Incidental Mutation 'R1823:Igf1r'
| ID |
206573 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Igf1r
|
| Ensembl Gene |
ENSMUSG00000005533 |
| Gene Name |
insulin-like growth factor I receptor |
| Synonyms |
line 186, A330103N21Rik, CD221, hyft, IGF-1R |
| MMRRC Submission |
039851-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1823 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
67952827-68233668 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 68194981 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 834
(D834G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000005671
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000005671]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000005671
AA Change: D834G
PolyPhen 2
Score 0.771 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000005671
Gene: ENSMUSG00000005533
AA Change: D834G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Recep_L_domain
|
51 |
161 |
1.6e-29 |
PFAM |
|
FU
|
227 |
270 |
2.98e-12 |
SMART |
|
Pfam:Recep_L_domain
|
353 |
467 |
3.8e-32 |
PFAM |
|
FN3
|
490 |
593 |
4.67e-2 |
SMART |
|
FN3
|
612 |
815 |
1.95e-4 |
SMART |
|
FN3
|
833 |
915 |
7.4e-5 |
SMART |
|
low complexity region
|
937 |
954 |
N/A |
INTRINSIC |
|
TyrKc
|
1000 |
1268 |
8.51e-141 |
SMART |
|
low complexity region
|
1285 |
1303 |
N/A |
INTRINSIC |
|
low complexity region
|
1306 |
1319 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000208348
|
| Meta Mutation Damage Score |
0.1503 |
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.1%
- 20x: 91.6%
|
| Validation Efficiency |
98% (87/89) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
PHENOTYPE: Targeted null mutants die at birth of respiratory failure; fetuses exhibit retarded growth, organ hypoplasia, ossification delay and nervous system and epidermal abnormalities. hyft homozygous fetuses are growth retarded and exhibit hydrops fetalis and focal hepatic ischemia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 85 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1810041L15Rik |
T |
C |
15: 84,406,468 (GRCm38) |
T213A |
probably benign |
Het |
| Adcy1 |
G |
A |
11: 7,161,312 (GRCm38) |
V868I |
probably benign |
Het |
| Ahnak |
G |
T |
19: 9,004,905 (GRCm38) |
M1184I |
probably damaging |
Het |
| Akap11 |
T |
C |
14: 78,511,488 (GRCm38) |
E1153G |
probably damaging |
Het |
| Amy1 |
T |
C |
3: 113,562,727 (GRCm38) |
N260S |
probably null |
Het |
| Ankrd6 |
A |
G |
4: 32,824,427 (GRCm38) |
L129P |
probably damaging |
Het |
| Aox2 |
A |
T |
1: 58,312,359 (GRCm38) |
T702S |
probably benign |
Het |
| Apobec1 |
G |
T |
6: 122,578,886 (GRCm38) |
T204K |
possibly damaging |
Het |
| Arhgef19 |
A |
G |
4: 141,249,146 (GRCm38) |
R433G |
probably benign |
Het |
| Atf6b |
T |
A |
17: 34,648,644 (GRCm38) |
H110Q |
possibly damaging |
Het |
| Btnl4 |
C |
T |
17: 34,475,852 (GRCm38) |
|
probably null |
Het |
| Camsap2 |
T |
C |
1: 136,273,783 (GRCm38) |
T662A |
possibly damaging |
Het |
| Cbs |
G |
A |
17: 31,624,271 (GRCm38) |
H229Y |
probably damaging |
Het |
| Cct8 |
G |
A |
16: 87,490,554 (GRCm38) |
R111* |
probably null |
Het |
| Cdc42bpb |
C |
T |
12: 111,327,559 (GRCm38) |
A250T |
probably damaging |
Het |
| Chrd |
A |
G |
16: 20,741,347 (GRCm38) |
|
probably benign |
Het |
| Ckap2l |
A |
G |
2: 129,275,579 (GRCm38) |
F559L |
probably damaging |
Het |
| D630003M21Rik |
T |
C |
2: 158,217,557 (GRCm38) |
Y141C |
probably damaging |
Het |
| Dbf4 |
T |
C |
5: 8,397,539 (GRCm38) |
N557S |
probably benign |
Het |
| Dct |
T |
G |
14: 118,036,523 (GRCm38) |
N324T |
probably benign |
Het |
| Dip2a |
A |
T |
10: 76,278,502 (GRCm38) |
L999* |
probably null |
Het |
| Dock10 |
T |
A |
1: 80,543,097 (GRCm38) |
|
probably null |
Het |
| Dync2li1 |
A |
T |
17: 84,649,797 (GRCm38) |
D330V |
probably damaging |
Het |
| Eif4g3 |
T |
A |
4: 138,180,491 (GRCm38) |
D1267E |
probably benign |
Het |
| Enc1 |
A |
G |
13: 97,245,978 (GRCm38) |
E332G |
possibly damaging |
Het |
| Fat2 |
C |
T |
11: 55,256,780 (GRCm38) |
V3879I |
probably benign |
Het |
| Fh1 |
A |
T |
1: 175,616,548 (GRCm38) |
I117K |
probably damaging |
Het |
| Fkbp15 |
A |
G |
4: 62,337,091 (GRCm38) |
L227P |
probably damaging |
Het |
| Fpr1 |
T |
A |
17: 17,877,053 (GRCm38) |
M225L |
probably benign |
Het |
| Fras1 |
A |
T |
5: 96,770,688 (GRCm38) |
I3528F |
probably damaging |
Het |
| Grm7 |
A |
G |
6: 111,207,769 (GRCm38) |
T354A |
probably benign |
Het |
| Ift27 |
T |
A |
15: 78,173,778 (GRCm38) |
I9F |
possibly damaging |
Het |
| Igsf9b |
T |
A |
9: 27,331,732 (GRCm38) |
L738Q |
probably damaging |
Het |
| Itgam |
A |
T |
7: 128,064,732 (GRCm38) |
T44S |
probably benign |
Het |
| Ivd |
T |
A |
2: 118,862,034 (GRCm38) |
I5N |
probably benign |
Het |
| Jcad |
T |
C |
18: 4,675,780 (GRCm38) |
S1181P |
probably damaging |
Het |
| Kctd18 |
A |
G |
1: 57,956,365 (GRCm38) |
V251A |
probably benign |
Het |
| Mycbp2 |
A |
G |
14: 103,252,509 (GRCm38) |
V953A |
possibly damaging |
Het |
| Myo18a |
T |
C |
11: 77,825,097 (GRCm38) |
|
probably benign |
Het |
| Myo3a |
A |
T |
2: 22,340,280 (GRCm38) |
Y509F |
probably damaging |
Het |
| Myocd |
C |
A |
11: 65,178,670 (GRCm38) |
M909I |
probably benign |
Het |
| Ndufv3 |
G |
A |
17: 31,531,245 (GRCm38) |
R467Q |
probably damaging |
Het |
| Nkpd1 |
G |
A |
7: 19,523,252 (GRCm38) |
V319M |
probably damaging |
Het |
| Olfr1216 |
A |
G |
2: 89,013,378 (GRCm38) |
S229P |
probably benign |
Het |
| Olfr1342 |
T |
A |
4: 118,690,192 (GRCm38) |
N87Y |
probably damaging |
Het |
| Olfr1453 |
C |
A |
19: 13,027,817 (GRCm38) |
V171L |
probably benign |
Het |
| Olfr31 |
T |
A |
14: 14,328,774 (GRCm38) |
L221Q |
probably damaging |
Het |
| Olfr366 |
T |
C |
2: 37,220,332 (GRCm38) |
V281A |
probably damaging |
Het |
| Olfr406 |
C |
T |
11: 74,270,217 (GRCm38) |
A276V |
probably damaging |
Het |
| Olfr450 |
G |
T |
6: 42,818,268 (GRCm38) |
A266S |
possibly damaging |
Het |
| Parp4 |
T |
C |
14: 56,589,872 (GRCm38) |
|
probably benign |
Het |
| Pcdhb9 |
A |
G |
18: 37,402,818 (GRCm38) |
T622A |
probably benign |
Het |
| Pdpk1 |
A |
T |
17: 24,098,176 (GRCm38) |
|
probably benign |
Het |
| Pkhd1 |
C |
A |
1: 20,347,457 (GRCm38) |
G2490V |
probably damaging |
Het |
| Plekhg1 |
G |
T |
10: 3,903,658 (GRCm38) |
|
probably null |
Het |
| Plekhh2 |
A |
G |
17: 84,575,189 (GRCm38) |
Y708C |
probably damaging |
Het |
| Pnp |
T |
C |
14: 50,950,329 (GRCm38) |
F107L |
probably damaging |
Het |
| Postn |
T |
A |
3: 54,385,287 (GRCm38) |
|
probably null |
Het |
| Prcp |
A |
T |
7: 92,928,675 (GRCm38) |
D349V |
probably damaging |
Het |
| Prl3a1 |
A |
T |
13: 27,270,194 (GRCm38) |
I52F |
probably damaging |
Het |
| Pym1 |
G |
A |
10: 128,766,044 (GRCm38) |
|
probably benign |
Het |
| Rad9a |
A |
T |
19: 4,197,242 (GRCm38) |
I248N |
probably damaging |
Het |
| Ror2 |
T |
G |
13: 53,110,305 (GRCm38) |
E917A |
probably benign |
Het |
| Rsf1 |
G |
A |
7: 97,579,910 (GRCm38) |
|
probably benign |
Het |
| Sema6d |
A |
G |
2: 124,659,556 (GRCm38) |
|
probably null |
Het |
| Slc4a2 |
C |
T |
5: 24,427,620 (GRCm38) |
A12V |
probably damaging |
Het |
| Slco6b1 |
T |
G |
1: 96,961,176 (GRCm38) |
|
noncoding transcript |
Het |
| Slf2 |
A |
T |
19: 44,935,248 (GRCm38) |
H167L |
possibly damaging |
Het |
| Snx9 |
G |
T |
17: 5,920,671 (GRCm38) |
G429V |
probably damaging |
Het |
| Sod3 |
G |
T |
5: 52,368,162 (GRCm38) |
V68L |
probably benign |
Het |
| Spta1 |
T |
A |
1: 174,246,549 (GRCm38) |
D2351E |
probably benign |
Het |
| Srpk3 |
G |
A |
X: 73,777,955 (GRCm38) |
R425Q |
possibly damaging |
Het |
| Tatdn1 |
C |
T |
15: 58,916,156 (GRCm38) |
G171E |
probably damaging |
Het |
| Tbc1d22a |
T |
C |
15: 86,235,569 (GRCm38) |
V22A |
possibly damaging |
Het |
| Tmem27 |
A |
G |
X: 164,118,234 (GRCm38) |
D184G |
possibly damaging |
Het |
| Tnfsf9 |
A |
G |
17: 57,105,738 (GRCm38) |
T103A |
probably benign |
Het |
| Tpm3-rs7 |
T |
C |
14: 113,315,163 (GRCm38) |
L163P |
possibly damaging |
Het |
| Trim52 |
T |
A |
14: 106,106,967 (GRCm38) |
C20S |
probably damaging |
Het |
| Ucp1 |
C |
T |
8: 83,294,032 (GRCm38) |
T157I |
probably damaging |
Het |
| Uspl1 |
T |
A |
5: 149,214,414 (GRCm38) |
L794Q |
probably benign |
Het |
| Vmn1r5 |
T |
A |
6: 56,985,595 (GRCm38) |
V85E |
probably damaging |
Het |
| Vmn1r58 |
A |
G |
7: 5,410,406 (GRCm38) |
I275T |
possibly damaging |
Het |
| Vmn2r79 |
A |
G |
7: 87,037,872 (GRCm38) |
I820M |
probably damaging |
Het |
| Wscd1 |
C |
A |
11: 71,760,218 (GRCm38) |
P124T |
probably benign |
Het |
| Zfp780b |
A |
T |
7: 27,963,100 (GRCm38) |
C677S |
possibly damaging |
Het |
|
| Other mutations in Igf1r |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00742:Igf1r
|
APN |
7 |
68,190,023 (GRCm38) |
missense |
probably benign |
|
|
IGL00837:Igf1r
|
APN |
7 |
68,201,352 (GRCm38) |
splice site |
probably benign |
|
|
IGL01515:Igf1r
|
APN |
7 |
68,207,452 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01572:Igf1r
|
APN |
7 |
68,193,441 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL02100:Igf1r
|
APN |
7 |
68,189,958 (GRCm38) |
missense |
probably benign |
0.05 |
|
IGL02506:Igf1r
|
APN |
7 |
68,193,396 (GRCm38) |
missense |
probably benign |
|
|
IGL02672:Igf1r
|
APN |
7 |
68,190,033 (GRCm38) |
missense |
probably benign |
0.05 |
|
IGL02701:Igf1r
|
APN |
7 |
68,201,249 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
IGL02742:Igf1r
|
APN |
7 |
68,189,991 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
IGL03073:Igf1r
|
APN |
7 |
68,215,043 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03257:Igf1r
|
APN |
7 |
68,214,940 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Frufru
|
UTSW |
7 |
68,004,163 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Hungarian
|
UTSW |
7 |
68,214,997 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Mimi
|
UTSW |
7 |
68,195,026 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
Piroshka
|
UTSW |
7 |
68,207,336 (GRCm38) |
nonsense |
probably null |
|
|
Romanian
|
UTSW |
7 |
68,004,137 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
Sublime
|
UTSW |
7 |
68,004,179 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Toy
|
UTSW |
7 |
68,003,972 (GRCm38) |
missense |
probably damaging |
1.00 |
|
BB009:Igf1r
|
UTSW |
7 |
68,212,054 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
BB019:Igf1r
|
UTSW |
7 |
68,212,054 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
FR4548:Igf1r
|
UTSW |
7 |
68,226,186 (GRCm38) |
small insertion |
probably benign |
|
|
FR4737:Igf1r
|
UTSW |
7 |
68,226,181 (GRCm38) |
small insertion |
probably benign |
|
|
FR4976:Igf1r
|
UTSW |
7 |
68,226,186 (GRCm38) |
small insertion |
probably benign |
|
|
FR4976:Igf1r
|
UTSW |
7 |
68,226,181 (GRCm38) |
small insertion |
probably benign |
|
|
PIT4445001:Igf1r
|
UTSW |
7 |
68,207,463 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0003:Igf1r
|
UTSW |
7 |
68,165,242 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0184:Igf1r
|
UTSW |
7 |
68,226,193 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R0538:Igf1r
|
UTSW |
7 |
68,207,826 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0632:Igf1r
|
UTSW |
7 |
68,165,155 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0727:Igf1r
|
UTSW |
7 |
68,212,158 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0750:Igf1r
|
UTSW |
7 |
68,212,091 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1104:Igf1r
|
UTSW |
7 |
68,195,026 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R1169:Igf1r
|
UTSW |
7 |
68,165,127 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1348:Igf1r
|
UTSW |
7 |
68,218,468 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1471:Igf1r
|
UTSW |
7 |
68,003,837 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R1580:Igf1r
|
UTSW |
7 |
68,207,869 (GRCm38) |
missense |
probably benign |
|
|
R1745:Igf1r
|
UTSW |
7 |
68,169,913 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1772:Igf1r
|
UTSW |
7 |
68,195,074 (GRCm38) |
missense |
probably benign |
0.03 |
|
R1789:Igf1r
|
UTSW |
7 |
68,214,933 (GRCm38) |
nonsense |
probably null |
|
|
R1902:Igf1r
|
UTSW |
7 |
68,201,249 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R1962:Igf1r
|
UTSW |
7 |
68,207,275 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2179:Igf1r
|
UTSW |
7 |
68,003,950 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2215:Igf1r
|
UTSW |
7 |
68,165,234 (GRCm38) |
missense |
probably benign |
|
|
R2221:Igf1r
|
UTSW |
7 |
68,201,962 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2233:Igf1r
|
UTSW |
7 |
68,212,080 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2234:Igf1r
|
UTSW |
7 |
68,212,080 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2235:Igf1r
|
UTSW |
7 |
68,212,080 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3023:Igf1r
|
UTSW |
7 |
68,183,399 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4044:Igf1r
|
UTSW |
7 |
68,190,062 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R4226:Igf1r
|
UTSW |
7 |
68,195,078 (GRCm38) |
nonsense |
probably null |
|
|
R4387:Igf1r
|
UTSW |
7 |
68,170,009 (GRCm38) |
missense |
probably benign |
|
|
R4388:Igf1r
|
UTSW |
7 |
68,170,009 (GRCm38) |
missense |
probably benign |
|
|
R4728:Igf1r
|
UTSW |
7 |
68,189,624 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4781:Igf1r
|
UTSW |
7 |
68,165,199 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
R5254:Igf1r
|
UTSW |
7 |
68,207,319 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5278:Igf1r
|
UTSW |
7 |
68,193,418 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R5510:Igf1r
|
UTSW |
7 |
68,193,359 (GRCm38) |
missense |
probably benign |
0.19 |
|
R5522:Igf1r
|
UTSW |
7 |
68,183,510 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R5527:Igf1r
|
UTSW |
7 |
68,207,821 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5761:Igf1r
|
UTSW |
7 |
68,207,253 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5849:Igf1r
|
UTSW |
7 |
68,190,033 (GRCm38) |
missense |
probably benign |
|
|
R6189:Igf1r
|
UTSW |
7 |
68,207,336 (GRCm38) |
nonsense |
probably null |
|
|
R6262:Igf1r
|
UTSW |
7 |
68,003,972 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6285:Igf1r
|
UTSW |
7 |
68,004,137 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R6318:Igf1r
|
UTSW |
7 |
68,165,233 (GRCm38) |
missense |
probably benign |
0.02 |
|
R6365:Igf1r
|
UTSW |
7 |
68,190,050 (GRCm38) |
missense |
probably benign |
0.26 |
|
R6377:Igf1r
|
UTSW |
7 |
68,201,250 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6831:Igf1r
|
UTSW |
7 |
68,207,319 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
R6848:Igf1r
|
UTSW |
7 |
68,004,179 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6902:Igf1r
|
UTSW |
7 |
68,004,163 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7193:Igf1r
|
UTSW |
7 |
68,187,157 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7373:Igf1r
|
UTSW |
7 |
68,195,078 (GRCm38) |
nonsense |
probably null |
|
|
R7442:Igf1r
|
UTSW |
7 |
68,173,278 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7903:Igf1r
|
UTSW |
7 |
68,184,752 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7923:Igf1r
|
UTSW |
7 |
68,190,101 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7932:Igf1r
|
UTSW |
7 |
68,212,054 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R8368:Igf1r
|
UTSW |
7 |
68,187,048 (GRCm38) |
missense |
probably benign |
0.03 |
|
R8458:Igf1r
|
UTSW |
7 |
68,195,629 (GRCm38) |
missense |
probably benign |
|
|
R8539:Igf1r
|
UTSW |
7 |
68,003,848 (GRCm38) |
missense |
probably benign |
0.06 |
|
R8704:Igf1r
|
UTSW |
7 |
68,170,054 (GRCm38) |
splice site |
probably benign |
|
|
R8746:Igf1r
|
UTSW |
7 |
68,214,997 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8829:Igf1r
|
UTSW |
7 |
68,226,021 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8832:Igf1r
|
UTSW |
7 |
68,226,021 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8859:Igf1r
|
UTSW |
7 |
68,183,463 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
R9057:Igf1r
|
UTSW |
7 |
68,183,438 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9243:Igf1r
|
UTSW |
7 |
68,212,027 (GRCm38) |
missense |
probably benign |
0.11 |
|
R9342:Igf1r
|
UTSW |
7 |
68,194,998 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9412:Igf1r
|
UTSW |
7 |
68,207,253 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9525:Igf1r
|
UTSW |
7 |
68,214,934 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9727:Igf1r
|
UTSW |
7 |
68,207,806 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9730:Igf1r
|
UTSW |
7 |
68,189,675 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9779:Igf1r
|
UTSW |
7 |
68,004,317 (GRCm38) |
missense |
probably damaging |
1.00 |
|
RF025:Igf1r
|
UTSW |
7 |
68,226,179 (GRCm38) |
small insertion |
probably benign |
|
|
RF032:Igf1r
|
UTSW |
7 |
68,226,179 (GRCm38) |
small insertion |
probably benign |
|
|
RF034:Igf1r
|
UTSW |
7 |
68,226,176 (GRCm38) |
small insertion |
probably benign |
|
|
RF037:Igf1r
|
UTSW |
7 |
68,226,176 (GRCm38) |
small insertion |
probably benign |
|
|
RF039:Igf1r
|
UTSW |
7 |
68,226,176 (GRCm38) |
small insertion |
probably benign |
|
|
RF044:Igf1r
|
UTSW |
7 |
68,226,179 (GRCm38) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
68,226,168 (GRCm38) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
68,226,182 (GRCm38) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
68,226,180 (GRCm38) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
68,226,174 (GRCm38) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
68,226,169 (GRCm38) |
small insertion |
probably benign |
|
|
Z1191:Igf1r
|
UTSW |
7 |
68,226,170 (GRCm38) |
small insertion |
probably benign |
|
|
Z1191:Igf1r
|
UTSW |
7 |
68,226,169 (GRCm38) |
small insertion |
probably benign |
|
|
Z1191:Igf1r
|
UTSW |
7 |
68,226,173 (GRCm38) |
small insertion |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GTGATCACTTGTACTTGGCCAC -3'
(R):5'- TCAGCGCTGAAACACATGC -3'
Sequencing Primer
(F):5'- TTTCAGTCAGAGGGGATGGAG -3'
(R):5'- GCTGAAACACATGCAGCTG -3'
|
| Posted On |
2014-06-23 |
Incidental Mutation