Incidental Mutation 'R1855:Marchf10'
ID 206047
Institutional Source Beutler Lab
Gene Symbol Marchf10
Ensembl Gene ENSMUSG00000078627
Gene Name membrane associated ring-CH-type finger 10
Synonyms Rnf190, 4933417C16Rik, OTTMUSG00000002847, March10
MMRRC Submission 039879-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R1855 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 105251624-105347561 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 105281218 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 356 (T356A)
Ref Sequence ENSEMBL: ENSMUSP00000121919 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049995] [ENSMUST00000138977]
AlphaFold E9PX79
Predicted Effect probably benign
Transcript: ENSMUST00000049995
AA Change: T356A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000063198
Gene: ENSMUSG00000078627
AA Change: T356A

DomainStartEndE-ValueType
low complexity region 36 49 N/A INTRINSIC
low complexity region 56 71 N/A INTRINSIC
low complexity region 114 130 N/A INTRINSIC
low complexity region 292 304 N/A INTRINSIC
RINGv 638 695 7.45e-22 SMART
low complexity region 728 737 N/A INTRINSIC
low complexity region 767 781 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000138977
AA Change: T356A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000121919
Gene: ENSMUSG00000078627
AA Change: T356A

DomainStartEndE-ValueType
low complexity region 36 49 N/A INTRINSIC
low complexity region 56 71 N/A INTRINSIC
low complexity region 114 130 N/A INTRINSIC
low complexity region 292 304 N/A INTRINSIC
RINGv 638 695 7.45e-22 SMART
low complexity region 728 737 N/A INTRINSIC
low complexity region 767 781 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153672
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 97.4%
  • 3x: 96.9%
  • 10x: 95.3%
  • 20x: 92.4%
Validation Efficiency 97% (72/74)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] MARCH10 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A830018L16Rik T A 1: 11,818,195 (GRCm39) L285Q probably damaging Het
Acaca T C 11: 84,262,380 (GRCm39) L1994P probably damaging Het
Adamts9 A G 6: 92,878,350 (GRCm39) probably benign Het
Aff3 T C 1: 38,249,385 (GRCm39) E574G probably benign Het
Ankrd1 T C 19: 36,096,635 (GRCm39) K64R probably damaging Het
Arhgap23 T C 11: 97,339,523 (GRCm39) I163T probably damaging Het
Ascc3 A T 10: 50,494,018 (GRCm39) Q151L probably benign Het
Atad2 G A 15: 57,960,685 (GRCm39) P971L possibly damaging Het
C1s1 A C 6: 124,511,315 (GRCm39) probably null Het
Ccdc150 T C 1: 54,407,069 (GRCm39) probably benign Het
Cdhr3 A T 12: 33,110,351 (GRCm39) I311N probably damaging Het
Chad T A 11: 94,456,303 (GRCm39) L127H probably damaging Het
Clasp1 G A 1: 118,436,624 (GRCm39) A303T probably damaging Het
Clptm1 A G 7: 19,372,134 (GRCm39) V234A probably benign Het
Cnih3 C A 1: 181,282,186 (GRCm39) S140* probably null Het
Col24a1 G A 3: 145,164,895 (GRCm39) G1033D probably damaging Het
Csnk1a1 T A 18: 61,708,498 (GRCm39) probably null Het
Cttnbp2 T A 6: 18,378,412 (GRCm39) I1475L probably benign Het
Dnah5 T C 15: 28,411,815 (GRCm39) V3728A possibly damaging Het
Dock9 C A 14: 121,877,571 (GRCm39) V391F probably damaging Het
Ehmt2 A T 17: 35,129,752 (GRCm39) I949F probably damaging Het
Eif4g1 C A 16: 20,505,911 (GRCm39) T1025K possibly damaging Het
Enpp2 C T 15: 54,709,219 (GRCm39) E803K probably damaging Het
Esrrg A T 1: 187,943,295 (GRCm39) M423L probably damaging Het
Etnppl A T 3: 130,414,371 (GRCm39) I89F probably benign Het
Fabp3 C T 4: 130,206,180 (GRCm39) T57I probably benign Het
Fbln7 A G 2: 128,735,755 (GRCm39) T248A possibly damaging Het
Galnt9 C T 5: 110,763,390 (GRCm39) T465M probably damaging Het
Grcc10 A G 6: 124,717,541 (GRCm39) V57A probably benign Het
Herc1 T A 9: 66,298,708 (GRCm39) M614K possibly damaging Het
Itch C T 2: 155,014,374 (GRCm39) probably benign Het
Kdm6b C A 11: 69,298,112 (GRCm39) A167S probably damaging Het
Kidins220 C T 12: 25,106,590 (GRCm39) R1348C probably damaging Het
Kif17 T C 4: 138,015,582 (GRCm39) L577P probably benign Het
Krt25 A T 11: 99,209,141 (GRCm39) L258Q probably damaging Het
Mical2 G A 7: 111,944,489 (GRCm39) A940T probably benign Het
Mrpl4 A G 9: 20,914,667 (GRCm39) E81G possibly damaging Het
Mtcl1 A G 17: 66,686,509 (GRCm39) V447A probably benign Het
Mtor C A 4: 148,637,546 (GRCm39) N2502K probably benign Het
Notch4 G A 17: 34,799,936 (GRCm39) D966N probably benign Het
Oip5 C A 2: 119,442,271 (GRCm39) K214N probably benign Het
Or8a1b A T 9: 37,623,266 (GRCm39) F103Y possibly damaging Het
Pabir2 T A X: 52,342,933 (GRCm39) Q201H probably benign Het
Pak5 A T 2: 135,929,429 (GRCm39) S585T probably benign Het
Pard3 T A 8: 128,174,293 (GRCm39) probably null Het
Pcnx2 A T 8: 126,534,735 (GRCm39) probably benign Het
Pcsk5 T C 19: 17,492,556 (GRCm39) Y939C possibly damaging Het
Pde1a A G 2: 79,728,408 (GRCm39) probably null Het
Pde9a C T 17: 31,674,094 (GRCm39) P60S probably damaging Het
Pikfyve C A 1: 65,297,957 (GRCm39) T1562K probably benign Het
Plekhg6 A T 6: 125,352,802 (GRCm39) M115K probably damaging Het
Pogz C T 3: 94,786,160 (GRCm39) T863I probably benign Het
Ppp1r3a A T 6: 14,754,993 (GRCm39) W85R probably damaging Het
Rnf123 C A 9: 107,938,990 (GRCm39) R826L probably damaging Het
Slc1a6 T A 10: 78,648,758 (GRCm39) V493E probably damaging Het
Slc22a2 A G 17: 12,805,699 (GRCm39) D150G probably damaging Het
Snap47 C T 11: 59,319,159 (GRCm39) probably benign Het
Spata22 A G 11: 73,231,385 (GRCm39) D213G probably benign Het
St6galnac2 T A 11: 116,581,141 (GRCm39) R60S probably benign Het
Stk32c A G 7: 138,701,363 (GRCm39) F263S probably damaging Het
Supt6 T C 11: 78,123,366 (GRCm39) I104V possibly damaging Het
Tex2 T C 11: 106,437,702 (GRCm39) E158G possibly damaging Het
Tiam2 C T 17: 3,465,410 (GRCm39) R380C probably damaging Het
Trim25 C T 11: 88,906,407 (GRCm39) T410I probably benign Het
Usp18 T A 6: 121,239,076 (GRCm39) C212S probably benign Het
Vmn1r2 A G 4: 3,172,588 (GRCm39) Y169C probably damaging Het
Wdr33 A T 18: 32,039,909 (GRCm39) probably benign Het
Xpr1 A G 1: 155,159,002 (GRCm39) Y597H probably benign Het
Yy1 CGGG CGGGGGGGGG 12: 108,759,916 (GRCm39) probably benign Het
Zfp54 T A 17: 21,654,404 (GRCm39) Y299* probably null Het
Zfp566 T G 7: 29,777,927 (GRCm39) S85R probably benign Het
Other mutations in Marchf10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00434:Marchf10 APN 11 105,293,014 (GRCm39) missense possibly damaging 0.82
IGL01461:Marchf10 APN 11 105,280,431 (GRCm39) missense probably damaging 1.00
IGL01473:Marchf10 APN 11 105,280,431 (GRCm39) missense probably damaging 1.00
Forward UTSW 11 105,273,063 (GRCm39) missense probably damaging 1.00
PIT4142001:Marchf10 UTSW 11 105,281,346 (GRCm39) missense probably benign 0.17
R0195:Marchf10 UTSW 11 105,276,351 (GRCm39) missense probably damaging 1.00
R0520:Marchf10 UTSW 11 105,280,708 (GRCm39) missense probably benign
R0628:Marchf10 UTSW 11 105,280,986 (GRCm39) missense probably benign 0.00
R1087:Marchf10 UTSW 11 105,281,488 (GRCm39) missense probably damaging 1.00
R1440:Marchf10 UTSW 11 105,281,409 (GRCm39) missense probably damaging 1.00
R1802:Marchf10 UTSW 11 105,280,741 (GRCm39) missense probably benign 0.00
R1860:Marchf10 UTSW 11 105,287,904 (GRCm39) missense probably damaging 0.99
R2504:Marchf10 UTSW 11 105,276,398 (GRCm39) missense probably damaging 1.00
R3788:Marchf10 UTSW 11 105,287,905 (GRCm39) missense probably damaging 1.00
R4629:Marchf10 UTSW 11 105,280,664 (GRCm39) missense probably benign 0.28
R4755:Marchf10 UTSW 11 105,255,302 (GRCm39) intron probably benign
R4776:Marchf10 UTSW 11 105,280,863 (GRCm39) missense probably benign 0.42
R5067:Marchf10 UTSW 11 105,280,933 (GRCm39) missense possibly damaging 0.51
R5192:Marchf10 UTSW 11 105,262,752 (GRCm39) missense possibly damaging 0.68
R5436:Marchf10 UTSW 11 105,292,991 (GRCm39) missense possibly damaging 0.92
R5541:Marchf10 UTSW 11 105,280,957 (GRCm39) missense probably damaging 1.00
R5888:Marchf10 UTSW 11 105,292,972 (GRCm39) missense possibly damaging 0.92
R5908:Marchf10 UTSW 11 105,281,065 (GRCm39) missense probably benign 0.00
R5914:Marchf10 UTSW 11 105,276,308 (GRCm39) missense probably damaging 1.00
R6038:Marchf10 UTSW 11 105,292,877 (GRCm39) missense probably damaging 0.96
R6178:Marchf10 UTSW 11 105,280,440 (GRCm39) missense probably damaging 1.00
R6300:Marchf10 UTSW 11 105,273,063 (GRCm39) missense probably damaging 1.00
R6612:Marchf10 UTSW 11 105,287,904 (GRCm39) missense probably damaging 0.99
R6894:Marchf10 UTSW 11 105,287,787 (GRCm39) missense possibly damaging 0.94
R6921:Marchf10 UTSW 11 105,280,603 (GRCm39) missense probably benign 0.00
R7134:Marchf10 UTSW 11 105,299,502 (GRCm39) missense probably benign
R7199:Marchf10 UTSW 11 105,281,532 (GRCm39) missense probably damaging 0.99
R7546:Marchf10 UTSW 11 105,280,906 (GRCm39) missense not run
R7792:Marchf10 UTSW 11 105,281,054 (GRCm39) missense probably benign
R8241:Marchf10 UTSW 11 105,280,741 (GRCm39) missense probably benign 0.00
R8467:Marchf10 UTSW 11 105,280,979 (GRCm39) nonsense probably null
R8843:Marchf10 UTSW 11 105,292,802 (GRCm39) missense possibly damaging 0.83
R8962:Marchf10 UTSW 11 105,280,815 (GRCm39) nonsense probably null
R9214:Marchf10 UTSW 11 105,281,100 (GRCm39) missense probably benign 0.02
R9323:Marchf10 UTSW 11 105,280,581 (GRCm39) missense probably damaging 0.98
Z1088:Marchf10 UTSW 11 105,281,185 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTCTCGTGATTTTGAACAGCAGAC -3'
(R):5'- CTCACATGGAGGAAGAGCTC -3'

Sequencing Primer
(F):5'- TTCCACAGTACCACCGCTGG -3'
(R):5'- CTCCTGCTGTCTGGGATGC -3'
Posted On 2014-06-23