Mutagenetix > Incidental Mutation

Incidental Mutation 'R1827:Dock10'

206870

Institutional Source

Beutler Lab

Gene Symbol

Dock10

Ensembl Gene

ENSMUSG00000038608

Gene Name

dedicator of cytokinesis 10

Synonyms

Zizimin3, A630054M16Rik, Jr5, ZIZ3, Jr4, 9330153B10Rik

MMRRC Submission

039854-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.487) question?

Stock #

R1827 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

80478790-80736244 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 80508009 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 1647 (N1647S)

Ref Sequence

ENSEMBL: ENSMUSP00000077099 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077946] [ENSMUST00000187774] [ENSMUST00000190595] [ENSMUST00000190983]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000077946
AA Change: N1647S

PolyPhen 2 Score 0.066 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000077099
Gene: ENSMUSG00000038608
AA Change: N1647S

Domain	Start	End	E-Value	Type
low complexity region	25	42	N/A	INTRINSIC
Pfam:DUF3398	61	153	1.7e-36	PFAM
PH	182	292	8.5e-17	SMART
Blast:PH	350	458	7e-18	BLAST
Pfam:DOCK-C2	668	859	1e-50	PFAM
low complexity region	1269	1279	N/A	INTRINSIC
low complexity region	1284	1295	N/A	INTRINSIC
Pfam:DHR-2	1592	2143	1.3e-216	PFAM
low complexity region	2174	2187	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000187774
AA Change: N1635S

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000140085
Gene: ENSMUSG00000038608
AA Change: N1635S

Domain	Start	End	E-Value	Type
Pfam:DUF3398	46	141	9e-29	PFAM
PH	170	280	3.9e-19	SMART
Blast:PH	338	446	7e-18	BLAST
Pfam:DOCK-C2	655	848	1.5e-54	PFAM
low complexity region	1257	1267	N/A	INTRINSIC
low complexity region	1272	1283	N/A	INTRINSIC
low complexity region	1870	1890	N/A	INTRINSIC
Pfam:Ded_cyto	1954	2131	3.4e-65	PFAM
low complexity region	2162	2175	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000189486

Predicted Effect

probably benign
Transcript: ENSMUST00000190595
AA Change: N1300S

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000139567
Gene: ENSMUSG00000038608
AA Change: N1300S

Domain	Start	End	E-Value	Type
Blast:PH	3	111	5e-18	BLAST
Pfam:DOCK-C2	320	513	1.2e-54	PFAM
low complexity region	922	932	N/A	INTRINSIC
low complexity region	937	948	N/A	INTRINSIC
low complexity region	1508	1522	N/A	INTRINSIC
Pfam:Ded_cyto	1588	1765	2.7e-65	PFAM
low complexity region	1783	1795	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000190983
AA Change: N1634S

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000140719
Gene: ENSMUSG00000038608
AA Change: N1634S

Domain	Start	End	E-Value	Type
Pfam:DUF3398	45	140	8.9e-29	PFAM
PH	169	279	3.9e-19	SMART
Blast:PH	337	445	7e-18	BLAST
Pfam:DOCK-C2	654	847	1.5e-54	PFAM
low complexity region	1256	1266	N/A	INTRINSIC
low complexity region	1271	1282	N/A	INTRINSIC
low complexity region	1869	1889	N/A	INTRINSIC
Pfam:Ded_cyto	1953	2130	3.4e-65	PFAM

Coding Region Coverage

1x: 97.4%
3x: 96.8%
10x: 95.0%
20x: 91.6%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit a reduction of B cell numbers in secondary lymphoid organs. Follicular B cells show membrane CD23 overexpression. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 87 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acadsb	G	C	7: 131,043,004 (GRCm39)	R355T	probably damaging	Het
Ackr2	C	T	9: 121,738,581 (GRCm39)	R319C	probably benign	Het
Acot4	G	A	12: 84,088,712 (GRCm39)	A187T	probably damaging	Het
Adgrb2	A	C	4: 129,906,350 (GRCm39)	Q926P	probably damaging	Het
Adgrb3	T	C	1: 25,571,658 (GRCm39)	T420A	probably damaging	Het
Adra1b	A	T	11: 43,726,476 (GRCm39)	V147E	probably damaging	Het
Bco1	A	G	8: 117,832,498 (GRCm39)	Y98C	probably damaging	Het
Car5a	C	T	8: 122,650,547 (GRCm39)	V166M	probably benign	Het
Cdh5	T	C	8: 104,839,541 (GRCm39)	L4P	possibly damaging	Het
Clec12a	A	G	6: 129,330,762 (GRCm39)	T115A	probably damaging	Het
Cmya5	G	A	13: 93,210,956 (GRCm39)	T3279I	possibly damaging	Het
Col4a4	C	T	1: 82,517,709 (GRCm39)	G105D	unknown	Het
Cyp2d34	A	T	15: 82,500,295 (GRCm39)	H481Q	probably benign	Het
Dhx15	A	T	5: 52,327,422 (GRCm39)	C307*	probably null	Het
Dnah9	A	G	11: 65,740,887 (GRCm39)	Y4100H	probably damaging	Het
Duox1	T	A	2: 122,177,861 (GRCm39)	Y1548*	probably null	Het
Esyt1	T	C	10: 128,352,238 (GRCm39)	E763G	probably benign	Het
Fbh1	G	T	2: 11,768,699 (GRCm39)	D332E	possibly damaging	Het
Fndc8	G	A	11: 82,790,355 (GRCm39)	V275M	probably damaging	Het
Focad	T	G	4: 88,147,620 (GRCm39)	Y420D	probably benign	Het
Gml	A	T	15: 74,688,280 (GRCm39)	H62Q	probably benign	Het
Gpr158	A	T	2: 21,832,129 (GRCm39)	L1076F	probably benign	Het
Gpr161	A	G	1: 165,134,136 (GRCm39)	T133A	possibly damaging	Het
Gpr83	G	T	9: 14,779,629 (GRCm39)	C269F	possibly damaging	Het
Gsg1l	A	T	7: 125,509,369 (GRCm39)	I256K	possibly damaging	Het
Hao1	T	A	2: 134,372,584 (GRCm39)	R141S	probably benign	Het
Hnf1a	G	A	5: 115,098,254 (GRCm39)	A116V	probably damaging	Het
Hrh4	A	T	18: 13,155,261 (GRCm39)	T267S	probably damaging	Het
Igfals	A	T	17: 25,099,278 (GRCm39)	N123I	probably benign	Het
Iglon5	T	A	7: 43,128,545 (GRCm39)	T91S	probably benign	Het
Impg2	A	T	16: 56,087,583 (GRCm39)	N1134I	possibly damaging	Het
Incenp	A	G	19: 9,850,093 (GRCm39)	V860A	possibly damaging	Het
Irf5	A	T	6: 29,536,672 (GRCm39)	H461L	possibly damaging	Het
Itpr2	A	G	6: 146,229,830 (GRCm39)	L1255P	probably damaging	Het
Kank2	A	G	9: 21,706,761 (GRCm39)	S86P	probably damaging	Het
Kcnma1	C	A	14: 23,380,997 (GRCm39)	D903Y	probably damaging	Het
Kcnn3	A	T	3: 89,428,301 (GRCm39)	M176L	possibly damaging	Het
Mccc1	A	T	3: 36,039,150 (GRCm39)	I281N	probably damaging	Het
Mms19	G	A	19: 41,942,116 (GRCm39)	A584V	probably benign	Het
Mon2	A	T	10: 122,882,216 (GRCm39)	D184E	probably damaging	Het
Mrpl1	T	C	5: 96,374,202 (GRCm39)	V159A	possibly damaging	Het
Mtrex	C	A	13: 113,049,633 (GRCm39)		probably null	Het
Myo18a	C	T	11: 77,709,597 (GRCm39)	T190I	probably benign	Het
Myo7a	A	T	7: 97,725,938 (GRCm39)	M1038K	probably damaging	Het
Myrfl	T	A	10: 116,668,852 (GRCm39)	I304F	probably damaging	Het
Neo1	G	A	9: 58,824,314 (GRCm39)	R705*	probably null	Het
Nfat5	T	C	8: 108,093,966 (GRCm39)	S736P	probably benign	Het
Nlrp4c	C	T	7: 6,068,765 (GRCm39)	P222L	probably damaging	Het
Nmt1	T	A	11: 102,955,664 (GRCm39)	W481R	probably damaging	Het
Ntrk3	T	A	7: 77,897,049 (GRCm39)	I663L	probably damaging	Het
Nup210l	A	T	3: 90,061,864 (GRCm39)	E681V	probably damaging	Het
Nxpe2	T	C	9: 48,237,914 (GRCm39)	T114A	probably damaging	Het
Or4c105	A	T	2: 88,648,402 (GRCm39)	I296F	probably benign	Het
Or55b3	A	G	7: 102,126,720 (GRCm39)	L119P	probably damaging	Het
Or56b1b	A	T	7: 108,164,282 (GRCm39)	V240D	probably benign	Het
Pald1	ATGCTGCTGCTGCTGC	ATGCTGCTGCTGC	10: 61,191,701 (GRCm39)		probably benign	Het
Ppm1e	T	C	11: 87,122,521 (GRCm39)	T479A	probably damaging	Het
Ppp1r7	A	G	1: 93,288,518 (GRCm39)	E298G	probably benign	Het
Pramel29	G	A	4: 143,936,180 (GRCm39)	P27S	probably damaging	Het
Prkaca	T	C	8: 84,717,616 (GRCm39)		probably null	Het
Prss36	A	G	7: 127,532,664 (GRCm39)	V718A	probably damaging	Het
Pxk	C	T	14: 8,151,507 (GRCm38)	R441*	probably null	Het
Rnf182	G	A	13: 43,822,010 (GRCm39)	W187*	probably null	Het
Rrp12	G	C	19: 41,868,920 (GRCm39)	D519E	possibly damaging	Het
Rufy4	T	C	1: 74,173,279 (GRCm39)	L415P	probably damaging	Het
Ryk	T	A	9: 102,765,706 (GRCm39)	D335E	probably benign	Het
S100a11	A	T	3: 93,433,428 (GRCm39)	I91F	probably benign	Het
Scin	T	C	12: 40,118,922 (GRCm39)	R625G	possibly damaging	Het
Simc1	T	A	13: 54,672,452 (GRCm39)	C267S	probably benign	Het
Slc28a1	T	C	7: 80,787,950 (GRCm39)	V279A	possibly damaging	Het
Slc30a8	T	A	15: 52,194,953 (GRCm39)		probably null	Het
Slco6d1	A	G	1: 98,348,941 (GRCm39)	D4G	probably damaging	Het
Tmem127	G	A	2: 127,098,094 (GRCm39)		probably null	Het
Trpm1	G	A	7: 63,884,755 (GRCm39)	R812H	probably damaging	Het
Tsga10	T	A	1: 37,874,661 (GRCm39)	I75F	probably damaging	Het
Tyms	C	T	5: 30,267,014 (GRCm39)		probably null	Het
Ubr4	A	G	4: 139,153,008 (GRCm39)		probably null	Het
Unc45a	A	G	7: 79,981,488 (GRCm39)	V438A	possibly damaging	Het
Usf2	T	C	7: 30,654,765 (GRCm39)	D110G	probably damaging	Het
Vit	T	C	17: 78,853,875 (GRCm39)		probably null	Het
Vmn2r104	A	T	17: 20,262,497 (GRCm39)	M211K	probably damaging	Het
Vmn2r11	T	C	5: 109,199,938 (GRCm39)	H505R	probably benign	Het
Vmn2r77	G	A	7: 86,450,821 (GRCm39)	A236T	probably damaging	Het
Xpo1	T	C	11: 23,235,155 (GRCm39)	M608T	probably benign	Het
Zfp112	T	C	7: 23,824,385 (GRCm39)	F116L	probably damaging	Het
Zfp84	A	G	7: 29,476,768 (GRCm39)	T487A	possibly damaging	Het
Zfpl1	A	C	19: 6,131,901 (GRCm39)	L241R	probably benign	Het

Other mutations in Dock10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00569:Dock10	APN	1	80,562,729 (GRCm39)	missense	probably damaging	1.00
IGL00783:Dock10	APN	1	80,550,166 (GRCm39)	splice site	probably benign
IGL00784:Dock10	APN	1	80,550,166 (GRCm39)	splice site	probably benign
IGL00858:Dock10	APN	1	80,545,720 (GRCm39)	missense	possibly damaging	0.48
IGL01298:Dock10	APN	1	80,508,962 (GRCm39)	missense	probably damaging	1.00
IGL01351:Dock10	APN	1	80,570,876 (GRCm39)	missense	probably damaging	1.00
IGL01356:Dock10	APN	1	80,501,459 (GRCm39)	missense	probably damaging	1.00
IGL01584:Dock10	APN	1	80,511,567 (GRCm39)	missense	probably damaging	0.99
IGL01619:Dock10	APN	1	80,612,015 (GRCm39)	splice site	probably benign
IGL01678:Dock10	APN	1	80,521,069 (GRCm39)	missense	probably damaging	1.00
IGL01759:Dock10	APN	1	80,503,990 (GRCm39)	missense	probably damaging	1.00
IGL02238:Dock10	APN	1	80,511,510 (GRCm39)	missense	probably damaging	0.99
IGL02352:Dock10	APN	1	80,483,378 (GRCm39)	missense	probably damaging	1.00
IGL02359:Dock10	APN	1	80,483,378 (GRCm39)	missense	probably damaging	1.00
IGL02377:Dock10	APN	1	80,562,711 (GRCm39)	critical splice donor site	probably null
IGL02433:Dock10	APN	1	80,507,905 (GRCm39)	missense	probably damaging	1.00
IGL02471:Dock10	APN	1	80,493,339 (GRCm39)	missense	probably damaging	0.99
IGL02645:Dock10	APN	1	80,551,840 (GRCm39)	missense	probably damaging	1.00
IGL02646:Dock10	APN	1	80,551,840 (GRCm39)	missense	probably damaging	1.00
IGL02648:Dock10	APN	1	80,551,840 (GRCm39)	missense	probably damaging	1.00
IGL02649:Dock10	APN	1	80,551,840 (GRCm39)	missense	probably damaging	1.00
IGL02650:Dock10	APN	1	80,551,840 (GRCm39)	missense	probably damaging	1.00
IGL02652:Dock10	APN	1	80,570,561 (GRCm39)	splice site	probably null
IGL02718:Dock10	APN	1	80,501,535 (GRCm39)	missense	probably benign	0.00
IGL02998:Dock10	APN	1	80,551,259 (GRCm39)	missense	probably damaging	1.00
IGL03057:Dock10	APN	1	80,545,088 (GRCm39)	missense	probably damaging	1.00
IGL03066:Dock10	APN	1	80,562,758 (GRCm39)	missense	probably benign	0.00
IGL03106:Dock10	APN	1	80,546,551 (GRCm39)	missense	probably damaging	0.98
IGL03148:Dock10	APN	1	80,518,075 (GRCm39)	missense	probably benign	0.01
IGL03271:Dock10	APN	1	80,483,126 (GRCm39)	missense	probably damaging	1.00
IGL03352:Dock10	APN	1	80,584,013 (GRCm39)	splice site	probably benign
LCD18:Dock10	UTSW	1	80,716,623 (GRCm38)	intron	probably benign
PIT4366001:Dock10	UTSW	1	80,573,438 (GRCm39)	missense	probably benign	0.30
PIT4581001:Dock10	UTSW	1	80,483,163 (GRCm39)	missense	probably damaging	1.00
R0019:Dock10	UTSW	1	80,583,642 (GRCm39)	missense	probably damaging	1.00
R0081:Dock10	UTSW	1	80,584,295 (GRCm39)	missense	probably damaging	0.99
R0095:Dock10	UTSW	1	80,501,788 (GRCm39)	missense	probably benign	0.00
R0241:Dock10	UTSW	1	80,556,340 (GRCm39)	missense	probably benign
R0241:Dock10	UTSW	1	80,556,340 (GRCm39)	missense	probably benign
R0255:Dock10	UTSW	1	80,583,593 (GRCm39)	missense	probably damaging	1.00
R0267:Dock10	UTSW	1	80,490,171 (GRCm39)	missense	probably damaging	1.00
R0299:Dock10	UTSW	1	80,514,646 (GRCm39)	missense	probably damaging	0.99
R0365:Dock10	UTSW	1	80,573,400 (GRCm39)	missense	probably damaging	1.00
R0387:Dock10	UTSW	1	80,517,993 (GRCm39)	missense	probably damaging	1.00
R0403:Dock10	UTSW	1	80,501,787 (GRCm39)	missense	possibly damaging	0.94
R0408:Dock10	UTSW	1	80,518,193 (GRCm39)	missense	probably benign	0.03
R0414:Dock10	UTSW	1	80,513,650 (GRCm39)	missense	possibly damaging	0.93
R0591:Dock10	UTSW	1	80,518,936 (GRCm39)	splice site	probably benign
R0698:Dock10	UTSW	1	80,507,895 (GRCm39)	missense	probably damaging	1.00
R0711:Dock10	UTSW	1	80,501,692 (GRCm39)	missense	probably damaging	1.00
R0925:Dock10	UTSW	1	80,514,657 (GRCm39)	missense	probably benign	0.20
R1162:Dock10	UTSW	1	80,546,559 (GRCm39)	missense	possibly damaging	0.58
R1370:Dock10	UTSW	1	80,518,060 (GRCm39)	missense	probably damaging	1.00
R1440:Dock10	UTSW	1	80,526,853 (GRCm39)	missense	probably benign	0.03
R1469:Dock10	UTSW	1	80,490,275 (GRCm39)	missense	probably benign	0.05
R1469:Dock10	UTSW	1	80,490,275 (GRCm39)	missense	probably benign	0.05
R1525:Dock10	UTSW	1	80,583,881 (GRCm39)	critical splice donor site	probably null
R1544:Dock10	UTSW	1	80,570,352 (GRCm39)	missense	probably benign	0.00
R1601:Dock10	UTSW	1	80,527,519 (GRCm39)	missense	probably benign	0.00
R1757:Dock10	UTSW	1	80,511,586 (GRCm39)	missense	probably damaging	1.00
R1765:Dock10	UTSW	1	80,583,540 (GRCm39)	missense	probably damaging	1.00
R1783:Dock10	UTSW	1	80,551,897 (GRCm39)	missense	probably benign	0.17
R1823:Dock10	UTSW	1	80,520,814 (GRCm39)	splice site	probably null
R1844:Dock10	UTSW	1	80,520,918 (GRCm39)	missense	probably damaging	0.99
R1856:Dock10	UTSW	1	80,584,285 (GRCm39)	missense	possibly damaging	0.46
R1974:Dock10	UTSW	1	80,488,143 (GRCm39)	missense	possibly damaging	0.50
R2006:Dock10	UTSW	1	80,527,506 (GRCm39)	missense	possibly damaging	0.95
R2112:Dock10	UTSW	1	80,483,360 (GRCm39)	missense	probably damaging	0.99
R2112:Dock10	UTSW	1	80,483,359 (GRCm39)	missense	probably damaging	1.00
R2113:Dock10	UTSW	1	80,584,280 (GRCm39)	missense	probably damaging	1.00
R2439:Dock10	UTSW	1	80,510,149 (GRCm39)	missense	probably damaging	1.00
R2566:Dock10	UTSW	1	80,517,970 (GRCm39)	missense	possibly damaging	0.88
R3086:Dock10	UTSW	1	80,510,074 (GRCm39)	missense	possibly damaging	0.91
R3766:Dock10	UTSW	1	80,514,643 (GRCm39)	missense	probably damaging	0.99
R3768:Dock10	UTSW	1	80,510,085 (GRCm39)	missense	probably damaging	1.00
R4009:Dock10	UTSW	1	80,510,148 (GRCm39)	missense	probably damaging	1.00
R4016:Dock10	UTSW	1	80,584,286 (GRCm39)	missense	probably damaging	1.00
R4179:Dock10	UTSW	1	80,488,134 (GRCm39)	missense	probably benign	0.00
R4243:Dock10	UTSW	1	80,544,472 (GRCm39)	missense	probably benign	0.00
R4244:Dock10	UTSW	1	80,544,472 (GRCm39)	missense	probably benign	0.00
R4245:Dock10	UTSW	1	80,544,472 (GRCm39)	missense	probably benign	0.00
R4674:Dock10	UTSW	1	80,584,337 (GRCm39)	missense	possibly damaging	0.79
R4696:Dock10	UTSW	1	80,493,330 (GRCm39)	missense	possibly damaging	0.95
R4789:Dock10	UTSW	1	80,518,998 (GRCm39)	missense	probably damaging	1.00
R4851:Dock10	UTSW	1	80,526,874 (GRCm39)	missense	probably benign	0.33
R4911:Dock10	UTSW	1	80,583,953 (GRCm39)	missense	probably damaging	1.00
R4976:Dock10	UTSW	1	80,545,711 (GRCm39)	critical splice donor site	probably null
R5086:Dock10	UTSW	1	80,529,189 (GRCm39)	missense	possibly damaging	0.89
R5119:Dock10	UTSW	1	80,545,711 (GRCm39)	critical splice donor site	probably null
R5301:Dock10	UTSW	1	80,625,973 (GRCm39)	missense	probably benign	0.41
R5404:Dock10	UTSW	1	80,481,630 (GRCm39)	intron	probably benign
R5457:Dock10	UTSW	1	80,501,781 (GRCm39)	missense	probably damaging	1.00
R5790:Dock10	UTSW	1	80,482,887 (GRCm39)	missense	probably benign	0.00
R5845:Dock10	UTSW	1	80,483,459 (GRCm39)	intron	probably benign
R5871:Dock10	UTSW	1	80,519,057 (GRCm39)	critical splice acceptor site	probably null
R5873:Dock10	UTSW	1	80,551,855 (GRCm39)	missense	probably damaging	1.00
R5881:Dock10	UTSW	1	80,538,640 (GRCm39)	missense	probably benign	0.19
R5895:Dock10	UTSW	1	80,514,676 (GRCm39)	missense	probably benign
R5935:Dock10	UTSW	1	80,483,304 (GRCm39)	intron	probably benign
R5965:Dock10	UTSW	1	80,546,461 (GRCm39)	splice site	probably null
R5966:Dock10	UTSW	1	80,546,225 (GRCm39)	missense	possibly damaging	0.84
R6008:Dock10	UTSW	1	80,583,890 (GRCm39)	missense	probably damaging	0.98
R6029:Dock10	UTSW	1	80,514,663 (GRCm39)	missense	possibly damaging	0.68
R6083:Dock10	UTSW	1	80,510,148 (GRCm39)	missense	probably damaging	1.00
R6145:Dock10	UTSW	1	80,553,621 (GRCm39)	nonsense	probably null
R6257:Dock10	UTSW	1	80,481,413 (GRCm39)	intron	probably benign
R6274:Dock10	UTSW	1	80,516,540 (GRCm39)	missense	probably damaging	1.00
R6324:Dock10	UTSW	1	80,482,893 (GRCm39)	missense	probably benign	0.03
R6346:Dock10	UTSW	1	80,553,573 (GRCm39)	splice site	probably null
R6476:Dock10	UTSW	1	80,518,959 (GRCm39)	nonsense	probably null
R6516:Dock10	UTSW	1	80,518,178 (GRCm39)	missense	probably damaging	1.00
R6526:Dock10	UTSW	1	80,564,068 (GRCm39)	missense	probably damaging	0.97
R6534:Dock10	UTSW	1	80,481,388 (GRCm39)	missense	probably benign	0.01
R6620:Dock10	UTSW	1	80,570,355 (GRCm39)	missense	probably benign	0.01
R6640:Dock10	UTSW	1	80,511,555 (GRCm39)	nonsense	probably null
R6669:Dock10	UTSW	1	80,570,572 (GRCm39)	missense	probably damaging	1.00
R6672:Dock10	UTSW	1	80,490,248 (GRCm39)	missense	probably benign	0.00
R6679:Dock10	UTSW	1	80,544,514 (GRCm39)	missense	probably benign	0.11
R6682:Dock10	UTSW	1	80,490,338 (GRCm39)	missense	probably damaging	1.00
R6712:Dock10	UTSW	1	80,514,583 (GRCm39)	missense	probably benign	0.00
R6726:Dock10	UTSW	1	80,490,147 (GRCm39)	missense	probably damaging	1.00
R6788:Dock10	UTSW	1	80,508,962 (GRCm39)	missense	probably damaging	1.00
R6805:Dock10	UTSW	1	80,564,407 (GRCm39)	missense	probably benign
R6815:Dock10	UTSW	1	80,516,576 (GRCm39)	missense	possibly damaging	0.94
R6818:Dock10	UTSW	1	80,593,082 (GRCm39)	missense	possibly damaging	0.95
R6867:Dock10	UTSW	1	80,508,976 (GRCm39)	missense	probably damaging	1.00
R6964:Dock10	UTSW	1	80,481,365 (GRCm39)	intron	probably benign
R7026:Dock10	UTSW	1	80,479,504 (GRCm39)	missense	probably benign	0.40
R7084:Dock10	UTSW	1	80,481,573 (GRCm39)	missense
R7087:Dock10	UTSW	1	80,570,543 (GRCm39)	missense	probably benign
R7158:Dock10	UTSW	1	80,564,589 (GRCm39)	critical splice acceptor site	probably null
R7191:Dock10	UTSW	1	80,518,048 (GRCm39)	missense	possibly damaging	0.93
R7214:Dock10	UTSW	1	80,546,246 (GRCm39)	missense	probably benign	0.01
R7255:Dock10	UTSW	1	80,520,816 (GRCm39)	critical splice donor site	probably null
R7320:Dock10	UTSW	1	80,527,421 (GRCm39)	critical splice donor site	probably null
R7359:Dock10	UTSW	1	80,687,065 (GRCm39)	missense	probably benign	0.01
R7423:Dock10	UTSW	1	80,501,497 (GRCm39)	missense	possibly damaging	0.67
R7464:Dock10	UTSW	1	80,518,032 (GRCm39)	missense	probably damaging	0.99
R7483:Dock10	UTSW	1	80,493,283 (GRCm39)	missense	probably benign	0.01
R7487:Dock10	UTSW	1	80,562,765 (GRCm39)	missense	probably benign	0.00
R7789:Dock10	UTSW	1	80,536,930 (GRCm39)	missense	possibly damaging	0.82
R7943:Dock10	UTSW	1	80,626,006 (GRCm39)	missense	probably damaging	0.98
R7962:Dock10	UTSW	1	80,564,085 (GRCm39)	missense	possibly damaging	0.88
R8079:Dock10	UTSW	1	80,556,421 (GRCm39)	missense	probably benign	0.00
R8086:Dock10	UTSW	1	80,481,707 (GRCm39)	missense	probably benign	0.17
R8184:Dock10	UTSW	1	80,530,469 (GRCm39)	missense	probably damaging	1.00
R8220:Dock10	UTSW	1	80,506,366 (GRCm39)	missense	probably null	1.00
R8225:Dock10	UTSW	1	80,481,447 (GRCm39)	nonsense	probably null
R8267:Dock10	UTSW	1	80,518,045 (GRCm39)	missense	probably benign	0.00
R8276:Dock10	UTSW	1	80,505,998 (GRCm39)	missense	probably benign
R8294:Dock10	UTSW	1	80,488,079 (GRCm39)	missense	possibly damaging	0.88
R8298:Dock10	UTSW	1	80,514,654 (GRCm39)	missense	probably benign	0.00
R8326:Dock10	UTSW	1	80,583,892 (GRCm39)	missense	possibly damaging	0.77
R8724:Dock10	UTSW	1	80,570,344 (GRCm39)	missense	probably benign	0.00
R8828:Dock10	UTSW	1	80,521,134 (GRCm39)	missense	probably damaging	1.00
R8846:Dock10	UTSW	1	80,545,786 (GRCm39)	missense	possibly damaging	0.93
R8919:Dock10	UTSW	1	80,483,147 (GRCm39)	missense	probably benign	0.00
R8950:Dock10	UTSW	1	80,519,016 (GRCm39)	missense	probably benign
R8993:Dock10	UTSW	1	80,551,888 (GRCm39)	missense	probably benign	0.21
R9028:Dock10	UTSW	1	80,584,012 (GRCm39)	splice site	probably benign
R9115:Dock10	UTSW	1	80,490,156 (GRCm39)	missense	probably damaging	1.00
R9327:Dock10	UTSW	1	80,510,184 (GRCm39)	missense	probably damaging	1.00
R9342:Dock10	UTSW	1	80,570,360 (GRCm39)	missense	probably benign
R9421:Dock10	UTSW	1	80,501,509 (GRCm39)	missense	probably damaging	1.00
R9431:Dock10	UTSW	1	80,583,593 (GRCm39)	missense	probably damaging	1.00
R9486:Dock10	UTSW	1	80,479,452 (GRCm39)	missense	unknown
R9521:Dock10	UTSW	1	80,501,763 (GRCm39)	missense	probably damaging	1.00
R9598:Dock10	UTSW	1	80,625,939 (GRCm39)	missense	probably benign	0.15
R9629:Dock10	UTSW	1	80,481,389 (GRCm39)	missense
R9703:Dock10	UTSW	1	80,517,540 (GRCm39)	missense	probably damaging	0.98
RF021:Dock10	UTSW	1	80,542,290 (GRCm39)	critical splice acceptor site	probably null
X0025:Dock10	UTSW	1	80,514,637 (GRCm39)	missense	probably damaging	0.98
X0065:Dock10	UTSW	1	80,518,977 (GRCm39)	missense	probably damaging	1.00
Z1088:Dock10	UTSW	1	80,510,064 (GRCm39)	missense	probably damaging	1.00
Z1176:Dock10	UTSW	1	80,538,671 (GRCm39)	missense	probably benign
Z1177:Dock10	UTSW	1	80,536,917 (GRCm39)	missense	probably benign	0.04

Predicted Primers

PCR Primer
(F):5'- AGACAGGTCTCCATTTCTTGC -3'
(R):5'- AGACAGTAAAGTTGACCATGCTTC -3'

Sequencing Primer
(F):5'- GCATGAATCTTGGCCATGC -3'
(R):5'- AAGTTGACCATGCTTCTTATTACC -3'

Posted On

2014-06-23