|Institutional Source||Beutler Lab|
|Gene Name||potassium inwardly-rectifying channel, subfamily K, member 6|
|Synonyms||Twik2, Toss, D7Ertd764e|
|Is this an essential gene?||Probably non essential (E-score: 0.211)|
|Stock #||R0113 (G1)|
|Chromosomal Location||29221926-29232515 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 29232209 bp|
|Amino Acid Change||Aspartic acid to Glycine at position 92 (D92G)|
|Ref Sequence||ENSEMBL: ENSMUSP00000082975 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000085818]|
|Predicted Effect||probably damaging
AA Change: D92G
PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
AA Change: D92G
|Predicted Effect||noncoding transcript
|Meta Mutation Damage Score||0.5019|
|Coding Region Coverage||
|Validation Efficiency||99% (70/71)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008]
PHENOTYPE: Male mice homozygous for a knock-out allele exhibit vascular dysfunction and hypertension. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Kcnk6||
(F):5'- GGAATGGAGGTTGTTCTGAGAGCAC -3'
(R):5'- TTCAGGCAGGAAAGGACTCCGC -3'
(F):5'- TTCTGAGAGCACCAGGACG -3'
(R):5'- TCAGTTTCCCAGCGTCAGG -3'