Incidental Mutation 'R0112:Vmn2r108'
ID 20553
Institutional Source Beutler Lab
Gene Symbol Vmn2r108
Ensembl Gene ENSMUSG00000091805
Gene Name vomeronasal 2, receptor 108
Synonyms EG627805
MMRRC Submission 038398-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R0112 (G1)
Quality Score 225
Status Validated (trace)
Chromosome 17
Chromosomal Location 20682635-20701498 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 20691897 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 209 (M209V)
Ref Sequence ENSEMBL: ENSMUSP00000130373 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167314]
AlphaFold E9PYS0
Predicted Effect probably benign
Transcript: ENSMUST00000167314
AA Change: M209V

PolyPhen 2 Score 0.066 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000130373
Gene: ENSMUSG00000091805
AA Change: M209V

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:ANF_receptor 83 467 6e-33 PFAM
Pfam:NCD3G 510 563 9.2e-22 PFAM
Pfam:7tm_3 593 831 2.2e-51 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 96.0%
  • 20x: 91.8%
Validation Efficiency 100% (86/86)
Allele List at MGI
Other mutations in this stock
Total: 81 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930568D16Rik T A 2: 35,244,815 (GRCm39) Y179F probably benign Het
Abcd4 A G 12: 84,659,673 (GRCm39) probably benign Het
Abhd12b C T 12: 70,227,791 (GRCm39) T191M probably benign Het
Adcy5 A G 16: 34,976,548 (GRCm39) E27G possibly damaging Het
Adgb G A 10: 10,282,902 (GRCm39) probably benign Het
Afdn T C 17: 14,104,899 (GRCm39) S1186P probably damaging Het
Atf6b G T 17: 34,870,600 (GRCm39) R351L probably damaging Het
Axin2 T C 11: 108,830,223 (GRCm39) S348P possibly damaging Het
Bfsp1 A C 2: 143,669,563 (GRCm39) probably null Het
Brd1 A G 15: 88,614,586 (GRCm39) V103A probably benign Het
Ccdc13 C A 9: 121,642,547 (GRCm39) K392N probably damaging Het
Ccdc18 A G 5: 108,321,627 (GRCm39) K577R probably damaging Het
Csmd2 G T 4: 128,389,822 (GRCm39) G2186C probably damaging Het
Cyp2j5 A T 4: 96,517,760 (GRCm39) M484K probably benign Het
Defb3 T A 8: 19,343,423 (GRCm39) L12Q probably null Het
Defb7 G T 8: 19,545,186 (GRCm39) probably null Het
Dhx35 T A 2: 158,682,540 (GRCm39) M491K probably damaging Het
Dnah17 T C 11: 117,965,260 (GRCm39) S2261G possibly damaging Het
Dnah5 A C 15: 28,263,825 (GRCm39) E853D probably benign Het
Dner C A 1: 84,560,774 (GRCm39) A23S probably benign Het
Dock5 A C 14: 68,057,090 (GRCm39) S539A probably benign Het
Dsg2 T A 18: 20,716,099 (GRCm39) F317I probably benign Het
Enox1 A T 14: 77,936,638 (GRCm39) I539F possibly damaging Het
Eogt G A 6: 97,112,245 (GRCm39) probably benign Het
Fbxo22 A G 9: 55,130,630 (GRCm39) T300A probably benign Het
Fes T C 7: 80,033,753 (GRCm39) D166G probably damaging Het
Fn1 A G 1: 71,648,812 (GRCm39) S1366P probably damaging Het
Fndc3a A T 14: 72,777,935 (GRCm39) probably benign Het
Foxh1 T C 15: 76,553,210 (GRCm39) H168R probably benign Het
Galnt14 T G 17: 73,881,979 (GRCm39) probably benign Het
Gdf6 A G 4: 9,844,482 (GRCm39) D2G probably damaging Het
Gp6 C A 7: 4,373,183 (GRCm39) A247S probably benign Het
Gp6 G C 7: 4,374,626 (GRCm39) P232A probably benign Het
Grin2c A G 11: 115,141,960 (GRCm39) Y820H probably damaging Het
Gtf2h4 T C 17: 35,981,340 (GRCm39) T198A possibly damaging Het
Helz T C 11: 107,563,774 (GRCm39) probably benign Het
Htr1d A G 4: 136,170,311 (GRCm39) E180G probably benign Het
Igsf10 A G 3: 59,233,429 (GRCm39) V1768A probably benign Het
Ints10 A T 8: 69,279,954 (GRCm39) T694S probably damaging Het
Krt81 C A 15: 101,361,508 (GRCm39) R24L possibly damaging Het
Lipc T A 9: 70,727,709 (GRCm39) Y131F probably damaging Het
Litaf G T 16: 10,784,375 (GRCm39) T45K probably damaging Het
Lmo7 A T 14: 102,124,629 (GRCm39) R363* probably null Het
Lrrc37a A T 11: 103,391,739 (GRCm39) Y1229N probably benign Het
Man2a2 C T 7: 80,008,024 (GRCm39) A943T probably damaging Het
Mtor A G 4: 148,565,380 (GRCm39) Y1030C probably damaging Het
Naalad2 G T 9: 18,262,743 (GRCm39) Y384* probably null Het
Nat2 C T 8: 67,954,378 (GRCm39) Q163* probably null Het
Nell2 A G 15: 95,329,562 (GRCm39) probably benign Het
Nphp3 C T 9: 103,914,547 (GRCm39) H102Y possibly damaging Het
Olr1 T C 6: 129,465,869 (GRCm39) S46G possibly damaging Het
Or2y13 A T 11: 49,414,961 (GRCm39) H137L possibly damaging Het
Or52x1 A T 7: 104,852,866 (GRCm39) M228K probably benign Het
Or5b94 C T 19: 12,652,121 (GRCm39) T184I probably benign Het
Parg C A 14: 31,924,390 (GRCm39) A63E probably damaging Het
Pik3cg A G 12: 32,245,714 (GRCm39) probably benign Het
Ripk4 A G 16: 97,544,761 (GRCm39) C629R probably benign Het
Rnf145 A G 11: 44,454,978 (GRCm39) T620A probably benign Het
Rskr T C 11: 78,182,507 (GRCm39) probably benign Het
Samd9l T G 6: 3,376,031 (GRCm39) D410A possibly damaging Het
Serpinb9f A T 13: 33,511,934 (GRCm39) probably benign Het
Slc19a1 T C 10: 76,877,999 (GRCm39) I178T probably benign Het
Slco1b2 A T 6: 141,616,837 (GRCm39) Y390F probably benign Het
Speg A G 1: 75,361,676 (GRCm39) E230G possibly damaging Het
Tbc1d9 C A 8: 83,991,466 (GRCm39) probably benign Het
Tmem131l G A 3: 83,847,894 (GRCm39) Q324* probably null Het
Trf A G 9: 103,104,155 (GRCm39) probably benign Het
Trp53 T G 11: 69,479,505 (GRCm39) Y202D probably damaging Het
Trpv1 T A 11: 73,144,098 (GRCm39) M618K probably damaging Het
Trrap C A 5: 144,759,571 (GRCm39) Y2250* probably null Het
Ttc3 A G 16: 94,186,181 (GRCm39) probably benign Het
Ubtfl1 T G 9: 18,321,083 (GRCm39) S204A probably benign Het
Uck2 A T 1: 167,055,340 (GRCm39) Y203N probably damaging Het
Utrn A T 10: 12,562,209 (GRCm39) L1280* probably null Het
Vmn1r178 A T 7: 23,593,609 (GRCm39) H146L possibly damaging Het
Vmn2r100 C A 17: 19,742,382 (GRCm39) P252Q possibly damaging Het
Vmn2r9 G A 5: 108,990,991 (GRCm39) T790I probably damaging Het
Vmn2r94 C A 17: 18,463,866 (GRCm39) R808L probably benign Het
Zbtb7c A T 18: 76,269,962 (GRCm39) S17C probably damaging Het
Zfp811 C T 17: 33,016,738 (GRCm39) R434Q probably damaging Het
Zkscan6 A T 11: 65,705,689 (GRCm39) probably benign Het
Other mutations in Vmn2r108
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00903:Vmn2r108 APN 17 20,682,774 (GRCm39) missense probably damaging 0.98
IGL01143:Vmn2r108 APN 17 20,682,727 (GRCm39) missense possibly damaging 0.82
IGL01311:Vmn2r108 APN 17 20,682,939 (GRCm39) nonsense probably null
IGL01411:Vmn2r108 APN 17 20,691,282 (GRCm39) missense probably benign 0.01
IGL01414:Vmn2r108 APN 17 20,691,942 (GRCm39) missense probably benign 0.00
IGL01536:Vmn2r108 APN 17 20,683,543 (GRCm39) missense probably damaging 1.00
IGL01748:Vmn2r108 APN 17 20,683,476 (GRCm39) missense probably benign 0.03
IGL01769:Vmn2r108 APN 17 20,691,280 (GRCm39) missense probably benign 0.02
IGL02022:Vmn2r108 APN 17 20,691,987 (GRCm39) missense possibly damaging 0.77
IGL02041:Vmn2r108 APN 17 20,683,398 (GRCm39) missense probably damaging 1.00
IGL02049:Vmn2r108 APN 17 20,691,608 (GRCm39) missense probably benign 0.00
IGL02344:Vmn2r108 APN 17 20,689,405 (GRCm39) missense probably damaging 1.00
IGL02939:Vmn2r108 APN 17 20,691,545 (GRCm39) missense probably benign 0.05
IGL03202:Vmn2r108 APN 17 20,691,319 (GRCm39) nonsense probably null
PIT4498001:Vmn2r108 UTSW 17 20,683,279 (GRCm39) missense probably damaging 1.00
R0505:Vmn2r108 UTSW 17 20,683,096 (GRCm39) missense possibly damaging 0.77
R0833:Vmn2r108 UTSW 17 20,691,721 (GRCm39) missense probably benign
R0836:Vmn2r108 UTSW 17 20,691,721 (GRCm39) missense probably benign
R0943:Vmn2r108 UTSW 17 20,691,397 (GRCm39) nonsense probably null
R1411:Vmn2r108 UTSW 17 20,683,107 (GRCm39) missense probably damaging 0.98
R1442:Vmn2r108 UTSW 17 20,692,623 (GRCm39) nonsense probably null
R1587:Vmn2r108 UTSW 17 20,692,383 (GRCm39) missense probably damaging 1.00
R1751:Vmn2r108 UTSW 17 20,682,786 (GRCm39) missense probably damaging 1.00
R1773:Vmn2r108 UTSW 17 20,689,335 (GRCm39) missense probably damaging 1.00
R2021:Vmn2r108 UTSW 17 20,691,252 (GRCm39) missense probably benign 0.00
R2159:Vmn2r108 UTSW 17 20,689,363 (GRCm39) missense probably benign 0.41
R2224:Vmn2r108 UTSW 17 20,701,295 (GRCm39) nonsense probably null
R2226:Vmn2r108 UTSW 17 20,701,295 (GRCm39) nonsense probably null
R2517:Vmn2r108 UTSW 17 20,692,577 (GRCm39) missense probably damaging 1.00
R3710:Vmn2r108 UTSW 17 20,682,932 (GRCm39) missense probably benign
R4470:Vmn2r108 UTSW 17 20,682,990 (GRCm39) missense probably damaging 1.00
R4686:Vmn2r108 UTSW 17 20,691,636 (GRCm39) missense probably damaging 0.99
R4729:Vmn2r108 UTSW 17 20,692,632 (GRCm39) missense probably damaging 0.99
R4799:Vmn2r108 UTSW 17 20,682,891 (GRCm39) missense probably damaging 1.00
R4993:Vmn2r108 UTSW 17 20,701,449 (GRCm39) missense probably benign 0.04
R5088:Vmn2r108 UTSW 17 20,690,454 (GRCm39) missense possibly damaging 0.46
R5213:Vmn2r108 UTSW 17 20,691,755 (GRCm39) missense probably benign 0.00
R5289:Vmn2r108 UTSW 17 20,691,866 (GRCm39) missense probably damaging 1.00
R5290:Vmn2r108 UTSW 17 20,691,665 (GRCm39) missense probably benign 0.00
R5713:Vmn2r108 UTSW 17 20,691,290 (GRCm39) missense probably damaging 1.00
R5753:Vmn2r108 UTSW 17 20,683,179 (GRCm39) missense probably damaging 0.99
R5792:Vmn2r108 UTSW 17 20,683,398 (GRCm39) missense probably damaging 0.99
R5798:Vmn2r108 UTSW 17 20,692,545 (GRCm39) missense probably benign 0.39
R5897:Vmn2r108 UTSW 17 20,691,580 (GRCm39) missense probably benign 0.01
R6018:Vmn2r108 UTSW 17 20,683,268 (GRCm39) missense possibly damaging 0.83
R6093:Vmn2r108 UTSW 17 20,701,402 (GRCm39) missense probably benign 0.00
R6156:Vmn2r108 UTSW 17 20,692,447 (GRCm39) missense probably benign 0.03
R6199:Vmn2r108 UTSW 17 20,682,644 (GRCm39) missense probably benign 0.01
R6259:Vmn2r108 UTSW 17 20,683,371 (GRCm39) missense possibly damaging 0.95
R6309:Vmn2r108 UTSW 17 20,691,660 (GRCm39) missense probably damaging 0.98
R6324:Vmn2r108 UTSW 17 20,691,977 (GRCm39) nonsense probably null
R6364:Vmn2r108 UTSW 17 20,691,260 (GRCm39) missense probably benign 0.00
R6446:Vmn2r108 UTSW 17 20,692,609 (GRCm39) nonsense probably null
R6541:Vmn2r108 UTSW 17 20,701,480 (GRCm39) missense probably benign 0.02
R7025:Vmn2r108 UTSW 17 20,691,345 (GRCm39) missense possibly damaging 0.67
R7063:Vmn2r108 UTSW 17 20,701,410 (GRCm39) missense probably damaging 1.00
R7092:Vmn2r108 UTSW 17 20,701,338 (GRCm39) missense probably benign 0.10
R7096:Vmn2r108 UTSW 17 20,682,762 (GRCm39) missense probably damaging 1.00
R7203:Vmn2r108 UTSW 17 20,683,038 (GRCm39) missense probably benign 0.12
R7458:Vmn2r108 UTSW 17 20,692,532 (GRCm39) missense probably benign 0.17
R7619:Vmn2r108 UTSW 17 20,692,457 (GRCm39) missense probably benign 0.02
R7841:Vmn2r108 UTSW 17 20,690,305 (GRCm39) critical splice donor site probably null
R7944:Vmn2r108 UTSW 17 20,691,890 (GRCm39) missense probably damaging 0.99
R8048:Vmn2r108 UTSW 17 20,691,762 (GRCm39) missense probably benign 0.29
R8213:Vmn2r108 UTSW 17 20,690,350 (GRCm39) missense probably benign 0.03
R8218:Vmn2r108 UTSW 17 20,683,465 (GRCm39) missense probably damaging 1.00
R8507:Vmn2r108 UTSW 17 20,683,195 (GRCm39) nonsense probably null
R8708:Vmn2r108 UTSW 17 20,682,687 (GRCm39) missense probably damaging 0.98
R8845:Vmn2r108 UTSW 17 20,691,361 (GRCm39) missense probably benign 0.03
R9030:Vmn2r108 UTSW 17 20,690,312 (GRCm39) missense probably benign 0.01
R9226:Vmn2r108 UTSW 17 20,691,330 (GRCm39) missense probably benign
R9278:Vmn2r108 UTSW 17 20,692,561 (GRCm39) missense probably benign 0.11
X0022:Vmn2r108 UTSW 17 20,691,371 (GRCm39) missense probably damaging 1.00
Z1088:Vmn2r108 UTSW 17 20,691,375 (GRCm39) missense probably benign 0.01
Z1177:Vmn2r108 UTSW 17 20,691,219 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- ACACATCCAGAGAAGCATTGGGTTG -3'
(R):5'- GGTAGGTCCTTGAAACAGACAGGC -3'

Sequencing Primer
(F):5'- TCGCATTAGACCTGTGAGAGAATC -3'
(R):5'- GATGAAGCTACCTTTTTATCCTGTTG -3'
Posted On 2013-04-11