Mutagenetix > Incidental Mutation

Incidental Mutation 'R1838:Celsr3'

205519

Institutional Source

Beutler Lab

Gene Symbol

Celsr3

Ensembl Gene

ENSMUSG00000023473

Gene Name

cadherin, EGF LAG seven-pass G-type receptor 3

Synonyms

Fmi1, flamingo

MMRRC Submission

039865-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R1838 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

108826320-108852969 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 108829906 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Arginine at position 1196 (H1196R)

Ref Sequence

ENSEMBL: ENSMUSP00000150759 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000024238] [ENSMUST00000192235] [ENSMUST00000213524]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000024238
AA Change: H1196R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000024238
Gene: ENSMUSG00000023473
AA Change: H1196R

Domain	Start	End	E-Value	Type
signal peptide	1	31	N/A	INTRINSIC
low complexity region	264	293	N/A	INTRINSIC
CA	338	422	2.25e-27	SMART
CA	446	534	5.05e-30	SMART
CA	558	640	7.6e-25	SMART
CA	664	745	7.36e-32	SMART
CA	769	847	5.95e-18	SMART
CA	871	950	5.25e-28	SMART
CA	974	1056	2.67e-29	SMART
CA	1080	1158	1.18e-21	SMART
CA	1186	1262	3.2e-1	SMART
low complexity region	1328	1335	N/A	INTRINSIC
low complexity region	1350	1360	N/A	INTRINSIC
EGF	1369	1424	1.02e-2	SMART
EGF	1429	1464	3.23e0	SMART
EGF	1467	1503	8.78e-2	SMART
LamG	1524	1691	2.27e-35	SMART
EGF	1714	1747	4.22e-4	SMART
LamG	1774	1913	9.02e-21	SMART
EGF	1938	1971	2.43e-4	SMART
EGF	1973	2009	1.3e-4	SMART
EGF_Lam	2066	2111	5.08e-7	SMART
HormR	2114	2176	3.42e-21	SMART
Pfam:GAIN	2188	2441	1.1e-57	PFAM
GPS	2467	2520	7.92e-20	SMART
Pfam:7tm_2	2527	2758	1.5e-56	PFAM
low complexity region	2813	2829	N/A	INTRINSIC
low complexity region	2882	2906	N/A	INTRINSIC
low complexity region	3058	3072	N/A	INTRINSIC
low complexity region	3149	3189	N/A	INTRINSIC
low complexity region	3239	3261	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000192235

SMART Domains

Protein: ENSMUSP00000141429
Gene: ENSMUSG00000023473

Domain	Start	End	E-Value	Type
low complexity region	67	74	N/A	INTRINSIC
low complexity region	89	99	N/A	INTRINSIC
EGF	108	163	4.9e-5	SMART
EGF	168	201	2.6e-6	SMART
EGF_like	208	239	1.6e-1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000193114

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000193726

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000194742

Predicted Effect

probably benign
Transcript: ENSMUST00000213524
AA Change: H1196R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Meta Mutation Damage Score

0.0881

Coding Region Coverage

1x: 97.4%
3x: 96.9%
10x: 95.2%
20x: 92.4%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]
PHENOTYPE: Mice homozygous for a null allele exhibit neonatal lethality, abnormal neurvous system development, and abnormal respiratory system development. [provided by MGI curators]

Allele List at MGI

All alleles(4) : Targeted, knock-out(2) Targeted, other(2)

Other mutations in this stock

Total: 88 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A630073D07Rik	T	C	6: 132,626,727 (GRCm38)	D22G	unknown	Het
Abca4	G	A	3: 122,128,305 (GRCm38)	R1170K	probably benign	Het
Adam28	T	C	14: 68,639,210 (GRCm38)	N197S	possibly damaging	Het
Adamtsl3	G	T	7: 82,493,373 (GRCm38)	R267L	probably damaging	Het
Adgrb2	A	T	4: 130,010,231 (GRCm38)	T717S	probably benign	Het
Adgrb3	A	G	1: 25,084,270 (GRCm38)	S1417P	probably damaging	Het
Afg3l2	A	T	18: 67,414,172 (GRCm38)	V561D	probably damaging	Het
Atp13a2	T	A	4: 140,994,332 (GRCm38)	Y244*	probably null	Het
BB014433	C	G	8: 15,042,629 (GRCm38)	V75L	unknown	Het
Btnl6	T	A	17: 34,515,542 (GRCm38)	D82V	probably damaging	Het
Ccdc178	A	G	18: 22,067,638 (GRCm38)	Y421H	probably damaging	Het
Cdc123	A	T	2: 5,794,891 (GRCm38)		probably null	Het
Cdhr5	C	T	7: 141,272,603 (GRCm38)	V367I	possibly damaging	Het
Chd8	T	C	14: 52,204,883 (GRCm38)	S2077G	probably benign	Het
Col6a5	G	A	9: 105,864,833 (GRCm38)	H2296Y	probably benign	Het
Ctnna2	T	C	6: 77,845,542 (GRCm38)	D26G	probably damaging	Het
Ctr9	G	T	7: 111,052,303 (GRCm38)	R910L	possibly damaging	Het
Cyp2t4	G	T	7: 27,158,416 (GRCm38)	R455L	possibly damaging	Het
Cyp3a13	A	T	5: 137,911,632 (GRCm38)		probably null	Het
Dennd3	T	C	15: 73,565,100 (GRCm38)	S1059P	probably damaging	Het
Dennd4c	A	G	4: 86,825,178 (GRCm38)	T1135A	probably benign	Het
Dnah7b	C	A	1: 46,277,105 (GRCm38)	T3126K	probably damaging	Het
Dnah7b	T	C	1: 46,116,177 (GRCm38)	V295A	probably benign	Het
Ehbp1l1	C	T	19: 5,717,691 (GRCm38)	E1195K	probably benign	Het
Exoc6b	T	A	6: 84,853,678 (GRCm38)	I447L	probably benign	Het
Glt1d1	G	A	5: 127,678,129 (GRCm38)	V202I	probably benign	Het
Grk1	T	C	8: 13,416,155 (GRCm38)	V533A	possibly damaging	Het
Gsdma3	C	T	11: 98,629,858 (GRCm38)	A105V	probably benign	Het
Gzma	T	A	13: 113,095,984 (GRCm38)	I131F	probably damaging	Het
Helq	A	T	5: 100,771,879 (GRCm38)	L35*	probably null	Het
Hnrnpll	T	C	17: 80,038,623 (GRCm38)	N403S	probably damaging	Het
Hsf5	A	G	11: 87,636,055 (GRCm38)	K518E	probably benign	Het
Ighe	T	A	12: 113,271,850 (GRCm38)	H258L	unknown	Het
Il6ra	T	C	3: 89,890,272 (GRCm38)	D96G	probably benign	Het
Ints13	C	T	6: 146,566,611 (GRCm38)	A129T	possibly damaging	Het
Ipo7	T	A	7: 110,042,109 (GRCm38)	H345Q	probably damaging	Het
Kcna2	A	T	3: 107,104,512 (GRCm38)	E136D	probably benign	Het
Kif5a	G	A	10: 127,236,815 (GRCm38)	Q702*	probably null	Het
Klhdc7a	G	T	4: 139,967,070 (GRCm38)	P189T	probably benign	Het
Krtap4-9	A	G	11: 99,785,396 (GRCm38)		probably benign	Het
Lamc3	T	C	2: 31,925,582 (GRCm38)	S1097P	possibly damaging	Het
Ldlrad2	A	T	4: 137,572,170 (GRCm38)	N114K	probably benign	Het
Lrfn1	A	T	7: 28,459,768 (GRCm38)	I371L	probably damaging	Het
Lrwd1	A	G	5: 136,132,388 (GRCm38)	V240A	probably benign	Het
Lypd1	A	T	1: 125,873,371 (GRCm38)		probably benign	Het
Magi2	A	T	5: 20,465,827 (GRCm38)	T163S	probably damaging	Het
Man2c1	A	G	9: 57,137,337 (GRCm38)	N354S	probably benign	Het
Map3k13	T	C	16: 21,914,189 (GRCm38)	Y514H	possibly damaging	Het
Med15	T	C	16: 17,653,562 (GRCm38)	D577G	probably benign	Het
Mroh4	A	T	15: 74,616,113 (GRCm38)	M320K	probably benign	Het
Ms4a10	T	A	19: 10,964,047 (GRCm38)	D186V	possibly damaging	Het
Myh7	T	C	14: 54,973,180 (GRCm38)	N1725S	possibly damaging	Het
Myo5c	A	T	9: 75,273,553 (GRCm38)	R741S	probably damaging	Het
Naip6	T	C	13: 100,316,136 (GRCm38)	D139G	probably damaging	Het
Nat6	G	A	9: 107,583,017 (GRCm38)	R37H	possibly damaging	Het
Olfr1252	A	T	2: 89,721,709 (GRCm38)	M134K	probably damaging	Het
Olfr1370	A	T	13: 21,072,425 (GRCm38)	L292*	probably null	Het
Olfr229	A	T	9: 39,909,841 (GRCm38)	I13F	possibly damaging	Het
Olfr982	A	T	9: 40,074,309 (GRCm38)	M5L	probably benign	Het
Pcdhb3	A	G	18: 37,301,317 (GRCm38)	D112G	probably benign	Het
Pdpr	C	A	8: 111,134,734 (GRCm38)	P787T	probably damaging	Het
Pgm3	C	T	9: 86,569,233 (GRCm38)	V123I	probably benign	Het
Pms1	A	C	1: 53,192,098 (GRCm38)		probably null	Het
Prl2b1	A	G	13: 27,388,566 (GRCm38)	S14P	possibly damaging	Het
Prune2	T	A	19: 17,199,878 (GRCm38)	W212R	probably damaging	Het
Rabgef1	A	G	5: 130,213,021 (GRCm38)	E422G	probably benign	Het
Ralyl	A	G	3: 14,143,412 (GRCm38)	E204G	probably damaging	Het
Rbpms2	ACTGCTGCTGCTGCTGC	ACTGCTGCTGCTGCTGCTGC	9: 65,651,666 (GRCm38)		probably benign	Het
Rbpms2	TGCCGCCGCC	TGCCGCCGCCGCC	9: 65,651,680 (GRCm38)		probably benign	Het
Rit1	C	G	3: 88,729,170 (GRCm38)	T127S	probably damaging	Het
Slc16a7	C	T	10: 125,231,198 (GRCm38)	V191M	probably damaging	Het
Slc34a2	A	T	5: 53,058,436 (GRCm38)	H63L	probably benign	Het
Smpd4	G	A	16: 17,642,302 (GRCm38)		probably null	Het
Sp3	A	G	2: 72,938,176 (GRCm38)	S748P	possibly damaging	Het
Spata31d1b	G	A	13: 59,717,465 (GRCm38)	R809K	probably benign	Het
Spata31d1b	G	A	13: 59,715,857 (GRCm38)	C273Y	probably benign	Het
Tmco5	A	T	2: 116,880,879 (GRCm38)	E90V	probably damaging	Het
Tnxb	A	T	17: 34,678,910 (GRCm38)	D844V	probably damaging	Het
Tpi1	T	C	6: 124,814,152 (GRCm38)	T41A	probably benign	Het
Ttn	T	C	2: 76,727,192 (GRCm38)	I29853V	probably damaging	Het
Vmn2r26	C	T	6: 124,024,771 (GRCm38)	T5I	probably benign	Het
Wdr95	A	G	5: 149,599,366 (GRCm38)	D663G	probably benign	Het
Zbtb39	T	C	10: 127,742,700 (GRCm38)	F381S	probably damaging	Het
Zfp523	T	A	17: 28,194,993 (GRCm38)	I34N	probably damaging	Het
Zfp646	T	A	7: 127,879,739 (GRCm38)	Y363N	probably damaging	Het
Zfp712	A	C	13: 67,042,047 (GRCm38)	C139G	probably damaging	Het
Zfp958	A	G	8: 4,628,590 (GRCm38)	H205R	probably damaging	Het
Zfp974	G	A	7: 27,910,356 (GRCm38)	P648L	possibly damaging	Het

Other mutations in Celsr3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00233:Celsr3	APN	9	108,848,925 (GRCm38)	missense	probably damaging	1.00
IGL00536:Celsr3	APN	9	108,829,192 (GRCm38)	missense	probably benign	0.33
IGL00552:Celsr3	APN	9	108,841,263 (GRCm38)	missense	possibly damaging	0.88
IGL00801:Celsr3	APN	9	108,842,576 (GRCm38)	missense	probably benign
IGL01420:Celsr3	APN	9	108,841,190 (GRCm38)	critical splice acceptor site	probably null
IGL01541:Celsr3	APN	9	108,831,708 (GRCm38)	missense	probably damaging	1.00
IGL01619:Celsr3	APN	9	108,834,557 (GRCm38)	missense	probably damaging	1.00
IGL01619:Celsr3	APN	9	108,837,404 (GRCm38)	missense	probably benign	0.00
IGL01631:Celsr3	APN	9	108,837,404 (GRCm38)	missense	probably benign	0.00
IGL01777:Celsr3	APN	9	108,835,942 (GRCm38)	missense	probably benign	0.08
IGL01938:Celsr3	APN	9	108,828,415 (GRCm38)	missense	probably benign	0.34
IGL02135:Celsr3	APN	9	108,827,556 (GRCm38)	missense	probably benign	0.11
IGL02231:Celsr3	APN	9	108,842,510 (GRCm38)	missense	probably damaging	1.00
IGL02234:Celsr3	APN	9	108,829,960 (GRCm38)	missense	probably benign
IGL02392:Celsr3	APN	9	108,834,721 (GRCm38)	splice site	probably benign
IGL02416:Celsr3	APN	9	108,832,119 (GRCm38)	missense	probably damaging	1.00
IGL02421:Celsr3	APN	9	108,840,463 (GRCm38)	missense	probably damaging	1.00
IGL02455:Celsr3	APN	9	108,842,893 (GRCm38)	missense	probably benign	0.15
IGL02798:Celsr3	APN	9	108,843,575 (GRCm38)	missense	probably damaging	1.00
IGL02939:Celsr3	APN	9	108,849,453 (GRCm38)	missense	probably damaging	1.00
IGL02947:Celsr3	APN	9	108,845,935 (GRCm38)	missense	probably benign	0.12
IGL02986:Celsr3	APN	9	108,841,255 (GRCm38)	splice site	probably null
IGL03089:Celsr3	APN	9	108,826,607 (GRCm38)	missense	probably benign	0.04
IGL03162:Celsr3	APN	9	108,842,558 (GRCm38)	missense	probably damaging	1.00
IGL03267:Celsr3	APN	9	108,836,525 (GRCm38)	splice site	probably benign
Diminishment	UTSW	9	108,842,708 (GRCm38)	intron	probably benign
little_d	UTSW	9	108,827,692 (GRCm38)	missense	probably damaging	0.98
nogal	UTSW	9	108,835,838 (GRCm38)	missense	probably benign
F6893:Celsr3	UTSW	9	108,835,067 (GRCm38)	missense	probably benign	0.00
PIT4243001:Celsr3	UTSW	9	108,832,308 (GRCm38)	missense	probably benign	0.13
PIT4810001:Celsr3	UTSW	9	108,845,733 (GRCm38)	missense	probably damaging	1.00
R0110:Celsr3	UTSW	9	108,827,005 (GRCm38)	missense	possibly damaging	0.62
R0243:Celsr3	UTSW	9	108,843,724 (GRCm38)	splice site	probably benign
R0382:Celsr3	UTSW	9	108,829,218 (GRCm38)	missense	probably damaging	1.00
R0482:Celsr3	UTSW	9	108,829,073 (GRCm38)	nonsense	probably null
R0510:Celsr3	UTSW	9	108,827,005 (GRCm38)	missense	possibly damaging	0.62
R0630:Celsr3	UTSW	9	108,827,692 (GRCm38)	missense	probably damaging	0.98
R0656:Celsr3	UTSW	9	108,834,655 (GRCm38)	missense	possibly damaging	0.89
R0764:Celsr3	UTSW	9	108,827,818 (GRCm38)	missense	probably damaging	1.00
R0883:Celsr3	UTSW	9	108,842,633 (GRCm38)	missense	probably damaging	1.00
R0924:Celsr3	UTSW	9	108,846,025 (GRCm38)	missense	possibly damaging	0.78
R1015:Celsr3	UTSW	9	108,833,176 (GRCm38)	missense	probably benign	0.17
R1321:Celsr3	UTSW	9	108,835,870 (GRCm38)	missense	probably damaging	1.00
R1423:Celsr3	UTSW	9	108,826,905 (GRCm38)	missense	probably benign	0.00
R1497:Celsr3	UTSW	9	108,848,865 (GRCm38)	missense	probably benign	0.14
R1520:Celsr3	UTSW	9	108,848,658 (GRCm38)	missense	probably damaging	1.00
R1534:Celsr3	UTSW	9	108,848,884 (GRCm38)	missense	probably damaging	0.99
R1569:Celsr3	UTSW	9	108,829,068 (GRCm38)	missense	probably damaging	1.00
R1657:Celsr3	UTSW	9	108,842,952 (GRCm38)	nonsense	probably null
R1753:Celsr3	UTSW	9	108,831,857 (GRCm38)	missense	probably damaging	0.99
R1764:Celsr3	UTSW	9	108,828,958 (GRCm38)	missense	probably damaging	1.00
R1801:Celsr3	UTSW	9	108,834,626 (GRCm38)	missense	possibly damaging	0.88
R1839:Celsr3	UTSW	9	108,829,906 (GRCm38)	missense	probably benign
R1874:Celsr3	UTSW	9	108,835,838 (GRCm38)	missense	probably benign
R1875:Celsr3	UTSW	9	108,835,838 (GRCm38)	missense	probably benign
R1953:Celsr3	UTSW	9	108,843,182 (GRCm38)	missense	probably benign	0.19
R1960:Celsr3	UTSW	9	108,845,817 (GRCm38)	missense	probably benign
R2113:Celsr3	UTSW	9	108,838,470 (GRCm38)	missense	probably damaging	1.00
R2290:Celsr3	UTSW	9	108,843,224 (GRCm38)	missense	probably damaging	1.00
R2369:Celsr3	UTSW	9	108,842,552 (GRCm38)	missense	probably benign
R2373:Celsr3	UTSW	9	108,842,552 (GRCm38)	missense	probably benign
R2374:Celsr3	UTSW	9	108,842,552 (GRCm38)	missense	probably benign
R2375:Celsr3	UTSW	9	108,842,552 (GRCm38)	missense	probably benign
R2844:Celsr3	UTSW	9	108,829,308 (GRCm38)	missense	probably damaging	1.00
R2968:Celsr3	UTSW	9	108,832,191 (GRCm38)	missense	probably damaging	1.00
R3103:Celsr3	UTSW	9	108,837,139 (GRCm38)	missense	probably benign	0.31
R3159:Celsr3	UTSW	9	108,827,710 (GRCm38)	missense	possibly damaging	0.94
R3791:Celsr3	UTSW	9	108,842,552 (GRCm38)	missense	probably benign
R4194:Celsr3	UTSW	9	108,843,302 (GRCm38)	critical splice donor site	probably null
R4329:Celsr3	UTSW	9	108,846,049 (GRCm38)	missense	probably benign	0.00
R4365:Celsr3	UTSW	9	108,829,847 (GRCm38)	missense	possibly damaging	0.47
R4419:Celsr3	UTSW	9	108,843,244 (GRCm38)	missense	possibly damaging	0.84
R4484:Celsr3	UTSW	9	108,846,063 (GRCm38)	critical splice donor site	probably null
R4582:Celsr3	UTSW	9	108,845,723 (GRCm38)	missense	probably damaging	1.00
R4681:Celsr3	UTSW	9	108,827,754 (GRCm38)	missense	possibly damaging	0.58
R4729:Celsr3	UTSW	9	108,847,652 (GRCm38)	missense	probably benign	0.05
R4881:Celsr3	UTSW	9	108,843,941 (GRCm38)	missense	probably damaging	1.00
R4893:Celsr3	UTSW	9	108,849,421 (GRCm38)	missense	probably damaging	1.00
R5183:Celsr3	UTSW	9	108,837,560 (GRCm38)	missense	probably damaging	0.99
R5207:Celsr3	UTSW	9	108,832,759 (GRCm38)	missense	probably benign	0.01
R5290:Celsr3	UTSW	9	108,843,158 (GRCm38)	missense	probably benign	0.01
R5327:Celsr3	UTSW	9	108,842,708 (GRCm38)	intron	probably benign
R5345:Celsr3	UTSW	9	108,832,124 (GRCm38)	missense	probably damaging	1.00
R5358:Celsr3	UTSW	9	108,832,025 (GRCm38)	missense	possibly damaging	0.96
R5396:Celsr3	UTSW	9	108,828,582 (GRCm38)	missense	probably damaging	1.00
R5414:Celsr3	UTSW	9	108,840,042 (GRCm38)	missense	possibly damaging	0.88
R5452:Celsr3	UTSW	9	108,844,034 (GRCm38)	missense	possibly damaging	0.68
R5467:Celsr3	UTSW	9	108,828,637 (GRCm38)	missense	probably damaging	1.00
R5479:Celsr3	UTSW	9	108,844,544 (GRCm38)	critical splice donor site	probably null
R5629:Celsr3	UTSW	9	108,849,067 (GRCm38)	missense	probably benign	0.41
R5637:Celsr3	UTSW	9	108,837,133 (GRCm38)	missense	probably damaging	1.00
R5652:Celsr3	UTSW	9	108,838,472 (GRCm38)	missense	probably benign	0.03
R5739:Celsr3	UTSW	9	108,827,158 (GRCm38)	missense	probably benign
R5785:Celsr3	UTSW	9	108,827,797 (GRCm38)	missense	probably damaging	1.00
R5877:Celsr3	UTSW	9	108,845,727 (GRCm38)	missense	probably damaging	0.98
R5961:Celsr3	UTSW	9	108,831,794 (GRCm38)	missense	probably damaging	1.00
R6046:Celsr3	UTSW	9	108,837,151 (GRCm38)	missense	probably benign	0.01
R6176:Celsr3	UTSW	9	108,828,355 (GRCm38)	missense	probably damaging	1.00
R6291:Celsr3	UTSW	9	108,828,842 (GRCm38)	missense	probably damaging	1.00
R6468:Celsr3	UTSW	9	108,835,790 (GRCm38)	missense	probably benign	0.08
R6481:Celsr3	UTSW	9	108,837,084 (GRCm38)	missense	possibly damaging	0.92
R6547:Celsr3	UTSW	9	108,829,128 (GRCm38)	missense	probably damaging	1.00
R6763:Celsr3	UTSW	9	108,827,350 (GRCm38)	missense	probably damaging	1.00
R6870:Celsr3	UTSW	9	108,829,191 (GRCm38)	missense	probably benign	0.02
R6977:Celsr3	UTSW	9	108,827,715 (GRCm38)	missense	probably benign
R7061:Celsr3	UTSW	9	108,847,594 (GRCm38)	nonsense	probably null
R7122:Celsr3	UTSW	9	108,828,567 (GRCm38)	missense	possibly damaging	0.90
R7156:Celsr3	UTSW	9	108,838,004 (GRCm38)	missense	possibly damaging	0.95
R7166:Celsr3	UTSW	9	108,842,951 (GRCm38)	missense	probably damaging	1.00
R7176:Celsr3	UTSW	9	108,845,762 (GRCm38)	missense	probably benign
R7213:Celsr3	UTSW	9	108,849,040 (GRCm38)	missense	probably damaging	0.98
R7314:Celsr3	UTSW	9	108,829,144 (GRCm38)	missense	probably damaging	1.00
R7478:Celsr3	UTSW	9	108,843,578 (GRCm38)	missense	probably benign	0.37
R7508:Celsr3	UTSW	9	108,836,622 (GRCm38)	missense	probably benign
R7554:Celsr3	UTSW	9	108,841,209 (GRCm38)	missense	probably benign
R7615:Celsr3	UTSW	9	108,837,652 (GRCm38)	missense	possibly damaging	0.75
R7653:Celsr3	UTSW	9	108,835,070 (GRCm38)	nonsense	probably null
R7747:Celsr3	UTSW	9	108,829,978 (GRCm38)	missense	possibly damaging	0.61
R7881:Celsr3	UTSW	9	108,828,072 (GRCm38)	missense	probably benign	0.28
R7935:Celsr3	UTSW	9	108,829,641 (GRCm38)	missense	probably benign	0.01
R7995:Celsr3	UTSW	9	108,845,083 (GRCm38)	missense	probably damaging	0.99
R8006:Celsr3	UTSW	9	108,829,107 (GRCm38)	missense	probably damaging	1.00
R8077:Celsr3	UTSW	9	108,828,331 (GRCm38)	missense	probably benign	0.15
R8284:Celsr3	UTSW	9	108,846,413 (GRCm38)	missense	probably damaging	0.99
R8291:Celsr3	UTSW	9	108,837,970 (GRCm38)	missense	probably damaging	1.00
R8322:Celsr3	UTSW	9	108,848,794 (GRCm38)	missense	probably damaging	1.00
R8334:Celsr3	UTSW	9	108,841,272 (GRCm38)	frame shift	probably null
R8337:Celsr3	UTSW	9	108,841,272 (GRCm38)	frame shift	probably null
R8338:Celsr3	UTSW	9	108,827,340 (GRCm38)	nonsense	probably null
R8353:Celsr3	UTSW	9	108,826,535 (GRCm38)	missense	probably benign	0.00
R8407:Celsr3	UTSW	9	108,829,057 (GRCm38)	missense	probably damaging	1.00
R8408:Celsr3	UTSW	9	108,831,789 (GRCm38)	missense	probably damaging	1.00
R8459:Celsr3	UTSW	9	108,829,630 (GRCm38)	missense	probably damaging	1.00
R8510:Celsr3	UTSW	9	108,838,120 (GRCm38)	missense	possibly damaging	0.93
R8713:Celsr3	UTSW	9	108,829,863 (GRCm38)	missense	probably benign
R8728:Celsr3	UTSW	9	108,846,741 (GRCm38)	missense	probably benign	0.24
R8829:Celsr3	UTSW	9	108,840,383 (GRCm38)	missense	probably benign
R8877:Celsr3	UTSW	9	108,829,678 (GRCm38)	missense	probably damaging	1.00
R8905:Celsr3	UTSW	9	108,841,302 (GRCm38)	missense	probably damaging	1.00
R9008:Celsr3	UTSW	9	108,828,952 (GRCm38)	missense	possibly damaging	0.94
R9072:Celsr3	UTSW	9	108,827,094 (GRCm38)	missense	probably benign
R9157:Celsr3	UTSW	9	108,829,986 (GRCm38)	missense	probably damaging	1.00
R9183:Celsr3	UTSW	9	108,829,396 (GRCm38)	missense	probably damaging	1.00
R9275:Celsr3	UTSW	9	108,838,490 (GRCm38)	missense	probably benign	0.27
R9361:Celsr3	UTSW	9	108,849,322 (GRCm38)	missense	probably damaging	1.00
R9382:Celsr3	UTSW	9	108,829,762 (GRCm38)	missense	possibly damaging	0.60
R9407:Celsr3	UTSW	9	108,846,397 (GRCm38)	missense	probably damaging	1.00
R9432:Celsr3	UTSW	9	108,848,833 (GRCm38)	missense	probably benign	0.00
R9607:Celsr3	UTSW	9	108,840,502 (GRCm38)	critical splice donor site	probably null
R9626:Celsr3	UTSW	9	108,849,322 (GRCm38)	missense	probably damaging	1.00
R9628:Celsr3	UTSW	9	108,826,360 (GRCm38)	nonsense	probably null
R9630:Celsr3	UTSW	9	108,827,097 (GRCm38)	missense	probably benign
R9645:Celsr3	UTSW	9	108,827,492 (GRCm38)	nonsense	probably null
R9683:Celsr3	UTSW	9	108,827,323 (GRCm38)	missense	probably damaging	1.00
R9794:Celsr3	UTSW	9	108,851,303 (GRCm38)	missense	probably benign	0.00
R9798:Celsr3	UTSW	9	108,828,595 (GRCm38)	missense	probably damaging	1.00
RF020:Celsr3	UTSW	9	108,849,057 (GRCm38)	missense	probably benign
X0018:Celsr3	UTSW	9	108,840,412 (GRCm38)	missense	probably benign	0.01
X0018:Celsr3	UTSW	9	108,827,778 (GRCm38)	missense	possibly damaging	0.65
X0026:Celsr3	UTSW	9	108,828,930 (GRCm38)	missense	probably damaging	0.99
Z1177:Celsr3	UTSW	9	108,826,477 (GRCm38)	missense	probably benign	0.34

Predicted Primers

PCR Primer
(F):5'- TGACCTGGATTATGAGGCTCG -3'
(R):5'- AGATTGTTAGGTTACTTGCCTACCC -3'

Sequencing Primer
(F):5'- ATTATGAGGCTCGTCAGGAATATG -3'
(R):5'- AGGTTACTTGCCTACCCAGCAC -3'

Posted On

2014-06-23