|Institutional Source||Beutler Lab|
|Gene Name||syndecan 4|
|Synonyms||ryudocan, syndecan-4, Synd4|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R1839 (G1)|
|Chromosomal Location||164424247-164443887 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 164429012 bp|
|Amino Acid Change||Glutamic Acid to Glycine at position 109 (E109G)|
|Ref Sequence||ENSEMBL: ENSMUSP00000017153 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000017153]|
|Predicted Effect||probably benign
AA Change: E109G
PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
AA Change: E109G
|Predicted Effect||noncoding transcript
|Meta Mutation Damage Score||0.0616|
|Coding Region Coverage||
|Validation Efficiency||98% (90/92)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous or heterozygous for a knock-out allele show delayed wound healing and impaired angiogenesis. Homozygotes for a different knock-out allele exhibit degenerated fetal vessels in the placental labyrinth, abnormal cell adhesion, and high susceptibility to induced renal and hepatic injury. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Sdc4||
(F):5'- GAAGACTAAAGACCTGCCTGTC -3'
(R):5'- ATGACCTGTACTGGCTGCTC -3'
(F):5'- AAAGACCTGCCTGTCTGCTTC -3'
(R):5'- ACACCCCGCCTGTGTTCG -3'