm38) L1440F probably benign Het
Usp16 A G 16: 87,480,907 (GRCm38) K682E probably damaging Het
Virma T C 4: 11,540,511 (GRCm38) S1471P probably benign Het
Vmn1r177 A T 7: 23,865,686 (GRCm38) I255N probably damaging Het
Vmn2r61 A T 7: 42,266,652 (GRCm38) R230* probably null Het
Vps13c T A 9: 67,993,013 (GRCm38) F3671L probably benign Het
Washc5 T C 15: 59,359,340 (GRCm38) N358S possibly damaging Het
Wdr72 A G 9: 74,151,617 (GRCm38) K331E probably damaging Het
Zfp986 A T 4: 145,899,235 (GRCm38) K155I probably benign Het
Other mutations in Myo10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00557:Myo10 APN 15 25,776,380 (GRCm38) missense probably damaging 1.00
IGL01068:Myo10 APN 15 25,739,309 (GRCm38) missense possibly damaging 0.93
IGL01352:Myo10 APN 15 25,701,697 (GRCm38) missense probably damaging 1.00
IGL01388:Myo10 APN 15 25,736,617 (GRCm38) missense possibly damaging 0.55
IGL01460:Myo10 APN 15 25,714,108 (GRCm38) missense probably benign 0.00
IGL01553:Myo10 APN 15 25,776,329 (GRCm38) missense probably damaging 1.00
IGL01732:Myo10 APN 15 25,732,063 (GRCm38) missense probably benign 0.10
IGL01992:Myo10 APN 15 25,799,548 (GRCm38) missense possibly damaging 0.92
IGL02000:Myo10 APN 15 25,808,066 (GRCm38) missense probably damaging 1.00
IGL02045:Myo10 APN 15 25,726,488 (GRCm38) missense probably benign 0.03
IGL02307:Myo10 APN 15 25,776,315 (GRCm38) splice site probably benign
IGL02511:Myo10 APN 15 25,723,889 (GRCm38) missense probably damaging 0.97
IGL03240:Myo10 APN 15 25,701,602 (GRCm38) missense probably damaging 1.00
least UTSW 15 25,726,475 (GRCm38) nonsense probably null
R0037:Myo10 UTSW 15 25,666,532 (GRCm38) intron probably benign
R0153:Myo10 UTSW 15 25,781,238 (GRCm38) missense possibly damaging 0.84
R0282:Myo10 UTSW 15 25,793,167 (GRCm38) missense probably damaging 1.00
R0360:Myo10 UTSW 15 25,804,368 (GRCm38) missense probably damaging 1.00
R0585:Myo10 UTSW 15 25,736,455 (GRCm38) missense probably damaging 1.00
R0617:Myo10 UTSW 15 25,738,005 (GRCm38) missense probably damaging 1.00
R0729:Myo10 UTSW 15 25,722,157 (GRCm38) splice site probably benign
R0771:Myo10 UTSW 15 25,778,178 (GRCm38) missense probably damaging 1.00
R0960:Myo10 UTSW 15 25,801,189 (GRCm38) missense probably damaging 1.00
R1562:Myo10 UTSW 15 25,780,411 (GRCm38) missense possibly damaging 0.81
R1651:Myo10 UTSW 15 25,742,369 (GRCm38) missense probably damaging 1.00
R1789:Myo10 UTSW 15 25,726,525 (GRCm38) critical splice donor site probably null
R1816:Myo10 UTSW 15 25,800,200 (GRCm38) missense probably damaging 1.00
R1908:Myo10 UTSW 15 25,801,222 (GRCm38) missense probably damaging 1.00
R2082:Myo10 UTSW 15 25,785,993 (GRCm38) missense probably damaging 1.00
R2101:Myo10 UTSW 15 25,722,259 (GRCm38) missense probably benign 0.26
R2129:Myo10 UTSW 15 25,781,799 (GRCm38) missense probably benign 0.09
R2141:Myo10 UTSW 15 25,714,108 (GRCm38) missense probably benign
R2142:Myo10 UTSW 15 25,714,108 (GRCm38) missense probably benign
R2920:Myo10 UTSW 15 25,801,140 (GRCm38) missense probably damaging 1.00
R2938:Myo10 UTSW 15 25,795,717 (GRCm38) missense probably damaging 0.99
R3723:Myo10 UTSW 15 25,803,288 (GRCm38) missense probably damaging 1.00
R3852:Myo10 UTSW 15 25,779,626 (GRCm38) missense probably damaging 1.00
R4162:Myo10 UTSW 15 25,726,415 (GRCm38) splice site probably null
R4163:Myo10 UTSW 15 25,726,415 (GRCm38) splice site probably null
R4164:Myo10 UTSW 15 25,726,415 (GRCm38) splice site probably null
R4177:Myo10 UTSW 15 25,734,051 (GRCm38) missense possibly damaging 0.81
R4409:Myo10 UTSW 15 25,807,869 (GRCm38) missense probably damaging 1.00
R4667:Myo10 UTSW 15 25,793,153 (GRCm38) missense possibly damaging 0.91
R4905:Myo10 UTSW 15 25,800,212 (GRCm38) missense probably damaging 0.99
R4933:Myo10 UTSW 15 25,781,118 (GRCm38) missense probably damaging 0.96
R4968:Myo10 UTSW 15 25,808,184 (GRCm38) missense probably damaging 1.00
R5081:Myo10 UTSW 15 25,785,940 (GRCm38) missense probably damaging 1.00
R5123:Myo10 UTSW 15 25,726,483 (GRCm38) missense possibly damaging 0.94
R5310:Myo10 UTSW 15 25,778,078 (GRCm38) splice site probably null
R6073:Myo10 UTSW 15 25,736,642 (GRCm38) missense probably damaging 1.00
R6117:Myo10 UTSW 15 25,805,659 (GRCm38) missense probably benign 0.00
R6185:Myo10 UTSW 15 25,726,510 (GRCm38) missense probably damaging 0.99
R6749:Myo10 UTSW 15 25,714,110 (GRCm38) missense probably damaging 1.00
R6819:Myo10 UTSW 15 25,781,410 (GRCm38) missense possibly damaging 0.80
R6875:Myo10 UTSW 15 25,805,659 (GRCm38) missense probably benign 0.00
R6908:Myo10 UTSW 15 25,804,383 (GRCm38) missense probably damaging 1.00
R6963:Myo10 UTSW 15 25,734,063 (GRCm38) missense probably benign 0.31
R7144:Myo10 UTSW 15 25,723,925 (GRCm38) missense probably damaging 1.00
R7266:Myo10 UTSW 15 25,782,981 (GRCm38) missense probably damaging 1.00
R7380:Myo10 UTSW 15 25,779,620 (GRCm38) missense probably benign 0.01
R7460:Myo10 UTSW 15 25,807,827 (GRCm38) missense probably damaging 1.00
R7614:Myo10 UTSW 15 25,701,623 (GRCm38) missense probably benign 0.00
R7618:Myo10 UTSW 15 25,726,475 (GRCm38) nonsense probably null
R7717:Myo10 UTSW 15 25,731,970 (GRCm38) missense probably benign 0.01
R7811:Myo10 UTSW 15 25,804,524 (GRCm38) missense probably damaging 1.00
R7830:Myo10 UTSW 15 25,737,971 (GRCm38) nonsense probably null
R7862:Myo10 UTSW 15 25,666,436 (GRCm38) missense probably damaging 1.00
R8232:Myo10 UTSW 15 25,804,314 (GRCm38) missense possibly damaging 0.89
R8264:Myo10 UTSW 15 25,800,109 (GRCm38) missense probably damaging 0.99
R8377:Myo10 UTSW 15 25,804,395 (GRCm38) missense possibly damaging 0.94
R8385:Myo10 UTSW 15 25,804,398 (GRCm38) missense probably damaging 1.00
R8426:Myo10 UTSW 15 25,799,490 (GRCm38) missense probably damaging 0.99
R8439:Myo10 UTSW 15 25,725,072 (GRCm38) missense probably benign 0.00
R8696:Myo10 UTSW 15 25,799,486 (GRCm38) missense probably damaging 1.00
R8775:Myo10 UTSW 15 25,800,059 (GRCm38) missense probably damaging 0.97
R8775-TAIL:Myo10 UTSW 15 25,800,059 (GRCm38) missense probably damaging 0.97
R8970:Myo10 UTSW 15 25,803,381 (GRCm38) missense possibly damaging 0.82
R9024:Myo10 UTSW 15 25,793,209 (GRCm38) missense possibly damaging 0.53
R9196:Myo10 UTSW 15 25,805,630 (GRCm38) missense probably damaging 0.96
R9224:Myo10 UTSW 15 25,807,995 (GRCm38) missense probably benign 0.33
R9308:Myo10 UTSW 15 25,781,776 (GRCm38) missense probably damaging 0.99
R9358:Myo10 UTSW 15 25,781,434 (GRCm38) missense possibly damaging 0.69
R9606:Myo10 UTSW 15 25,776,315 (GRCm38) frame shift probably null
R9722:Myo10 UTSW 15 25,801,141 (GRCm38) missense probably damaging 1.00
RF013:Myo10 UTSW 15 25,799,479 (GRCm38) missense probably damaging 0.99
Z1177:Myo10 UTSW 15 25,799,554 (GRCm38) critical splice donor site probably null
Z1177:Myo10 UTSW 15 25,781,401 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCACTCCTGTCACCACAAGG -3'
(R):5'- ACATTCAGGTACCACAGGC -3'

Sequencing Primer
(F):5'- TCACCACAAGGGGGCAG -3'
(R):5'- CATTCAGGTACCACAGGCGTATG -3'
Posted On 2014-06-23