Incidental Mutation 'R0113:Gpr87'
ID 20571
Institutional Source Beutler Lab
Gene Symbol Gpr87
Ensembl Gene ENSMUSG00000051431
Gene Name G protein-coupled receptor 87
Synonyms
MMRRC Submission 038399-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0113 (G1)
Quality Score 225
Status Validated (trace)
Chromosome 3
Chromosomal Location 59086344-59102525 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 59086932 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 192 (D192G)
Ref Sequence ENSEMBL: ENSMUSP00000059272 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040325] [ENSMUST00000056898] [ENSMUST00000164225] [ENSMUST00000199659] [ENSMUST00000200095]
AlphaFold Q99MT7
Predicted Effect probably benign
Transcript: ENSMUST00000040325
SMART Domains Protein: ENSMUSP00000042269
Gene: ENSMUSG00000056476

DomainStartEndE-ValueType
Med12 101 161 1.71e-24 SMART
low complexity region 216 224 N/A INTRINSIC
low complexity region 269 278 N/A INTRINSIC
Pfam:Med12-LCEWAV 282 730 2.6e-207 PFAM
low complexity region 744 758 N/A INTRINSIC
low complexity region 853 872 N/A INTRINSIC
low complexity region 1455 1466 N/A INTRINSIC
low complexity region 1728 1742 N/A INTRINSIC
low complexity region 1769 1783 N/A INTRINSIC
Pfam:Med12-PQL 1803 2029 2.3e-14 PFAM
low complexity region 2055 2076 N/A INTRINSIC
low complexity region 2083 2101 N/A INTRINSIC
low complexity region 2116 2136 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000056898
AA Change: D192G

PolyPhen 2 Score 0.860 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000059272
Gene: ENSMUSG00000051431
AA Change: D192G

DomainStartEndE-ValueType
Pfam:7tm_1 60 315 1.4e-36 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000164225
SMART Domains Protein: ENSMUSP00000127038
Gene: ENSMUSG00000056476

DomainStartEndE-ValueType
Med12 101 161 1.71e-24 SMART
low complexity region 216 224 N/A INTRINSIC
low complexity region 269 278 N/A INTRINSIC
Pfam:Med12-LCEWAV 283 765 5e-187 PFAM
low complexity region 779 793 N/A INTRINSIC
low complexity region 888 907 N/A INTRINSIC
low complexity region 1490 1501 N/A INTRINSIC
low complexity region 1763 1777 N/A INTRINSIC
low complexity region 1804 1818 N/A INTRINSIC
Pfam:Med12-PQL 1840 2063 9.7e-66 PFAM
low complexity region 2090 2111 N/A INTRINSIC
low complexity region 2118 2136 N/A INTRINSIC
low complexity region 2151 2171 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000199659
SMART Domains Protein: ENSMUSP00000142903
Gene: ENSMUSG00000056476

DomainStartEndE-ValueType
Med12 101 161 1.71e-24 SMART
low complexity region 216 224 N/A INTRINSIC
low complexity region 269 278 N/A INTRINSIC
Pfam:Med12-LCEWAV 282 765 5.5e-209 PFAM
low complexity region 779 793 N/A INTRINSIC
low complexity region 888 907 N/A INTRINSIC
low complexity region 1490 1501 N/A INTRINSIC
low complexity region 1761 1775 N/A INTRINSIC
low complexity region 1802 1816 N/A INTRINSIC
Pfam:Med12-PQL 1836 2062 1.7e-15 PFAM
low complexity region 2088 2130 N/A INTRINSIC
low complexity region 2144 2164 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199833
Predicted Effect possibly damaging
Transcript: ENSMUST00000200095
AA Change: D191G

PolyPhen 2 Score 0.707 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000143683
Gene: ENSMUSG00000051431
AA Change: D191G

DomainStartEndE-ValueType
Pfam:7tm_1 59 314 3.5e-37 PFAM
Meta Mutation Damage Score 0.2846 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.1%
  • 10x: 95.2%
  • 20x: 87.5%
Validation Efficiency 99% (70/71)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G protein-coupled receptor and is located in a cluster of G protein-couple receptor genes on chromosome 3. The encoded protein has been shown to be overexpressed in lung squamous cell carcinoma (PMID:18057535) and regulated by p53 (PMID:19602589). [provided by RefSeq, Nov 2011]
PHENOTYPE: Mice homozygous for a null allele exhibit decreased mean vertebral and femoral bone measurements. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3930402G23Rik A G 8: 10,976,126 (GRCm39) noncoding transcript Het
Abca13 A T 11: 9,242,114 (GRCm39) I1326F possibly damaging Het
Arnt2 G A 7: 83,996,738 (GRCm39) R63C probably damaging Het
Aspscr1 C G 11: 120,579,751 (GRCm39) Q97E probably damaging Het
Atad2 A G 15: 57,984,330 (GRCm39) probably benign Het
Atcay A T 10: 81,050,554 (GRCm39) probably null Het
Brme1 C T 8: 84,893,871 (GRCm39) T311I probably damaging Het
C4b T A 17: 34,960,214 (GRCm39) Y279F probably damaging Het
Cav1 A T 6: 17,308,048 (GRCm39) S67C possibly damaging Het
Ceacam23 G A 7: 17,642,873 (GRCm39) noncoding transcript Het
Celf2 A C 2: 6,629,525 (GRCm39) H113Q probably damaging Het
Cep170 A C 1: 176,586,021 (GRCm39) N590K probably damaging Het
Ces1f A T 8: 94,006,327 (GRCm39) M1K probably null Het
Chrna1 C A 2: 73,397,180 (GRCm39) D370Y possibly damaging Het
Csmd1 C A 8: 16,034,849 (GRCm39) G2441C probably damaging Het
D630003M21Rik C T 2: 158,038,495 (GRCm39) D984N possibly damaging Het
Dhrs1 T C 14: 55,977,396 (GRCm39) T241A probably benign Het
Edar A C 10: 58,465,271 (GRCm39) C31G probably damaging Het
Eps8 A G 6: 137,514,682 (GRCm39) S24P possibly damaging Het
Fam149a T C 8: 45,794,061 (GRCm39) E669G probably damaging Het
Fcrla A T 1: 170,749,868 (GRCm39) M1K probably null Het
G3bp1 T A 11: 55,386,252 (GRCm39) V237E probably benign Het
Galnt5 A G 2: 57,888,889 (GRCm39) E163G probably benign Het
Ino80 G A 2: 119,213,441 (GRCm39) R1249C probably damaging Het
Ints1 T C 5: 139,750,968 (GRCm39) T810A Het
Kalrn A G 16: 33,870,306 (GRCm39) probably benign Het
Kcnk6 T C 7: 28,931,634 (GRCm39) D92G probably damaging Het
Marf1 C T 16: 13,960,398 (GRCm39) A549T probably damaging Het
Mfsd13a C T 19: 46,354,943 (GRCm39) T40I probably benign Het
Mfsd6 A T 1: 52,748,348 (GRCm39) N172K probably damaging Het
Mtcl1 G T 17: 66,661,237 (GRCm39) Q1225K possibly damaging Het
Nav2 C T 7: 49,185,701 (GRCm39) T948M probably damaging Het
Nfic T C 10: 81,256,419 (GRCm39) K104E probably damaging Het
Nup58 G A 14: 60,488,740 (GRCm39) probably benign Het
Nwd2 A T 5: 63,965,241 (GRCm39) K1608N probably damaging Het
Or10n1 T A 9: 39,525,298 (GRCm39) I145K probably benign Het
Or1j21 G A 2: 36,684,006 (GRCm39) G253R probably damaging Het
Or1j21 G T 2: 36,684,007 (GRCm39) G253V probably damaging Het
Phf21b T C 15: 84,688,968 (GRCm39) D186G probably damaging Het
Poli C T 18: 70,661,829 (GRCm39) C57Y probably damaging Het
Ppp1r16a C T 15: 76,574,999 (GRCm39) probably benign Het
Psg23 T C 7: 18,345,927 (GRCm39) Y256C probably benign Het
Satb1 C A 17: 52,089,726 (GRCm39) E374* probably null Het
Scn4a C T 11: 106,236,262 (GRCm39) E333K probably benign Het
Sec14l2 C T 11: 4,053,661 (GRCm39) probably benign Het
Slain1 T C 14: 103,923,261 (GRCm39) probably benign Het
Snapc1 C T 12: 74,021,806 (GRCm39) R81C probably damaging Het
Syne2 T C 12: 75,977,352 (GRCm39) S1266P probably damaging Het
Syne2 A G 12: 76,080,496 (GRCm39) E4810G probably damaging Het
Tbck T C 3: 132,448,841 (GRCm39) I618T probably damaging Het
Tmem132d A T 5: 127,861,657 (GRCm39) N821K probably benign Het
Trim28 T A 7: 12,762,628 (GRCm39) V381E probably damaging Het
Ttc1 T C 11: 43,636,115 (GRCm39) S43G probably benign Het
Ube2u A G 4: 100,338,852 (GRCm39) E39G possibly damaging Het
Urb2 T C 8: 124,757,665 (GRCm39) V1124A probably benign Het
Usp13 A G 3: 32,872,025 (GRCm39) probably benign Het
Vmn1r216 A T 13: 23,283,631 (GRCm39) S105C probably damaging Het
Yipf2 T C 9: 21,501,412 (GRCm39) T23A probably damaging Het
Zfp521 G A 18: 13,978,148 (GRCm39) T755M probably damaging Het
Zfp619 T A 7: 39,187,183 (GRCm39) M1071K probably benign Het
Zfp942 A T 17: 22,148,066 (GRCm39) C188S probably benign Het
Other mutations in Gpr87
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00496:Gpr87 APN 3 59,087,211 (GRCm39) missense probably damaging 1.00
IGL02309:Gpr87 APN 3 59,086,975 (GRCm39) missense possibly damaging 0.74
IGL02614:Gpr87 APN 3 59,086,738 (GRCm39) missense probably damaging 1.00
R0097:Gpr87 UTSW 3 59,086,506 (GRCm39) missense probably damaging 1.00
R0097:Gpr87 UTSW 3 59,086,506 (GRCm39) missense probably damaging 1.00
R1801:Gpr87 UTSW 3 59,086,813 (GRCm39) missense possibly damaging 0.92
R2213:Gpr87 UTSW 3 59,086,465 (GRCm39) missense probably damaging 0.99
R2698:Gpr87 UTSW 3 59,086,587 (GRCm39) missense probably damaging 1.00
R5459:Gpr87 UTSW 3 59,087,148 (GRCm39) missense possibly damaging 0.89
R5490:Gpr87 UTSW 3 59,086,747 (GRCm39) missense probably damaging 0.99
R5963:Gpr87 UTSW 3 59,086,690 (GRCm39) nonsense probably null
R6189:Gpr87 UTSW 3 59,086,650 (GRCm39) missense probably damaging 1.00
R6251:Gpr87 UTSW 3 59,086,528 (GRCm39) missense probably damaging 0.99
R7863:Gpr87 UTSW 3 59,087,317 (GRCm39) missense probably damaging 1.00
R8008:Gpr87 UTSW 3 59,087,466 (GRCm39) missense probably benign
R8065:Gpr87 UTSW 3 59,087,308 (GRCm39) missense probably damaging 1.00
R8067:Gpr87 UTSW 3 59,087,308 (GRCm39) missense probably damaging 1.00
R8096:Gpr87 UTSW 3 59,087,229 (GRCm39) missense possibly damaging 0.70
R8141:Gpr87 UTSW 3 59,087,020 (GRCm39) missense probably damaging 1.00
R8326:Gpr87 UTSW 3 59,102,395 (GRCm39) start gained probably benign
R9326:Gpr87 UTSW 3 59,086,609 (GRCm39) missense probably damaging 1.00
R9485:Gpr87 UTSW 3 59,087,005 (GRCm39) missense possibly damaging 0.85
Z1177:Gpr87 UTSW 3 59,087,491 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TGTGCTGATTCATCCAGAAGCCTG -3'
(R):5'- GGTGGTAAAGCCCTTTGGTGACTC -3'

Sequencing Primer
(F):5'- CCAGAAGCCTGTCTAAGTTACTG -3'
(R):5'- GGTGACTCTCGCATGTACAG -3'
Posted On 2013-04-11