Incidental Mutation 'R1854:Trip12'
| ID |
205868 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trip12
|
| Ensembl Gene |
ENSMUSG00000026219 |
| Gene Name |
thyroid hormone receptor interactor 12 |
| Synonyms |
Gtl6, 1110036I07Rik, 6720416K24Rik |
| MMRRC Submission |
039878-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1854 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
84698910-84818237 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 84705866 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Tyrosine
at position 655
(N655Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000140789
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027421]
[ENSMUST00000186465]
[ENSMUST00000186648]
[ENSMUST00000187733]
[ENSMUST00000189670]
|
| AlphaFold |
G5E870 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000027421
AA Change: N1850Y
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000027421
Gene: ENSMUSG00000026219
AA Change: N1850Y
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
379 |
391 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
406 |
N/A |
INTRINSIC |
|
low complexity region
|
416 |
427 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
446 |
660 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
447 |
641 |
1e-5 |
PDB |
|
Pfam:WWE
|
765 |
831 |
7.6e-22 |
PFAM |
|
low complexity region
|
983 |
1006 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1047 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1073 |
N/A |
INTRINSIC |
|
low complexity region
|
1333 |
1344 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1362 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1363 |
1417 |
8e-8 |
BLAST |
|
Blast:HECTc
|
1573 |
1629 |
2e-24 |
BLAST |
|
HECTc
|
1636 |
2025 |
1.29e-177 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000185720
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000186465
AA Change: N1850Y
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000140224
Gene: ENSMUSG00000026219
AA Change: N1850Y
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
379 |
391 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
406 |
N/A |
INTRINSIC |
|
low complexity region
|
416 |
427 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
446 |
660 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
447 |
641 |
1e-5 |
PDB |
|
Pfam:WWE
|
761 |
831 |
2.2e-22 |
PFAM |
|
low complexity region
|
983 |
1006 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1047 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1073 |
N/A |
INTRINSIC |
|
low complexity region
|
1333 |
1344 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1362 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1363 |
1417 |
8e-8 |
BLAST |
|
Blast:HECTc
|
1573 |
1629 |
2e-24 |
BLAST |
|
HECTc
|
1636 |
2025 |
1.29e-177 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000186648
AA Change: N1817Y
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000139563
Gene: ENSMUSG00000026219
AA Change: N1817Y
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
386 |
400 |
N/A |
INTRINSIC |
|
low complexity region
|
410 |
421 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
440 |
654 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
441 |
635 |
1e-5 |
PDB |
|
low complexity region
|
950 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1000 |
1014 |
N/A |
INTRINSIC |
|
low complexity region
|
1029 |
1040 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1311 |
N/A |
INTRINSIC |
|
low complexity region
|
1312 |
1329 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1330 |
1384 |
7e-8 |
BLAST |
|
Blast:HECTc
|
1540 |
1596 |
2e-24 |
BLAST |
|
HECTc
|
1603 |
1992 |
6.2e-180 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000187733
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000189670
AA Change: N655Y
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000140789
Gene: ENSMUSG00000026219
AA Change: N655Y
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
138 |
149 |
N/A |
INTRINSIC |
|
low complexity region
|
150 |
167 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
168 |
222 |
5e-8 |
BLAST |
|
Blast:HECTc
|
378 |
434 |
1e-24 |
BLAST |
|
HECTc
|
441 |
830 |
6.2e-180 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000191187
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.9%
- 10x: 95.3%
- 20x: 92.5%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a targeted allele exhibit complete embryonic lethality during organogenesis associated with embryonic growth retardation and abnormal placenta development. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 113 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310061N02Rik |
C |
T |
16: 88,504,668 (GRCm39) |
R43K |
possibly damaging |
Het |
| Acp1 |
A |
G |
12: 30,947,804 (GRCm39) |
I78T |
possibly damaging |
Het |
| Afap1l1 |
G |
T |
18: 61,876,365 (GRCm39) |
D417E |
probably benign |
Het |
| Agap2 |
G |
A |
10: 126,916,385 (GRCm39) |
V299I |
unknown |
Het |
| Ahnak |
C |
T |
19: 8,991,196 (GRCm39) |
A4160V |
possibly damaging |
Het |
| Anapc1 |
T |
C |
2: 128,517,810 (GRCm39) |
E278G |
probably damaging |
Het |
| Atad2 |
G |
A |
15: 57,960,685 (GRCm39) |
P971L |
possibly damaging |
Het |
| Atg2a |
A |
G |
19: 6,302,461 (GRCm39) |
E928G |
probably benign |
Het |
| Atp2b2 |
A |
C |
6: 113,819,244 (GRCm39) |
N16K |
probably damaging |
Het |
| Atp6ap1l |
T |
C |
13: 91,031,707 (GRCm39) |
E325G |
probably damaging |
Het |
| Bfsp2 |
C |
T |
9: 103,327,030 (GRCm39) |
G236S |
probably benign |
Het |
| Ccar1 |
A |
T |
10: 62,600,296 (GRCm39) |
I545N |
probably damaging |
Het |
| Ccser2 |
A |
G |
14: 36,640,548 (GRCm39) |
C11R |
possibly damaging |
Het |
| Cdc42bpg |
A |
T |
19: 6,370,837 (GRCm39) |
H1310L |
possibly damaging |
Het |
| Ces1h |
T |
C |
8: 94,085,450 (GRCm39) |
K339E |
probably benign |
Het |
| Cfap91 |
T |
C |
16: 38,144,659 (GRCm39) |
|
probably null |
Het |
| Cit |
A |
G |
5: 116,011,960 (GRCm39) |
Y189C |
probably damaging |
Het |
| Cnih3 |
C |
A |
1: 181,282,186 (GRCm39) |
S140* |
probably null |
Het |
| Cntrl |
A |
G |
2: 35,012,696 (GRCm39) |
D278G |
probably damaging |
Het |
| Col24a1 |
G |
A |
3: 145,164,895 (GRCm39) |
G1033D |
probably damaging |
Het |
| Col6a1 |
T |
G |
10: 76,557,783 (GRCm39) |
Y151S |
probably damaging |
Het |
| Col6a2 |
T |
A |
10: 76,450,646 (GRCm39) |
Q95L |
probably damaging |
Het |
| Cpd |
G |
T |
11: 76,677,164 (GRCm39) |
P1185Q |
probably damaging |
Het |
| Cycs |
T |
A |
6: 50,542,309 (GRCm39) |
I76F |
possibly damaging |
Het |
| Cyp4f16 |
T |
A |
17: 32,756,073 (GRCm39) |
I34N |
probably damaging |
Het |
| Ddx1 |
A |
C |
12: 13,279,332 (GRCm39) |
S436A |
probably benign |
Het |
| Defa30 |
A |
G |
8: 21,625,500 (GRCm39) |
Y88C |
probably damaging |
Het |
| Dhx30 |
G |
A |
9: 109,917,740 (GRCm39) |
L317F |
probably damaging |
Het |
| Dll3 |
C |
A |
7: 27,995,835 (GRCm39) |
G322V |
probably damaging |
Het |
| Dnah10 |
G |
A |
5: 124,881,753 (GRCm39) |
D2843N |
probably damaging |
Het |
| Dnaja3 |
C |
T |
16: 4,515,133 (GRCm39) |
T266I |
probably damaging |
Het |
| Dpp9 |
T |
C |
17: 56,509,885 (GRCm39) |
I314V |
probably benign |
Het |
| E030025P04Rik |
A |
G |
11: 109,034,744 (GRCm39) |
V48A |
unknown |
Het |
| Enpp2 |
C |
T |
15: 54,709,219 (GRCm39) |
E803K |
probably damaging |
Het |
| Eri3 |
G |
A |
4: 117,506,562 (GRCm39) |
G297D |
probably benign |
Het |
| Esp34 |
A |
G |
17: 38,870,424 (GRCm39) |
E38G |
possibly damaging |
Het |
| Fabp3 |
C |
T |
4: 130,206,180 (GRCm39) |
T57I |
probably benign |
Het |
| Frzb |
A |
G |
2: 80,276,724 (GRCm39) |
V154A |
possibly damaging |
Het |
| Fsip2 |
G |
T |
2: 82,823,601 (GRCm39) |
A6445S |
possibly damaging |
Het |
| Gm11938 |
G |
A |
11: 99,493,843 (GRCm39) |
T84I |
possibly damaging |
Het |
| Gm4787 |
T |
A |
12: 81,425,108 (GRCm39) |
H350L |
probably damaging |
Het |
| Gpa33 |
A |
G |
1: 165,992,759 (GRCm39) |
I291V |
probably benign |
Het |
| Gpr158 |
A |
G |
2: 21,373,935 (GRCm39) |
Y290C |
probably damaging |
Het |
| Gpsm1 |
G |
T |
2: 26,234,725 (GRCm39) |
G84W |
probably damaging |
Het |
| Hormad1 |
A |
G |
3: 95,487,317 (GRCm39) |
N267S |
probably benign |
Het |
| Htr2a |
A |
T |
14: 74,943,193 (GRCm39) |
I258F |
probably damaging |
Het |
| Htra4 |
T |
C |
8: 25,523,597 (GRCm39) |
T323A |
probably damaging |
Het |
| Ift140 |
T |
A |
17: 25,254,813 (GRCm39) |
F162Y |
probably benign |
Het |
| Islr2 |
T |
C |
9: 58,107,099 (GRCm39) |
T54A |
probably damaging |
Het |
| Kcna4 |
T |
G |
2: 107,126,829 (GRCm39) |
V521G |
probably damaging |
Het |
| Kdr |
C |
T |
5: 76,113,565 (GRCm39) |
G768S |
possibly damaging |
Het |
| Kif6 |
G |
T |
17: 50,208,799 (GRCm39) |
A740S |
probably benign |
Het |
| Lad1 |
T |
A |
1: 135,755,468 (GRCm39) |
V248E |
probably damaging |
Het |
| Lamb1 |
T |
G |
12: 31,368,271 (GRCm39) |
C1134G |
probably damaging |
Het |
| Lamc1 |
A |
G |
1: 153,125,618 (GRCm39) |
Y552H |
probably damaging |
Het |
| Mctp1 |
A |
T |
13: 76,973,860 (GRCm39) |
T706S |
probably damaging |
Het |
| Med12l |
A |
G |
3: 59,168,193 (GRCm39) |
Y1541C |
probably damaging |
Het |
| Mnx1 |
C |
T |
5: 29,682,780 (GRCm39) |
S165N |
unknown |
Het |
| Morn3 |
A |
T |
5: 123,184,692 (GRCm39) |
|
probably null |
Het |
| Nalcn |
C |
T |
14: 123,697,824 (GRCm39) |
R484Q |
probably damaging |
Het |
| Nr4a1 |
T |
C |
15: 101,169,645 (GRCm39) |
I305T |
probably benign |
Het |
| Or1j11 |
C |
T |
2: 36,311,886 (GRCm39) |
H159Y |
probably damaging |
Het |
| Or2z2 |
G |
A |
11: 58,346,257 (GRCm39) |
R173W |
probably damaging |
Het |
| Pabir2 |
T |
A |
X: 52,342,933 (GRCm39) |
Q201H |
probably benign |
Het |
| Pcdhb5 |
T |
C |
18: 37,455,393 (GRCm39) |
V591A |
possibly damaging |
Het |
| Pdia3 |
T |
C |
2: 121,262,144 (GRCm39) |
I205T |
probably benign |
Het |
| Pdia4 |
A |
T |
6: 47,790,161 (GRCm39) |
D26E |
unknown |
Het |
| Phactr3 |
C |
A |
2: 177,924,940 (GRCm39) |
L292M |
probably damaging |
Het |
| Phf21b |
T |
A |
15: 84,738,963 (GRCm39) |
I21F |
probably benign |
Het |
| Pign |
A |
G |
1: 105,482,223 (GRCm39) |
V791A |
probably damaging |
Het |
| Pitpna |
A |
G |
11: 75,499,929 (GRCm39) |
|
probably null |
Het |
| Piwil1 |
G |
T |
5: 128,824,903 (GRCm39) |
E534* |
probably null |
Het |
| Plcz1 |
T |
A |
6: 139,938,775 (GRCm39) |
I526F |
probably benign |
Het |
| Pms2 |
A |
T |
5: 143,862,714 (GRCm39) |
K607I |
probably benign |
Het |
| Pnn |
T |
A |
12: 59,118,399 (GRCm39) |
N327K |
probably damaging |
Het |
| Pogz |
C |
T |
3: 94,786,160 (GRCm39) |
T863I |
probably benign |
Het |
| Polq |
C |
T |
16: 36,882,471 (GRCm39) |
T1545I |
probably benign |
Het |
| Psd4 |
G |
A |
2: 24,287,468 (GRCm39) |
E467K |
probably benign |
Het |
| Pstpip2 |
T |
A |
18: 77,959,499 (GRCm39) |
L198Q |
probably damaging |
Het |
| Pzp |
T |
C |
6: 128,479,188 (GRCm39) |
Y655C |
probably damaging |
Het |
| Qrsl1 |
C |
T |
10: 43,770,541 (GRCm39) |
G117E |
probably damaging |
Het |
| Rad54b |
G |
A |
4: 11,601,669 (GRCm39) |
C408Y |
probably damaging |
Het |
| Ralb |
T |
A |
1: 119,403,797 (GRCm39) |
Q110L |
possibly damaging |
Het |
| Rrm2 |
A |
G |
12: 24,763,151 (GRCm39) |
K218E |
probably damaging |
Het |
| Siglece |
A |
G |
7: 43,309,360 (GRCm39) |
F66S |
probably benign |
Het |
| Slc17a8 |
A |
T |
10: 89,442,627 (GRCm39) |
C69S |
unknown |
Het |
| Slc1a6 |
T |
A |
10: 78,648,758 (GRCm39) |
V493E |
probably damaging |
Het |
| Slc38a11 |
A |
T |
2: 65,193,860 (GRCm39) |
|
probably null |
Het |
| Smarcal1 |
G |
A |
1: 72,625,258 (GRCm39) |
G135D |
possibly damaging |
Het |
| Snrnp70 |
T |
A |
7: 45,026,644 (GRCm39) |
R242* |
probably null |
Het |
| St3gal5 |
T |
C |
6: 72,109,077 (GRCm39) |
L55P |
probably damaging |
Het |
| Sulf1 |
A |
G |
1: 12,908,661 (GRCm39) |
N558S |
probably benign |
Het |
| Supt6 |
T |
C |
11: 78,123,366 (GRCm39) |
I104V |
possibly damaging |
Het |
| Tas2r113 |
T |
A |
6: 132,870,292 (GRCm39) |
Y107N |
probably damaging |
Het |
| Tcf7 |
A |
G |
11: 52,147,891 (GRCm39) |
V187A |
probably benign |
Het |
| Tdrd9 |
G |
A |
12: 112,011,246 (GRCm39) |
G1152R |
probably damaging |
Het |
| Tfpi |
A |
G |
2: 84,288,451 (GRCm39) |
Y9H |
probably benign |
Het |
| Tnk2 |
G |
A |
16: 32,498,960 (GRCm39) |
V758I |
probably damaging |
Het |
| Trim72 |
A |
G |
7: 127,608,254 (GRCm39) |
I251V |
probably benign |
Het |
| Ttn |
A |
G |
2: 76,581,773 (GRCm39) |
V23040A |
probably damaging |
Het |
| Tulp2 |
T |
A |
7: 45,167,367 (GRCm39) |
N188K |
probably damaging |
Het |
| Ube2c |
C |
T |
2: 164,613,282 (GRCm39) |
H67Y |
probably damaging |
Het |
| Unc80 |
C |
A |
1: 66,670,573 (GRCm39) |
P1899T |
possibly damaging |
Het |
| Usp34 |
C |
T |
11: 23,376,153 (GRCm39) |
A1879V |
probably benign |
Het |
| Vmn2r118 |
G |
A |
17: 55,918,556 (GRCm39) |
S112L |
possibly damaging |
Het |
| Wdfy3 |
A |
T |
5: 102,036,052 (GRCm39) |
V2122E |
probably benign |
Het |
| Zcchc4 |
A |
G |
5: 52,973,168 (GRCm39) |
Y344C |
probably damaging |
Het |
| Zdbf2 |
GAAAAA |
GAAAAAA |
1: 63,344,701 (GRCm39) |
|
probably null |
Het |
| Zdhhc25 |
A |
T |
15: 88,484,689 (GRCm39) |
H8L |
probably benign |
Het |
| Zfp455 |
A |
T |
13: 67,355,881 (GRCm39) |
H383L |
probably damaging |
Het |
| Zfp663 |
A |
G |
2: 165,195,211 (GRCm39) |
I336T |
probably benign |
Het |
| Zfp738 |
T |
A |
13: 67,818,476 (GRCm39) |
H505L |
probably damaging |
Het |
| Zfp84 |
T |
G |
7: 29,474,796 (GRCm39) |
F23V |
possibly damaging |
Het |
|
| Other mutations in Trip12 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00331:Trip12
|
APN |
1 |
84,708,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00430:Trip12
|
APN |
1 |
84,741,582 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00465:Trip12
|
APN |
1 |
84,741,582 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00819:Trip12
|
APN |
1 |
84,731,993 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00900:Trip12
|
APN |
1 |
84,702,485 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL00990:Trip12
|
APN |
1 |
84,729,605 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01087:Trip12
|
APN |
1 |
84,735,580 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01400:Trip12
|
APN |
1 |
84,729,699 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01521:Trip12
|
APN |
1 |
84,743,919 (GRCm39) |
splice site |
probably benign |
|
|
IGL01619:Trip12
|
APN |
1 |
84,792,631 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01796:Trip12
|
APN |
1 |
84,705,999 (GRCm39) |
missense |
probably benign |
0.42 |
|
IGL01975:Trip12
|
APN |
1 |
84,792,534 (GRCm39) |
splice site |
probably benign |
|
|
IGL02190:Trip12
|
APN |
1 |
84,743,791 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02474:Trip12
|
APN |
1 |
84,771,854 (GRCm39) |
missense |
probably benign |
|
|
IGL02517:Trip12
|
APN |
1 |
84,721,535 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02631:Trip12
|
APN |
1 |
84,743,729 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02991:Trip12
|
APN |
1 |
84,716,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03161:Trip12
|
APN |
1 |
84,738,853 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03388:Trip12
|
APN |
1 |
84,720,907 (GRCm39) |
missense |
probably damaging |
0.99 |
|
cardamom
|
UTSW |
1 |
84,726,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
pungent
|
UTSW |
1 |
84,771,636 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
spices
|
UTSW |
1 |
84,771,596 (GRCm39) |
missense |
probably benign |
0.10 |
|
sulfuric
|
UTSW |
1 |
84,736,771 (GRCm39) |
missense |
probably benign |
0.19 |
|
Turmeric
|
UTSW |
1 |
84,732,064 (GRCm39) |
missense |
probably benign |
0.07 |
|
LCD18:Trip12
|
UTSW |
1 |
84,754,482 (GRCm38) |
unclassified |
probably benign |
|
|
R0090:Trip12
|
UTSW |
1 |
84,709,857 (GRCm39) |
splice site |
probably benign |
|
|
R0111:Trip12
|
UTSW |
1 |
84,736,854 (GRCm39) |
unclassified |
probably benign |
|
|
R0471:Trip12
|
UTSW |
1 |
84,703,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0486:Trip12
|
UTSW |
1 |
84,738,805 (GRCm39) |
nonsense |
probably null |
|
|
R0557:Trip12
|
UTSW |
1 |
84,702,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0570:Trip12
|
UTSW |
1 |
84,729,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0614:Trip12
|
UTSW |
1 |
84,735,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0627:Trip12
|
UTSW |
1 |
84,746,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0630:Trip12
|
UTSW |
1 |
84,771,636 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R0657:Trip12
|
UTSW |
1 |
84,736,771 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0741:Trip12
|
UTSW |
1 |
84,722,902 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0862:Trip12
|
UTSW |
1 |
84,721,730 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0864:Trip12
|
UTSW |
1 |
84,721,730 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1124:Trip12
|
UTSW |
1 |
84,714,758 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1252:Trip12
|
UTSW |
1 |
84,754,071 (GRCm39) |
nonsense |
probably null |
|
|
R1455:Trip12
|
UTSW |
1 |
84,736,821 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1487:Trip12
|
UTSW |
1 |
84,746,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1702:Trip12
|
UTSW |
1 |
84,722,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1781:Trip12
|
UTSW |
1 |
84,708,342 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1847:Trip12
|
UTSW |
1 |
84,726,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1866:Trip12
|
UTSW |
1 |
84,722,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1926:Trip12
|
UTSW |
1 |
84,727,012 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1935:Trip12
|
UTSW |
1 |
84,771,822 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1950:Trip12
|
UTSW |
1 |
84,738,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1994:Trip12
|
UTSW |
1 |
84,726,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2014:Trip12
|
UTSW |
1 |
84,738,587 (GRCm39) |
nonsense |
probably null |
|
|
R2391:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R2423:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R2433:Trip12
|
UTSW |
1 |
84,721,544 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R2905:Trip12
|
UTSW |
1 |
84,732,064 (GRCm39) |
missense |
probably benign |
0.07 |
|
R3040:Trip12
|
UTSW |
1 |
84,719,966 (GRCm39) |
missense |
probably benign |
0.13 |
|
R3735:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R3907:Trip12
|
UTSW |
1 |
84,709,827 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4394:Trip12
|
UTSW |
1 |
84,703,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4540:Trip12
|
UTSW |
1 |
84,726,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4859:Trip12
|
UTSW |
1 |
84,771,531 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5240:Trip12
|
UTSW |
1 |
84,771,854 (GRCm39) |
missense |
probably benign |
|
|
R5278:Trip12
|
UTSW |
1 |
84,739,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5377:Trip12
|
UTSW |
1 |
84,735,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5510:Trip12
|
UTSW |
1 |
84,746,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5542:Trip12
|
UTSW |
1 |
84,727,065 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5550:Trip12
|
UTSW |
1 |
84,738,820 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5886:Trip12
|
UTSW |
1 |
84,708,179 (GRCm39) |
intron |
probably benign |
|
|
R5893:Trip12
|
UTSW |
1 |
84,736,884 (GRCm39) |
unclassified |
probably benign |
|
|
R5914:Trip12
|
UTSW |
1 |
84,741,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5925:Trip12
|
UTSW |
1 |
84,726,974 (GRCm39) |
nonsense |
probably null |
|
|
R5985:Trip12
|
UTSW |
1 |
84,703,492 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6135:Trip12
|
UTSW |
1 |
84,738,559 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6158:Trip12
|
UTSW |
1 |
84,738,733 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6419:Trip12
|
UTSW |
1 |
84,771,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6816:Trip12
|
UTSW |
1 |
84,771,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7144:Trip12
|
UTSW |
1 |
84,771,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7194:Trip12
|
UTSW |
1 |
84,771,943 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7355:Trip12
|
UTSW |
1 |
84,792,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7361:Trip12
|
UTSW |
1 |
84,728,163 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7588:Trip12
|
UTSW |
1 |
84,738,604 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7705:Trip12
|
UTSW |
1 |
84,755,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7818:Trip12
|
UTSW |
1 |
84,738,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7918:Trip12
|
UTSW |
1 |
84,722,784 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8127:Trip12
|
UTSW |
1 |
84,716,463 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8221:Trip12
|
UTSW |
1 |
84,743,771 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8336:Trip12
|
UTSW |
1 |
84,743,762 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8373:Trip12
|
UTSW |
1 |
84,773,488 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8719:Trip12
|
UTSW |
1 |
84,722,790 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8771:Trip12
|
UTSW |
1 |
84,721,018 (GRCm39) |
unclassified |
probably benign |
|
|
R8997:Trip12
|
UTSW |
1 |
84,771,596 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9146:Trip12
|
UTSW |
1 |
84,771,881 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9236:Trip12
|
UTSW |
1 |
84,703,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9338:Trip12
|
UTSW |
1 |
84,727,019 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9391:Trip12
|
UTSW |
1 |
84,773,473 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9516:Trip12
|
UTSW |
1 |
84,735,215 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0023:Trip12
|
UTSW |
1 |
84,738,508 (GRCm39) |
missense |
probably benign |
0.12 |
|
X0065:Trip12
|
UTSW |
1 |
84,726,884 (GRCm39) |
missense |
probably benign |
0.21 |
|
Z1088:Trip12
|
UTSW |
1 |
84,743,889 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTGTTCTCAACAAAGCACACAG -3'
(R):5'- AGGCACTAAAGGAACCATCAATTG -3'
Sequencing Primer
(F):5'- GCACACAGAAGCTTACAAAGG -3'
(R):5'- AATTTTGCATGTATTTTTGTGCTTCC -3'
|
| Posted On |
2014-06-23 |
Incidental Mutation