Incidental Mutation 'R1824:Brca2'
ID 206659
Institutional Source Beutler Lab
Gene Symbol Brca2
Ensembl Gene ENSMUSG00000041147
Gene Name breast cancer 2, early onset
Synonyms Fancd1, RAB163
MMRRC Submission 039852-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R1824 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 150446095-150493794 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 150460387 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 554 (T554I)
Ref Sequence ENSEMBL: ENSMUSP00000144676 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044620] [ENSMUST00000202003] [ENSMUST00000202313]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000044620
AA Change: T554I

PolyPhen 2 Score 0.399 (Sensitivity: 0.89; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000038576
Gene: ENSMUSG00000041147
AA Change: T554I

DomainStartEndE-ValueType
low complexity region 36 51 N/A INTRINSIC
low complexity region 100 123 N/A INTRINSIC
low complexity region 187 199 N/A INTRINSIC
low complexity region 746 761 N/A INTRINSIC
low complexity region 904 917 N/A INTRINSIC
Pfam:BRCA2 982 1014 2.6e-13 PFAM
Pfam:BRCA2 1193 1225 3.9e-16 PFAM
low complexity region 1239 1252 N/A INTRINSIC
Pfam:BRCA2 1395 1425 1.4e-13 PFAM
Pfam:BRCA2 1492 1524 1.8e-13 PFAM
Pfam:BRCA2 1624 1655 8.4e-12 PFAM
Pfam:BRCA2 1925 1957 8e-15 PFAM
Pfam:BRCA2 2005 2037 1.7e-11 PFAM
Pfam:BRCA-2_helical 2402 2588 1.3e-94 PFAM
Pfam:BRCA-2_OB1 2591 2717 5.3e-44 PFAM
Tower 2752 2793 2.37e-18 SMART
Pfam:BRCA-2_OB3 2971 3104 1.5e-49 PFAM
low complexity region 3197 3208 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201149
Predicted Effect possibly damaging
Transcript: ENSMUST00000202003
AA Change: T554I

PolyPhen 2 Score 0.938 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000144676
Gene: ENSMUSG00000041147
AA Change: T554I

DomainStartEndE-ValueType
low complexity region 36 51 N/A INTRINSIC
low complexity region 100 123 N/A INTRINSIC
low complexity region 187 199 N/A INTRINSIC
low complexity region 746 761 N/A INTRINSIC
low complexity region 904 917 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000202313
AA Change: T554I

PolyPhen 2 Score 0.399 (Sensitivity: 0.89; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000144150
Gene: ENSMUSG00000041147
AA Change: T554I

DomainStartEndE-ValueType
low complexity region 36 51 N/A INTRINSIC
low complexity region 100 123 N/A INTRINSIC
low complexity region 187 199 N/A INTRINSIC
low complexity region 746 761 N/A INTRINSIC
low complexity region 904 917 N/A INTRINSIC
Pfam:BRCA2 982 1014 2.6e-13 PFAM
Pfam:BRCA2 1193 1225 3.9e-16 PFAM
low complexity region 1239 1252 N/A INTRINSIC
Pfam:BRCA2 1395 1425 1.4e-13 PFAM
Pfam:BRCA2 1492 1524 1.8e-13 PFAM
Pfam:BRCA2 1624 1655 8.4e-12 PFAM
Pfam:BRCA2 1925 1957 8e-15 PFAM
Pfam:BRCA2 2005 2037 1.7e-11 PFAM
Pfam:BRCA-2_helical 2402 2588 1.3e-94 PFAM
Pfam:BRCA-2_OB1 2591 2717 5.3e-44 PFAM
Tower 2752 2793 2.37e-18 SMART
Pfam:BRCA-2_OB3 2971 3104 1.5e-49 PFAM
low complexity region 3197 3208 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202975
Coding Region Coverage
  • 1x: 97.4%
  • 3x: 96.8%
  • 10x: 95.2%
  • 20x: 92.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]
PHENOTYPE: Homozygous null mutants are embryonic lethal with abnormalities including growth retardation, neural tube defects, and mesoderm abnormalities; conditional mutations cause genetic instability and enhanced tumor formation; mutants with truncated BRCA2 protein survive, are small, infertile, show improper tissue differentiation and develop lymphomas and carcinomas. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 103 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930533K18Rik T C 10: 70,708,086 (GRCm39) noncoding transcript Het
Aadacl2fm1 C A 3: 59,840,001 (GRCm39) Y24* probably null Het
Abl1 T A 2: 31,690,656 (GRCm39) M706K probably benign Het
Abtb1 T C 6: 88,813,536 (GRCm39) T401A probably benign Het
Acd A G 8: 106,427,122 (GRCm39) L96P probably damaging Het
Arsi T A 18: 61,045,369 (GRCm39) W20R probably damaging Het
Arsi G A 18: 61,049,723 (GRCm39) G202E probably benign Het
Asic3 C T 5: 24,618,749 (GRCm39) Q14* probably null Het
Asxl3 T A 18: 22,655,125 (GRCm39) I1045N probably damaging Het
Atr T C 9: 95,818,474 (GRCm39) I2149T probably damaging Het
Begain A G 12: 108,999,025 (GRCm39) probably null Het
Brd10 T C 19: 29,693,814 (GRCm39) N1960S probably damaging Het
C1s2 C T 6: 124,612,641 (GRCm39) V11I probably benign Het
Cacna1i T C 15: 80,260,990 (GRCm39) F1333L possibly damaging Het
Camsap2 T C 1: 136,201,521 (GRCm39) T662A possibly damaging Het
Cep164 C T 9: 45,690,226 (GRCm39) V1367M probably damaging Het
Cfap46 C A 7: 139,219,518 (GRCm39) A1316S probably benign Het
Cic T C 7: 24,987,691 (GRCm39) S553P probably damaging Het
Cilk1 T A 9: 78,065,144 (GRCm39) D351E probably benign Het
Clcn2 C T 16: 20,534,712 (GRCm39) A12T probably benign Het
Clip2 A G 5: 134,532,081 (GRCm39) Y540H probably benign Het
Coil A G 11: 88,872,923 (GRCm39) N428S possibly damaging Het
Cpxm1 A C 2: 130,237,617 (GRCm39) V196G probably damaging Het
Cr2 A G 1: 194,839,624 (GRCm39) V601A probably damaging Het
Cyp3a25 T A 5: 145,921,763 (GRCm39) K390N probably damaging Het
Dclre1a T C 19: 56,535,150 (GRCm39) probably null Het
Dennd4a G C 9: 64,766,640 (GRCm39) probably null Het
Dlg5 T C 14: 24,199,512 (GRCm39) H1464R probably benign Het
Dmac2 T G 7: 25,324,217 (GRCm39) M225R probably damaging Het
Dnah8 T C 17: 30,950,154 (GRCm39) V1991A possibly damaging Het
Dscam A C 16: 96,626,781 (GRCm39) V376G probably benign Het
Dync1li1 A G 9: 114,538,252 (GRCm39) D203G probably benign Het
Eva1c A G 16: 90,663,331 (GRCm39) T22A probably benign Het
Fam110b A G 4: 5,799,029 (GRCm39) D149G probably benign Het
Fras1 A T 5: 96,918,547 (GRCm39) I3528F probably damaging Het
Fsip1 T C 2: 118,063,389 (GRCm39) D360G probably damaging Het
Galnt14 T C 17: 74,016,934 (GRCm39) T41A probably benign Het
Gdf3 T A 6: 122,586,921 (GRCm39) Q2L probably benign Het
Glrp1 A G 1: 88,437,511 (GRCm39) probably null Het
Gm3336 C G 8: 71,173,066 (GRCm39) probably null Het
Gm8674 C T 13: 50,054,844 (GRCm39) noncoding transcript Het
Gnat1 A G 9: 107,553,774 (GRCm39) Y226H probably damaging Het
Grk5 T C 19: 61,078,410 (GRCm39) V489A probably damaging Het
H1f8 A G 6: 115,925,719 (GRCm39) Y1C probably null Het
Igfbpl1 C A 4: 45,826,406 (GRCm39) A130S probably benign Het
Impdh1 T A 6: 29,205,087 (GRCm39) D261V probably benign Het
Itgal T A 7: 126,913,232 (GRCm39) S610T probably damaging Het
Jcad A G 18: 4,649,293 (GRCm39) T55A probably benign Het
Jup G A 11: 100,264,963 (GRCm39) R663* probably null Het
Kalrn C T 16: 34,114,585 (GRCm39) G556D probably damaging Het
Krt81 T C 15: 101,358,020 (GRCm39) E411G probably damaging Het
Lcat T C 8: 106,666,520 (GRCm39) E334G probably damaging Het
Lhcgr T C 17: 89,057,585 (GRCm39) E302G probably benign Het
Magi1 A G 6: 93,676,620 (GRCm39) V913A possibly damaging Het
Mrpl19 A T 6: 81,941,060 (GRCm39) probably null Het
Muc4 G T 16: 32,576,307 (GRCm39) probably benign Het
Mycbp2 A G 14: 103,489,945 (GRCm39) V953A possibly damaging Het
Myo3a G A 2: 22,401,054 (GRCm39) V600I probably benign Het
Ndufv3 G A 17: 31,750,219 (GRCm39) R467Q probably damaging Het
Ngef A G 1: 87,430,986 (GRCm39) probably null Het
Nisch A T 14: 30,898,389 (GRCm39) probably benign Het
Nlrp4c G A 7: 6,069,955 (GRCm39) probably null Het
Nup153 A T 13: 46,867,223 (GRCm39) S154T probably damaging Het
Obscn A G 11: 58,885,658 (GRCm39) probably benign Het
Or2t1 T A 14: 14,328,774 (GRCm38) L221Q probably damaging Het
Or4a74 G T 2: 89,439,693 (GRCm39) P251H probably damaging Het
Or6c219 T C 10: 129,781,206 (GRCm39) M242V possibly damaging Het
Otogl T C 10: 107,615,692 (GRCm39) N1869S probably benign Het
Phf24 G T 4: 42,934,661 (GRCm39) C136F probably damaging Het
Phldb2 A T 16: 45,646,374 (GRCm39) V65E probably benign Het
Pkhd1 C A 1: 20,417,681 (GRCm39) G2490V probably damaging Het
Prl8a8 A T 13: 27,692,433 (GRCm39) M186K probably damaging Het
Qars1 T C 9: 108,391,809 (GRCm39) V70A probably damaging Het
Rac1 C T 5: 143,502,980 (GRCm39) V14I probably benign Het
Rapgef5 T A 12: 117,652,419 (GRCm39) probably null Het
Slc16a12 G A 19: 34,648,278 (GRCm39) T405M possibly damaging Het
Slc17a6 A G 7: 51,311,294 (GRCm39) Y336C probably damaging Het
Slc30a9 T C 5: 67,505,395 (GRCm39) L441P probably damaging Het
Slc45a2 T C 15: 11,022,172 (GRCm39) S305P probably damaging Het
Sod3 G T 5: 52,525,504 (GRCm39) V68L probably benign Het
Sp1 T G 15: 102,339,438 (GRCm39) S773A possibly damaging Het
Spen C A 4: 141,200,096 (GRCm39) G2821C probably damaging Het
Tagap1 A G 17: 7,223,425 (GRCm39) S424P probably benign Het
Tbc1d22a T C 15: 86,119,770 (GRCm39) V22A possibly damaging Het
Tfec C T 6: 16,840,467 (GRCm39) probably null Het
Thsd7a A T 6: 12,409,041 (GRCm39) probably null Het
Tnfsf15 C A 4: 63,651,588 (GRCm39) G112V probably benign Het
Tnfsf9 A G 17: 57,412,738 (GRCm39) T103A probably benign Het
Tnxb C T 17: 34,911,307 (GRCm39) R1537* probably null Het
Tpra1 A G 6: 88,888,805 (GRCm39) N329S probably benign Het
Ttc12 A G 9: 49,368,184 (GRCm39) F281S probably damaging Het
Unc79 A G 12: 103,025,579 (GRCm39) N322S probably damaging Het
Unk G T 11: 115,921,268 (GRCm39) probably benign Het
Usp4 G T 9: 108,225,207 (GRCm39) G31W probably damaging Het
Vcan G T 13: 89,853,331 (GRCm39) A543D possibly damaging Het
Vil1 A C 1: 74,457,606 (GRCm39) I80L probably benign Het
Vmn2r27 C T 6: 124,208,593 (GRCm39) G51S probably benign Het
Vpreb1a A G 16: 16,686,935 (GRCm39) probably null Het
Zbtb6 C T 2: 37,319,829 (GRCm39) C33Y probably damaging Het
Zfp330 A T 8: 83,492,644 (GRCm39) C189* probably null Het
Zfp942 T A 17: 22,147,522 (GRCm39) H369L probably damaging Het
Zfp943 T A 17: 22,211,361 (GRCm39) I149K probably benign Het
Zfyve19 G A 2: 119,042,016 (GRCm39) V162M probably benign Het
Other mutations in Brca2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00332:Brca2 APN 5 150,463,363 (GRCm39) missense probably benign 0.18
IGL00392:Brca2 APN 5 150,464,705 (GRCm39) missense probably benign 0.02
IGL00557:Brca2 APN 5 150,484,003 (GRCm39) missense probably benign
IGL00798:Brca2 APN 5 150,462,928 (GRCm39) missense probably benign 0.30
IGL00933:Brca2 APN 5 150,465,869 (GRCm39) missense probably benign 0.04
IGL00964:Brca2 APN 5 150,455,775 (GRCm39) missense probably damaging 1.00
IGL01152:Brca2 APN 5 150,465,855 (GRCm39) missense probably damaging 0.99
IGL01577:Brca2 APN 5 150,465,085 (GRCm39) nonsense probably null
IGL01585:Brca2 APN 5 150,462,981 (GRCm39) missense possibly damaging 0.76
IGL01732:Brca2 APN 5 150,465,852 (GRCm39) missense probably benign 0.13
IGL01809:Brca2 APN 5 150,454,526 (GRCm39) splice site probably null
IGL01911:Brca2 APN 5 150,491,078 (GRCm39) missense probably damaging 0.96
IGL02113:Brca2 APN 5 150,464,444 (GRCm39) missense possibly damaging 0.95
IGL02313:Brca2 APN 5 150,462,126 (GRCm39) missense probably damaging 1.00
IGL02342:Brca2 APN 5 150,466,289 (GRCm39) missense possibly damaging 0.94
IGL02508:Brca2 APN 5 150,466,773 (GRCm39) missense possibly damaging 0.85
IGL02532:Brca2 APN 5 150,474,327 (GRCm39) missense probably damaging 1.00
IGL02646:Brca2 APN 5 150,484,255 (GRCm39) missense possibly damaging 0.89
IGL02738:Brca2 APN 5 150,490,500 (GRCm39) missense probably damaging 1.00
IGL02833:Brca2 APN 5 150,465,255 (GRCm39) missense possibly damaging 0.83
IGL02871:Brca2 APN 5 150,466,017 (GRCm39) missense probably benign 0.13
IGL02995:Brca2 APN 5 150,452,953 (GRCm39) missense probably damaging 1.00
IGL03105:Brca2 APN 5 150,483,950 (GRCm39) missense probably benign 0.02
BB007:Brca2 UTSW 5 150,481,975 (GRCm39) missense probably damaging 0.96
BB017:Brca2 UTSW 5 150,481,975 (GRCm39) missense probably damaging 0.96
R0219:Brca2 UTSW 5 150,446,640 (GRCm39) splice site probably benign
R0416:Brca2 UTSW 5 150,492,857 (GRCm39) missense possibly damaging 0.93
R0441:Brca2 UTSW 5 150,465,322 (GRCm39) missense probably damaging 0.96
R0548:Brca2 UTSW 5 150,468,400 (GRCm39) missense probably damaging 0.96
R0745:Brca2 UTSW 5 150,468,347 (GRCm39) splice site probably benign
R0799:Brca2 UTSW 5 150,483,658 (GRCm39) missense probably damaging 0.99
R1165:Brca2 UTSW 5 150,466,212 (GRCm39) missense probably damaging 0.98
R1247:Brca2 UTSW 5 150,464,739 (GRCm39) missense probably damaging 1.00
R1403:Brca2 UTSW 5 150,466,114 (GRCm39) missense probably benign 0.22
R1403:Brca2 UTSW 5 150,466,114 (GRCm39) missense probably benign 0.22
R1444:Brca2 UTSW 5 150,465,915 (GRCm39) missense probably benign
R1466:Brca2 UTSW 5 150,475,723 (GRCm39) missense probably damaging 0.99
R1466:Brca2 UTSW 5 150,475,723 (GRCm39) missense probably damaging 0.99
R1584:Brca2 UTSW 5 150,475,723 (GRCm39) missense probably damaging 0.99
R1599:Brca2 UTSW 5 150,472,178 (GRCm39) nonsense probably null
R1600:Brca2 UTSW 5 150,484,295 (GRCm39) splice site probably benign
R1822:Brca2 UTSW 5 150,463,663 (GRCm39) missense probably benign 0.06
R2037:Brca2 UTSW 5 150,464,134 (GRCm39) missense probably benign
R2131:Brca2 UTSW 5 150,480,594 (GRCm39) missense probably damaging 1.00
R2203:Brca2 UTSW 5 150,462,967 (GRCm39) missense possibly damaging 0.58
R2208:Brca2 UTSW 5 150,455,809 (GRCm39) missense probably damaging 0.96
R2293:Brca2 UTSW 5 150,483,999 (GRCm39) missense possibly damaging 0.86
R2517:Brca2 UTSW 5 150,463,137 (GRCm39) missense probably benign 0.04
R2566:Brca2 UTSW 5 150,465,227 (GRCm39) missense probably benign 0.03
R3422:Brca2 UTSW 5 150,466,586 (GRCm39) missense possibly damaging 0.91
R3917:Brca2 UTSW 5 150,464,292 (GRCm39) missense probably damaging 0.96
R3946:Brca2 UTSW 5 150,460,169 (GRCm39) missense probably damaging 0.96
R4176:Brca2 UTSW 5 150,463,098 (GRCm39) nonsense probably null
R4255:Brca2 UTSW 5 150,464,634 (GRCm39) missense possibly damaging 0.92
R4450:Brca2 UTSW 5 150,459,518 (GRCm39) missense probably damaging 0.96
R4603:Brca2 UTSW 5 150,459,630 (GRCm39) missense possibly damaging 0.86
R4681:Brca2 UTSW 5 150,475,863 (GRCm39) splice site probably null
R4755:Brca2 UTSW 5 150,483,452 (GRCm39) splice site probably null
R4762:Brca2 UTSW 5 150,454,581 (GRCm39) missense probably benign 0.00
R4824:Brca2 UTSW 5 150,463,200 (GRCm39) missense probably damaging 1.00
R4887:Brca2 UTSW 5 150,480,402 (GRCm39) missense probably damaging 1.00
R5020:Brca2 UTSW 5 150,483,901 (GRCm39) missense probably damaging 1.00
R5159:Brca2 UTSW 5 150,465,573 (GRCm39) missense possibly damaging 0.93
R5216:Brca2 UTSW 5 150,466,445 (GRCm39) missense probably damaging 0.99
R5269:Brca2 UTSW 5 150,462,688 (GRCm39) missense possibly damaging 0.75
R5274:Brca2 UTSW 5 150,463,154 (GRCm39) missense probably benign 0.00
R5589:Brca2 UTSW 5 150,480,597 (GRCm39) missense possibly damaging 0.67
R5619:Brca2 UTSW 5 150,480,579 (GRCm39) missense probably damaging 0.96
R5641:Brca2 UTSW 5 150,480,364 (GRCm39) missense probably damaging 1.00
R5686:Brca2 UTSW 5 150,464,369 (GRCm39) missense probably benign 0.00
R5730:Brca2 UTSW 5 150,492,470 (GRCm39) missense possibly damaging 0.85
R5763:Brca2 UTSW 5 150,471,471 (GRCm39) missense possibly damaging 0.85
R5877:Brca2 UTSW 5 150,466,686 (GRCm39) missense possibly damaging 0.53
R5893:Brca2 UTSW 5 150,492,603 (GRCm39) missense probably benign 0.02
R5900:Brca2 UTSW 5 150,464,597 (GRCm39) missense probably benign 0.01
R5926:Brca2 UTSW 5 150,458,087 (GRCm39) missense probably benign 0.07
R5966:Brca2 UTSW 5 150,466,716 (GRCm39) missense probably damaging 0.99
R6025:Brca2 UTSW 5 150,465,040 (GRCm39) frame shift probably null
R6062:Brca2 UTSW 5 150,480,354 (GRCm39) missense probably damaging 0.96
R6141:Brca2 UTSW 5 150,464,102 (GRCm39) missense possibly damaging 0.91
R6244:Brca2 UTSW 5 150,490,443 (GRCm39) missense probably benign 0.08
R6508:Brca2 UTSW 5 150,460,058 (GRCm39) missense possibly damaging 0.91
R6519:Brca2 UTSW 5 150,464,444 (GRCm39) missense probably damaging 0.99
R6611:Brca2 UTSW 5 150,459,658 (GRCm39) missense probably damaging 0.99
R6698:Brca2 UTSW 5 150,455,859 (GRCm39) missense probably damaging 1.00
R6856:Brca2 UTSW 5 150,463,673 (GRCm39) missense possibly damaging 0.68
R6912:Brca2 UTSW 5 150,465,207 (GRCm39) missense probably damaging 0.99
R7002:Brca2 UTSW 5 150,463,383 (GRCm39) missense probably benign
R7025:Brca2 UTSW 5 150,463,943 (GRCm39) missense probably benign 0.39
R7151:Brca2 UTSW 5 150,464,901 (GRCm39) missense probably benign 0.12
R7202:Brca2 UTSW 5 150,455,819 (GRCm39) missense probably benign 0.03
R7365:Brca2 UTSW 5 150,455,802 (GRCm39) missense probably damaging 0.99
R7510:Brca2 UTSW 5 150,460,156 (GRCm39) missense possibly damaging 0.85
R7612:Brca2 UTSW 5 150,464,076 (GRCm39) missense probably benign 0.03
R7682:Brca2 UTSW 5 150,466,618 (GRCm39) missense probably benign
R7890:Brca2 UTSW 5 150,462,846 (GRCm39) missense possibly damaging 0.83
R7930:Brca2 UTSW 5 150,481,975 (GRCm39) missense probably damaging 0.96
R7940:Brca2 UTSW 5 150,462,198 (GRCm39) missense probably benign
R8054:Brca2 UTSW 5 150,459,969 (GRCm39) missense probably benign 0.02
R8056:Brca2 UTSW 5 150,492,771 (GRCm39) missense possibly damaging 0.85
R8080:Brca2 UTSW 5 150,463,357 (GRCm39) missense probably benign 0.11
R8094:Brca2 UTSW 5 150,459,634 (GRCm39) missense possibly damaging 0.85
R8306:Brca2 UTSW 5 150,460,128 (GRCm39) missense possibly damaging 0.91
R8401:Brca2 UTSW 5 150,475,817 (GRCm39) missense probably damaging 1.00
R8523:Brca2 UTSW 5 150,483,613 (GRCm39) missense possibly damaging 0.75
R8784:Brca2 UTSW 5 150,472,126 (GRCm39) nonsense probably null
R8791:Brca2 UTSW 5 150,466,061 (GRCm39) missense possibly damaging 0.92
R8832:Brca2 UTSW 5 150,465,611 (GRCm39) missense possibly damaging 0.91
R8838:Brca2 UTSW 5 150,465,005 (GRCm39) missense possibly damaging 0.91
R8845:Brca2 UTSW 5 150,466,847 (GRCm39) missense possibly damaging 0.85
R8898:Brca2 UTSW 5 150,492,498 (GRCm39) missense possibly damaging 0.53
R8914:Brca2 UTSW 5 150,465,208 (GRCm39) missense probably damaging 0.96
R8935:Brca2 UTSW 5 150,492,446 (GRCm39) missense possibly damaging 0.70
R9014:Brca2 UTSW 5 150,465,219 (GRCm39) missense probably benign
R9023:Brca2 UTSW 5 150,465,360 (GRCm39) missense probably benign 0.07
R9094:Brca2 UTSW 5 150,475,770 (GRCm39) missense probably benign 0.08
R9195:Brca2 UTSW 5 150,463,418 (GRCm39) missense possibly damaging 0.83
R9198:Brca2 UTSW 5 150,459,977 (GRCm39) missense possibly damaging 0.91
R9314:Brca2 UTSW 5 150,474,359 (GRCm39) missense probably damaging 0.96
R9408:Brca2 UTSW 5 150,464,982 (GRCm39) missense probably damaging 1.00
R9459:Brca2 UTSW 5 150,464,094 (GRCm39) missense probably damaging 0.98
R9512:Brca2 UTSW 5 150,454,546 (GRCm39) missense probably benign 0.40
R9622:Brca2 UTSW 5 150,480,410 (GRCm39) missense probably damaging 0.96
R9777:Brca2 UTSW 5 150,480,579 (GRCm39) missense probably damaging 0.99
Z1088:Brca2 UTSW 5 150,466,228 (GRCm39) missense probably damaging 0.96
Z1186:Brca2 UTSW 5 150,460,048 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TGTCTTTCTCCGAGTATCAGGAAG -3'
(R):5'- ATGGTACTTCAAAAGCACTTGC -3'

Sequencing Primer
(F):5'- GTCTATATTCAAGATGAGAGAGCCAC -3'
(R):5'- ACTTGCTTCAAGCTGGGC -3'
Posted On 2014-06-23