Incidental Mutation 'R1856:Dop1a'
| ID |
206135 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dop1a
|
| Ensembl Gene |
ENSMUSG00000034973 |
| Gene Name |
DOP1 leucine zipper like protein A |
| Synonyms |
D9Ertd809e, B130005I07Rik, Dopey1 |
| MMRRC Submission |
039880-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.374)
|
| Stock # |
R1856 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
9 |
| Chromosomal Location |
86349194-86436683 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 86374057 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 172
(V172A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000140740
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000034987]
[ENSMUST00000185919]
[ENSMUST00000188675]
[ENSMUST00000190957]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000034987
AA Change: V172A
PolyPhen 2
Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000034987
Gene: ENSMUSG00000034973
AA Change: V172A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Dopey_N
|
11 |
300 |
1e-117 |
PFAM |
|
low complexity region
|
631 |
649 |
N/A |
INTRINSIC |
|
low complexity region
|
961 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1073 |
1084 |
N/A |
INTRINSIC |
|
low complexity region
|
1105 |
1118 |
N/A |
INTRINSIC |
|
low complexity region
|
1268 |
1281 |
N/A |
INTRINSIC |
|
low complexity region
|
1296 |
1318 |
N/A |
INTRINSIC |
|
low complexity region
|
1335 |
1344 |
N/A |
INTRINSIC |
|
low complexity region
|
1362 |
1373 |
N/A |
INTRINSIC |
|
low complexity region
|
1575 |
1589 |
N/A |
INTRINSIC |
|
low complexity region
|
2217 |
2227 |
N/A |
INTRINSIC |
|
low complexity region
|
2351 |
2362 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000185919
AA Change: V172A
PolyPhen 2
Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000140040
Gene: ENSMUSG00000034973
AA Change: V172A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Dopey_N
|
10 |
306 |
1.9e-106 |
PFAM |
|
low complexity region
|
629 |
647 |
N/A |
INTRINSIC |
|
low complexity region
|
959 |
971 |
N/A |
INTRINSIC |
|
low complexity region
|
1071 |
1082 |
N/A |
INTRINSIC |
|
low complexity region
|
1103 |
1116 |
N/A |
INTRINSIC |
|
low complexity region
|
1266 |
1279 |
N/A |
INTRINSIC |
|
low complexity region
|
1294 |
1316 |
N/A |
INTRINSIC |
|
low complexity region
|
1333 |
1342 |
N/A |
INTRINSIC |
|
low complexity region
|
1360 |
1371 |
N/A |
INTRINSIC |
|
low complexity region
|
1573 |
1587 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000186290
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000186841
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000187607
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000188675
AA Change: V172A
PolyPhen 2
Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000139413
Gene: ENSMUSG00000034973
AA Change: V172A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Dopey_N
|
10 |
306 |
3e-106 |
PFAM |
|
low complexity region
|
622 |
640 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000190407
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000190957
AA Change: V172A
PolyPhen 2
Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000140740
Gene: ENSMUSG00000034973
AA Change: V172A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Dopey_N
|
10 |
305 |
1.3e-108 |
PFAM |
|
low complexity region
|
631 |
649 |
N/A |
INTRINSIC |
|
low complexity region
|
961 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1073 |
1084 |
N/A |
INTRINSIC |
|
low complexity region
|
1105 |
1118 |
N/A |
INTRINSIC |
|
low complexity region
|
1268 |
1281 |
N/A |
INTRINSIC |
|
low complexity region
|
1296 |
1318 |
N/A |
INTRINSIC |
|
low complexity region
|
1335 |
1344 |
N/A |
INTRINSIC |
|
low complexity region
|
1362 |
1373 |
N/A |
INTRINSIC |
|
low complexity region
|
1575 |
1589 |
N/A |
INTRINSIC |
|
low complexity region
|
2217 |
2227 |
N/A |
INTRINSIC |
|
low complexity region
|
2351 |
2362 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000190906
|
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.1%
- 20x: 91.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 113 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aadacl4fm5 |
T |
A |
4: 144,504,453 (GRCm39) |
M233L |
probably benign |
Het |
| Abca14 |
T |
G |
7: 119,877,404 (GRCm39) |
F1017L |
probably damaging |
Het |
| Abcb11 |
A |
C |
2: 69,076,267 (GRCm39) |
V1147G |
probably damaging |
Het |
| Abcc10 |
T |
A |
17: 46,617,529 (GRCm39) |
S1128C |
probably damaging |
Het |
| Adam6a |
G |
A |
12: 113,508,923 (GRCm39) |
C432Y |
probably damaging |
Het |
| Adamdec1 |
C |
T |
14: 68,808,397 (GRCm39) |
V318M |
probably damaging |
Het |
| Ahnak |
C |
A |
19: 8,979,412 (GRCm39) |
S232Y |
possibly damaging |
Het |
| Amt |
A |
C |
9: 108,174,361 (GRCm39) |
H42P |
probably damaging |
Het |
| Anapc1 |
A |
T |
2: 128,501,708 (GRCm39) |
L778Q |
probably damaging |
Het |
| Ankhd1 |
G |
A |
18: 36,777,580 (GRCm39) |
A1588T |
probably benign |
Het |
| Anln |
A |
T |
9: 22,264,627 (GRCm39) |
L881Q |
probably damaging |
Het |
| Appl1 |
A |
G |
14: 26,649,706 (GRCm39) |
S607P |
probably damaging |
Het |
| Arg2 |
G |
T |
12: 79,194,436 (GRCm39) |
V87L |
probably benign |
Het |
| Atp13a2 |
C |
T |
4: 140,731,323 (GRCm39) |
P869L |
probably benign |
Het |
| Atxn7l1 |
T |
A |
12: 33,408,769 (GRCm39) |
D310E |
probably damaging |
Het |
| Cd6 |
A |
T |
19: 10,775,966 (GRCm39) |
D164E |
probably damaging |
Het |
| Cdan1 |
C |
A |
2: 120,555,417 (GRCm39) |
V775L |
probably benign |
Het |
| Cep164 |
A |
T |
9: 45,687,056 (GRCm39) |
|
probably null |
Het |
| Cep41 |
A |
G |
6: 30,661,005 (GRCm39) |
S61P |
probably damaging |
Het |
| Clcn7 |
C |
A |
17: 25,379,445 (GRCm39) |
D764E |
probably damaging |
Het |
| Cog2 |
G |
A |
8: 125,278,142 (GRCm39) |
G703S |
possibly damaging |
Het |
| Cramp1 |
T |
C |
17: 25,187,952 (GRCm39) |
D1214G |
probably damaging |
Het |
| Cst7 |
G |
T |
2: 150,419,628 (GRCm39) |
C98F |
probably damaging |
Het |
| Ctc1 |
T |
A |
11: 68,925,484 (GRCm39) |
L1007Q |
probably damaging |
Het |
| Cyb5r4 |
G |
A |
9: 86,904,262 (GRCm39) |
A11T |
possibly damaging |
Het |
| Dcaf8 |
A |
G |
1: 172,003,120 (GRCm39) |
D306G |
probably damaging |
Het |
| Defb38 |
T |
A |
8: 19,073,592 (GRCm39) |
K27I |
probably benign |
Het |
| Disp3 |
T |
C |
4: 148,356,089 (GRCm39) |
E257G |
probably damaging |
Het |
| Dnajc6 |
T |
C |
4: 101,456,185 (GRCm39) |
S58P |
probably damaging |
Het |
| Dock10 |
A |
T |
1: 80,584,285 (GRCm39) |
D140E |
possibly damaging |
Het |
| Dync1h1 |
G |
A |
12: 110,602,943 (GRCm39) |
E2195K |
probably benign |
Het |
| Eci3 |
C |
T |
13: 35,137,011 (GRCm39) |
A171T |
possibly damaging |
Het |
| Eml2 |
A |
G |
7: 18,927,986 (GRCm39) |
D284G |
probably damaging |
Het |
| Eml5 |
T |
C |
12: 98,776,843 (GRCm39) |
D1377G |
probably damaging |
Het |
| Fam186a |
T |
C |
15: 99,838,183 (GRCm39) |
E2687G |
possibly damaging |
Het |
| Fut9 |
A |
C |
4: 25,620,352 (GRCm39) |
L154R |
probably damaging |
Het |
| Gabrb2 |
A |
G |
11: 42,517,540 (GRCm39) |
N454S |
probably benign |
Het |
| Gpr183 |
T |
A |
14: 122,192,153 (GRCm39) |
I123L |
probably benign |
Het |
| Gucy1b1 |
A |
T |
3: 81,965,659 (GRCm39) |
N62K |
probably benign |
Het |
| Hcrtr2 |
T |
C |
9: 76,167,067 (GRCm39) |
N90S |
probably damaging |
Het |
| Hectd1 |
A |
T |
12: 51,791,577 (GRCm39) |
L2556Q |
probably damaging |
Het |
| Hfm1 |
T |
A |
5: 106,995,542 (GRCm39) |
M1290L |
probably benign |
Het |
| Hgsnat |
A |
G |
8: 26,447,284 (GRCm39) |
W337R |
probably benign |
Het |
| Hmbox1 |
T |
C |
14: 65,066,097 (GRCm39) |
Y291C |
probably damaging |
Het |
| Hmcn1 |
T |
C |
1: 150,597,415 (GRCm39) |
N1749S |
probably benign |
Het |
| Igsf10 |
T |
C |
3: 59,238,693 (GRCm39) |
D496G |
possibly damaging |
Het |
| Iqch |
C |
T |
9: 63,441,619 (GRCm39) |
|
probably null |
Het |
| Irf6 |
A |
G |
1: 192,849,843 (GRCm39) |
D255G |
probably benign |
Het |
| Kif9 |
G |
A |
9: 110,346,787 (GRCm39) |
G642R |
probably null |
Het |
| Klhl20 |
A |
G |
1: 160,934,312 (GRCm39) |
Y236H |
probably benign |
Het |
| Krt39 |
T |
A |
11: 99,409,914 (GRCm39) |
K208* |
probably null |
Het |
| Lama3 |
T |
A |
18: 12,670,838 (GRCm39) |
L808* |
probably null |
Het |
| Lrp5 |
C |
T |
19: 3,647,346 (GRCm39) |
A1299T |
probably benign |
Het |
| Lysmd4 |
A |
G |
7: 66,875,979 (GRCm39) |
Q214R |
probably benign |
Het |
| Macf1 |
T |
A |
4: 123,263,641 (GRCm39) |
E6960V |
probably damaging |
Het |
| Mcpt2 |
A |
G |
14: 56,281,156 (GRCm39) |
E120G |
probably benign |
Het |
| Mpeg1 |
A |
G |
19: 12,439,720 (GRCm39) |
T393A |
probably benign |
Het |
| Myh4 |
G |
A |
11: 67,146,508 (GRCm39) |
E1494K |
probably damaging |
Het |
| Nbas |
T |
G |
12: 13,524,230 (GRCm39) |
S1695R |
possibly damaging |
Het |
| Nlgn1 |
G |
T |
3: 25,494,201 (GRCm39) |
Y249* |
probably null |
Het |
| Ntn4 |
C |
T |
10: 93,543,215 (GRCm39) |
R314W |
probably damaging |
Het |
| Nup107 |
A |
G |
10: 117,586,811 (GRCm39) |
L910P |
probably damaging |
Het |
| Obscn |
T |
A |
11: 58,931,122 (GRCm39) |
D5838V |
probably damaging |
Het |
| Or10g7 |
T |
C |
9: 39,905,655 (GRCm39) |
I183T |
probably benign |
Het |
| Or1j18 |
T |
C |
2: 36,624,357 (GRCm39) |
I8T |
probably benign |
Het |
| Or4c113 |
G |
A |
2: 88,885,203 (GRCm39) |
T189M |
possibly damaging |
Het |
| Or8d2b |
T |
C |
9: 38,788,892 (GRCm39) |
I140T |
possibly damaging |
Het |
| Otogl |
G |
T |
10: 107,690,125 (GRCm39) |
S915Y |
possibly damaging |
Het |
| P2rx7 |
T |
A |
5: 122,819,095 (GRCm39) |
C506S |
probably damaging |
Het |
| P4hb |
T |
C |
11: 120,454,044 (GRCm39) |
E350G |
probably benign |
Het |
| Papolg |
A |
T |
11: 23,817,379 (GRCm39) |
V606E |
probably benign |
Het |
| Pappa |
A |
T |
4: 65,258,980 (GRCm39) |
D1576V |
probably damaging |
Het |
| Pclo |
G |
T |
5: 14,828,566 (GRCm39) |
V1402F |
probably damaging |
Het |
| Pdcd11 |
A |
G |
19: 47,086,626 (GRCm39) |
T211A |
probably benign |
Het |
| Pdzd2 |
T |
C |
15: 12,373,941 (GRCm39) |
R2065G |
possibly damaging |
Het |
| Plcl2 |
T |
C |
17: 50,914,878 (GRCm39) |
V629A |
probably benign |
Het |
| Prkcsh |
G |
A |
9: 21,915,871 (GRCm39) |
V92I |
possibly damaging |
Het |
| Prpf19 |
G |
T |
19: 10,879,780 (GRCm39) |
V320F |
probably damaging |
Het |
| Ptpn3 |
T |
A |
4: 57,239,682 (GRCm39) |
I283F |
probably damaging |
Het |
| Rcc2 |
T |
A |
4: 140,447,915 (GRCm39) |
D480E |
probably benign |
Het |
| Rnf182 |
G |
A |
13: 43,821,518 (GRCm39) |
C23Y |
probably damaging |
Het |
| Rnf186 |
C |
T |
4: 138,694,673 (GRCm39) |
T71I |
probably benign |
Het |
| Scyl3 |
A |
G |
1: 163,761,265 (GRCm39) |
|
probably null |
Het |
| Slc12a6 |
G |
T |
2: 112,166,272 (GRCm39) |
|
probably null |
Het |
| Slc1a2 |
C |
A |
2: 102,607,912 (GRCm39) |
S520Y |
probably damaging |
Het |
| Slc35e2 |
T |
A |
4: 155,696,186 (GRCm39) |
L191Q |
probably damaging |
Het |
| Snrnp40 |
C |
G |
4: 130,271,836 (GRCm39) |
|
probably null |
Het |
| Snx33 |
T |
C |
9: 56,833,295 (GRCm39) |
H258R |
possibly damaging |
Het |
| Tecpr2 |
A |
T |
12: 110,899,498 (GRCm39) |
H622L |
probably benign |
Het |
| Thbs3 |
A |
T |
3: 89,133,713 (GRCm39) |
E888D |
probably damaging |
Het |
| Tlk2 |
T |
C |
11: 105,112,124 (GRCm39) |
L159P |
probably benign |
Het |
| Tmem70 |
A |
T |
1: 16,747,497 (GRCm39) |
T205S |
probably damaging |
Het |
| Trappc10 |
T |
A |
10: 78,032,285 (GRCm39) |
H1001L |
probably benign |
Het |
| Trim12a |
T |
C |
7: 103,950,064 (GRCm39) |
T292A |
probably benign |
Het |
| Trip11 |
G |
A |
12: 101,849,592 (GRCm39) |
R92* |
probably null |
Het |
| Trpa1 |
G |
A |
1: 14,969,612 (GRCm39) |
Q386* |
probably null |
Het |
| Trpc4 |
T |
A |
3: 54,187,410 (GRCm39) |
V454D |
probably damaging |
Het |
| Ttc36 |
A |
T |
9: 44,714,051 (GRCm39) |
D22E |
probably benign |
Het |
| Ttk |
A |
T |
9: 83,751,316 (GRCm39) |
I798F |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,573,977 (GRCm39) |
I17312V |
probably damaging |
Het |
| Txndc15 |
A |
T |
13: 55,865,875 (GRCm39) |
E113V |
possibly damaging |
Het |
| Ube2d4 |
T |
A |
15: 58,718,448 (GRCm39) |
|
noncoding transcript |
Het |
| Urb1 |
T |
A |
16: 90,558,583 (GRCm39) |
T1723S |
probably benign |
Het |
| Vmn1r65 |
A |
T |
7: 6,011,265 (GRCm39) |
V323D |
possibly damaging |
Het |
| Vmn2r54 |
A |
G |
7: 12,366,238 (GRCm39) |
M232T |
probably benign |
Het |
| Wdr59 |
A |
G |
8: 112,202,813 (GRCm39) |
S577P |
probably damaging |
Het |
| Wfikkn2 |
C |
T |
11: 94,128,949 (GRCm39) |
W397* |
probably null |
Het |
| Ypel1 |
T |
A |
16: 16,899,511 (GRCm39) |
|
probably null |
Het |
| Ythdf1 |
T |
A |
2: 180,552,763 (GRCm39) |
D484V |
probably damaging |
Het |
| Zdhhc17 |
A |
G |
10: 110,783,154 (GRCm39) |
|
probably null |
Het |
| Zfp472 |
A |
T |
17: 33,184,887 (GRCm39) |
H2L |
possibly damaging |
Het |
| Zfp953 |
A |
T |
13: 67,493,422 (GRCm39) |
M74K |
probably benign |
Het |
| Zmat4 |
C |
T |
8: 24,419,151 (GRCm39) |
T61M |
probably benign |
Het |
|
| Other mutations in Dop1a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00226:Dop1a
|
APN |
9 |
86,433,732 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
IGL00427:Dop1a
|
APN |
9 |
86,403,552 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00427:Dop1a
|
APN |
9 |
86,403,551 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL00427:Dop1a
|
APN |
9 |
86,403,553 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL00577:Dop1a
|
APN |
9 |
86,402,999 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00741:Dop1a
|
APN |
9 |
86,404,859 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL00959:Dop1a
|
APN |
9 |
86,369,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01339:Dop1a
|
APN |
9 |
86,433,730 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01608:Dop1a
|
APN |
9 |
86,389,614 (GRCm39) |
missense |
probably benign |
0.23 |
|
IGL01760:Dop1a
|
APN |
9 |
86,401,976 (GRCm39) |
missense |
probably benign |
|
|
IGL01788:Dop1a
|
APN |
9 |
86,413,772 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01844:Dop1a
|
APN |
9 |
86,396,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01923:Dop1a
|
APN |
9 |
86,404,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02036:Dop1a
|
APN |
9 |
86,413,818 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL02308:Dop1a
|
APN |
9 |
86,402,141 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02494:Dop1a
|
APN |
9 |
86,408,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02698:Dop1a
|
APN |
9 |
86,406,412 (GRCm39) |
splice site |
probably benign |
|
|
IGL02731:Dop1a
|
APN |
9 |
86,369,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02821:Dop1a
|
APN |
9 |
86,402,209 (GRCm39) |
missense |
probably benign |
|
|
IGL02952:Dop1a
|
APN |
9 |
86,414,975 (GRCm39) |
splice site |
probably benign |
|
|
IGL03071:Dop1a
|
APN |
9 |
86,371,668 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL03271:Dop1a
|
APN |
9 |
86,386,275 (GRCm39) |
nonsense |
probably null |
|
|
IGL03344:Dop1a
|
APN |
9 |
86,418,197 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Beg
|
UTSW |
9 |
86,430,225 (GRCm39) |
nonsense |
probably null |
|
|
covet
|
UTSW |
9 |
86,397,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
crave
|
UTSW |
9 |
86,399,092 (GRCm39) |
missense |
probably benign |
|
|
desire
|
UTSW |
9 |
86,402,109 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
groak
|
UTSW |
9 |
86,403,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Querer
|
UTSW |
9 |
86,386,265 (GRCm39) |
missense |
probably damaging |
1.00 |
|
yearn
|
UTSW |
9 |
86,386,220 (GRCm39) |
splice site |
probably null |
|
|
R0055:Dop1a
|
UTSW |
9 |
86,394,705 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0285:Dop1a
|
UTSW |
9 |
86,394,692 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0415:Dop1a
|
UTSW |
9 |
86,388,555 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0427:Dop1a
|
UTSW |
9 |
86,389,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0514:Dop1a
|
UTSW |
9 |
86,402,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0538:Dop1a
|
UTSW |
9 |
86,367,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1118:Dop1a
|
UTSW |
9 |
86,397,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1158:Dop1a
|
UTSW |
9 |
86,367,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1272:Dop1a
|
UTSW |
9 |
86,403,477 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1448:Dop1a
|
UTSW |
9 |
86,424,785 (GRCm39) |
splice site |
probably null |
|
|
R1584:Dop1a
|
UTSW |
9 |
86,430,225 (GRCm39) |
nonsense |
probably null |
|
|
R1601:Dop1a
|
UTSW |
9 |
86,418,303 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1674:Dop1a
|
UTSW |
9 |
86,418,213 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1706:Dop1a
|
UTSW |
9 |
86,436,133 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1926:Dop1a
|
UTSW |
9 |
86,405,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1929:Dop1a
|
UTSW |
9 |
86,376,471 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2029:Dop1a
|
UTSW |
9 |
86,403,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2125:Dop1a
|
UTSW |
9 |
86,403,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2206:Dop1a
|
UTSW |
9 |
86,403,652 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2271:Dop1a
|
UTSW |
9 |
86,376,471 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2312:Dop1a
|
UTSW |
9 |
86,403,495 (GRCm39) |
nonsense |
probably null |
|
|
R2379:Dop1a
|
UTSW |
9 |
86,403,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2507:Dop1a
|
UTSW |
9 |
86,395,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3737:Dop1a
|
UTSW |
9 |
86,376,486 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3804:Dop1a
|
UTSW |
9 |
86,403,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3916:Dop1a
|
UTSW |
9 |
86,403,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3921:Dop1a
|
UTSW |
9 |
86,402,324 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4035:Dop1a
|
UTSW |
9 |
86,376,486 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4392:Dop1a
|
UTSW |
9 |
86,385,196 (GRCm39) |
intron |
probably benign |
|
|
R4404:Dop1a
|
UTSW |
9 |
86,404,866 (GRCm39) |
nonsense |
probably null |
|
|
R4513:Dop1a
|
UTSW |
9 |
86,402,612 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4624:Dop1a
|
UTSW |
9 |
86,403,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4659:Dop1a
|
UTSW |
9 |
86,384,085 (GRCm39) |
intron |
probably benign |
|
|
R4910:Dop1a
|
UTSW |
9 |
86,374,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4919:Dop1a
|
UTSW |
9 |
86,402,109 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R5061:Dop1a
|
UTSW |
9 |
86,385,161 (GRCm39) |
splice site |
probably benign |
|
|
R5079:Dop1a
|
UTSW |
9 |
86,369,474 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5118:Dop1a
|
UTSW |
9 |
86,388,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5169:Dop1a
|
UTSW |
9 |
86,415,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5176:Dop1a
|
UTSW |
9 |
86,403,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5190:Dop1a
|
UTSW |
9 |
86,369,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5256:Dop1a
|
UTSW |
9 |
86,397,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5346:Dop1a
|
UTSW |
9 |
86,402,835 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5484:Dop1a
|
UTSW |
9 |
86,427,341 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5501:Dop1a
|
UTSW |
9 |
86,389,783 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5554:Dop1a
|
UTSW |
9 |
86,403,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5707:Dop1a
|
UTSW |
9 |
86,385,050 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5826:Dop1a
|
UTSW |
9 |
86,389,623 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5921:Dop1a
|
UTSW |
9 |
86,383,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5934:Dop1a
|
UTSW |
9 |
86,424,495 (GRCm39) |
nonsense |
probably null |
|
|
R5936:Dop1a
|
UTSW |
9 |
86,418,565 (GRCm39) |
nonsense |
probably null |
|
|
R6046:Dop1a
|
UTSW |
9 |
86,397,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6053:Dop1a
|
UTSW |
9 |
86,397,347 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6072:Dop1a
|
UTSW |
9 |
86,389,750 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6104:Dop1a
|
UTSW |
9 |
86,402,860 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6125:Dop1a
|
UTSW |
9 |
86,403,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6299:Dop1a
|
UTSW |
9 |
86,386,265 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6930:Dop1a
|
UTSW |
9 |
86,413,825 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6949:Dop1a
|
UTSW |
9 |
86,382,913 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6979:Dop1a
|
UTSW |
9 |
86,403,695 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R7035:Dop1a
|
UTSW |
9 |
86,406,355 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7069:Dop1a
|
UTSW |
9 |
86,432,222 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7101:Dop1a
|
UTSW |
9 |
86,389,722 (GRCm39) |
missense |
probably benign |
|
|
R7202:Dop1a
|
UTSW |
9 |
86,386,220 (GRCm39) |
splice site |
probably null |
|
|
R7222:Dop1a
|
UTSW |
9 |
86,404,929 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7233:Dop1a
|
UTSW |
9 |
86,403,749 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7236:Dop1a
|
UTSW |
9 |
86,397,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7252:Dop1a
|
UTSW |
9 |
86,382,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7268:Dop1a
|
UTSW |
9 |
86,394,830 (GRCm39) |
nonsense |
probably null |
|
|
R7353:Dop1a
|
UTSW |
9 |
86,394,912 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7481:Dop1a
|
UTSW |
9 |
86,417,985 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7498:Dop1a
|
UTSW |
9 |
86,376,464 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7507:Dop1a
|
UTSW |
9 |
86,418,002 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7525:Dop1a
|
UTSW |
9 |
86,388,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7539:Dop1a
|
UTSW |
9 |
86,403,626 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7751:Dop1a
|
UTSW |
9 |
86,389,783 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7753:Dop1a
|
UTSW |
9 |
86,371,755 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7839:Dop1a
|
UTSW |
9 |
86,424,818 (GRCm39) |
nonsense |
probably null |
|
|
R7868:Dop1a
|
UTSW |
9 |
86,384,037 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8061:Dop1a
|
UTSW |
9 |
86,403,246 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8067:Dop1a
|
UTSW |
9 |
86,400,392 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8156:Dop1a
|
UTSW |
9 |
86,376,510 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8196:Dop1a
|
UTSW |
9 |
86,405,151 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8223:Dop1a
|
UTSW |
9 |
86,400,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8267:Dop1a
|
UTSW |
9 |
86,396,054 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8276:Dop1a
|
UTSW |
9 |
86,399,092 (GRCm39) |
missense |
probably benign |
|
|
R8306:Dop1a
|
UTSW |
9 |
86,402,259 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8353:Dop1a
|
UTSW |
9 |
86,403,639 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8362:Dop1a
|
UTSW |
9 |
86,395,941 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8403:Dop1a
|
UTSW |
9 |
86,382,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8817:Dop1a
|
UTSW |
9 |
86,396,003 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8862:Dop1a
|
UTSW |
9 |
86,406,404 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8888:Dop1a
|
UTSW |
9 |
86,403,587 (GRCm39) |
missense |
probably benign |
|
|
R8972:Dop1a
|
UTSW |
9 |
86,403,300 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R9001:Dop1a
|
UTSW |
9 |
86,436,374 (GRCm39) |
makesense |
probably null |
|
|
R9011:Dop1a
|
UTSW |
9 |
86,397,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9021:Dop1a
|
UTSW |
9 |
86,402,490 (GRCm39) |
missense |
probably benign |
0.35 |
|
R9039:Dop1a
|
UTSW |
9 |
86,382,870 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9128:Dop1a
|
UTSW |
9 |
86,395,208 (GRCm39) |
missense |
probably benign |
|
|
R9178:Dop1a
|
UTSW |
9 |
86,371,796 (GRCm39) |
nonsense |
probably null |
|
|
R9238:Dop1a
|
UTSW |
9 |
86,415,027 (GRCm39) |
missense |
probably benign |
|
|
R9313:Dop1a
|
UTSW |
9 |
86,406,641 (GRCm39) |
makesense |
probably null |
|
|
R9334:Dop1a
|
UTSW |
9 |
86,403,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9422:Dop1a
|
UTSW |
9 |
86,425,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9562:Dop1a
|
UTSW |
9 |
86,424,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9584:Dop1a
|
UTSW |
9 |
86,385,151 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R9677:Dop1a
|
UTSW |
9 |
86,425,098 (GRCm39) |
missense |
|
|
|
RF004:Dop1a
|
UTSW |
9 |
86,436,244 (GRCm39) |
missense |
probably benign |
|
|
X0019:Dop1a
|
UTSW |
9 |
86,413,803 (GRCm39) |
missense |
probably damaging |
0.98 |
|
X0019:Dop1a
|
UTSW |
9 |
86,388,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
ZE80:Dop1a
|
UTSW |
9 |
86,382,895 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TAGGAAGTGTATGCTTCAAGACTCAC -3'
(R):5'- TCTGGAATGTCTGGCTCTAGAG -3'
Sequencing Primer
(F):5'- AAGACTCACTCACTTGTTTGCAGG -3'
(R):5'- CTGGCTCTAGAGAAACACTTGTAGC -3'
|
| Posted On |
2014-06-23 |
Incidental Mutation