Mutagenetix > Incidental Mutation

Incidental Mutation 'R1836:Vps13b'

205335

Institutional Source

Beutler Lab

Gene Symbol

Vps13b

Ensembl Gene

ENSMUSG00000037646

Gene Name

vacuolar protein sorting 13B

Synonyms

2310042E16Rik, 1810042B05Rik, Coh1, C330002D13Rik

MMRRC Submission

039863-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1836 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

35371160-35931229 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 35910232 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 3381 (S3381P)

Ref Sequence

ENSEMBL: ENSMUSP00000045490 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000048646]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000048646
AA Change: S3381P

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000045490
Gene: ENSMUSG00000037646
AA Change: S3381P

Domain	Start	End	E-Value	Type
Pfam:Chorein_N	2	120	1e-29	PFAM
low complexity region	128	137	N/A	INTRINSIC
low complexity region	143	160	N/A	INTRINSIC
low complexity region	975	984	N/A	INTRINSIC
low complexity region	1007	1018	N/A	INTRINSIC
low complexity region	1876	1883	N/A	INTRINSIC
low complexity region	2042	2054	N/A	INTRINSIC
low complexity region	2414	2423	N/A	INTRINSIC
Pfam:SHR-BD	2601	2700	8.4e-10	PFAM
low complexity region	2954	2964	N/A	INTRINSIC
Pfam:VPS13_C	3539	3706	2.6e-30	PFAM

Coding Region Coverage

1x: 97.4%
3x: 96.8%
10x: 95.1%
20x: 91.8%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a potential transmembrane protein that may function in vesicle-mediated transport and sorting of proteins within the cell. This protein may play a role in the development and the function of the eye, hematological system, and central nervous system. Mutations in this gene have been associated with Cohen syndrome. Multiple splice variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 108 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700029P11Rik	T	C	15: 81,980,867 (GRCm38)	V103A	probably damaging	Het
2210408I21Rik	A	G	13: 77,323,374 (GRCm38)	E966G	probably benign	Het
7420426K07Rik	C	A	9: 98,903,482 (GRCm38)	R67S	probably benign	Het
9330159F19Rik	T	C	10: 29,221,799 (GRCm38)	V64A	probably damaging	Het
Abcb5	G	T	12: 118,867,961 (GRCm38)	Q1219K	possibly damaging	Het
Acox2	A	T	14: 8,248,059 (GRCm38)	C408S	possibly damaging	Het
Acsf3	T	A	8: 122,780,183 (GRCm38)	Y72N	probably damaging	Het
Acss2	T	A	2: 155,558,630 (GRCm38)	Y530N	probably damaging	Het
Adam28	T	C	14: 68,649,421 (GRCm38)	E48G	possibly damaging	Het
Adgrv1	A	C	13: 81,504,113 (GRCm38)	M2957R	probably benign	Het
Adi1	C	A	12: 28,679,563 (GRCm38)	D138E	probably benign	Het
Alk	A	C	17: 71,891,037 (GRCm38)	L1228R	probably damaging	Het
Alms1	T	A	6: 85,678,503 (GRCm38)	S3344T	possibly damaging	Het
Aox2	G	A	1: 58,308,991 (GRCm38)	A623T	probably benign	Het
Arhgef2	C	T	3: 88,639,459 (GRCm38)	T545I	probably damaging	Het
Atp8a2	T	A	14: 60,006,366 (GRCm38)	N630I	possibly damaging	Het
Bcl9	G	T	3: 97,205,870 (GRCm38)	Q1090K	probably damaging	Het
Bdp1	A	G	13: 100,035,145 (GRCm38)	S2152P	probably benign	Het
Birc6	T	A	17: 74,614,390 (GRCm38)	S2155T	probably benign	Het
Camk2b	T	C	11: 5,972,384 (GRCm38)	E488G	probably damaging	Het
Capn9	T	A	8: 124,605,565 (GRCm38)		probably null	Het
Cd209f	A	G	8: 4,104,491 (GRCm38)	S119P	probably damaging	Het
Cep78	T	C	19: 15,969,169 (GRCm38)	E433G	probably damaging	Het
Chid1	G	T	7: 141,526,496 (GRCm38)		probably null	Het
Cldnd2	T	C	7: 43,442,925 (GRCm38)	S129P	possibly damaging	Het
Cobll1	A	T	2: 65,126,236 (GRCm38)	F289Y	probably damaging	Het
Creb1	C	T	1: 64,550,950 (GRCm38)	Q32*	probably null	Het
Creb3l4	G	T	3: 90,238,903 (GRCm38)	S182Y	probably benign	Het
Dgcr2	A	T	16: 17,849,720 (GRCm38)	C292S	probably damaging	Het
Dnah8	T	C	17: 30,874,927 (GRCm38)	V4665A	possibly damaging	Het
Dnah9	A	T	11: 66,118,841 (GRCm38)	M740K	probably benign	Het
Dnmt1	G	A	9: 20,918,246 (GRCm38)	T687I	probably damaging	Het
Ece1	C	T	4: 137,958,001 (GRCm38)	R601W	probably damaging	Het
Echdc2	C	A	4: 108,165,535 (GRCm38)	R3S	probably damaging	Het
Ep400	A	T	5: 110,705,054 (GRCm38)	L1275Q	unknown	Het
Epha6	A	T	16: 60,205,745 (GRCm38)	W445R	probably damaging	Het
Ercc5	T	A	1: 44,180,875 (GRCm38)	S1102R	probably benign	Het
Fam228a	T	G	12: 4,715,620 (GRCm38)	T264P	probably damaging	Het
Fzd6	T	A	15: 39,033,920 (GRCm38)	I488N	probably damaging	Het
Gabrg3	T	G	7: 56,729,641 (GRCm38)	N338H	probably damaging	Het
Gde1	A	G	7: 118,695,134 (GRCm38)	F39L	possibly damaging	Het
Gjb3	G	A	4: 127,326,431 (GRCm38)	R103W	probably damaging	Het
Gm4781	T	A	10: 100,396,720 (GRCm38)		noncoding transcript	Het
Gm4846	T	A	1: 166,483,923 (GRCm38)	T456S	probably benign	Het
Gm5415	T	G	1: 32,545,677 (GRCm38)	D384A	probably damaging	Het
Gpx5	A	G	13: 21,287,454 (GRCm38)	I193T	probably benign	Het
Herc2	A	T	7: 56,155,105 (GRCm38)	K2294*	probably null	Het
Hist1h3b	T	A	13: 23,752,732 (GRCm38)	V118D	probably damaging	Het
Iqgap3	T	A	3: 88,108,368 (GRCm38)	V19D	probably damaging	Het
Itga5	T	C	15: 103,346,014 (GRCm38)	I1006V	probably damaging	Het
Lamb1	C	T	12: 31,301,094 (GRCm38)	T781I	probably benign	Het
Lias	A	G	5: 65,392,343 (GRCm38)	T57A	probably benign	Het
Lin37	C	A	7: 30,556,943 (GRCm38)	R108L	probably damaging	Het
Lrrd1	A	T	5: 3,865,709 (GRCm38)	T769S	probably benign	Het
Mamstr	T	C	7: 45,644,963 (GRCm38)	W414R	probably damaging	Het
Mtmr11	T	G	3: 96,164,786 (GRCm38)	S233R	probably damaging	Het
Myh1	A	T	11: 67,204,822 (GRCm38)	I266F	probably damaging	Het
Myt1	C	A	2: 181,797,275 (GRCm38)	Q197K	probably benign	Het
Naip5	G	T	13: 100,219,687 (GRCm38)	T1140K	probably benign	Het
Ncf2	G	A	1: 152,808,071 (GRCm38)	V14M	probably damaging	Het
Nhsl1	G	T	10: 18,524,905 (GRCm38)	R626S	possibly damaging	Het
Nol12	T	A	15: 78,937,889 (GRCm38)	V108E	probably damaging	Het
Nr1i2	G	T	16: 38,249,282 (GRCm38)	P420Q	probably damaging	Het
Nup155	A	G	15: 8,154,980 (GRCm38)	I1286M	possibly damaging	Het
Ocrl	T	A	X: 47,962,116 (GRCm38)	I74N	probably damaging	Het
Olfr1257	A	C	2: 89,881,285 (GRCm38)	H153P	probably damaging	Het
Olfr64	A	G	7: 103,893,385 (GRCm38)	S117P	probably damaging	Het
Olfr993	A	G	2: 85,414,405 (GRCm38)	V158A	probably benign	Het
Pard3b	C	T	1: 62,637,604 (GRCm38)	S999L	probably benign	Het
Pax9	A	G	12: 56,700,054 (GRCm38)	E225G	probably benign	Het
Pdcd4	T	G	19: 53,926,219 (GRCm38)	L335R	probably damaging	Het
Pdgfra	T	A	5: 75,183,014 (GRCm38)	M732K	possibly damaging	Het
Pkhd1	G	T	1: 20,117,069 (GRCm38)	Q3672K	probably benign	Het
Pold2	A	G	11: 5,873,454 (GRCm38)	L325P	possibly damaging	Het
Pom121l2	A	T	13: 21,983,784 (GRCm38)	T742S	probably benign	Het
Ppfia1	C	T	7: 144,519,631 (GRCm38)	E208K	probably benign	Het
Prex2	A	T	1: 11,136,780 (GRCm38)	R521W	probably damaging	Het
Rhpn2	T	C	7: 35,372,388 (GRCm38)	L226P	probably benign	Het
Rps12	C	A	10: 23,785,629 (GRCm38)	D95Y	probably damaging	Het
Sardh	T	A	2: 27,215,182 (GRCm38)	D643V	possibly damaging	Het
Sars	T	C	3: 108,435,944 (GRCm38)	D77G	probably benign	Het
Scin	C	A	12: 40,124,698 (GRCm38)	V129F	probably damaging	Het
Sftpa1	T	A	14: 41,132,846 (GRCm38)	M66K	possibly damaging	Het
Sgo1	T	C	17: 53,687,771 (GRCm38)	K28E	probably damaging	Het
Sim2	G	T	16: 94,123,577 (GRCm38)		probably null	Het
Srp54b	T	A	12: 55,250,160 (GRCm38)		probably null	Het
Stard7	T	C	2: 127,295,560 (GRCm38)	V310A	probably benign	Het
Tasp1	T	C	2: 139,951,557 (GRCm38)	D233G	probably damaging	Het
Tdrd6	G	T	17: 43,625,589 (GRCm38)	L1523M	probably benign	Het
Tle3	A	G	9: 61,414,023 (GRCm38)	D639G	probably damaging	Het
Tmem128	A	G	5: 38,260,406 (GRCm38)	D2G	probably damaging	Het
Tmem163	A	G	1: 127,677,509 (GRCm38)	S41P	probably benign	Het
Ttn	C	T	2: 76,729,161 (GRCm38)	S29632N	probably damaging	Het
Tuba4a	A	G	1: 75,216,110 (GRCm38)	S287P	probably benign	Het
Ubn1	G	C	16: 5,077,391 (GRCm38)	G767A	probably benign	Het
Ugdh	A	T	5: 65,420,291 (GRCm38)	C288*	probably null	Het
Upf2	T	A	2: 6,050,324 (GRCm38)		probably null	Het
Vmn1r2	T	C	4: 3,172,836 (GRCm38)	S252P	probably damaging	Het
Vmn1r28	A	C	6: 58,265,252 (GRCm38)	T27P	probably damaging	Het
Vmn1r77	T	C	7: 12,041,411 (GRCm38)	I38T	probably benign	Het
Vmn2r51	C	A	7: 10,098,163 (GRCm38)	E499*	probably null	Het
Vmn2r51	G	T	7: 10,098,164 (GRCm38)	Y498*	probably null	Het
Vmn2r53	A	T	7: 12,600,885 (GRCm38)	W283R	probably damaging	Het
Vpreb1	T	A	16: 16,869,069 (GRCm38)	T15S	probably benign	Het
Wnt2	A	T	6: 18,023,235 (GRCm38)	D138E	probably damaging	Het
Zdhhc22	A	G	12: 86,983,430 (GRCm38)	V248A	probably benign	Het
Zfp30	T	A	7: 29,793,380 (GRCm38)	I434N	probably damaging	Het
Zfp316	A	G	5: 143,253,423 (GRCm38)	L947P	probably damaging	Het

Other mutations in Vps13b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00402:Vps13b	APN	15	35,926,226 (GRCm38)	missense	possibly damaging	0.52
IGL00513:Vps13b	APN	15	35,793,884 (GRCm38)	missense	probably damaging	1.00
IGL00516:Vps13b	APN	15	35,640,557 (GRCm38)	missense	probably damaging	1.00
IGL00640:Vps13b	APN	15	35,417,577 (GRCm38)	missense	probably benign
IGL00753:Vps13b	APN	15	35,372,031 (GRCm38)	missense	probably damaging	0.99
IGL00784:Vps13b	APN	15	35,846,900 (GRCm38)	missense	probably damaging	1.00
IGL01138:Vps13b	APN	15	35,446,770 (GRCm38)	splice site	probably benign
IGL01349:Vps13b	APN	15	35,793,945 (GRCm38)	missense	probably benign	0.00
IGL01403:Vps13b	APN	15	35,709,479 (GRCm38)	missense	probably benign	0.00
IGL01535:Vps13b	APN	15	35,454,957 (GRCm38)	missense	possibly damaging	0.67
IGL01571:Vps13b	APN	15	35,877,489 (GRCm38)	splice site	probably benign
IGL01642:Vps13b	APN	15	35,792,072 (GRCm38)	missense	probably benign	0.43
IGL01658:Vps13b	APN	15	35,671,333 (GRCm38)	missense	probably damaging	0.99
IGL01759:Vps13b	APN	15	35,878,789 (GRCm38)	missense	probably damaging	1.00
IGL01763:Vps13b	APN	15	35,709,799 (GRCm38)	missense	possibly damaging	0.72
IGL01906:Vps13b	APN	15	35,639,847 (GRCm38)	splice site	probably benign
IGL01982:Vps13b	APN	15	35,438,904 (GRCm38)	nonsense	probably null
IGL01997:Vps13b	APN	15	35,709,224 (GRCm38)	missense	probably damaging	1.00
IGL02041:Vps13b	APN	15	35,423,245 (GRCm38)	missense	probably damaging	0.98
IGL02073:Vps13b	APN	15	35,875,586 (GRCm38)	missense	possibly damaging	0.52
IGL02077:Vps13b	APN	15	35,910,613 (GRCm38)	missense	possibly damaging	0.68
IGL02141:Vps13b	APN	15	35,572,081 (GRCm38)	missense	probably benign	0.09
IGL02146:Vps13b	APN	15	35,646,333 (GRCm38)	missense	probably benign	0.36
IGL02197:Vps13b	APN	15	35,930,056 (GRCm38)	missense	probably benign	0.02
IGL02311:Vps13b	APN	15	35,709,514 (GRCm38)	missense	probably benign	0.08
IGL02466:Vps13b	APN	15	35,770,741 (GRCm38)	missense	possibly damaging	0.86
IGL02506:Vps13b	APN	15	35,917,162 (GRCm38)	missense	probably damaging	1.00
IGL02550:Vps13b	APN	15	35,572,096 (GRCm38)	missense	probably benign
IGL02553:Vps13b	APN	15	35,646,301 (GRCm38)	missense	probably benign	0.00
IGL02674:Vps13b	APN	15	35,639,958 (GRCm38)	missense	probably benign	0.41
IGL02690:Vps13b	APN	15	35,917,142 (GRCm38)	missense	probably damaging	1.00
IGL02731:Vps13b	APN	15	35,917,128 (GRCm38)	missense	probably benign	0.00
IGL02739:Vps13b	APN	15	35,879,900 (GRCm38)	missense	probably damaging	1.00
IGL02868:Vps13b	APN	15	35,884,519 (GRCm38)	missense	probably benign	0.03
IGL03081:Vps13b	APN	15	35,875,820 (GRCm38)	missense	probably damaging	0.97
IGL03178:Vps13b	APN	15	35,869,300 (GRCm38)	missense	probably damaging	1.00
IGL03343:Vps13b	APN	15	35,917,170 (GRCm38)	missense	possibly damaging	0.76
IGL03407:Vps13b	APN	15	35,639,866 (GRCm38)	missense	possibly damaging	0.95
IGL03410:Vps13b	APN	15	35,910,340 (GRCm38)	missense	probably benign
omlette	UTSW	15	35,671,400 (GRCm38)	missense	probably benign	0.13
swiss	UTSW	15	35,709,673 (GRCm38)	missense	possibly damaging	0.80
FR4449:Vps13b	UTSW	15	35,846,957 (GRCm38)	missense	probably damaging	1.00
FR4548:Vps13b	UTSW	15	35,846,957 (GRCm38)	missense	probably damaging	1.00
FR4737:Vps13b	UTSW	15	35,846,957 (GRCm38)	missense	probably damaging	1.00
FR4976:Vps13b	UTSW	15	35,846,957 (GRCm38)	missense	probably damaging	1.00
LCD18:Vps13b	UTSW	15	35,846,957 (GRCm38)	missense	probably damaging	1.00
PIT4531001:Vps13b	UTSW	15	35,878,825 (GRCm38)	missense	probably damaging	1.00
PIT4581001:Vps13b	UTSW	15	35,534,263 (GRCm38)	missense	probably damaging	1.00
PIT4618001:Vps13b	UTSW	15	35,709,240 (GRCm38)	missense	probably damaging	1.00
R0026:Vps13b	UTSW	15	35,923,301 (GRCm38)	missense	possibly damaging	0.62
R0026:Vps13b	UTSW	15	35,923,301 (GRCm38)	missense	possibly damaging	0.62
R0108:Vps13b	UTSW	15	35,572,119 (GRCm38)	missense	probably benign	0.20
R0109:Vps13b	UTSW	15	35,572,119 (GRCm38)	missense	probably benign	0.20
R0109:Vps13b	UTSW	15	35,572,119 (GRCm38)	missense	probably benign	0.20
R0116:Vps13b	UTSW	15	35,423,155 (GRCm38)	missense	probably damaging	0.99
R0123:Vps13b	UTSW	15	35,887,261 (GRCm38)	missense	probably benign	0.01
R0124:Vps13b	UTSW	15	35,576,528 (GRCm38)	critical splice donor site	probably null
R0134:Vps13b	UTSW	15	35,887,261 (GRCm38)	missense	probably benign	0.01
R0137:Vps13b	UTSW	15	35,926,219 (GRCm38)	missense	probably benign	0.06
R0195:Vps13b	UTSW	15	35,471,899 (GRCm38)	missense	probably benign	0.00
R0225:Vps13b	UTSW	15	35,887,261 (GRCm38)	missense	probably benign	0.01
R0320:Vps13b	UTSW	15	35,674,828 (GRCm38)	missense	probably damaging	0.98
R0333:Vps13b	UTSW	15	35,879,803 (GRCm38)	missense	probably damaging	1.00
R0336:Vps13b	UTSW	15	35,455,133 (GRCm38)	nonsense	probably null
R0463:Vps13b	UTSW	15	35,597,409 (GRCm38)	missense	probably damaging	0.98
R0466:Vps13b	UTSW	15	35,445,602 (GRCm38)	nonsense	probably null
R0472:Vps13b	UTSW	15	35,417,633 (GRCm38)	critical splice donor site	probably null
R0523:Vps13b	UTSW	15	35,472,050 (GRCm38)	missense	probably benign	0.20
R0602:Vps13b	UTSW	15	35,422,368 (GRCm38)	missense	probably damaging	1.00
R0612:Vps13b	UTSW	15	35,623,657 (GRCm38)	missense	probably benign	0.12
R0627:Vps13b	UTSW	15	35,371,999 (GRCm38)	nonsense	probably null
R0679:Vps13b	UTSW	15	35,709,703 (GRCm38)	missense	possibly damaging	0.73
R0742:Vps13b	UTSW	15	35,794,361 (GRCm38)	missense	probably benign	0.22
R1053:Vps13b	UTSW	15	35,652,363 (GRCm38)	missense	probably damaging	1.00
R1355:Vps13b	UTSW	15	35,422,454 (GRCm38)	missense	probably damaging	1.00
R1386:Vps13b	UTSW	15	35,923,312 (GRCm38)	missense	probably damaging	0.99
R1403:Vps13b	UTSW	15	35,709,122 (GRCm38)	splice site	probably benign
R1453:Vps13b	UTSW	15	35,422,444 (GRCm38)	missense	probably damaging	0.97
R1464:Vps13b	UTSW	15	35,709,484 (GRCm38)	missense	probably benign	0.14
R1464:Vps13b	UTSW	15	35,709,484 (GRCm38)	missense	probably benign	0.14
R1511:Vps13b	UTSW	15	35,841,573 (GRCm38)	missense	probably benign	0.00
R1511:Vps13b	UTSW	15	35,839,975 (GRCm38)	missense	probably damaging	0.99
R1513:Vps13b	UTSW	15	35,438,730 (GRCm38)	nonsense	probably null
R1536:Vps13b	UTSW	15	35,875,566 (GRCm38)	missense	probably damaging	0.98
R1537:Vps13b	UTSW	15	35,792,181 (GRCm38)	missense	possibly damaging	0.62
R1558:Vps13b	UTSW	15	35,534,319 (GRCm38)	missense	probably damaging	1.00
R1601:Vps13b	UTSW	15	35,642,436 (GRCm38)	missense	probably benign	0.11
R1653:Vps13b	UTSW	15	35,607,272 (GRCm38)	nonsense	probably null
R1695:Vps13b	UTSW	15	35,576,521 (GRCm38)	missense	probably benign	0.05
R1760:Vps13b	UTSW	15	35,884,619 (GRCm38)	missense	possibly damaging	0.54
R1785:Vps13b	UTSW	15	35,879,791 (GRCm38)	missense	probably damaging	1.00
R1786:Vps13b	UTSW	15	35,879,791 (GRCm38)	missense	probably damaging	1.00
R1803:Vps13b	UTSW	15	35,430,205 (GRCm38)	nonsense	probably null
R1804:Vps13b	UTSW	15	35,917,137 (GRCm38)	missense	probably damaging	1.00
R1808:Vps13b	UTSW	15	35,792,059 (GRCm38)	missense	probably benign	0.00
R1817:Vps13b	UTSW	15	35,910,642 (GRCm38)	missense	possibly damaging	0.86
R1818:Vps13b	UTSW	15	35,877,577 (GRCm38)	missense	probably benign	0.00
R1850:Vps13b	UTSW	15	35,674,959 (GRCm38)	splice site	probably benign
R1884:Vps13b	UTSW	15	35,430,291 (GRCm38)	splice site	probably benign
R1938:Vps13b	UTSW	15	35,709,507 (GRCm38)	missense	probably damaging	1.00
R1955:Vps13b	UTSW	15	35,925,408 (GRCm38)	critical splice donor site	probably null
R1956:Vps13b	UTSW	15	35,869,407 (GRCm38)	missense	probably damaging	1.00
R1958:Vps13b	UTSW	15	35,878,689 (GRCm38)	missense	probably damaging	0.99
R2013:Vps13b	UTSW	15	35,607,142 (GRCm38)	missense	probably damaging	0.99
R2014:Vps13b	UTSW	15	35,607,142 (GRCm38)	missense	probably damaging	0.99
R2015:Vps13b	UTSW	15	35,607,142 (GRCm38)	missense	probably damaging	0.99
R2038:Vps13b	UTSW	15	35,884,741 (GRCm38)	missense	probably damaging	1.00
R2058:Vps13b	UTSW	15	35,841,447 (GRCm38)	missense	probably damaging	1.00
R2082:Vps13b	UTSW	15	35,910,746 (GRCm38)	missense	possibly damaging	0.70
R2087:Vps13b	UTSW	15	35,597,493 (GRCm38)	missense	probably damaging	0.99
R2124:Vps13b	UTSW	15	35,646,080 (GRCm38)	missense	probably benign	0.08
R2130:Vps13b	UTSW	15	35,671,400 (GRCm38)	missense	probably benign	0.13
R2168:Vps13b	UTSW	15	35,792,188 (GRCm38)	missense	probably damaging	1.00
R2168:Vps13b	UTSW	15	35,792,189 (GRCm38)	missense	probably damaging	1.00
R2171:Vps13b	UTSW	15	35,887,197 (GRCm38)	missense	probably benign	0.44
R2221:Vps13b	UTSW	15	35,884,597 (GRCm38)	missense	probably benign
R2263:Vps13b	UTSW	15	35,646,181 (GRCm38)	missense	probably benign	0.02
R2289:Vps13b	UTSW	15	35,572,105 (GRCm38)	missense	probably damaging	1.00
R2316:Vps13b	UTSW	15	35,674,899 (GRCm38)	nonsense	probably null
R2351:Vps13b	UTSW	15	35,869,311 (GRCm38)	missense	probably damaging	1.00
R2512:Vps13b	UTSW	15	35,884,555 (GRCm38)	missense	probably benign	0.35
R3054:Vps13b	UTSW	15	35,646,361 (GRCm38)	missense	probably damaging	0.99
R3055:Vps13b	UTSW	15	35,646,361 (GRCm38)	missense	probably damaging	0.99
R3196:Vps13b	UTSW	15	35,869,395 (GRCm38)	missense	probably damaging	1.00
R3236:Vps13b	UTSW	15	35,910,304 (GRCm38)	missense	probably benign	0.40
R3404:Vps13b	UTSW	15	35,926,054 (GRCm38)	missense	probably damaging	1.00
R3722:Vps13b	UTSW	15	35,671,382 (GRCm38)	missense	probably damaging	0.99
R4077:Vps13b	UTSW	15	35,455,128 (GRCm38)	missense	probably damaging	0.99
R4153:Vps13b	UTSW	15	35,792,027 (GRCm38)	splice site	probably null
R4224:Vps13b	UTSW	15	35,876,419 (GRCm38)	missense	probably damaging	0.99
R4408:Vps13b	UTSW	15	35,709,294 (GRCm38)	missense	probably damaging	0.98
R4431:Vps13b	UTSW	15	35,770,753 (GRCm38)	missense	probably damaging	1.00
R4449:Vps13b	UTSW	15	35,876,793 (GRCm38)	missense	possibly damaging	0.86
R4508:Vps13b	UTSW	15	35,709,673 (GRCm38)	missense	possibly damaging	0.80
R4631:Vps13b	UTSW	15	35,646,132 (GRCm38)	missense	possibly damaging	0.95
R4655:Vps13b	UTSW	15	35,770,689 (GRCm38)	missense	probably benign
R4666:Vps13b	UTSW	15	35,640,544 (GRCm38)	missense	probably benign	0.13
R4684:Vps13b	UTSW	15	35,879,821 (GRCm38)	missense	probably benign
R4684:Vps13b	UTSW	15	35,841,341 (GRCm38)	missense	probably benign
R4684:Vps13b	UTSW	15	35,646,178 (GRCm38)	missense	probably damaging	0.98
R4721:Vps13b	UTSW	15	35,910,718 (GRCm38)	nonsense	probably null
R4771:Vps13b	UTSW	15	35,910,800 (GRCm38)	missense	probably damaging	1.00
R4830:Vps13b	UTSW	15	35,452,224 (GRCm38)	missense	possibly damaging	0.94
R4835:Vps13b	UTSW	15	35,869,372 (GRCm38)	missense	probably damaging	1.00
R4835:Vps13b	UTSW	15	35,910,293 (GRCm38)	missense	probably benign
R4857:Vps13b	UTSW	15	35,456,654 (GRCm38)	missense	probably benign	0.01
R4891:Vps13b	UTSW	15	35,640,515 (GRCm38)	splice site	probably null
R5095:Vps13b	UTSW	15	35,923,202 (GRCm38)	missense	probably damaging	1.00
R5110:Vps13b	UTSW	15	35,770,809 (GRCm38)	missense	probably damaging	0.99
R5147:Vps13b	UTSW	15	35,456,678 (GRCm38)	missense	probably benign	0.32
R5153:Vps13b	UTSW	15	35,422,453 (GRCm38)	missense	probably damaging	0.99
R5257:Vps13b	UTSW	15	35,794,421 (GRCm38)	missense	possibly damaging	0.75
R5258:Vps13b	UTSW	15	35,794,421 (GRCm38)	missense	possibly damaging	0.75
R5296:Vps13b	UTSW	15	35,876,413 (GRCm38)	missense	probably damaging	1.00
R5386:Vps13b	UTSW	15	35,640,528 (GRCm38)	critical splice acceptor site	probably null
R5396:Vps13b	UTSW	15	35,886,948 (GRCm38)	missense	probably damaging	0.99
R5412:Vps13b	UTSW	15	35,533,385 (GRCm38)	missense	probably damaging	1.00
R5488:Vps13b	UTSW	15	35,770,542 (GRCm38)	missense	probably benign
R5489:Vps13b	UTSW	15	35,770,542 (GRCm38)	missense	probably benign
R5503:Vps13b	UTSW	15	35,452,166 (GRCm38)	missense	probably damaging	0.97
R5575:Vps13b	UTSW	15	35,929,919 (GRCm38)	missense	probably damaging	1.00
R5781:Vps13b	UTSW	15	35,794,035 (GRCm38)	missense	probably damaging	0.97
R5872:Vps13b	UTSW	15	35,869,351 (GRCm38)	missense	possibly damaging	0.56
R5876:Vps13b	UTSW	15	35,917,061 (GRCm38)	missense	probably damaging	0.99
R5994:Vps13b	UTSW	15	35,875,772 (GRCm38)	missense	probably damaging	1.00
R6031:Vps13b	UTSW	15	35,471,968 (GRCm38)	missense	probably damaging	1.00
R6031:Vps13b	UTSW	15	35,471,968 (GRCm38)	missense	probably damaging	1.00
R6045:Vps13b	UTSW	15	35,671,316 (GRCm38)	missense	probably damaging	0.99
R6143:Vps13b	UTSW	15	35,668,738 (GRCm38)	missense	probably damaging	0.99
R6147:Vps13b	UTSW	15	35,930,031 (GRCm38)	missense	probably benign	0.16
R6218:Vps13b	UTSW	15	35,770,464 (GRCm38)	missense	probably benign	0.00
R6447:Vps13b	UTSW	15	35,572,126 (GRCm38)	missense	probably benign	0.02
R6555:Vps13b	UTSW	15	35,846,847 (GRCm38)	missense	probably damaging	1.00
R6578:Vps13b	UTSW	15	35,446,101 (GRCm38)	missense	probably damaging	0.99
R6640:Vps13b	UTSW	15	35,617,696 (GRCm38)	missense	possibly damaging	0.93
R6645:Vps13b	UTSW	15	35,910,305 (GRCm38)	missense	probably benign	0.25
R6711:Vps13b	UTSW	15	35,887,249 (GRCm38)	missense	probably damaging	1.00
R6727:Vps13b	UTSW	15	35,770,683 (GRCm38)	missense	probably benign	0.19
R6737:Vps13b	UTSW	15	35,910,611 (GRCm38)	missense	probably damaging	1.00
R6844:Vps13b	UTSW	15	35,877,590 (GRCm38)	missense	probably benign	0.06
R6849:Vps13b	UTSW	15	35,905,309 (GRCm38)	missense	probably damaging	1.00
R6861:Vps13b	UTSW	15	35,576,395 (GRCm38)	missense	probably damaging	0.99
R6938:Vps13b	UTSW	15	35,423,198 (GRCm38)	missense	probably damaging	0.99
R6943:Vps13b	UTSW	15	35,448,689 (GRCm38)	missense	possibly damaging	0.95
R6989:Vps13b	UTSW	15	35,448,581 (GRCm38)	missense	probably benign	0.02
R7092:Vps13b	UTSW	15	35,640,634 (GRCm38)	missense	probably damaging	1.00
R7232:Vps13b	UTSW	15	35,877,557 (GRCm38)	missense	probably damaging	1.00
R7307:Vps13b	UTSW	15	35,841,545 (GRCm38)	missense	probably benign
R7400:Vps13b	UTSW	15	35,378,900 (GRCm38)	missense	probably damaging	1.00
R7414:Vps13b	UTSW	15	35,910,827 (GRCm38)	missense	probably damaging	1.00
R7497:Vps13b	UTSW	15	35,876,697 (GRCm38)	missense	probably benign	0.38
R7500:Vps13b	UTSW	15	35,910,524 (GRCm38)	missense	possibly damaging	0.74
R7603:Vps13b	UTSW	15	35,576,439 (GRCm38)	missense	probably damaging	0.98
R7605:Vps13b	UTSW	15	35,770,646 (GRCm38)	missense	probably damaging	0.97
R7849:Vps13b	UTSW	15	35,423,232 (GRCm38)	missense	probably damaging	0.99
R7984:Vps13b	UTSW	15	35,879,913 (GRCm38)	missense	probably benign
R8094:Vps13b	UTSW	15	35,668,906 (GRCm38)	critical splice donor site	probably null
R8097:Vps13b	UTSW	15	35,709,346 (GRCm38)	missense	probably benign	0.38
R8131:Vps13b	UTSW	15	35,372,109 (GRCm38)	critical splice donor site	probably null
R8139:Vps13b	UTSW	15	35,607,272 (GRCm38)	nonsense	probably null
R8174:Vps13b	UTSW	15	35,709,310 (GRCm38)	nonsense	probably null
R8225:Vps13b	UTSW	15	35,794,382 (GRCm38)	missense	probably damaging	0.99
R8239:Vps13b	UTSW	15	35,597,404 (GRCm38)	missense	probably damaging	1.00
R8244:Vps13b	UTSW	15	35,917,203 (GRCm38)	missense	probably damaging	1.00
R8303:Vps13b	UTSW	15	35,639,917 (GRCm38)	missense	probably damaging	1.00
R8311:Vps13b	UTSW	15	35,886,954 (GRCm38)	missense	probably benign	0.37
R8443:Vps13b	UTSW	15	35,455,100 (GRCm38)	missense	probably benign
R8494:Vps13b	UTSW	15	35,422,448 (GRCm38)	missense	probably damaging	0.99
R8499:Vps13b	UTSW	15	35,841,320 (GRCm38)	missense	probably damaging	1.00
R8506:Vps13b	UTSW	15	35,446,745 (GRCm38)	missense	probably benign	0.31
R8559:Vps13b	UTSW	15	35,876,642 (GRCm38)	missense	probably damaging	1.00
R8686:Vps13b	UTSW	15	35,925,389 (GRCm38)	missense	probably damaging	0.99
R8782:Vps13b	UTSW	15	35,422,337 (GRCm38)	missense	possibly damaging	0.93
R8806:Vps13b	UTSW	15	35,472,066 (GRCm38)	critical splice donor site	probably benign
R8824:Vps13b	UTSW	15	35,533,299 (GRCm38)	missense	probably damaging	0.99
R9024:Vps13b	UTSW	15	35,923,324 (GRCm38)	missense	probably damaging	0.97
R9038:Vps13b	UTSW	15	35,875,785 (GRCm38)	missense	possibly damaging	0.70
R9054:Vps13b	UTSW	15	35,422,391 (GRCm38)	missense	probably damaging	1.00
R9091:Vps13b	UTSW	15	35,770,773 (GRCm38)	missense	probably benign	0.13
R9129:Vps13b	UTSW	15	35,448,647 (GRCm38)	missense	probably damaging	1.00
R9214:Vps13b	UTSW	15	35,623,746 (GRCm38)	missense	probably damaging	0.99
R9237:Vps13b	UTSW	15	35,841,333 (GRCm38)	missense	probably damaging	1.00
R9256:Vps13b	UTSW	15	35,623,779 (GRCm38)	missense	possibly damaging	0.95
R9270:Vps13b	UTSW	15	35,770,773 (GRCm38)	missense	probably benign	0.13
R9279:Vps13b	UTSW	15	35,572,144 (GRCm38)	missense	probably damaging	0.97
R9291:Vps13b	UTSW	15	35,846,913 (GRCm38)	missense	probably damaging	1.00
R9342:Vps13b	UTSW	15	35,455,054 (GRCm38)	missense	possibly damaging	0.94
R9404:Vps13b	UTSW	15	35,876,419 (GRCm38)	missense	probably damaging	1.00
R9488:Vps13b	UTSW	15	35,447,734 (GRCm38)	missense	possibly damaging	0.77
R9509:Vps13b	UTSW	15	35,841,311 (GRCm38)	missense	possibly damaging	0.79
R9610:Vps13b	UTSW	15	35,642,409 (GRCm38)	missense	possibly damaging	0.85
R9611:Vps13b	UTSW	15	35,642,409 (GRCm38)	missense	possibly damaging	0.85
R9658:Vps13b	UTSW	15	35,623,628 (GRCm38)	missense	probably benign	0.00
R9674:Vps13b	UTSW	15	35,607,234 (GRCm38)	missense	probably damaging	0.98
R9696:Vps13b	UTSW	15	35,674,887 (GRCm38)	missense	possibly damaging	0.56
R9767:Vps13b	UTSW	15	35,910,257 (GRCm38)	missense	probably damaging	1.00
R9797:Vps13b	UTSW	15	35,674,876 (GRCm38)	missense	probably damaging	1.00
RF020:Vps13b	UTSW	15	35,925,406 (GRCm38)	missense	probably null	1.00
X0026:Vps13b	UTSW	15	35,910,646 (GRCm38)	missense	probably damaging	1.00
X0028:Vps13b	UTSW	15	35,709,431 (GRCm38)	missense	probably benign	0.00
Z1177:Vps13b	UTSW	15	35,668,885 (GRCm38)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- CCAGACGTGTTGAGTTCTTCC -3'
(R):5'- AATACTGAGCAGGGTCTGTTCTC -3'

Sequencing Primer
(F):5'- CTTGTTATGAGAGTCTGTCCTAAAAC -3'
(R):5'- GAGCAGGGTCTGTTCTCTCTCC -3'

Posted On

2014-06-23