Incidental Mutation 'R1822:Ralgapb'
| ID |
206444 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ralgapb
|
| Ensembl Gene |
ENSMUSG00000027652 |
| Gene Name |
Ral GTPase activating protein, beta subunit (non-catalytic) |
| Synonyms |
B230339M05Rik |
| MMRRC Submission |
039850-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1822 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
158251768-158341173 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 158334372 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glutamic Acid
at position 1027
(V1027E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000116481
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000046274]
[ENSMUST00000109485]
[ENSMUST00000109486]
[ENSMUST00000141497]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000046274
AA Change: V1345E
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000048430
Gene: ENSMUSG00000027652
AA Change: V1345E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
166 |
178 |
N/A |
INTRINSIC |
|
low complexity region
|
610 |
625 |
N/A |
INTRINSIC |
|
low complexity region
|
775 |
788 |
N/A |
INTRINSIC |
|
low complexity region
|
910 |
920 |
N/A |
INTRINSIC |
|
low complexity region
|
1086 |
1097 |
N/A |
INTRINSIC |
|
low complexity region
|
1309 |
1321 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000109485
AA Change: V1361E
PolyPhen 2
Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000105111
Gene: ENSMUSG00000027652
AA Change: V1361E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
166 |
178 |
N/A |
INTRINSIC |
|
low complexity region
|
622 |
637 |
N/A |
INTRINSIC |
|
low complexity region
|
791 |
804 |
N/A |
INTRINSIC |
|
low complexity region
|
926 |
936 |
N/A |
INTRINSIC |
|
low complexity region
|
1102 |
1113 |
N/A |
INTRINSIC |
|
low complexity region
|
1325 |
1337 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000109486
AA Change: V1349E
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000105112
Gene: ENSMUSG00000027652
AA Change: V1349E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
166 |
178 |
N/A |
INTRINSIC |
|
low complexity region
|
610 |
625 |
N/A |
INTRINSIC |
|
low complexity region
|
779 |
792 |
N/A |
INTRINSIC |
|
low complexity region
|
914 |
924 |
N/A |
INTRINSIC |
|
low complexity region
|
1090 |
1101 |
N/A |
INTRINSIC |
|
low complexity region
|
1313 |
1325 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000122695
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000141497
AA Change: V1027E
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000116481
Gene: ENSMUSG00000027652
AA Change: V1027E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
288 |
303 |
N/A |
INTRINSIC |
|
low complexity region
|
457 |
470 |
N/A |
INTRINSIC |
|
low complexity region
|
592 |
602 |
N/A |
INTRINSIC |
|
low complexity region
|
768 |
779 |
N/A |
INTRINSIC |
|
low complexity region
|
991 |
1003 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.2121 |
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.9%
- 10x: 95.4%
- 20x: 92.7%
|
| Validation Efficiency |
97% (105/108) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca8b |
G |
T |
11: 109,847,901 (GRCm39) |
T798K |
possibly damaging |
Het |
| Abtb1 |
T |
C |
6: 88,813,536 (GRCm39) |
T401A |
probably benign |
Het |
| Adsl |
G |
T |
15: 80,846,943 (GRCm39) |
E70* |
probably null |
Het |
| Ahcyl2 |
A |
G |
6: 29,768,583 (GRCm39) |
|
probably benign |
Het |
| Akr1a1 |
A |
G |
4: 116,493,850 (GRCm39) |
V310A |
probably benign |
Het |
| Alpk3 |
T |
A |
7: 80,726,679 (GRCm39) |
C121* |
probably null |
Het |
| Amph |
T |
A |
13: 19,132,625 (GRCm39) |
I8N |
probably damaging |
Het |
| Ano2 |
G |
A |
6: 125,840,420 (GRCm39) |
A364T |
probably damaging |
Het |
| Apbb2 |
T |
C |
5: 66,557,520 (GRCm39) |
T314A |
probably benign |
Het |
| Arsi |
G |
A |
18: 61,049,723 (GRCm39) |
G202E |
probably benign |
Het |
| Atf7ip |
A |
G |
6: 136,564,258 (GRCm39) |
T834A |
probably benign |
Het |
| Brca2 |
T |
G |
5: 150,463,663 (GRCm39) |
D1142E |
probably benign |
Het |
| Brd10 |
T |
C |
19: 29,693,814 (GRCm39) |
N1960S |
probably damaging |
Het |
| Cap2 |
A |
G |
13: 46,768,823 (GRCm39) |
S210G |
probably benign |
Het |
| Capn2 |
C |
A |
1: 182,300,525 (GRCm39) |
E596D |
possibly damaging |
Het |
| Cdc27 |
A |
T |
11: 104,413,648 (GRCm39) |
S358R |
probably benign |
Het |
| Cdhr3 |
C |
T |
12: 33,095,204 (GRCm39) |
G622S |
probably null |
Het |
| Clip2 |
A |
G |
5: 134,532,081 (GRCm39) |
Y540H |
probably benign |
Het |
| Crhr1 |
A |
T |
11: 104,023,898 (GRCm39) |
M1L |
probably benign |
Het |
| Csmd1 |
T |
C |
8: 16,273,340 (GRCm39) |
T831A |
probably damaging |
Het |
| Cwc22 |
T |
C |
2: 77,755,003 (GRCm39) |
|
probably benign |
Het |
| Cyp3a25 |
T |
A |
5: 145,921,763 (GRCm39) |
K390N |
probably damaging |
Het |
| Cyp4a31 |
T |
C |
4: 115,423,810 (GRCm39) |
|
probably null |
Het |
| Cytip |
A |
C |
2: 58,024,158 (GRCm39) |
S221A |
probably benign |
Het |
| Dagla |
G |
A |
19: 10,240,550 (GRCm39) |
R227C |
possibly damaging |
Het |
| Dhx57 |
A |
G |
17: 80,560,514 (GRCm39) |
|
probably null |
Het |
| Dnah2 |
A |
T |
11: 69,405,630 (GRCm39) |
D627E |
probably damaging |
Het |
| Dock8 |
A |
G |
19: 25,138,422 (GRCm39) |
E1249G |
probably benign |
Het |
| Dpysl3 |
A |
G |
18: 43,475,393 (GRCm39) |
V31A |
probably benign |
Het |
| Ecpas |
A |
G |
4: 58,805,539 (GRCm39) |
|
probably null |
Het |
| Fan1 |
T |
C |
7: 64,022,554 (GRCm39) |
N233S |
probably benign |
Het |
| Fras1 |
A |
T |
5: 96,918,547 (GRCm39) |
I3528F |
probably damaging |
Het |
| Glipr1 |
T |
A |
10: 111,832,765 (GRCm39) |
M58L |
possibly damaging |
Het |
| Gm10509 |
C |
T |
17: 21,909,765 (GRCm39) |
P31S |
possibly damaging |
Het |
| Gm5070 |
T |
C |
3: 95,318,355 (GRCm39) |
|
noncoding transcript |
Het |
| Gramd1a |
T |
C |
7: 30,841,998 (GRCm39) |
N138S |
probably damaging |
Het |
| Grk5 |
T |
C |
19: 61,078,410 (GRCm39) |
V489A |
probably damaging |
Het |
| Hmcn2 |
C |
T |
2: 31,273,704 (GRCm39) |
S1352L |
probably damaging |
Het |
| Hoxa5 |
G |
A |
6: 52,179,712 (GRCm39) |
T221I |
probably damaging |
Het |
| Hsd17b2 |
C |
A |
8: 118,485,488 (GRCm39) |
P317Q |
possibly damaging |
Het |
| Ifi213 |
T |
A |
1: 173,417,408 (GRCm39) |
S335C |
probably damaging |
Het |
| Izumo4 |
A |
T |
10: 80,539,729 (GRCm39) |
D156V |
probably damaging |
Het |
| Khnyn |
A |
T |
14: 56,123,309 (GRCm39) |
E21V |
probably damaging |
Het |
| Kmt2d |
C |
T |
15: 98,759,661 (GRCm39) |
G1199E |
unknown |
Het |
| Lipk |
T |
C |
19: 34,016,491 (GRCm39) |
W240R |
probably benign |
Het |
| Lpar5 |
A |
G |
6: 125,058,378 (GRCm39) |
D33G |
possibly damaging |
Het |
| Lrp11 |
A |
G |
10: 7,471,961 (GRCm39) |
D219G |
probably damaging |
Het |
| Lrrcc1 |
T |
C |
3: 14,624,285 (GRCm39) |
|
probably benign |
Het |
| Man2a1 |
T |
C |
17: 65,047,837 (GRCm39) |
C252R |
probably damaging |
Het |
| Map2k5 |
A |
G |
9: 63,142,585 (GRCm39) |
F354L |
possibly damaging |
Het |
| Mlh3 |
T |
C |
12: 85,312,919 (GRCm39) |
|
probably benign |
Het |
| Mmp28 |
A |
G |
11: 83,335,045 (GRCm39) |
I331T |
probably damaging |
Het |
| Muc4 |
G |
C |
16: 32,753,919 (GRCm38) |
R1265P |
probably benign |
Het |
| Myo3a |
A |
T |
2: 22,345,091 (GRCm39) |
Y509F |
probably damaging |
Het |
| Nckap1 |
A |
G |
2: 80,348,242 (GRCm39) |
S898P |
possibly damaging |
Het |
| Nectin1 |
T |
A |
9: 43,702,374 (GRCm39) |
Y40* |
probably null |
Het |
| Neurl1a |
T |
A |
19: 47,245,898 (GRCm39) |
V493E |
probably benign |
Het |
| Ntf3 |
A |
C |
6: 126,079,209 (GRCm39) |
I99S |
probably benign |
Het |
| Or10ag53 |
T |
C |
2: 87,083,054 (GRCm39) |
S258P |
possibly damaging |
Het |
| Or1l4 |
C |
G |
2: 37,091,992 (GRCm39) |
H246Q |
probably damaging |
Het |
| Or1p1c |
A |
G |
11: 74,161,066 (GRCm39) |
T284A |
probably benign |
Het |
| Or2ak5 |
A |
T |
11: 58,611,133 (GRCm39) |
V247E |
probably damaging |
Het |
| Or2i1 |
A |
G |
17: 37,507,722 (GRCm39) |
|
probably benign |
Het |
| Or2y1c |
T |
A |
11: 49,361,795 (GRCm39) |
F272L |
probably benign |
Het |
| Or6k8-ps1 |
C |
T |
1: 173,979,780 (GRCm39) |
R233C |
probably benign |
Het |
| Otof |
G |
A |
5: 30,536,054 (GRCm39) |
T1343I |
probably benign |
Het |
| Otop2 |
A |
T |
11: 115,215,454 (GRCm39) |
Y125F |
probably benign |
Het |
| Pate3 |
G |
A |
9: 35,557,401 (GRCm39) |
T85I |
probably benign |
Het |
| Pdpk1 |
A |
T |
17: 24,317,150 (GRCm39) |
|
probably benign |
Het |
| Phf11d |
T |
C |
14: 59,593,778 (GRCm39) |
H132R |
probably benign |
Het |
| Pik3c3 |
G |
A |
18: 30,477,130 (GRCm39) |
|
probably null |
Het |
| Pkhd1 |
C |
A |
1: 20,417,681 (GRCm39) |
G2490V |
probably damaging |
Het |
| Prkdc |
G |
A |
16: 15,577,469 (GRCm39) |
D2372N |
probably damaging |
Het |
| Ptprq |
C |
T |
10: 107,554,339 (GRCm39) |
E129K |
probably damaging |
Het |
| Pym1 |
G |
A |
10: 128,601,913 (GRCm39) |
|
probably benign |
Het |
| Rita1 |
T |
C |
5: 120,747,645 (GRCm39) |
T218A |
possibly damaging |
Het |
| Rrh |
T |
A |
3: 129,606,282 (GRCm39) |
T218S |
probably damaging |
Het |
| Scaper |
C |
T |
9: 55,767,184 (GRCm39) |
A416T |
probably damaging |
Het |
| Scn3a |
A |
G |
2: 65,314,716 (GRCm39) |
L1115P |
probably damaging |
Het |
| Serpinb6e |
A |
T |
13: 34,017,217 (GRCm39) |
S268T |
probably damaging |
Het |
| Skic3 |
C |
A |
13: 76,278,407 (GRCm39) |
H574N |
probably benign |
Het |
| Slc1a6 |
G |
A |
10: 78,648,765 (GRCm39) |
W495* |
probably null |
Het |
| Slc32a1 |
A |
G |
2: 158,453,298 (GRCm39) |
H46R |
probably benign |
Het |
| Slc37a1 |
C |
T |
17: 31,519,405 (GRCm39) |
|
probably benign |
Het |
| Slc6a5 |
T |
A |
7: 49,606,173 (GRCm39) |
W694R |
probably benign |
Het |
| Smarcd2 |
A |
T |
11: 106,158,222 (GRCm39) |
D113E |
probably benign |
Het |
| Sod3 |
G |
T |
5: 52,525,504 (GRCm39) |
V68L |
probably benign |
Het |
| Srpk3 |
G |
A |
X: 72,821,561 (GRCm39) |
R425Q |
possibly damaging |
Het |
| Sspo |
A |
T |
6: 48,469,820 (GRCm39) |
Q4506L |
possibly damaging |
Het |
| Stam2 |
T |
A |
2: 52,606,539 (GRCm39) |
E115D |
probably damaging |
Het |
| Sult1c2 |
A |
T |
17: 54,280,953 (GRCm39) |
L50H |
probably damaging |
Het |
| Tbc1d22a |
T |
C |
15: 86,119,770 (GRCm39) |
V22A |
possibly damaging |
Het |
| Togaram1 |
T |
G |
12: 65,042,409 (GRCm39) |
V1156G |
probably damaging |
Het |
| Tpp1 |
T |
C |
7: 105,398,854 (GRCm39) |
T192A |
probably benign |
Het |
| Ush1c |
A |
G |
7: 45,859,325 (GRCm39) |
L498P |
probably damaging |
Het |
| Vit |
A |
C |
17: 78,930,265 (GRCm39) |
Q410P |
probably benign |
Het |
| Vmn2r27 |
C |
T |
6: 124,208,593 (GRCm39) |
G51S |
probably benign |
Het |
| Zfp341 |
A |
G |
2: 154,488,054 (GRCm39) |
E839G |
possibly damaging |
Het |
| Zhx3 |
G |
A |
2: 160,622,275 (GRCm39) |
L631F |
probably benign |
Het |
| Zmpste24 |
T |
C |
4: 120,944,513 (GRCm39) |
E95G |
possibly damaging |
Het |
|
| Other mutations in Ralgapb |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00094:Ralgapb
|
APN |
2 |
158,262,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00534:Ralgapb
|
APN |
2 |
158,272,420 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL01362:Ralgapb
|
APN |
2 |
158,277,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01653:Ralgapb
|
APN |
2 |
158,304,079 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01704:Ralgapb
|
APN |
2 |
158,262,795 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02000:Ralgapb
|
APN |
2 |
158,296,034 (GRCm39) |
splice site |
probably benign |
|
|
IGL02169:Ralgapb
|
APN |
2 |
158,268,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02516:Ralgapb
|
APN |
2 |
158,307,735 (GRCm39) |
splice site |
probably benign |
|
|
IGL02548:Ralgapb
|
APN |
2 |
158,286,585 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02550:Ralgapb
|
APN |
2 |
158,290,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02653:Ralgapb
|
APN |
2 |
158,285,229 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02744:Ralgapb
|
APN |
2 |
158,288,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02804:Ralgapb
|
APN |
2 |
158,268,204 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL02937:Ralgapb
|
APN |
2 |
158,334,936 (GRCm39) |
splice site |
probably null |
|
|
IGL02993:Ralgapb
|
APN |
2 |
158,279,314 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03154:Ralgapb
|
APN |
2 |
158,274,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03204:Ralgapb
|
APN |
2 |
158,307,832 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL03347:Ralgapb
|
APN |
2 |
158,307,880 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
Chacha
|
UTSW |
2 |
158,334,372 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Gato
|
UTSW |
2 |
158,286,540 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Kibble
|
UTSW |
2 |
158,279,060 (GRCm39) |
missense |
probably damaging |
1.00 |
|
ralston
|
UTSW |
2 |
158,296,197 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4142001:Ralgapb
|
UTSW |
2 |
158,272,342 (GRCm39) |
missense |
probably benign |
0.34 |
|
R0037:Ralgapb
|
UTSW |
2 |
158,279,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0037:Ralgapb
|
UTSW |
2 |
158,279,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0077:Ralgapb
|
UTSW |
2 |
158,315,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0581:Ralgapb
|
UTSW |
2 |
158,334,881 (GRCm39) |
missense |
probably benign |
|
|
R0629:Ralgapb
|
UTSW |
2 |
158,281,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0839:Ralgapb
|
UTSW |
2 |
158,315,203 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1331:Ralgapb
|
UTSW |
2 |
158,272,453 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1468:Ralgapb
|
UTSW |
2 |
158,304,173 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1468:Ralgapb
|
UTSW |
2 |
158,304,173 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1540:Ralgapb
|
UTSW |
2 |
158,307,746 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1572:Ralgapb
|
UTSW |
2 |
158,288,119 (GRCm39) |
splice site |
probably benign |
|
|
R1628:Ralgapb
|
UTSW |
2 |
158,272,383 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1718:Ralgapb
|
UTSW |
2 |
158,285,200 (GRCm39) |
nonsense |
probably null |
|
|
R1777:Ralgapb
|
UTSW |
2 |
158,304,115 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1903:Ralgapb
|
UTSW |
2 |
158,337,483 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1909:Ralgapb
|
UTSW |
2 |
158,286,595 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2157:Ralgapb
|
UTSW |
2 |
158,279,392 (GRCm39) |
missense |
probably benign |
0.15 |
|
R4524:Ralgapb
|
UTSW |
2 |
158,279,226 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4946:Ralgapb
|
UTSW |
2 |
158,282,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4975:Ralgapb
|
UTSW |
2 |
158,277,428 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R5014:Ralgapb
|
UTSW |
2 |
158,337,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5165:Ralgapb
|
UTSW |
2 |
158,307,832 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R5465:Ralgapb
|
UTSW |
2 |
158,290,325 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5526:Ralgapb
|
UTSW |
2 |
158,274,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5566:Ralgapb
|
UTSW |
2 |
158,336,630 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5949:Ralgapb
|
UTSW |
2 |
158,296,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6140:Ralgapb
|
UTSW |
2 |
158,298,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6175:Ralgapb
|
UTSW |
2 |
158,288,075 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6192:Ralgapb
|
UTSW |
2 |
158,291,367 (GRCm39) |
splice site |
probably null |
|
|
R6364:Ralgapb
|
UTSW |
2 |
158,304,029 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6458:Ralgapb
|
UTSW |
2 |
158,286,540 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6746:Ralgapb
|
UTSW |
2 |
158,318,056 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6782:Ralgapb
|
UTSW |
2 |
158,278,486 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6788:Ralgapb
|
UTSW |
2 |
158,278,486 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7017:Ralgapb
|
UTSW |
2 |
158,290,257 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7108:Ralgapb
|
UTSW |
2 |
158,336,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7108:Ralgapb
|
UTSW |
2 |
158,334,380 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7236:Ralgapb
|
UTSW |
2 |
158,282,747 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7454:Ralgapb
|
UTSW |
2 |
158,274,822 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7485:Ralgapb
|
UTSW |
2 |
158,285,275 (GRCm39) |
missense |
probably benign |
0.35 |
|
R7595:Ralgapb
|
UTSW |
2 |
158,268,085 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7615:Ralgapb
|
UTSW |
2 |
158,292,190 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7728:Ralgapb
|
UTSW |
2 |
158,324,423 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7913:Ralgapb
|
UTSW |
2 |
158,307,859 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7953:Ralgapb
|
UTSW |
2 |
158,307,803 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8245:Ralgapb
|
UTSW |
2 |
158,285,256 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8337:Ralgapb
|
UTSW |
2 |
158,292,192 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8363:Ralgapb
|
UTSW |
2 |
158,268,119 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8429:Ralgapb
|
UTSW |
2 |
158,268,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8673:Ralgapb
|
UTSW |
2 |
158,292,133 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8955:Ralgapb
|
UTSW |
2 |
158,337,389 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8955:Ralgapb
|
UTSW |
2 |
158,279,264 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8992:Ralgapb
|
UTSW |
2 |
158,296,197 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9013:Ralgapb
|
UTSW |
2 |
158,279,060 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9141:Ralgapb
|
UTSW |
2 |
158,262,811 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R9166:Ralgapb
|
UTSW |
2 |
158,274,842 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9242:Ralgapb
|
UTSW |
2 |
158,277,386 (GRCm39) |
missense |
probably benign |
0.13 |
|
R9274:Ralgapb
|
UTSW |
2 |
158,278,539 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9354:Ralgapb
|
UTSW |
2 |
158,279,313 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9454:Ralgapb
|
UTSW |
2 |
158,315,072 (GRCm39) |
missense |
probably benign |
0.30 |
|
R9489:Ralgapb
|
UTSW |
2 |
158,268,283 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9490:Ralgapb
|
UTSW |
2 |
158,334,350 (GRCm39) |
missense |
probably benign |
0.29 |
|
R9510:Ralgapb
|
UTSW |
2 |
158,285,856 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1177:Ralgapb
|
UTSW |
2 |
158,277,475 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGCTTTGGTGACATAAACACATC -3'
(R):5'- GCTGAGGTTCTAACATTGCTTACAC -3'
Sequencing Primer
(F):5'- TGGTGACATAAACACATCACTAATC -3'
(R):5'- TTACCCATGGCAAAACTTTAACAGG -3'
|
| Posted On |
2014-06-23 |
Incidental Mutation