Incidental Mutation 'R1840:Ascc3'
| ID |
205721 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ascc3
|
| Ensembl Gene |
ENSMUSG00000038774 |
| Gene Name |
activating signal cointegrator 1 complex subunit 3 |
| Synonyms |
Helic1, B630009I04Rik, ASC1p200 |
| MMRRC Submission |
039866-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.963)
|
| Stock # |
R1840 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
50468756-50727300 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 50566257 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 734
(M734K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000036726
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000035606]
|
| AlphaFold |
E9PZJ8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000035606
AA Change: M734K
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000036726
Gene: ENSMUSG00000038774
AA Change: M734K
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
55 |
79 |
N/A |
INTRINSIC |
|
low complexity region
|
124 |
135 |
N/A |
INTRINSIC |
|
coiled coil region
|
329 |
356 |
N/A |
INTRINSIC |
|
DEXDc
|
474 |
686 |
1.71e-29 |
SMART |
|
AAA
|
492 |
674 |
8.15e-2 |
SMART |
|
Blast:DEXDc
|
718 |
763 |
4e-18 |
BLAST |
|
HELICc
|
770 |
858 |
6.01e-16 |
SMART |
|
Sec63
|
979 |
1288 |
3.53e-111 |
SMART |
|
DEXDc
|
1324 |
1528 |
8.88e-28 |
SMART |
|
AAA
|
1342 |
1492 |
4.27e-1 |
SMART |
|
HELICc
|
1605 |
1695 |
2.28e-16 |
SMART |
|
Sec63
|
1813 |
2178 |
6.37e-118 |
SMART |
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.8%
- 10x: 95.2%
- 20x: 92.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
|
| Allele List at MGI |
All alleles(16) : Targeted(2) Gene trapped(14)
|
| Other mutations in this stock |
Total: 118 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2510009E07Rik |
T |
A |
16: 21,472,236 (GRCm39) |
M85L |
probably benign |
Het |
| Aatk |
T |
G |
11: 119,904,558 (GRCm39) |
D206A |
probably damaging |
Het |
| Agap3 |
A |
G |
5: 24,705,229 (GRCm39) |
D719G |
probably damaging |
Het |
| Agrn |
G |
A |
4: 156,251,872 (GRCm39) |
R1797C |
probably damaging |
Het |
| Asph |
T |
A |
4: 9,601,340 (GRCm39) |
M136L |
possibly damaging |
Het |
| Atm |
A |
T |
9: 53,367,830 (GRCm39) |
V2431E |
probably damaging |
Het |
| Atp2b1 |
A |
G |
10: 98,858,791 (GRCm39) |
H1158R |
probably benign |
Het |
| Atxn7l1 |
A |
G |
12: 33,421,032 (GRCm39) |
|
probably null |
Het |
| BC024139 |
G |
T |
15: 76,004,842 (GRCm39) |
S611R |
probably benign |
Het |
| Becn1 |
C |
T |
11: 101,186,392 (GRCm39) |
G105S |
probably damaging |
Het |
| Bud13 |
A |
G |
9: 46,197,706 (GRCm39) |
E70G |
probably damaging |
Het |
| Cacul1 |
A |
T |
19: 60,522,688 (GRCm39) |
L282* |
probably null |
Het |
| Catspere2 |
A |
G |
1: 177,830,581 (GRCm39) |
D30G |
possibly damaging |
Het |
| Ccar1 |
T |
A |
10: 62,599,289 (GRCm39) |
K614M |
probably damaging |
Het |
| Cd96 |
T |
C |
16: 45,919,455 (GRCm39) |
T189A |
probably benign |
Het |
| Cdh5 |
C |
A |
8: 104,853,248 (GRCm39) |
Y189* |
probably null |
Het |
| Chka |
A |
G |
19: 3,936,460 (GRCm39) |
N284S |
probably benign |
Het |
| Cntn6 |
A |
T |
6: 104,751,441 (GRCm39) |
I366F |
probably damaging |
Het |
| Csmd3 |
C |
T |
15: 47,470,560 (GRCm39) |
G3372E |
probably damaging |
Het |
| Cyp4f16 |
T |
C |
17: 32,761,980 (GRCm39) |
|
probably null |
Het |
| Dcaf6 |
A |
G |
1: 165,227,317 (GRCm39) |
V270A |
probably damaging |
Het |
| Ddx60 |
T |
A |
8: 62,422,587 (GRCm39) |
I608N |
probably damaging |
Het |
| Dnah9 |
A |
T |
11: 65,725,024 (GRCm39) |
C1849* |
probably null |
Het |
| Eci3 |
C |
A |
13: 35,144,024 (GRCm39) |
V34L |
probably benign |
Het |
| Eif1ad9 |
T |
C |
12: 88,296,181 (GRCm39) |
V53A |
probably benign |
Het |
| Entrep2 |
C |
A |
7: 64,408,943 (GRCm39) |
V484L |
probably benign |
Het |
| Epha1 |
C |
T |
6: 42,340,522 (GRCm39) |
R583H |
probably damaging |
Het |
| Erbin |
A |
T |
13: 103,971,455 (GRCm39) |
N720K |
probably benign |
Het |
| Eya1 |
T |
A |
1: 14,299,728 (GRCm39) |
R346* |
probably null |
Het |
| Fhdc1 |
G |
A |
3: 84,353,128 (GRCm39) |
T699I |
possibly damaging |
Het |
| Flvcr2 |
T |
C |
12: 85,849,995 (GRCm39) |
V427A |
possibly damaging |
Het |
| Frey1 |
T |
C |
2: 92,213,554 (GRCm39) |
S36P |
probably benign |
Het |
| Fzd9 |
T |
A |
5: 135,278,425 (GRCm39) |
T487S |
probably benign |
Het |
| Gas2l3 |
T |
C |
10: 89,258,113 (GRCm39) |
Y160C |
possibly damaging |
Het |
| Gm10269 |
T |
C |
18: 20,815,866 (GRCm39) |
K52R |
probably damaging |
Het |
| Gm8674 |
A |
T |
13: 50,055,801 (GRCm39) |
|
noncoding transcript |
Het |
| Gpr61 |
A |
G |
3: 108,057,797 (GRCm39) |
V288A |
possibly damaging |
Het |
| Gramd4 |
T |
C |
15: 86,014,393 (GRCm39) |
|
probably null |
Het |
| Gtpbp4 |
A |
G |
13: 9,029,500 (GRCm39) |
L403P |
probably benign |
Het |
| H6pd |
A |
T |
4: 150,066,507 (GRCm39) |
D626E |
possibly damaging |
Het |
| Herc6 |
T |
A |
6: 57,635,091 (GRCm39) |
L769* |
probably null |
Het |
| Hes5 |
A |
G |
4: 155,045,711 (GRCm39) |
K58R |
probably damaging |
Het |
| Heyl |
A |
G |
4: 123,135,183 (GRCm39) |
I59V |
probably damaging |
Het |
| Hpca |
A |
G |
4: 129,012,393 (GRCm39) |
F48L |
probably damaging |
Het |
| Ice1 |
C |
T |
13: 70,754,337 (GRCm39) |
R583Q |
probably benign |
Het |
| Ints2 |
C |
T |
11: 86,123,911 (GRCm39) |
G626R |
probably damaging |
Het |
| Kansl1l |
T |
A |
1: 66,817,191 (GRCm39) |
I390F |
probably damaging |
Het |
| Kat5 |
C |
T |
19: 5,659,266 (GRCm39) |
V95M |
possibly damaging |
Het |
| Kcnh4 |
T |
A |
11: 100,636,167 (GRCm39) |
I827F |
possibly damaging |
Het |
| Kif1b |
C |
T |
4: 149,272,589 (GRCm39) |
R138Q |
probably damaging |
Het |
| Kirrel1 |
C |
T |
3: 86,996,458 (GRCm39) |
M380I |
probably null |
Het |
| Lats1 |
T |
A |
10: 7,586,703 (GRCm39) |
L955* |
probably null |
Het |
| Ldlrad2 |
A |
C |
4: 137,299,495 (GRCm39) |
C110G |
possibly damaging |
Het |
| Lgi3 |
G |
A |
14: 70,772,216 (GRCm39) |
|
probably null |
Het |
| Lingo1 |
A |
G |
9: 56,527,842 (GRCm39) |
M249T |
probably benign |
Het |
| Lrig3 |
A |
T |
10: 125,849,258 (GRCm39) |
R993* |
probably null |
Het |
| Lsm14b |
T |
A |
2: 179,668,521 (GRCm39) |
I74N |
probably damaging |
Het |
| Lyplal1 |
T |
A |
1: 185,832,414 (GRCm39) |
I114F |
probably damaging |
Het |
| Mmp15 |
A |
G |
8: 96,092,048 (GRCm39) |
Y86C |
probably damaging |
Het |
| Myh2 |
A |
G |
11: 67,077,313 (GRCm39) |
E816G |
probably benign |
Het |
| Myo5c |
A |
G |
9: 75,157,017 (GRCm39) |
N151S |
probably damaging |
Het |
| Nckap1 |
T |
A |
2: 80,332,594 (GRCm39) |
E1082V |
possibly damaging |
Het |
| Nrg4 |
A |
C |
9: 55,189,890 (GRCm39) |
|
probably benign |
Het |
| Nrp2 |
T |
C |
1: 62,777,498 (GRCm39) |
L101P |
probably damaging |
Het |
| Or14j5 |
A |
T |
17: 38,161,639 (GRCm39) |
D52V |
probably damaging |
Het |
| Or2at1 |
A |
T |
7: 99,416,803 (GRCm39) |
T145S |
probably benign |
Het |
| Or4p19 |
T |
C |
2: 88,242,411 (GRCm39) |
D197G |
probably benign |
Het |
| Or51q1c |
A |
G |
7: 103,653,324 (GRCm39) |
I281V |
probably benign |
Het |
| Or5ak22 |
G |
A |
2: 85,230,512 (GRCm39) |
R122C |
probably benign |
Het |
| Parp14 |
T |
A |
16: 35,683,819 (GRCm39) |
E169V |
probably damaging |
Het |
| Pcolce2 |
A |
T |
9: 95,552,256 (GRCm39) |
N130Y |
probably benign |
Het |
| Pcolce2 |
G |
A |
9: 95,552,170 (GRCm39) |
R101H |
probably damaging |
Het |
| Plscr1 |
A |
T |
9: 92,140,127 (GRCm39) |
S5C |
unknown |
Het |
| Plxdc2 |
T |
C |
2: 16,674,667 (GRCm39) |
V338A |
probably benign |
Het |
| Psg23 |
T |
A |
7: 18,344,363 (GRCm39) |
N364I |
possibly damaging |
Het |
| Psmg4 |
A |
G |
13: 34,362,039 (GRCm39) |
E109G |
probably damaging |
Het |
| Ptk2 |
T |
C |
15: 73,082,733 (GRCm39) |
E908G |
probably damaging |
Het |
| Ptpn14 |
G |
A |
1: 189,519,048 (GRCm39) |
R26H |
probably damaging |
Het |
| Ranbp2 |
T |
A |
10: 58,314,588 (GRCm39) |
N1769K |
probably benign |
Het |
| Rbm14 |
C |
T |
19: 4,851,823 (GRCm39) |
|
probably benign |
Het |
| Rgs7 |
A |
T |
1: 174,980,714 (GRCm39) |
D103E |
probably damaging |
Het |
| Rmnd5a |
G |
A |
6: 71,375,439 (GRCm39) |
L80F |
probably benign |
Het |
| Rock2 |
T |
A |
12: 16,978,990 (GRCm39) |
D93E |
probably benign |
Het |
| Rps6ka6 |
A |
G |
X: 110,330,629 (GRCm39) |
I246T |
possibly damaging |
Het |
| Rubcn |
T |
C |
16: 32,646,542 (GRCm39) |
M803V |
possibly damaging |
Het |
| Ryr3 |
T |
C |
2: 112,581,165 (GRCm39) |
Y2889C |
probably damaging |
Het |
| Sall2 |
T |
C |
14: 52,551,182 (GRCm39) |
N671S |
probably damaging |
Het |
| Selplg |
T |
C |
5: 113,957,905 (GRCm39) |
T134A |
possibly damaging |
Het |
| Sez6 |
C |
A |
11: 77,844,543 (GRCm39) |
T122N |
possibly damaging |
Het |
| Slc9b1 |
T |
A |
3: 135,063,229 (GRCm39) |
D4E |
unknown |
Het |
| Smim18 |
A |
G |
8: 34,232,376 (GRCm39) |
M81T |
probably benign |
Het |
| Snap91 |
A |
T |
9: 86,697,518 (GRCm39) |
H281Q |
probably damaging |
Het |
| Sparc |
C |
A |
11: 55,286,692 (GRCm39) |
C302F |
probably damaging |
Het |
| Spg11 |
A |
G |
2: 121,932,237 (GRCm39) |
L535P |
probably damaging |
Het |
| Spsb1 |
G |
A |
4: 149,991,088 (GRCm39) |
T160I |
probably damaging |
Het |
| Stra6 |
A |
G |
9: 58,047,813 (GRCm39) |
N128S |
probably benign |
Het |
| Strc |
T |
C |
2: 121,209,777 (GRCm39) |
E182G |
probably damaging |
Het |
| Sult2a6 |
A |
G |
7: 13,988,754 (GRCm39) |
M2T |
probably benign |
Het |
| Sv2c |
T |
C |
13: 96,118,352 (GRCm39) |
N499S |
probably benign |
Het |
| Szt2 |
A |
T |
4: 118,222,854 (GRCm39) |
|
probably benign |
Het |
| Tbx20 |
A |
T |
9: 24,636,972 (GRCm39) |
S372T |
probably benign |
Het |
| Tcp11l2 |
T |
A |
10: 84,440,463 (GRCm39) |
S289T |
probably damaging |
Het |
| Tdrd1 |
A |
G |
19: 56,830,744 (GRCm39) |
E259G |
probably damaging |
Het |
| Thsd7a |
T |
A |
6: 12,330,973 (GRCm39) |
I1390L |
probably benign |
Het |
| Tln2 |
G |
A |
9: 67,249,325 (GRCm39) |
R921W |
probably damaging |
Het |
| Tmem126a |
C |
A |
7: 90,102,092 (GRCm39) |
G36* |
probably null |
Het |
| Tmem245 |
C |
T |
4: 56,903,947 (GRCm39) |
V606I |
probably benign |
Het |
| Trpm6 |
A |
G |
19: 18,843,631 (GRCm39) |
D1665G |
probably benign |
Het |
| Ubac2 |
T |
G |
14: 122,231,674 (GRCm39) |
V200G |
probably benign |
Het |
| Ubr5 |
G |
A |
15: 37,981,161 (GRCm39) |
A2372V |
possibly damaging |
Het |
| Ugcg |
C |
T |
4: 59,219,517 (GRCm39) |
P285S |
probably damaging |
Het |
| Vmn1r9 |
T |
C |
6: 57,048,522 (GRCm39) |
V199A |
probably damaging |
Het |
| Vmn2r118 |
T |
A |
17: 55,917,406 (GRCm39) |
K369* |
probably null |
Het |
| Xpnpep3 |
G |
T |
15: 81,311,554 (GRCm39) |
A87S |
probably benign |
Het |
| Zc3h7a |
C |
T |
16: 10,978,890 (GRCm39) |
R95H |
probably damaging |
Het |
| Zdhhc11 |
A |
G |
13: 74,122,771 (GRCm39) |
N169S |
probably damaging |
Het |
| Zfp62 |
T |
A |
11: 49,107,215 (GRCm39) |
D435E |
probably damaging |
Het |
| Zfyve16 |
T |
C |
13: 92,648,033 (GRCm39) |
D1007G |
possibly damaging |
Het |
|
| Other mutations in Ascc3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00264:Ascc3
|
APN |
10 |
50,590,531 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00690:Ascc3
|
APN |
10 |
50,576,039 (GRCm39) |
nonsense |
probably null |
|
|
IGL00897:Ascc3
|
APN |
10 |
50,604,187 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01077:Ascc3
|
APN |
10 |
50,525,413 (GRCm39) |
splice site |
probably benign |
|
|
IGL01124:Ascc3
|
APN |
10 |
50,608,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01555:Ascc3
|
APN |
10 |
50,626,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02019:Ascc3
|
APN |
10 |
50,566,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02161:Ascc3
|
APN |
10 |
50,726,623 (GRCm39) |
nonsense |
probably null |
|
|
IGL02247:Ascc3
|
APN |
10 |
50,526,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02318:Ascc3
|
APN |
10 |
50,604,250 (GRCm39) |
nonsense |
probably null |
|
|
IGL02428:Ascc3
|
APN |
10 |
50,721,791 (GRCm39) |
nonsense |
probably null |
|
|
IGL02432:Ascc3
|
APN |
10 |
50,576,589 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02449:Ascc3
|
APN |
10 |
50,576,695 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02640:Ascc3
|
APN |
10 |
50,643,470 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL02673:Ascc3
|
APN |
10 |
50,536,769 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03144:Ascc3
|
APN |
10 |
50,643,539 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL03161:Ascc3
|
APN |
10 |
50,494,168 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03218:Ascc3
|
APN |
10 |
50,699,949 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
algorithm
|
UTSW |
10 |
50,594,472 (GRCm39) |
missense |
probably damaging |
0.97 |
|
heuristic
|
UTSW |
10 |
50,718,289 (GRCm39) |
missense |
probably damaging |
0.99 |
|
network
|
UTSW |
10 |
50,630,175 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R0045:Ascc3
|
UTSW |
10 |
50,594,498 (GRCm39) |
nonsense |
probably null |
|
|
R0045:Ascc3
|
UTSW |
10 |
50,594,498 (GRCm39) |
nonsense |
probably null |
|
|
R0131:Ascc3
|
UTSW |
10 |
50,611,425 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0131:Ascc3
|
UTSW |
10 |
50,611,425 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0132:Ascc3
|
UTSW |
10 |
50,611,425 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0149:Ascc3
|
UTSW |
10 |
50,484,089 (GRCm39) |
missense |
probably benign |
0.31 |
|
R0165:Ascc3
|
UTSW |
10 |
50,718,223 (GRCm39) |
splice site |
probably null |
|
|
R0255:Ascc3
|
UTSW |
10 |
50,521,154 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0310:Ascc3
|
UTSW |
10 |
50,625,022 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0314:Ascc3
|
UTSW |
10 |
50,514,095 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0362:Ascc3
|
UTSW |
10 |
50,625,051 (GRCm39) |
splice site |
probably benign |
|
|
R0418:Ascc3
|
UTSW |
10 |
50,625,022 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0419:Ascc3
|
UTSW |
10 |
50,625,022 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0421:Ascc3
|
UTSW |
10 |
50,625,022 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0480:Ascc3
|
UTSW |
10 |
50,611,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0744:Ascc3
|
UTSW |
10 |
50,721,762 (GRCm39) |
missense |
probably benign |
0.17 |
|
R0833:Ascc3
|
UTSW |
10 |
50,721,762 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1231:Ascc3
|
UTSW |
10 |
50,699,756 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1264:Ascc3
|
UTSW |
10 |
50,518,615 (GRCm39) |
splice site |
probably benign |
|
|
R1302:Ascc3
|
UTSW |
10 |
50,480,890 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
R1751:Ascc3
|
UTSW |
10 |
50,594,472 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1767:Ascc3
|
UTSW |
10 |
50,594,472 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1769:Ascc3
|
UTSW |
10 |
50,576,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1855:Ascc3
|
UTSW |
10 |
50,494,018 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1953:Ascc3
|
UTSW |
10 |
50,721,726 (GRCm39) |
missense |
probably benign |
|
|
R1976:Ascc3
|
UTSW |
10 |
50,525,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2004:Ascc3
|
UTSW |
10 |
50,493,838 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2013:Ascc3
|
UTSW |
10 |
50,525,908 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2017:Ascc3
|
UTSW |
10 |
50,566,307 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2040:Ascc3
|
UTSW |
10 |
50,604,227 (GRCm39) |
missense |
probably benign |
|
|
R2043:Ascc3
|
UTSW |
10 |
50,576,616 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2165:Ascc3
|
UTSW |
10 |
50,597,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2226:Ascc3
|
UTSW |
10 |
50,630,148 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2310:Ascc3
|
UTSW |
10 |
50,624,988 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2405:Ascc3
|
UTSW |
10 |
50,607,774 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2424:Ascc3
|
UTSW |
10 |
50,494,297 (GRCm39) |
missense |
probably benign |
0.14 |
|
R3410:Ascc3
|
UTSW |
10 |
50,576,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3617:Ascc3
|
UTSW |
10 |
50,494,281 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3771:Ascc3
|
UTSW |
10 |
50,596,814 (GRCm39) |
splice site |
probably benign |
|
|
R3783:Ascc3
|
UTSW |
10 |
50,604,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3891:Ascc3
|
UTSW |
10 |
50,718,289 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3892:Ascc3
|
UTSW |
10 |
50,718,289 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4435:Ascc3
|
UTSW |
10 |
50,597,981 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4509:Ascc3
|
UTSW |
10 |
50,718,339 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4520:Ascc3
|
UTSW |
10 |
50,536,766 (GRCm39) |
missense |
probably benign |
|
|
R4521:Ascc3
|
UTSW |
10 |
50,536,766 (GRCm39) |
missense |
probably benign |
|
|
R4522:Ascc3
|
UTSW |
10 |
50,536,766 (GRCm39) |
missense |
probably benign |
|
|
R4524:Ascc3
|
UTSW |
10 |
50,536,766 (GRCm39) |
missense |
probably benign |
|
|
R4581:Ascc3
|
UTSW |
10 |
50,587,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4701:Ascc3
|
UTSW |
10 |
50,596,760 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4704:Ascc3
|
UTSW |
10 |
50,535,110 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4768:Ascc3
|
UTSW |
10 |
50,576,595 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4823:Ascc3
|
UTSW |
10 |
50,589,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4906:Ascc3
|
UTSW |
10 |
50,625,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4937:Ascc3
|
UTSW |
10 |
50,699,894 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5001:Ascc3
|
UTSW |
10 |
50,699,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5151:Ascc3
|
UTSW |
10 |
50,514,059 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5263:Ascc3
|
UTSW |
10 |
50,592,757 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5302:Ascc3
|
UTSW |
10 |
50,583,873 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5436:Ascc3
|
UTSW |
10 |
50,535,079 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5455:Ascc3
|
UTSW |
10 |
50,725,679 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5474:Ascc3
|
UTSW |
10 |
50,725,634 (GRCm39) |
missense |
probably benign |
0.25 |
|
R5744:Ascc3
|
UTSW |
10 |
50,586,977 (GRCm39) |
missense |
probably benign |
|
|
R5781:Ascc3
|
UTSW |
10 |
50,514,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5850:Ascc3
|
UTSW |
10 |
50,587,049 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5867:Ascc3
|
UTSW |
10 |
50,718,279 (GRCm39) |
nonsense |
probably null |
|
|
R5868:Ascc3
|
UTSW |
10 |
50,718,279 (GRCm39) |
nonsense |
probably null |
|
|
R5869:Ascc3
|
UTSW |
10 |
50,718,279 (GRCm39) |
nonsense |
probably null |
|
|
R6031:Ascc3
|
UTSW |
10 |
50,718,279 (GRCm39) |
nonsense |
probably null |
|
|
R6031:Ascc3
|
UTSW |
10 |
50,718,279 (GRCm39) |
nonsense |
probably null |
|
|
R6032:Ascc3
|
UTSW |
10 |
50,718,279 (GRCm39) |
nonsense |
probably null |
|
|
R6032:Ascc3
|
UTSW |
10 |
50,718,279 (GRCm39) |
nonsense |
probably null |
|
|
R6109:Ascc3
|
UTSW |
10 |
50,525,343 (GRCm39) |
missense |
probably benign |
0.37 |
|
R6122:Ascc3
|
UTSW |
10 |
50,494,021 (GRCm39) |
missense |
probably benign |
|
|
R6128:Ascc3
|
UTSW |
10 |
50,526,734 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6351:Ascc3
|
UTSW |
10 |
50,596,769 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6368:Ascc3
|
UTSW |
10 |
50,576,081 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6369:Ascc3
|
UTSW |
10 |
50,576,081 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6409:Ascc3
|
UTSW |
10 |
50,721,676 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6472:Ascc3
|
UTSW |
10 |
50,596,783 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6474:Ascc3
|
UTSW |
10 |
50,624,932 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6480:Ascc3
|
UTSW |
10 |
50,587,049 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6553:Ascc3
|
UTSW |
10 |
50,718,273 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6572:Ascc3
|
UTSW |
10 |
50,566,343 (GRCm39) |
nonsense |
probably null |
|
|
R6585:Ascc3
|
UTSW |
10 |
50,718,273 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6656:Ascc3
|
UTSW |
10 |
50,526,021 (GRCm39) |
nonsense |
probably null |
|
|
R6669:Ascc3
|
UTSW |
10 |
50,716,469 (GRCm39) |
missense |
probably benign |
|
|
R6675:Ascc3
|
UTSW |
10 |
50,626,659 (GRCm39) |
nonsense |
probably null |
|
|
R6790:Ascc3
|
UTSW |
10 |
50,521,808 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6856:Ascc3
|
UTSW |
10 |
50,625,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6862:Ascc3
|
UTSW |
10 |
50,725,742 (GRCm39) |
missense |
probably null |
0.51 |
|
R6919:Ascc3
|
UTSW |
10 |
50,521,849 (GRCm39) |
nonsense |
probably null |
|
|
R6936:Ascc3
|
UTSW |
10 |
50,606,057 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6953:Ascc3
|
UTSW |
10 |
50,521,762 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6957:Ascc3
|
UTSW |
10 |
50,604,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7022:Ascc3
|
UTSW |
10 |
50,592,725 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R7050:Ascc3
|
UTSW |
10 |
50,716,446 (GRCm39) |
missense |
probably benign |
0.43 |
|
R7358:Ascc3
|
UTSW |
10 |
50,590,448 (GRCm39) |
nonsense |
probably null |
|
|
R7479:Ascc3
|
UTSW |
10 |
50,525,895 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7538:Ascc3
|
UTSW |
10 |
50,721,796 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7838:Ascc3
|
UTSW |
10 |
50,604,393 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8021:Ascc3
|
UTSW |
10 |
50,607,744 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8134:Ascc3
|
UTSW |
10 |
50,643,554 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8252:Ascc3
|
UTSW |
10 |
50,518,706 (GRCm39) |
missense |
probably benign |
|
|
R8348:Ascc3
|
UTSW |
10 |
50,494,173 (GRCm39) |
missense |
probably benign |
|
|
R8351:Ascc3
|
UTSW |
10 |
50,725,693 (GRCm39) |
missense |
probably benign |
|
|
R8356:Ascc3
|
UTSW |
10 |
50,526,003 (GRCm39) |
missense |
probably benign |
0.38 |
|
R8362:Ascc3
|
UTSW |
10 |
50,518,692 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8395:Ascc3
|
UTSW |
10 |
50,525,400 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8448:Ascc3
|
UTSW |
10 |
50,494,173 (GRCm39) |
missense |
probably benign |
|
|
R8957:Ascc3
|
UTSW |
10 |
50,576,208 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9004:Ascc3
|
UTSW |
10 |
50,718,276 (GRCm39) |
missense |
probably benign |
|
|
R9133:Ascc3
|
UTSW |
10 |
50,630,175 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9200:Ascc3
|
UTSW |
10 |
50,521,787 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R9328:Ascc3
|
UTSW |
10 |
50,535,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9377:Ascc3
|
UTSW |
10 |
50,608,858 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R9412:Ascc3
|
UTSW |
10 |
50,525,230 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9576:Ascc3
|
UTSW |
10 |
50,494,254 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R9796:Ascc3
|
UTSW |
10 |
50,608,801 (GRCm39) |
nonsense |
probably null |
|
|
X0021:Ascc3
|
UTSW |
10 |
50,576,686 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
X0025:Ascc3
|
UTSW |
10 |
50,526,692 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0026:Ascc3
|
UTSW |
10 |
50,608,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Ascc3
|
UTSW |
10 |
50,594,517 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GCTGAATTTTAACTTCCTCTTATCAGG -3'
(R):5'- ATGACTCTAACATTACCTTCTCAGA -3'
Sequencing Primer
(F):5'- ATGTTGGCTAATTCAGAAATTGGAG -3'
(R):5'- ATGCATGTCCGTACTCTG -3'
|
| Posted On |
2014-06-23 |
Incidental Mutation