Incidental Mutation 'R0113:Fcrla'
ID 20563
Institutional Source Beutler Lab
Gene Symbol Fcrla
Ensembl Gene ENSMUSG00000038421
Gene Name Fc receptor-like A
Synonyms mFREB, Freb1, Fcrx, mFcrX, FREB, FCRL1
MMRRC Submission 038399-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0113 (G1)
Quality Score 225
Status Validated (trace)
Chromosome 1
Chromosomal Location 170745163-170755169 bp(-) (GRCm39)
Type of Mutation start codon destroyed
DNA Base Change (assembly) A to T at 170749868 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 1 (M1K)
Ref Sequence ENSEMBL: ENSMUSP00000124469 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046322] [ENSMUST00000159149] [ENSMUST00000159171] [ENSMUST00000162136] [ENSMUST00000162887]
AlphaFold Q920A9
Predicted Effect probably benign
Transcript: ENSMUST00000046322
AA Change: M63K

PolyPhen 2 Score 0.080 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000036380
Gene: ENSMUSG00000038421
AA Change: M63K

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
low complexity region 49 62 N/A INTRINSIC
IG 95 177 5.75e-4 SMART
IG 188 272 1.4e-7 SMART
low complexity region 281 296 N/A INTRINSIC
low complexity region 310 323 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000159149
AA Change: M34K

PolyPhen 2 Score 0.330 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000125074
Gene: ENSMUSG00000038421
AA Change: M34K

DomainStartEndE-ValueType
low complexity region 20 33 N/A INTRINSIC
IG 66 148 5.75e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000159171
AA Change: M62K

PolyPhen 2 Score 0.044 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000124853
Gene: ENSMUSG00000038421
AA Change: M62K

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
low complexity region 48 61 N/A INTRINSIC
IG 94 176 5.75e-4 SMART
IG 187 271 1.4e-7 SMART
low complexity region 280 295 N/A INTRINSIC
low complexity region 309 322 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159266
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161050
Predicted Effect probably benign
Transcript: ENSMUST00000162136
AA Change: M63K

PolyPhen 2 Score 0.300 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000124859
Gene: ENSMUSG00000038421
AA Change: M63K

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
low complexity region 49 62 N/A INTRINSIC
Pfam:Ig_2 83 150 2.2e-6 PFAM
Pfam:Ig_2 156 215 1e-3 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000162887
AA Change: M1K

PolyPhen 2 Score 0.044 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000124469
Gene: ENSMUSG00000038421
AA Change: M1K

DomainStartEndE-ValueType
Pfam:Ig_2 28 78 1.4e-7 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.1%
  • 10x: 95.2%
  • 20x: 87.5%
Validation Efficiency 99% (70/71)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by antibodies. This encoded protein is selectively expressed in B cells, and may be involved in their development. This protein may also be involved in the development of lymphomas. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
PHENOTYPE: Mice homozygous for a targeted allele exhibit largely normal T-dependent and T-independent antibody responses with an increase in IgG1 after secondary challenge with sheep red blood cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3930402G23Rik A G 8: 10,976,126 (GRCm39) noncoding transcript Het
Abca13 A T 11: 9,242,114 (GRCm39) I1326F possibly damaging Het
Arnt2 G A 7: 83,996,738 (GRCm39) R63C probably damaging Het
Aspscr1 C G 11: 120,579,751 (GRCm39) Q97E probably damaging Het
Atad2 A G 15: 57,984,330 (GRCm39) probably benign Het
Atcay A T 10: 81,050,554 (GRCm39) probably null Het
Brme1 C T 8: 84,893,871 (GRCm39) T311I probably damaging Het
C4b T A 17: 34,960,214 (GRCm39) Y279F probably damaging Het
Cav1 A T 6: 17,308,048 (GRCm39) S67C possibly damaging Het
Ceacam23 G A 7: 17,642,873 (GRCm39) noncoding transcript Het
Celf2 A C 2: 6,629,525 (GRCm39) H113Q probably damaging Het
Cep170 A C 1: 176,586,021 (GRCm39) N590K probably damaging Het
Ces1f A T 8: 94,006,327 (GRCm39) M1K probably null Het
Chrna1 C A 2: 73,397,180 (GRCm39) D370Y possibly damaging Het
Csmd1 C A 8: 16,034,849 (GRCm39) G2441C probably damaging Het
D630003M21Rik C T 2: 158,038,495 (GRCm39) D984N possibly damaging Het
Dhrs1 T C 14: 55,977,396 (GRCm39) T241A probably benign Het
Edar A C 10: 58,465,271 (GRCm39) C31G probably damaging Het
Eps8 A G 6: 137,514,682 (GRCm39) S24P possibly damaging Het
Fam149a T C 8: 45,794,061 (GRCm39) E669G probably damaging Het
G3bp1 T A 11: 55,386,252 (GRCm39) V237E probably benign Het
Galnt5 A G 2: 57,888,889 (GRCm39) E163G probably benign Het
Gpr87 T C 3: 59,086,932 (GRCm39) D192G possibly damaging Het
Ino80 G A 2: 119,213,441 (GRCm39) R1249C probably damaging Het
Ints1 T C 5: 139,750,968 (GRCm39) T810A Het
Kalrn A G 16: 33,870,306 (GRCm39) probably benign Het
Kcnk6 T C 7: 28,931,634 (GRCm39) D92G probably damaging Het
Marf1 C T 16: 13,960,398 (GRCm39) A549T probably damaging Het
Mfsd13a C T 19: 46,354,943 (GRCm39) T40I probably benign Het
Mfsd6 A T 1: 52,748,348 (GRCm39) N172K probably damaging Het
Mtcl1 G T 17: 66,661,237 (GRCm39) Q1225K possibly damaging Het
Nav2 C T 7: 49,185,701 (GRCm39) T948M probably damaging Het
Nfic T C 10: 81,256,419 (GRCm39) K104E probably damaging Het
Nup58 G A 14: 60,488,740 (GRCm39) probably benign Het
Nwd2 A T 5: 63,965,241 (GRCm39) K1608N probably damaging Het
Or10n1 T A 9: 39,525,298 (GRCm39) I145K probably benign Het
Or1j21 G A 2: 36,684,006 (GRCm39) G253R probably damaging Het
Or1j21 G T 2: 36,684,007 (GRCm39) G253V probably damaging Het
Phf21b T C 15: 84,688,968 (GRCm39) D186G probably damaging Het
Poli C T 18: 70,661,829 (GRCm39) C57Y probably damaging Het
Ppp1r16a C T 15: 76,574,999 (GRCm39) probably benign Het
Psg23 T C 7: 18,345,927 (GRCm39) Y256C probably benign Het
Satb1 C A 17: 52,089,726 (GRCm39) E374* probably null Het
Scn4a C T 11: 106,236,262 (GRCm39) E333K probably benign Het
Sec14l2 C T 11: 4,053,661 (GRCm39) probably benign Het
Slain1 T C 14: 103,923,261 (GRCm39) probably benign Het
Snapc1 C T 12: 74,021,806 (GRCm39) R81C probably damaging Het
Syne2 T C 12: 75,977,352 (GRCm39) S1266P probably damaging Het
Syne2 A G 12: 76,080,496 (GRCm39) E4810G probably damaging Het
Tbck T C 3: 132,448,841 (GRCm39) I618T probably damaging Het
Tmem132d A T 5: 127,861,657 (GRCm39) N821K probably benign Het
Trim28 T A 7: 12,762,628 (GRCm39) V381E probably damaging Het
Ttc1 T C 11: 43,636,115 (GRCm39) S43G probably benign Het
Ube2u A G 4: 100,338,852 (GRCm39) E39G possibly damaging Het
Urb2 T C 8: 124,757,665 (GRCm39) V1124A probably benign Het
Usp13 A G 3: 32,872,025 (GRCm39) probably benign Het
Vmn1r216 A T 13: 23,283,631 (GRCm39) S105C probably damaging Het
Yipf2 T C 9: 21,501,412 (GRCm39) T23A probably damaging Het
Zfp521 G A 18: 13,978,148 (GRCm39) T755M probably damaging Het
Zfp619 T A 7: 39,187,183 (GRCm39) M1071K probably benign Het
Zfp942 A T 17: 22,148,066 (GRCm39) C188S probably benign Het
Other mutations in Fcrla
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Fcrla APN 1 170,755,067 (GRCm39) missense probably benign 0.00
IGL01712:Fcrla APN 1 170,749,192 (GRCm39) splice site probably null
IGL03323:Fcrla APN 1 170,755,114 (GRCm39) utr 5 prime probably benign
R1457:Fcrla UTSW 1 170,748,573 (GRCm39) missense probably damaging 1.00
R1917:Fcrla UTSW 1 170,755,095 (GRCm39) nonsense probably null
R4331:Fcrla UTSW 1 170,749,245 (GRCm39) missense possibly damaging 0.74
R4819:Fcrla UTSW 1 170,748,508 (GRCm39) missense probably damaging 0.99
R4923:Fcrla UTSW 1 170,748,682 (GRCm39) missense probably damaging 1.00
R5000:Fcrla UTSW 1 170,749,959 (GRCm39) missense probably benign 0.03
R5441:Fcrla UTSW 1 170,752,991 (GRCm39) intron probably benign
R5459:Fcrla UTSW 1 170,745,738 (GRCm39) missense possibly damaging 0.68
R6575:Fcrla UTSW 1 170,749,797 (GRCm39) missense probably damaging 1.00
R7369:Fcrla UTSW 1 170,749,886 (GRCm39) missense probably benign 0.23
R7786:Fcrla UTSW 1 170,748,426 (GRCm39) missense possibly damaging 0.93
R9276:Fcrla UTSW 1 170,755,135 (GRCm39) unclassified probably benign
R9482:Fcrla UTSW 1 170,745,949 (GRCm39) missense probably benign 0.00
R9585:Fcrla UTSW 1 170,749,868 (GRCm39) start codon destroyed probably null 0.04
R9622:Fcrla UTSW 1 170,749,808 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- ATGGGGAACGTCTACCTATGCCAG -3'
(R):5'- AAGGTCAAAGCCATCCCAGTGAAG -3'

Sequencing Primer
(F):5'- CTATGCCAGTTCCCTGAGTGG -3'
(R):5'- TGAAGACCCATAGGAGCCTCTTAG -3'
Posted On 2013-04-11