Mutagenetix > Incidental Mutation

Incidental Mutation 'R1823:Vmn2r79'

206574

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r79

Ensembl Gene

ENSMUSG00000090362

Gene Name

vomeronasal 2, receptor 79

Synonyms

EG621430

MMRRC Submission

039851-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.101) question?

Stock #

R1823 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

86996465-87037968 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 87037872 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Methionine at position 820 (I820M)

Ref Sequence

ENSEMBL: ENSMUSP00000132478 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164462]

AlphaFold

E9Q067

Predicted Effect

probably damaging
Transcript: ENSMUST00000164462
AA Change: I820M

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000132478
Gene: ENSMUSG00000090362
AA Change: I820M

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	75	464	1.9e-31	PFAM
Pfam:NCD3G	506	559	3.1e-21	PFAM
Pfam:7tm_3	592	827	2.8e-53	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 97.4%
3x: 96.8%
10x: 95.1%
20x: 91.6%

Validation Efficiency

98% (87/89)

Allele List at MGI

Other mutations in this stock

Total: 85 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1810041L15Rik	T	C	15: 84,406,468	T213A	probably benign	Het
Adcy1	G	A	11: 7,161,312	V868I	probably benign	Het
Ahnak	G	T	19: 9,004,905	M1184I	probably damaging	Het
Akap11	T	C	14: 78,511,488	E1153G	probably damaging	Het
Amy1	T	C	3: 113,562,727	N260S	probably null	Het
Ankrd6	A	G	4: 32,824,427	L129P	probably damaging	Het
Aox2	A	T	1: 58,312,359	T702S	probably benign	Het
Apobec1	G	T	6: 122,578,886	T204K	possibly damaging	Het
Arhgef19	A	G	4: 141,249,146	R433G	probably benign	Het
Atf6b	T	A	17: 34,648,644	H110Q	possibly damaging	Het
Btnl4	C	T	17: 34,475,852		probably null	Het
Camsap2	T	C	1: 136,273,783	T662A	possibly damaging	Het
Cbs	G	A	17: 31,624,271	H229Y	probably damaging	Het
Cct8	G	A	16: 87,490,554	R111*	probably null	Het
Cdc42bpb	C	T	12: 111,327,559	A250T	probably damaging	Het
Chrd	A	G	16: 20,741,347		probably benign	Het
Ckap2l	A	G	2: 129,275,579	F559L	probably damaging	Het
D630003M21Rik	T	C	2: 158,217,557	Y141C	probably damaging	Het
Dbf4	T	C	5: 8,397,539	N557S	probably benign	Het
Dct	T	G	14: 118,036,523	N324T	probably benign	Het
Dip2a	A	T	10: 76,278,502	L999*	probably null	Het
Dock10	T	A	1: 80,543,097		probably null	Het
Dync2li1	A	T	17: 84,649,797	D330V	probably damaging	Het
Eif4g3	T	A	4: 138,180,491	D1267E	probably benign	Het
Enc1	A	G	13: 97,245,978	E332G	possibly damaging	Het
Fat2	C	T	11: 55,256,780	V3879I	probably benign	Het
Fh1	A	T	1: 175,616,548	I117K	probably damaging	Het
Fkbp15	A	G	4: 62,337,091	L227P	probably damaging	Het
Fpr1	T	A	17: 17,877,053	M225L	probably benign	Het
Fras1	A	T	5: 96,770,688	I3528F	probably damaging	Het
Grm7	A	G	6: 111,207,769	T354A	probably benign	Het
Ift27	T	A	15: 78,173,778	I9F	possibly damaging	Het
Igf1r	A	G	7: 68,194,981	D834G	possibly damaging	Het
Igsf9b	T	A	9: 27,331,732	L738Q	probably damaging	Het
Itgam	A	T	7: 128,064,732	T44S	probably benign	Het
Ivd	T	A	2: 118,862,034	I5N	probably benign	Het
Jcad	T	C	18: 4,675,780	S1181P	probably damaging	Het
Kctd18	A	G	1: 57,956,365	V251A	probably benign	Het
Mycbp2	A	G	14: 103,252,509	V953A	possibly damaging	Het
Myo18a	T	C	11: 77,825,097		probably benign	Het
Myo3a	A	T	2: 22,340,280	Y509F	probably damaging	Het
Myocd	C	A	11: 65,178,670	M909I	probably benign	Het
Ndufv3	G	A	17: 31,531,245	R467Q	probably damaging	Het
Nkpd1	G	A	7: 19,523,252	V319M	probably damaging	Het
Olfr1216	A	G	2: 89,013,378	S229P	probably benign	Het
Olfr1342	T	A	4: 118,690,192	N87Y	probably damaging	Het
Olfr1453	C	A	19: 13,027,817	V171L	probably benign	Het
Olfr31	T	A	14: 14,328,774	L221Q	probably damaging	Het
Olfr366	T	C	2: 37,220,332	V281A	probably damaging	Het
Olfr406	C	T	11: 74,270,217	A276V	probably damaging	Het
Olfr450	G	T	6: 42,818,268	A266S	possibly damaging	Het
Parp4	T	C	14: 56,589,872		probably benign	Het
Pcdhb9	A	G	18: 37,402,818	T622A	probably benign	Het
Pdpk1	A	T	17: 24,098,176		probably benign	Het
Pkhd1	C	A	1: 20,347,457	G2490V	probably damaging	Het
Plekhg1	G	T	10: 3,903,658		probably null	Het
Plekhh2	A	G	17: 84,575,189	Y708C	probably damaging	Het
Pnp	T	C	14: 50,950,329	F107L	probably damaging	Het
Postn	T	A	3: 54,385,287		probably null	Het
Prcp	A	T	7: 92,928,675	D349V	probably damaging	Het
Prl3a1	A	T	13: 27,270,194	I52F	probably damaging	Het
Pym1	G	A	10: 128,766,044		probably benign	Het
Rad9a	A	T	19: 4,197,242	I248N	probably damaging	Het
Ror2	T	G	13: 53,110,305	E917A	probably benign	Het
Rsf1	G	A	7: 97,579,910		probably benign	Het
Sema6d	A	G	2: 124,659,556		probably null	Het
Slc4a2	C	T	5: 24,427,620	A12V	probably damaging	Het
Slco6b1	T	G	1: 96,961,176		noncoding transcript	Het
Slf2	A	T	19: 44,935,248	H167L	possibly damaging	Het
Snx9	G	T	17: 5,920,671	G429V	probably damaging	Het
Sod3	G	T	5: 52,368,162	V68L	probably benign	Het
Spta1	T	A	1: 174,246,549	D2351E	probably benign	Het
Srpk3	G	A	X: 73,777,955	R425Q	possibly damaging	Het
Tatdn1	C	T	15: 58,916,156	G171E	probably damaging	Het
Tbc1d22a	T	C	15: 86,235,569	V22A	possibly damaging	Het
Tmem27	A	G	X: 164,118,234	D184G	possibly damaging	Het
Tnfsf9	A	G	17: 57,105,738	T103A	probably benign	Het
Tpm3-rs7	T	C	14: 113,315,163	L163P	possibly damaging	Het
Trim52	T	A	14: 106,106,967	C20S	probably damaging	Het
Ucp1	C	T	8: 83,294,032	T157I	probably damaging	Het
Uspl1	T	A	5: 149,214,414	L794Q	probably benign	Het
Vmn1r5	T	A	6: 56,985,595	V85E	probably damaging	Het
Vmn1r58	A	G	7: 5,410,406	I275T	possibly damaging	Het
Wscd1	C	A	11: 71,760,218	P124T	probably benign	Het
Zfp780b	A	T	7: 27,963,100	C677S	possibly damaging	Het

Other mutations in Vmn2r79

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01401:Vmn2r79	APN	7	87037273	missense	probably benign	0.01
IGL01675:Vmn2r79	APN	7	86996648	missense	probably benign	0.01
IGL01760:Vmn2r79	APN	7	87002158	missense	probably benign
IGL01834:Vmn2r79	APN	7	87037146	missense	probably benign	0.01
IGL01843:Vmn2r79	APN	7	87037277	missense	probably damaging	1.00
IGL01914:Vmn2r79	APN	7	87037363	missense	probably benign	0.14
IGL01980:Vmn2r79	APN	7	87037082	missense	possibly damaging	0.49
IGL02438:Vmn2r79	APN	7	87002536	missense	probably damaging	0.98
IGL02740:Vmn2r79	APN	7	87004158	missense	probably benign	0.00
IGL03052:Vmn2r79	UTSW	7	87003591	missense	probably benign	0.00
PIT4445001:Vmn2r79	UTSW	7	87002200	missense	possibly damaging	0.46
R0096:Vmn2r79	UTSW	7	87037319	missense	probably damaging	1.00
R0096:Vmn2r79	UTSW	7	87037319	missense	probably damaging	1.00
R0270:Vmn2r79	UTSW	7	87003386	missense	probably benign	0.00
R0336:Vmn2r79	UTSW	7	87002079	missense	probably benign	0.15
R0418:Vmn2r79	UTSW	7	87002403	missense	probably benign	0.18
R1070:Vmn2r79	UTSW	7	87003473	missense	probably damaging	1.00
R1234:Vmn2r79	UTSW	7	87004099	missense	possibly damaging	0.71
R1459:Vmn2r79	UTSW	7	87037794	missense	probably benign	0.01
R1513:Vmn2r79	UTSW	7	87037444	missense	probably benign	0.01
R1624:Vmn2r79	UTSW	7	87004039	critical splice acceptor site	probably null
R1633:Vmn2r79	UTSW	7	87037834	missense	possibly damaging	0.52
R1676:Vmn2r79	UTSW	7	87002631	missense	probably benign
R1781:Vmn2r79	UTSW	7	87002347	missense	probably benign	0.00
R1794:Vmn2r79	UTSW	7	87001413	missense	probably benign	0.37
R2013:Vmn2r79	UTSW	7	87004081	missense	possibly damaging	0.50
R2018:Vmn2r79	UTSW	7	87002426	missense	probably benign	0.07
R2019:Vmn2r79	UTSW	7	87002426	missense	probably benign	0.07
R2177:Vmn2r79	UTSW	7	86996631	missense	possibly damaging	0.94
R2984:Vmn2r79	UTSW	7	87001891	missense	possibly damaging	0.85
R3719:Vmn2r79	UTSW	7	87002037	missense	probably benign	0.05
R3798:Vmn2r79	UTSW	7	87002194	missense	possibly damaging	0.88
R3969:Vmn2r79	UTSW	7	87003593	missense	probably damaging	1.00
R4182:Vmn2r79	UTSW	7	87001891	missense	possibly damaging	0.85
R4183:Vmn2r79	UTSW	7	87001891	missense	possibly damaging	0.85
R4245:Vmn2r79	UTSW	7	87002416	missense	possibly damaging	0.73
R4301:Vmn2r79	UTSW	7	87001891	missense	possibly damaging	0.85
R4391:Vmn2r79	UTSW	7	87001891	missense	possibly damaging	0.85
R4393:Vmn2r79	UTSW	7	87001891	missense	possibly damaging	0.85
R4394:Vmn2r79	UTSW	7	87001891	missense	possibly damaging	0.85
R4396:Vmn2r79	UTSW	7	87001891	missense	possibly damaging	0.85
R4397:Vmn2r79	UTSW	7	87001891	missense	possibly damaging	0.85
R4592:Vmn2r79	UTSW	7	87004111	missense	possibly damaging	0.86
R4697:Vmn2r79	UTSW	7	87037960	missense	probably damaging	0.98
R4897:Vmn2r79	UTSW	7	87001467	missense	probably benign
R5016:Vmn2r79	UTSW	7	87037340	missense	probably benign	0.00
R5058:Vmn2r79	UTSW	7	87002215	missense	probably damaging	0.98
R5177:Vmn2r79	UTSW	7	87001969	missense	probably damaging	0.97
R6078:Vmn2r79	UTSW	7	87004111	missense	possibly damaging	0.86
R6079:Vmn2r79	UTSW	7	87004111	missense	possibly damaging	0.86
R6138:Vmn2r79	UTSW	7	87004111	missense	possibly damaging	0.86
R6257:Vmn2r79	UTSW	7	87002570	missense	probably benign	0.27
R6260:Vmn2r79	UTSW	7	87037157	missense	probably benign	0.00
R6307:Vmn2r79	UTSW	7	87037768	missense	probably damaging	1.00
R6323:Vmn2r79	UTSW	7	87001314	missense	probably benign	0.05
R6374:Vmn2r79	UTSW	7	87002290	missense	probably benign	0.02
R6530:Vmn2r79	UTSW	7	87002044	missense	possibly damaging	0.91
R6546:Vmn2r79	UTSW	7	87003533	missense	probably benign	0.01
R6682:Vmn2r79	UTSW	7	87004162	missense	possibly damaging	0.69
R6858:Vmn2r79	UTSW	7	87037372	missense	probably benign
R6965:Vmn2r79	UTSW	7	87001892	missense	probably benign	0.10
R7130:Vmn2r79	UTSW	7	87002266	missense	probably damaging	0.99
R7156:Vmn2r79	UTSW	7	87037643	missense	probably damaging	0.98
R7604:Vmn2r79	UTSW	7	87003384	critical splice acceptor site	probably null
R7691:Vmn2r79	UTSW	7	87037903	missense	probably damaging	0.96
R8055:Vmn2r79	UTSW	7	87037333	missense	possibly damaging	0.94
R8070:Vmn2r79	UTSW	7	87002128	missense	probably benign
R8073:Vmn2r79	UTSW	7	87002254	missense	probably benign	0.00
R8145:Vmn2r79	UTSW	7	87037654	missense	probably benign	0.02
R8263:Vmn2r79	UTSW	7	87037518	missense	possibly damaging	0.89
R8350:Vmn2r79	UTSW	7	87037533	nonsense	probably null
R8400:Vmn2r79	UTSW	7	87002100	missense	probably benign	0.00
R8814:Vmn2r79	UTSW	7	87002506	missense	probably benign	0.00
R8862:Vmn2r79	UTSW	7	86996504	missense	probably benign	0.23
R9146:Vmn2r79	UTSW	7	87001473	nonsense	probably null
R9276:Vmn2r79	UTSW	7	87037837	missense	probably damaging	1.00
R9361:Vmn2r79	UTSW	7	87003614	critical splice donor site	probably null
R9676:Vmn2r79	UTSW	7	87037244	missense	probably damaging	1.00
U15987:Vmn2r79	UTSW	7	87004111	missense	possibly damaging	0.86
X0054:Vmn2r79	UTSW	7	87004062	missense	probably benign	0.01
Z1088:Vmn2r79	UTSW	7	87002341	missense	probably damaging	1.00
Z1176:Vmn2r79	UTSW	7	87002318	missense	probably benign	0.00
Z1176:Vmn2r79	UTSW	7	87037169	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- GCAAGTTTCACTGTGGCTTTC -3'
(R):5'- CCAGGAGGTTATCTACATTTTCAATGG -3'

Sequencing Primer
(F):5'- CACTGTGGCTTTCCTGGC -3'
(R):5'- TCAATGGTAGAAACTCACATA -3'

Posted On

2014-06-23