Incidental Mutation 'R0113:Or10n1'
ID 20591
Institutional Source Beutler Lab
Gene Symbol Or10n1
Ensembl Gene ENSMUSG00000048299
Gene Name olfactory receptor family 10 subfamily N member 1
Synonyms MOR224-4, Olfr148, M30, GA_x6K02T2PVTD-33310486-33311418
MMRRC Submission 038399-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # R0113 (G1)
Quality Score 225
Status Validated (trace)
Chromosome 9
Chromosomal Location 39524865-39525797 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 39525298 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Lysine at position 145 (I145K)
Ref Sequence ENSEMBL: ENSMUSP00000150761 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050807] [ENSMUST00000216801]
AlphaFold Q60887
Predicted Effect probably benign
Transcript: ENSMUST00000050807
AA Change: I145K

PolyPhen 2 Score 0.113 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000096473
Gene: ENSMUSG00000048299
AA Change: I145K

DomainStartEndE-ValueType
Pfam:7tm_4 29 304 8.4e-46 PFAM
Pfam:7TM_GPCR_Srsx 33 301 5.8e-6 PFAM
Pfam:7tm_1 39 287 4.7e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216801
AA Change: I145K

PolyPhen 2 Score 0.113 (Sensitivity: 0.93; Specificity: 0.86)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.1%
  • 10x: 95.2%
  • 20x: 87.5%
Validation Efficiency 99% (70/71)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3930402G23Rik A G 8: 10,976,126 (GRCm39) noncoding transcript Het
Abca13 A T 11: 9,242,114 (GRCm39) I1326F possibly damaging Het
Arnt2 G A 7: 83,996,738 (GRCm39) R63C probably damaging Het
Aspscr1 C G 11: 120,579,751 (GRCm39) Q97E probably damaging Het
Atad2 A G 15: 57,984,330 (GRCm39) probably benign Het
Atcay A T 10: 81,050,554 (GRCm39) probably null Het
Brme1 C T 8: 84,893,871 (GRCm39) T311I probably damaging Het
C4b T A 17: 34,960,214 (GRCm39) Y279F probably damaging Het
Cav1 A T 6: 17,308,048 (GRCm39) S67C possibly damaging Het
Ceacam23 G A 7: 17,642,873 (GRCm39) noncoding transcript Het
Celf2 A C 2: 6,629,525 (GRCm39) H113Q probably damaging Het
Cep170 A C 1: 176,586,021 (GRCm39) N590K probably damaging Het
Ces1f A T 8: 94,006,327 (GRCm39) M1K probably null Het
Chrna1 C A 2: 73,397,180 (GRCm39) D370Y possibly damaging Het
Csmd1 C A 8: 16,034,849 (GRCm39) G2441C probably damaging Het
D630003M21Rik C T 2: 158,038,495 (GRCm39) D984N possibly damaging Het
Dhrs1 T C 14: 55,977,396 (GRCm39) T241A probably benign Het
Edar A C 10: 58,465,271 (GRCm39) C31G probably damaging Het
Eps8 A G 6: 137,514,682 (GRCm39) S24P possibly damaging Het
Fam149a T C 8: 45,794,061 (GRCm39) E669G probably damaging Het
Fcrla A T 1: 170,749,868 (GRCm39) M1K probably null Het
G3bp1 T A 11: 55,386,252 (GRCm39) V237E probably benign Het
Galnt5 A G 2: 57,888,889 (GRCm39) E163G probably benign Het
Gpr87 T C 3: 59,086,932 (GRCm39) D192G possibly damaging Het
Ino80 G A 2: 119,213,441 (GRCm39) R1249C probably damaging Het
Ints1 T C 5: 139,750,968 (GRCm39) T810A Het
Kalrn A G 16: 33,870,306 (GRCm39) probably benign Het
Kcnk6 T C 7: 28,931,634 (GRCm39) D92G probably damaging Het
Marf1 C T 16: 13,960,398 (GRCm39) A549T probably damaging Het
Mfsd13a C T 19: 46,354,943 (GRCm39) T40I probably benign Het
Mfsd6 A T 1: 52,748,348 (GRCm39) N172K probably damaging Het
Mtcl1 G T 17: 66,661,237 (GRCm39) Q1225K possibly damaging Het
Nav2 C T 7: 49,185,701 (GRCm39) T948M probably damaging Het
Nfic T C 10: 81,256,419 (GRCm39) K104E probably damaging Het
Nup58 G A 14: 60,488,740 (GRCm39) probably benign Het
Nwd2 A T 5: 63,965,241 (GRCm39) K1608N probably damaging Het
Or1j21 G A 2: 36,684,006 (GRCm39) G253R probably damaging Het
Or1j21 G T 2: 36,684,007 (GRCm39) G253V probably damaging Het
Phf21b T C 15: 84,688,968 (GRCm39) D186G probably damaging Het
Poli C T 18: 70,661,829 (GRCm39) C57Y probably damaging Het
Ppp1r16a C T 15: 76,574,999 (GRCm39) probably benign Het
Psg23 T C 7: 18,345,927 (GRCm39) Y256C probably benign Het
Satb1 C A 17: 52,089,726 (GRCm39) E374* probably null Het
Scn4a C T 11: 106,236,262 (GRCm39) E333K probably benign Het
Sec14l2 C T 11: 4,053,661 (GRCm39) probably benign Het
Slain1 T C 14: 103,923,261 (GRCm39) probably benign Het
Snapc1 C T 12: 74,021,806 (GRCm39) R81C probably damaging Het
Syne2 T C 12: 75,977,352 (GRCm39) S1266P probably damaging Het
Syne2 A G 12: 76,080,496 (GRCm39) E4810G probably damaging Het
Tbck T C 3: 132,448,841 (GRCm39) I618T probably damaging Het
Tmem132d A T 5: 127,861,657 (GRCm39) N821K probably benign Het
Trim28 T A 7: 12,762,628 (GRCm39) V381E probably damaging Het
Ttc1 T C 11: 43,636,115 (GRCm39) S43G probably benign Het
Ube2u A G 4: 100,338,852 (GRCm39) E39G possibly damaging Het
Urb2 T C 8: 124,757,665 (GRCm39) V1124A probably benign Het
Usp13 A G 3: 32,872,025 (GRCm39) probably benign Het
Vmn1r216 A T 13: 23,283,631 (GRCm39) S105C probably damaging Het
Yipf2 T C 9: 21,501,412 (GRCm39) T23A probably damaging Het
Zfp521 G A 18: 13,978,148 (GRCm39) T755M probably damaging Het
Zfp619 T A 7: 39,187,183 (GRCm39) M1071K probably benign Het
Zfp942 A T 17: 22,148,066 (GRCm39) C188S probably benign Het
Other mutations in Or10n1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1514:Or10n1 UTSW 9 39,524,992 (GRCm39) missense probably damaging 1.00
R1743:Or10n1 UTSW 9 39,524,916 (GRCm39) missense possibly damaging 0.48
R2061:Or10n1 UTSW 9 39,525,071 (GRCm39) missense probably benign
R2922:Or10n1 UTSW 9 39,525,060 (GRCm39) missense probably benign 0.00
R4207:Or10n1 UTSW 9 39,525,253 (GRCm39) missense possibly damaging 0.95
R4446:Or10n1 UTSW 9 39,525,294 (GRCm39) missense probably benign
R4667:Or10n1 UTSW 9 39,525,034 (GRCm39) missense probably damaging 1.00
R5407:Or10n1 UTSW 9 39,524,991 (GRCm39) missense probably damaging 1.00
R5439:Or10n1 UTSW 9 39,524,916 (GRCm39) missense probably benign 0.03
R5807:Or10n1 UTSW 9 39,525,759 (GRCm39) missense probably benign 0.12
R6606:Or10n1 UTSW 9 39,525,378 (GRCm39) missense probably damaging 1.00
R6729:Or10n1 UTSW 9 39,525,069 (GRCm39) missense probably benign
R7216:Or10n1 UTSW 9 39,525,790 (GRCm39) missense probably benign
R7470:Or10n1 UTSW 9 39,524,998 (GRCm39) missense probably benign 0.40
R7697:Or10n1 UTSW 9 39,525,157 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTACAAAGGATGTGCCGCCCAG -3'
(R):5'- CCTCAGAATGGCAACCCCAATGTG -3'

Sequencing Primer
(F):5'- AGCTCTTCTTTTATCACCTTCTGG -3'
(R):5'- GAGCCAGAAAGCCAACATTG -3'
Posted On 2013-04-11