Mutagenetix > Incidental Mutation

Incidental Mutation 'R1839:Unc13b'

205583

Institutional Source

Beutler Lab

Gene Symbol

Unc13b

Ensembl Gene

ENSMUSG00000028456

Gene Name

unc-13 homolog B (C. elegans)

Synonyms

Unc13h2, Munc13-2

MMRRC Submission

045015-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.259) question?

Stock #

R1839 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

43058953-43264871 bp(+) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 43258308 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000146589 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079978] [ENSMUST00000107952] [ENSMUST00000107953] [ENSMUST00000145899] [ENSMUST00000163653] [ENSMUST00000207569] [ENSMUST00000207708]

AlphaFold

Q9Z1N9

Predicted Effect

probably benign
Transcript: ENSMUST00000079978

SMART Domains

Protein: ENSMUSP00000078894
Gene: ENSMUSG00000028456

Domain	Start	End	E-Value	Type
C2	3	94	1.2e-9	SMART
low complexity region	179	193	N/A	INTRINSIC
low complexity region	292	303	N/A	INTRINSIC
low complexity region	322	333	N/A	INTRINSIC
C1	478	527	4.21e-18	SMART
C2	601	708	2.07e-22	SMART
DUF1041	917	1021	2.02e-53	SMART
Pfam:Membr_traf_MHD	1262	1404	4.8e-60	PFAM
C2	1438	1544	7.56e-16	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000107952

SMART Domains

Protein: ENSMUSP00000103586
Gene: ENSMUSG00000028456

Domain	Start	End	E-Value	Type
C2	3	94	1.2e-9	SMART
low complexity region	191	205	N/A	INTRINSIC
low complexity region	304	315	N/A	INTRINSIC
low complexity region	334	345	N/A	INTRINSIC
C1	490	539	4.21e-18	SMART
C2	613	720	2.07e-22	SMART
DUF1041	929	1033	2.02e-53	SMART
Pfam:Membr_traf_MHD	1274	1416	4.8e-60	PFAM
C2	1450	1556	7.56e-16	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000107953

SMART Domains

Protein: ENSMUSP00000103587
Gene: ENSMUSG00000028456

Domain	Start	End	E-Value	Type
C2	3	94	1.2e-9	SMART
low complexity region	179	193	N/A	INTRINSIC
low complexity region	292	303	N/A	INTRINSIC
low complexity region	322	333	N/A	INTRINSIC
C1	478	527	4.21e-18	SMART
C2	601	708	2.07e-22	SMART
DUF1041	917	1021	2.02e-53	SMART
Pfam:Membr_traf_MHD	1263	1403	2.3e-56	PFAM
C2	1457	1563	7.56e-16	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000143653

Predicted Effect

probably benign
Transcript: ENSMUST00000145899

SMART Domains

Protein: ENSMUSP00000128638
Gene: ENSMUSG00000028456

Domain	Start	End	E-Value	Type
PDB:3SWH\|B	16	190	1e-84	PDB
Blast:DUF1041	55	129	2e-6	BLAST

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000153168

Predicted Effect

probably benign
Transcript: ENSMUST00000163653

SMART Domains

Protein: ENSMUSP00000128608
Gene: ENSMUSG00000028456

Domain	Start	End	E-Value	Type
C2	3	94	1.2e-9	SMART
low complexity region	191	205	N/A	INTRINSIC
low complexity region	304	315	N/A	INTRINSIC
low complexity region	334	345	N/A	INTRINSIC
C1	490	539	4.21e-18	SMART
C2	613	720	2.07e-22	SMART
DUF1041	929	1032	4.64e-53	SMART
Pfam:Membr_traf_MHD	1273	1415	4.8e-60	PFAM
C2	1449	1555	7.56e-16	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000207569

Predicted Effect

probably benign
Transcript: ENSMUST00000207708

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 97.4%
3x: 96.7%
10x: 94.7%
20x: 90.6%

Validation Efficiency

98% (90/92)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutant mice are grossly phenotypically normal. Mice older than 12 months will exhibit sporadic seizures. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 84 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700006A11Rik	T	C	3: 124,409,720 (GRCm38)	T403A	probably damaging	Het
Acat3	T	A	17: 12,928,606 (GRCm38)	R175*	probably null	Het
Adam1b	C	A	5: 121,501,041 (GRCm38)	C647F	probably damaging	Het
Adam28	T	C	14: 68,639,210 (GRCm38)	N197S	possibly damaging	Het
Adcy2	C	T	13: 68,689,261 (GRCm38)		probably null	Het
Adcy5	A	T	16: 35,248,940 (GRCm38)	N426I	probably damaging	Het
Adgre1	T	C	17: 57,441,299 (GRCm38)	S500P	probably benign	Het
Aloxe3	A	G	11: 69,130,085 (GRCm38)	Y212C	probably damaging	Het
Ap3d1	A	G	10: 80,727,108 (GRCm38)	S180P	probably damaging	Het
Arhgap20	C	T	9: 51,849,326 (GRCm38)	R790W	probably damaging	Het
Atp8b4	C	A	2: 126,361,782 (GRCm38)	A757S	possibly damaging	Het
Begain	G	A	12: 109,035,323 (GRCm38)		probably benign	Het
Ccdc141	T	C	2: 77,011,665 (GRCm38)	E1474G	probably benign	Het
Ccdc88b	A	G	19: 6,854,109 (GRCm38)		probably benign	Het
Ccnk	A	G	12: 108,195,074 (GRCm38)	T195A	probably damaging	Het
Cd55b	C	A	1: 130,414,105 (GRCm38)	C265F	probably damaging	Het
Celsr3	A	G	9: 108,829,906 (GRCm38)	H1196R	probably benign	Het
Cenpt	T	C	8: 105,849,014 (GRCm38)	S190G	possibly damaging	Het
Chd8	T	C	14: 52,204,883 (GRCm38)	S2077G	probably benign	Het
Col6a5	G	A	9: 105,864,833 (GRCm38)	H2296Y	probably benign	Het
Cxxc4	C	A	3: 134,240,653 (GRCm38)	H332N	probably damaging	Het
Cyp24a1	T	C	2: 170,496,741 (GRCm38)	I12V	probably benign	Het
Cyp3a57	T	A	5: 145,381,301 (GRCm38)	L364Q	probably damaging	Het
Ddi2	T	C	4: 141,713,526 (GRCm38)	I47V	probably benign	Het
Ddx5	A	T	11: 106,784,897 (GRCm38)	D322E	probably benign	Het
Dhx40	A	G	11: 86,789,297 (GRCm38)	C405R	possibly damaging	Het
Emc1	T	C	4: 139,360,485 (GRCm38)	F100S	probably damaging	Het
Exoc2	T	C	13: 30,906,497 (GRCm38)		probably benign	Het
Gm10110	A	T	14: 89,897,836 (GRCm38)		noncoding transcript	Het
Gm17332	T	C	11: 31,182,386 (GRCm38)	H26R	possibly damaging	Het
Gna12	T	C	5: 140,762,612 (GRCm38)	N183S	probably benign	Het
Gpx6	A	G	13: 21,312,327 (GRCm38)	N24D	probably benign	Het
Gsdma3	C	T	11: 98,629,858 (GRCm38)	A105V	probably benign	Het
Hsd3b5	T	C	3: 98,619,728 (GRCm38)	Y134C	probably benign	Het
Ifi213	T	C	1: 173,589,600 (GRCm38)	I415M	probably damaging	Het
Ints9	C	A	14: 65,016,530 (GRCm38)	P278T	probably damaging	Het
Krt79	C	T	15: 101,937,938 (GRCm38)	E192K	possibly damaging	Het
Lrrk2	A	G	15: 91,683,134 (GRCm38)	N132S	probably benign	Het
Ltn1	T	A	16: 87,416,264 (GRCm38)	K470*	probably null	Het
Magi2	A	T	5: 20,465,827 (GRCm38)	T163S	probably damaging	Het
Mcm9	A	G	10: 53,541,553 (GRCm38)	M18T	probably damaging	Het
Med12l	A	G	3: 59,068,319 (GRCm38)	T212A	probably benign	Het
Mfhas1	T	C	8: 35,590,858 (GRCm38)	L829P	possibly damaging	Het
Mgme1	T	A	2: 144,279,487 (GRCm38)	C288S	probably benign	Het
Muc4	G	C	16: 32,753,919 (GRCm38)	R1265P	probably benign	Het
Myh7	T	C	14: 54,973,180 (GRCm38)	N1725S	possibly damaging	Het
Naa80	G	A	9: 107,583,017 (GRCm38)	R37H	possibly damaging	Het
Nme4	A	T	17: 26,092,097 (GRCm38)	W165R	probably damaging	Het
Nup205	T	A	6: 35,219,714 (GRCm38)	D1128E	probably benign	Het
Or2t48	A	T	11: 58,529,373 (GRCm38)	Y204*	probably null	Het
Or5ae2	T	C	7: 84,856,548 (GRCm38)	Y60H	probably damaging	Het
Pcdh1	T	C	18: 38,199,485 (GRCm38)	D155G	possibly damaging	Het
Pex12	A	T	11: 83,297,822 (GRCm38)	S116T	probably damaging	Het
Plekhh1	C	T	12: 79,078,957 (GRCm38)		probably benign	Het
Plekhh3	A	G	11: 101,163,600 (GRCm38)		probably benign	Het
Pnpt1	T	C	11: 29,154,342 (GRCm38)	M572T	possibly damaging	Het
Ppp1r12b	T	C	1: 134,837,981 (GRCm38)	R667G	probably benign	Het
Rbpms2	ACTGCTGCTGCTGCTGC	ACTGCTGCTGCTGCTGCTGC	9: 65,651,666 (GRCm38)		probably benign	Het
Rgs14	T	C	13: 55,382,838 (GRCm38)		probably benign	Het
Rhbdf2	A	T	11: 116,600,191 (GRCm38)	V645E	possibly damaging	Het
Robo3	A	G	9: 37,422,327 (GRCm38)	V696A	probably benign	Het
Sall1	A	G	8: 89,028,716 (GRCm38)	F1212L	possibly damaging	Het
Sdc4	T	C	2: 164,429,012 (GRCm38)	E109G	probably benign	Het
Serpind1	G	T	16: 17,342,992 (GRCm38)	R462L	probably damaging	Het
Smad9	CTTT	CTT	3: 54,789,179 (GRCm38)		probably benign	Het
Sstr4	C	A	2: 148,395,533 (GRCm38)	N21K	probably benign	Het
Tap1	C	T	17: 34,188,109 (GRCm38)	A77V	possibly damaging	Het
Thap4	T	C	1: 93,750,287 (GRCm38)	E259G	probably benign	Het
Thra	A	G	11: 98,756,143 (GRCm38)	N30S	probably benign	Het
Tmem207	A	T	16: 26,524,821 (GRCm38)	V27E	possibly damaging	Het
Top3a	A	G	11: 60,753,888 (GRCm38)	V305A	probably damaging	Het
Trim59	A	T	3: 69,037,638 (GRCm38)	I123K	probably damaging	Het
Ttn	T	C	2: 76,861,495 (GRCm38)		probably benign	Het
Ubac1	T	A	2: 26,007,738 (GRCm38)	E290V	possibly damaging	Het
Uri1	A	T	7: 37,967,389 (GRCm38)	D206E	probably benign	Het
Utp4	A	G	8: 106,913,454 (GRCm38)	H465R	probably benign	Het
Uvssa	T	C	5: 33,389,752 (GRCm38)	S221P	probably benign	Het
Vmn1r39	T	C	6: 66,805,233 (GRCm38)		probably null	Het
Vps39	A	T	2: 120,325,397 (GRCm38)	L514H	probably damaging	Het
Vps72	G	A	3: 95,119,218 (GRCm38)	R158Q	possibly damaging	Het
Wdr59	T	C	8: 111,485,340 (GRCm38)	D366G	probably benign	Het
Zfp366	C	A	13: 99,228,492 (GRCm38)	Q54K	probably damaging	Het
Zfp523	T	A	17: 28,194,993 (GRCm38)	I34N	probably damaging	Het
Zfp974	G	A	7: 27,910,356 (GRCm38)	P648L	possibly damaging	Het

Other mutations in Unc13b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00392:Unc13b	APN	4	43,240,285 (GRCm38)	missense	probably damaging	1.00
IGL00832:Unc13b	APN	4	43,258,921 (GRCm38)	missense	probably damaging	1.00
IGL01111:Unc13b	APN	4	43,096,927 (GRCm38)	missense	possibly damaging	0.76
IGL01115:Unc13b	APN	4	43,258,492 (GRCm38)	missense	probably damaging	1.00
IGL01137:Unc13b	APN	4	43,091,291 (GRCm38)	missense	probably damaging	1.00
IGL01637:Unc13b	APN	4	43,241,066 (GRCm38)	missense	probably damaging	1.00
IGL01789:Unc13b	APN	4	43,239,462 (GRCm38)	missense	probably damaging	1.00
IGL01792:Unc13b	APN	4	43,250,218 (GRCm38)	missense	probably damaging	0.99
IGL01877:Unc13b	APN	4	43,249,583 (GRCm38)	critical splice donor site	probably null
IGL01924:Unc13b	APN	4	43,239,385 (GRCm38)	nonsense	probably null
IGL02087:Unc13b	APN	4	43,091,270 (GRCm38)	missense	probably null	1.00
IGL02197:Unc13b	APN	4	43,165,828 (GRCm38)	missense	probably damaging	0.99
IGL02504:Unc13b	APN	4	43,263,031 (GRCm38)	missense	probably damaging	1.00
IGL02659:Unc13b	APN	4	43,235,332 (GRCm38)	missense	probably damaging	1.00
IGL03031:Unc13b	APN	4	43,235,368 (GRCm38)	missense	probably damaging	1.00
IGL03036:Unc13b	APN	4	43,235,249 (GRCm38)	missense	probably damaging	1.00
IGL03209:Unc13b	APN	4	43,239,351 (GRCm38)	missense	probably damaging	0.99
IGL03352:Unc13b	APN	4	43,237,110 (GRCm38)	missense	possibly damaging	0.90
BB006:Unc13b	UTSW	4	43,174,399 (GRCm38)	missense	unknown
BB016:Unc13b	UTSW	4	43,174,399 (GRCm38)	missense	unknown
G1Funyon:Unc13b	UTSW	4	43,263,568 (GRCm38)	missense	probably benign
P0028:Unc13b	UTSW	4	43,256,225 (GRCm38)	missense	probably damaging	1.00
PIT4585001:Unc13b	UTSW	4	43,091,298 (GRCm38)	missense	probably benign	0.03
R0019:Unc13b	UTSW	4	43,096,990 (GRCm38)	missense	possibly damaging	0.58
R0019:Unc13b	UTSW	4	43,096,990 (GRCm38)	missense	possibly damaging	0.58
R0335:Unc13b	UTSW	4	43,236,983 (GRCm38)	missense	possibly damaging	0.95
R0504:Unc13b	UTSW	4	43,263,559 (GRCm38)	missense	probably damaging	0.99
R0631:Unc13b	UTSW	4	43,182,849 (GRCm38)	missense	possibly damaging	0.47
R0748:Unc13b	UTSW	4	43,241,164 (GRCm38)	splice site	probably benign
R1275:Unc13b	UTSW	4	43,235,366 (GRCm38)	missense	probably damaging	1.00
R1293:Unc13b	UTSW	4	43,235,190 (GRCm38)	missense	probably damaging	1.00
R1434:Unc13b	UTSW	4	43,239,385 (GRCm38)	nonsense	probably null
R1552:Unc13b	UTSW	4	43,237,144 (GRCm38)	missense	probably damaging	0.99
R1591:Unc13b	UTSW	4	43,244,747 (GRCm38)	missense	probably damaging	1.00
R1628:Unc13b	UTSW	4	43,263,371 (GRCm38)	missense	probably damaging	1.00
R1740:Unc13b	UTSW	4	43,240,285 (GRCm38)	missense	probably damaging	1.00
R2045:Unc13b	UTSW	4	43,091,266 (GRCm38)	missense	probably damaging	1.00
R2191:Unc13b	UTSW	4	43,245,566 (GRCm38)	nonsense	probably null
R2259:Unc13b	UTSW	4	43,182,780 (GRCm38)	missense	possibly damaging	0.87
R2307:Unc13b	UTSW	4	43,239,854 (GRCm38)	missense	probably damaging	0.98
R2317:Unc13b	UTSW	4	43,245,514 (GRCm38)	missense	probably damaging	1.00
R2402:Unc13b	UTSW	4	43,095,843 (GRCm38)	missense	probably benign
R2847:Unc13b	UTSW	4	43,180,404 (GRCm38)	missense	probably benign	0.04
R3414:Unc13b	UTSW	4	43,234,658 (GRCm38)	splice site	probably benign
R3436:Unc13b	UTSW	4	43,097,028 (GRCm38)	splice site	probably benign
R3955:Unc13b	UTSW	4	43,256,834 (GRCm38)	missense	probably damaging	1.00
R3957:Unc13b	UTSW	4	43,256,834 (GRCm38)	missense	probably damaging	1.00
R4015:Unc13b	UTSW	4	43,237,801 (GRCm38)	missense	probably damaging	1.00
R4650:Unc13b	UTSW	4	43,261,035 (GRCm38)	missense	probably damaging	0.97
R4836:Unc13b	UTSW	4	43,237,137 (GRCm38)	missense	probably damaging	1.00
R5041:Unc13b	UTSW	4	43,237,836 (GRCm38)	missense	probably benign	0.41
R5413:Unc13b	UTSW	4	43,257,936 (GRCm38)	critical splice donor site	probably null
R5994:Unc13b	UTSW	4	43,172,596 (GRCm38)	intron	probably benign
R6015:Unc13b	UTSW	4	43,177,995 (GRCm38)	nonsense	probably null
R6090:Unc13b	UTSW	4	43,239,306 (GRCm38)	missense	probably damaging	1.00
R6242:Unc13b	UTSW	4	43,165,800 (GRCm38)	missense	possibly damaging	0.92
R6246:Unc13b	UTSW	4	43,216,246 (GRCm38)	missense	probably benign	0.18
R6427:Unc13b	UTSW	4	43,176,966 (GRCm38)	unclassified	probably benign
R6660:Unc13b	UTSW	4	43,177,412 (GRCm38)	unclassified	probably benign
R6670:Unc13b	UTSW	4	43,255,562 (GRCm38)	missense	probably damaging	0.99
R6753:Unc13b	UTSW	4	43,239,331 (GRCm38)	missense	probably damaging	1.00
R6858:Unc13b	UTSW	4	43,165,828 (GRCm38)	missense	possibly damaging	0.85
R6886:Unc13b	UTSW	4	43,170,156 (GRCm38)	intron	probably benign
R6969:Unc13b	UTSW	4	43,263,538 (GRCm38)	missense	possibly damaging	0.94
R6994:Unc13b	UTSW	4	43,173,203 (GRCm38)	intron	probably benign
R6994:Unc13b	UTSW	4	43,171,403 (GRCm38)	intron	probably benign
R7080:Unc13b	UTSW	4	43,171,926 (GRCm38)	missense	unknown
R7117:Unc13b	UTSW	4	43,216,544 (GRCm38)	missense	probably benign	0.33
R7132:Unc13b	UTSW	4	43,215,757 (GRCm38)	missense	probably benign	0.17
R7181:Unc13b	UTSW	4	43,258,893 (GRCm38)	missense	probably damaging	0.99
R7192:Unc13b	UTSW	4	43,258,519 (GRCm38)	missense	probably damaging	1.00
R7246:Unc13b	UTSW	4	43,172,910 (GRCm38)	missense	unknown
R7342:Unc13b	UTSW	4	43,258,703 (GRCm38)	missense	probably damaging	0.99
R7345:Unc13b	UTSW	4	43,173,966 (GRCm38)	missense	unknown
R7355:Unc13b	UTSW	4	43,237,754 (GRCm38)	missense	probably damaging	1.00
R7391:Unc13b	UTSW	4	43,216,459 (GRCm38)	missense	probably benign	0.03
R7419:Unc13b	UTSW	4	43,174,023 (GRCm38)	missense	unknown
R7424:Unc13b	UTSW	4	43,172,235 (GRCm38)	missense	unknown
R7517:Unc13b	UTSW	4	43,215,765 (GRCm38)	missense	probably benign
R7532:Unc13b	UTSW	4	43,249,565 (GRCm38)	missense	probably benign	0.44
R7564:Unc13b	UTSW	4	43,091,258 (GRCm38)	missense	probably damaging	1.00
R7598:Unc13b	UTSW	4	43,263,569 (GRCm38)	missense	probably benign	0.20
R7604:Unc13b	UTSW	4	43,256,776 (GRCm38)	missense	possibly damaging	0.95
R7604:Unc13b	UTSW	4	43,170,102 (GRCm38)	missense	unknown
R7643:Unc13b	UTSW	4	43,216,333 (GRCm38)	missense	probably benign
R7718:Unc13b	UTSW	4	43,173,854 (GRCm38)	missense	unknown
R7735:Unc13b	UTSW	4	43,165,791 (GRCm38)	missense	probably damaging	1.00
R7756:Unc13b	UTSW	4	43,177,312 (GRCm38)	small deletion	probably benign
R7757:Unc13b	UTSW	4	43,177,341 (GRCm38)	small insertion	probably benign
R7757:Unc13b	UTSW	4	43,177,330 (GRCm38)	small insertion	probably benign
R7757:Unc13b	UTSW	4	43,177,312 (GRCm38)	small deletion	probably benign
R7758:Unc13b	UTSW	4	43,177,344 (GRCm38)	small insertion	probably benign
R7758:Unc13b	UTSW	4	43,177,312 (GRCm38)	small insertion	probably benign
R7781:Unc13b	UTSW	4	43,259,546 (GRCm38)	missense	possibly damaging	0.87
R7793:Unc13b	UTSW	4	43,172,737 (GRCm38)	missense	unknown
R7858:Unc13b	UTSW	4	43,176,285 (GRCm38)	missense	unknown
R7867:Unc13b	UTSW	4	43,232,573 (GRCm38)	nonsense	probably null
R7897:Unc13b	UTSW	4	43,171,860 (GRCm38)	missense	unknown
R7904:Unc13b	UTSW	4	43,217,075 (GRCm38)	missense	probably benign
R7929:Unc13b	UTSW	4	43,174,399 (GRCm38)	missense	unknown
R7984:Unc13b	UTSW	4	43,173,973 (GRCm38)	missense	unknown
R8069:Unc13b	UTSW	4	43,177,597 (GRCm38)	missense	unknown
R8101:Unc13b	UTSW	4	43,239,918 (GRCm38)	missense	probably benign	0.08
R8246:Unc13b	UTSW	4	43,175,954 (GRCm38)	missense	unknown
R8289:Unc13b	UTSW	4	43,172,524 (GRCm38)	nonsense	probably null
R8301:Unc13b	UTSW	4	43,263,568 (GRCm38)	missense	probably benign
R8397:Unc13b	UTSW	4	43,217,290 (GRCm38)	missense	probably benign	0.12
R8421:Unc13b	UTSW	4	43,178,304 (GRCm38)	missense	unknown
R8738:Unc13b	UTSW	4	43,177,564 (GRCm38)	missense	unknown
R8746:Unc13b	UTSW	4	43,176,120 (GRCm38)	missense	unknown
R8766:Unc13b	UTSW	4	43,174,722 (GRCm38)	missense	unknown
R8825:Unc13b	UTSW	4	43,237,683 (GRCm38)	splice site	probably benign
R8834:Unc13b	UTSW	4	43,175,954 (GRCm38)	missense	unknown
R8862:Unc13b	UTSW	4	43,235,207 (GRCm38)	missense	probably damaging	1.00
R8864:Unc13b	UTSW	4	43,174,724 (GRCm38)	missense	unknown
R8889:Unc13b	UTSW	4	43,176,484 (GRCm38)	missense	unknown
R8892:Unc13b	UTSW	4	43,176,484 (GRCm38)	missense	unknown
R8904:Unc13b	UTSW	4	43,178,531 (GRCm38)	intron	probably benign
R9089:Unc13b	UTSW	4	43,095,847 (GRCm38)	missense	probably damaging	1.00
R9144:Unc13b	UTSW	4	43,173,649 (GRCm38)	missense	unknown
R9149:Unc13b	UTSW	4	43,176,186 (GRCm38)	missense	unknown
R9173:Unc13b	UTSW	4	43,177,421 (GRCm38)	missense	unknown
R9200:Unc13b	UTSW	4	43,257,352 (GRCm38)	missense	possibly damaging	0.50
R9232:Unc13b	UTSW	4	43,240,321 (GRCm38)	missense	probably benign	0.03
R9269:Unc13b	UTSW	4	43,171,955 (GRCm38)	missense	unknown
R9320:Unc13b	UTSW	4	43,171,044 (GRCm38)	missense	unknown
R9335:Unc13b	UTSW	4	43,255,551 (GRCm38)	missense	probably damaging	0.99
R9335:Unc13b	UTSW	4	43,216,123 (GRCm38)	missense	possibly damaging	0.86
R9352:Unc13b	UTSW	4	43,177,313 (GRCm38)	nonsense	probably null
R9352:Unc13b	UTSW	4	43,177,312 (GRCm38)	small insertion	probably benign
R9378:Unc13b	UTSW	4	43,173,282 (GRCm38)	missense	unknown
R9382:Unc13b	UTSW	4	43,172,512 (GRCm38)	missense	unknown
R9569:Unc13b	UTSW	4	43,177,312 (GRCm38)	small deletion	probably benign
R9622:Unc13b	UTSW	4	43,172,513 (GRCm38)	missense
R9687:Unc13b	UTSW	4	43,174,920 (GRCm38)	missense	unknown
R9704:Unc13b	UTSW	4	43,237,102 (GRCm38)	missense	probably benign	0.31
R9721:Unc13b	UTSW	4	43,101,869 (GRCm38)	missense	probably benign
R9753:Unc13b	UTSW	4	43,182,842 (GRCm38)	nonsense	probably null
RF016:Unc13b	UTSW	4	43,177,350 (GRCm38)	small insertion	probably benign
RF016:Unc13b	UTSW	4	43,177,347 (GRCm38)	small insertion	probably benign
RF041:Unc13b	UTSW	4	43,177,338 (GRCm38)	small insertion	probably benign
RF056:Unc13b	UTSW	4	43,177,359 (GRCm38)	small insertion	probably benign
Z1176:Unc13b	UTSW	4	43,177,764 (GRCm38)	missense	unknown
Z1176:Unc13b	UTSW	4	43,177,191 (GRCm38)	missense	unknown
Z1176:Unc13b	UTSW	4	43,171,419 (GRCm38)	missense	unknown
Z1176:Unc13b	UTSW	4	43,261,043 (GRCm38)	missense	probably benign	0.11
Z1177:Unc13b	UTSW	4	43,173,669 (GRCm38)	missense	unknown

Predicted Primers

PCR Primer
(F):5'- ACTGTCAGTGTGGGGAACAG -3'
(R):5'- CGCTCCATGGTGTTCATCAC -3'

Sequencing Primer
(F):5'- CTGCACTGTAGGCATATGTGTAGC -3'
(R):5'- TGTTCATCACCACCCGCCAG -3'

Posted On

2014-06-23