Incidental Mutation 'E0370:Trip13'
ID 206416
Institutional Source Beutler Lab
Gene Symbol Trip13
Ensembl Gene ENSMUSG00000021569
Gene Name thyroid hormone receptor interactor 13
Synonyms D13Ertd328e, 2410002G23Rik
Accession Numbers
Essential gene? Probably essential (E-score: 0.926) question?
Stock # E0370 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 74060577-74085855 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 74068558 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000022053 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022053] [ENSMUST00000222156]
AlphaFold Q3UA06
Predicted Effect probably benign
Transcript: ENSMUST00000022053
SMART Domains Protein: ENSMUSP00000022053
Gene: ENSMUSG00000021569

DomainStartEndE-ValueType
AAA 171 323 1.13e-10 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000175516
Predicted Effect unknown
Transcript: ENSMUST00000222156
AA Change: S18P
Coding Region Coverage
  • 1x: 97.4%
  • 3x: 96.8%
  • 10x: 95.0%
  • 20x: 91.1%
Validation Efficiency 100% (33/33)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer. [provided by RefSeq, Oct 2009]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit postnatal lethality, infertility, reduced gonad size, tail defects and meiotic arrest of sperm and oocytes associated with unrepaired double strand breaks. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930544D05Rik TGCAGCGACTGGACGGCGGCA TGCA 11: 70,507,252 (GRCm39) probably null Het
Aire T A 10: 77,877,897 (GRCm39) N180I probably damaging Het
Asic3 G T 5: 24,618,985 (GRCm39) L92F probably damaging Het
Birc6 G A 17: 74,984,352 (GRCm39) D4455N probably damaging Het
Cd36 A T 5: 17,990,747 (GRCm39) C464* probably null Het
Cdx1 A C 18: 61,153,501 (GRCm39) I179S probably damaging Het
Dnah2 A T 11: 69,406,441 (GRCm39) probably null Het
Dst A T 1: 34,288,552 (GRCm39) probably benign Het
Epb41l3 A G 17: 69,581,799 (GRCm39) N580S possibly damaging Het
Hnrnpm A T 17: 33,877,896 (GRCm39) probably benign Het
Katnip A G 7: 125,449,474 (GRCm39) D846G probably benign Het
Map2 A T 1: 66,455,883 (GRCm39) probably benign Het
Mapk11 T C 15: 89,030,716 (GRCm39) D88G probably damaging Het
Mbd4 C T 6: 115,826,116 (GRCm39) E271K possibly damaging Het
Mpp4 T G 1: 59,178,917 (GRCm39) probably benign Het
Mtarc1 T C 1: 184,527,425 (GRCm39) probably benign Het
Muc2 T C 7: 141,282,598 (GRCm39) Y609H probably damaging Het
Or8b3b A T 9: 38,583,857 (GRCm39) D307E probably damaging Het
Pex1 T A 5: 3,681,614 (GRCm39) probably null Het
Prdm11 T C 2: 92,810,924 (GRCm39) Y225C probably damaging Het
Psmc3 T A 2: 90,885,463 (GRCm39) probably null Het
Slc26a8 A T 17: 28,861,361 (GRCm39) D774E possibly damaging Het
Slc9a2 A T 1: 40,802,701 (GRCm39) probably null Het
Smc1b A G 15: 85,011,782 (GRCm39) Y168H probably damaging Het
Steap1 T C 5: 5,790,673 (GRCm39) R92G probably damaging Het
Tbx22 T C X: 106,728,759 (GRCm39) I430T probably benign Het
Tfap4 T A 16: 4,377,334 (GRCm39) H16L possibly damaging Het
Tnxb A G 17: 34,897,917 (GRCm39) D855G probably damaging Het
Ubxn4 G A 1: 128,190,641 (GRCm39) E256K probably benign Het
Vmn2r121 A G X: 123,037,617 (GRCm39) V801A probably benign Het
Wiz C T 17: 32,574,092 (GRCm39) R935Q probably damaging Het
Other mutations in Trip13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03094:Trip13 APN 13 74,081,075 (GRCm39) missense probably benign 0.00
R0153:Trip13 UTSW 13 74,068,183 (GRCm39) missense possibly damaging 0.52
R1945:Trip13 UTSW 13 74,076,043 (GRCm39) missense probably damaging 1.00
R3880:Trip13 UTSW 13 74,066,597 (GRCm39) missense probably damaging 1.00
R4206:Trip13 UTSW 13 74,081,009 (GRCm39) missense probably benign 0.00
R5758:Trip13 UTSW 13 74,085,614 (GRCm39) missense probably benign 0.00
R6278:Trip13 UTSW 13 74,061,439 (GRCm39) missense probably benign 0.00
R6298:Trip13 UTSW 13 74,084,378 (GRCm39) nonsense probably null
R7106:Trip13 UTSW 13 74,062,651 (GRCm39) missense probably benign 0.04
R7159:Trip13 UTSW 13 74,068,130 (GRCm39) missense probably benign 0.04
R7544:Trip13 UTSW 13 74,081,021 (GRCm39) missense probably benign 0.00
R8035:Trip13 UTSW 13 74,061,373 (GRCm39) missense probably benign
R8488:Trip13 UTSW 13 74,081,032 (GRCm39) missense probably benign
R8720:Trip13 UTSW 13 74,063,590 (GRCm39) missense probably benign
R8881:Trip13 UTSW 13 74,077,795 (GRCm39) missense possibly damaging 0.70
R8915:Trip13 UTSW 13 74,081,085 (GRCm39) missense probably benign
R9555:Trip13 UTSW 13 74,084,252 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- TTGCAACACCAAGTGAGAGG -3'
(R):5'- GTGCACTTGAGGTCACTTGC -3'

Sequencing Primer
(F):5'- GGCTCAGGCAGAAACAGC -3'
(R):5'- GACAGATGTCTCAGGTATCCACGTC -3'
Posted On 2014-06-23