Incidental Mutation 'R1855:Or8a1b'
ID 206032
Institutional Source Beutler Lab
Gene Symbol Or8a1b
Ensembl Gene ENSMUSG00000061165
Gene Name olfactory receptor family 8 subfamily A member 1B
Synonyms MOR171-3, M72, GA_x6K02T2PVTD-31389446-31388517, MOR171-3, Olfr160
MMRRC Submission 039879-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1855 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 37622644-37623576 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 37623266 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Tyrosine at position 103 (F103Y)
Ref Sequence ENSEMBL: ENSMUSP00000151178 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000104875] [ENSMUST00000211952] [ENSMUST00000215727]
AlphaFold Q8VGE3
Predicted Effect possibly damaging
Transcript: ENSMUST00000104875
AA Change: F103Y

PolyPhen 2 Score 0.918 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000100468
Gene: ENSMUSG00000061165
AA Change: F103Y

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 3.5e-48 PFAM
Pfam:7tm_1 41 290 6.7e-24 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000211952
AA Change: F103Y

PolyPhen 2 Score 0.918 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000215727
AA Change: F103Y

PolyPhen 2 Score 0.918 (Sensitivity: 0.81; Specificity: 0.94)
Meta Mutation Damage Score 0.1334 question?
Coding Region Coverage
  • 1x: 97.4%
  • 3x: 96.9%
  • 10x: 95.3%
  • 20x: 92.4%
Validation Efficiency 97% (72/74)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a reporter allele respond heterogeneously to odorants and display abnormal innervation of glomeruli by olfactory sensory axons in the olfactory bulb. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A830018L16Rik T A 1: 11,818,195 (GRCm39) L285Q probably damaging Het
Acaca T C 11: 84,262,380 (GRCm39) L1994P probably damaging Het
Adamts9 A G 6: 92,878,350 (GRCm39) probably benign Het
Aff3 T C 1: 38,249,385 (GRCm39) E574G probably benign Het
Ankrd1 T C 19: 36,096,635 (GRCm39) K64R probably damaging Het
Arhgap23 T C 11: 97,339,523 (GRCm39) I163T probably damaging Het
Ascc3 A T 10: 50,494,018 (GRCm39) Q151L probably benign Het
Atad2 G A 15: 57,960,685 (GRCm39) P971L possibly damaging Het
C1s1 A C 6: 124,511,315 (GRCm39) probably null Het
Ccdc150 T C 1: 54,407,069 (GRCm39) probably benign Het
Cdhr3 A T 12: 33,110,351 (GRCm39) I311N probably damaging Het
Chad T A 11: 94,456,303 (GRCm39) L127H probably damaging Het
Clasp1 G A 1: 118,436,624 (GRCm39) A303T probably damaging Het
Clptm1 A G 7: 19,372,134 (GRCm39) V234A probably benign Het
Cnih3 C A 1: 181,282,186 (GRCm39) S140* probably null Het
Col24a1 G A 3: 145,164,895 (GRCm39) G1033D probably damaging Het
Csnk1a1 T A 18: 61,708,498 (GRCm39) probably null Het
Cttnbp2 T A 6: 18,378,412 (GRCm39) I1475L probably benign Het
Dnah5 T C 15: 28,411,815 (GRCm39) V3728A possibly damaging Het
Dock9 C A 14: 121,877,571 (GRCm39) V391F probably damaging Het
Ehmt2 A T 17: 35,129,752 (GRCm39) I949F probably damaging Het
Eif4g1 C A 16: 20,505,911 (GRCm39) T1025K possibly damaging Het
Enpp2 C T 15: 54,709,219 (GRCm39) E803K probably damaging Het
Esrrg A T 1: 187,943,295 (GRCm39) M423L probably damaging Het
Etnppl A T 3: 130,414,371 (GRCm39) I89F probably benign Het
Fabp3 C T 4: 130,206,180 (GRCm39) T57I probably benign Het
Fbln7 A G 2: 128,735,755 (GRCm39) T248A possibly damaging Het
Galnt9 C T 5: 110,763,390 (GRCm39) T465M probably damaging Het
Grcc10 A G 6: 124,717,541 (GRCm39) V57A probably benign Het
Herc1 T A 9: 66,298,708 (GRCm39) M614K possibly damaging Het
Itch C T 2: 155,014,374 (GRCm39) probably benign Het
Kdm6b C A 11: 69,298,112 (GRCm39) A167S probably damaging Het
Kidins220 C T 12: 25,106,590 (GRCm39) R1348C probably damaging Het
Kif17 T C 4: 138,015,582 (GRCm39) L577P probably benign Het
Krt25 A T 11: 99,209,141 (GRCm39) L258Q probably damaging Het
Marchf10 T C 11: 105,281,218 (GRCm39) T356A probably benign Het
Mical2 G A 7: 111,944,489 (GRCm39) A940T probably benign Het
Mrpl4 A G 9: 20,914,667 (GRCm39) E81G possibly damaging Het
Mtcl1 A G 17: 66,686,509 (GRCm39) V447A probably benign Het
Mtor C A 4: 148,637,546 (GRCm39) N2502K probably benign Het
Notch4 G A 17: 34,799,936 (GRCm39) D966N probably benign Het
Oip5 C A 2: 119,442,271 (GRCm39) K214N probably benign Het
Pabir2 T A X: 52,342,933 (GRCm39) Q201H probably benign Het
Pak5 A T 2: 135,929,429 (GRCm39) S585T probably benign Het
Pard3 T A 8: 128,174,293 (GRCm39) probably null Het
Pcnx2 A T 8: 126,534,735 (GRCm39) probably benign Het
Pcsk5 T C 19: 17,492,556 (GRCm39) Y939C possibly damaging Het
Pde1a A G 2: 79,728,408 (GRCm39) probably null Het
Pde9a C T 17: 31,674,094 (GRCm39) P60S probably damaging Het
Pikfyve C A 1: 65,297,957 (GRCm39) T1562K probably benign Het
Plekhg6 A T 6: 125,352,802 (GRCm39) M115K probably damaging Het
Pogz C T 3: 94,786,160 (GRCm39) T863I probably benign Het
Ppp1r3a A T 6: 14,754,993 (GRCm39) W85R probably damaging Het
Rnf123 C A 9: 107,938,990 (GRCm39) R826L probably damaging Het
Slc1a6 T A 10: 78,648,758 (GRCm39) V493E probably damaging Het
Slc22a2 A G 17: 12,805,699 (GRCm39) D150G probably damaging Het
Snap47 C T 11: 59,319,159 (GRCm39) probably benign Het
Spata22 A G 11: 73,231,385 (GRCm39) D213G probably benign Het
St6galnac2 T A 11: 116,581,141 (GRCm39) R60S probably benign Het
Stk32c A G 7: 138,701,363 (GRCm39) F263S probably damaging Het
Supt6 T C 11: 78,123,366 (GRCm39) I104V possibly damaging Het
Tex2 T C 11: 106,437,702 (GRCm39) E158G possibly damaging Het
Tiam2 C T 17: 3,465,410 (GRCm39) R380C probably damaging Het
Trim25 C T 11: 88,906,407 (GRCm39) T410I probably benign Het
Usp18 T A 6: 121,239,076 (GRCm39) C212S probably benign Het
Vmn1r2 A G 4: 3,172,588 (GRCm39) Y169C probably damaging Het
Wdr33 A T 18: 32,039,909 (GRCm39) probably benign Het
Xpr1 A G 1: 155,159,002 (GRCm39) Y597H probably benign Het
Yy1 CGGG CGGGGGGGGG 12: 108,759,916 (GRCm39) probably benign Het
Zfp54 T A 17: 21,654,404 (GRCm39) Y299* probably null Het
Zfp566 T G 7: 29,777,927 (GRCm39) S85R probably benign Het
Other mutations in Or8a1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01989:Or8a1b APN 9 37,623,132 (GRCm39) missense probably damaging 0.98
IGL02195:Or8a1b APN 9 37,623,417 (GRCm39) missense probably benign
R0099:Or8a1b UTSW 9 37,622,750 (GRCm39) missense probably damaging 0.99
R0124:Or8a1b UTSW 9 37,622,759 (GRCm39) missense possibly damaging 0.79
R0129:Or8a1b UTSW 9 37,623,236 (GRCm39) missense probably damaging 1.00
R0882:Or8a1b UTSW 9 37,623,168 (GRCm39) missense probably benign 0.02
R1988:Or8a1b UTSW 9 37,622,993 (GRCm39) missense possibly damaging 0.50
R2346:Or8a1b UTSW 9 37,622,661 (GRCm39) missense possibly damaging 0.50
R4164:Or8a1b UTSW 9 37,622,994 (GRCm39) missense probably benign 0.03
R4274:Or8a1b UTSW 9 37,623,364 (GRCm39) missense probably damaging 1.00
R4504:Or8a1b UTSW 9 37,622,760 (GRCm39) missense probably benign 0.03
R4505:Or8a1b UTSW 9 37,622,760 (GRCm39) missense probably benign 0.03
R4506:Or8a1b UTSW 9 37,622,760 (GRCm39) missense probably benign 0.03
R5017:Or8a1b UTSW 9 37,622,821 (GRCm39) nonsense probably null
R5268:Or8a1b UTSW 9 37,623,300 (GRCm39) missense probably damaging 1.00
R5316:Or8a1b UTSW 9 37,622,981 (GRCm39) missense possibly damaging 0.90
R5372:Or8a1b UTSW 9 37,623,234 (GRCm39) missense possibly damaging 0.49
R5385:Or8a1b UTSW 9 37,623,317 (GRCm39) missense probably damaging 1.00
R5822:Or8a1b UTSW 9 37,623,087 (GRCm39) missense probably benign 0.01
R5906:Or8a1b UTSW 9 37,623,101 (GRCm39) missense probably benign 0.23
R5990:Or8a1b UTSW 9 37,623,406 (GRCm39) missense probably damaging 0.99
R6842:Or8a1b UTSW 9 37,622,885 (GRCm39) missense probably benign
R7712:Or8a1b UTSW 9 37,623,429 (GRCm39) missense probably damaging 1.00
R8132:Or8a1b UTSW 9 37,623,369 (GRCm39) missense probably benign 0.41
R8435:Or8a1b UTSW 9 37,622,846 (GRCm39) missense probably damaging 1.00
R9054:Or8a1b UTSW 9 37,623,204 (GRCm39) missense probably damaging 1.00
R9378:Or8a1b UTSW 9 37,623,473 (GRCm39) missense probably damaging 1.00
Z1177:Or8a1b UTSW 9 37,622,860 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- TAGTGGCTGATGAGGTCCTC -3'
(R):5'- TGGGCATGATCACCTTGATTGG -3'

Sequencing Primer
(F):5'- TGGCTGATGAGGTCCTCACAATAG -3'
(R):5'- GCATGATCACCTTGATTGGACTCAAC -3'
Posted On 2014-06-23