Incidental Mutation 'R1827:Duox1'
| ID |
206879 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Duox1
|
| Ensembl Gene |
ENSMUSG00000033268 |
| Gene Name |
dual oxidase 1 |
| Synonyms |
NOXEF1, LNOX1, 9930101G15Rik, THOX1 |
| MMRRC Submission |
039854-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1827 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
122146153-122178453 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
T to A
at 122177861 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Stop codon
at position 1548
(Y1548*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000097060
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000048635]
[ENSMUST00000099461]
[ENSMUST00000110530]
[ENSMUST00000110531]
[ENSMUST00000110532]
[ENSMUST00000121237]
[ENSMUST00000125826]
[ENSMUST00000139819]
|
| AlphaFold |
A2AQ92 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000048635
|
| SMART Domains |
Protein: ENSMUSP00000045135
Gene: ENSMUSG00000033256
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
48 |
67 |
N/A |
INTRINSIC |
|
SH2
|
136 |
220 |
9.16e-27 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000099461
AA Change: Y1548*
|
| SMART Domains |
Protein: ENSMUSP00000097060
Gene: ENSMUSG00000033268
AA Change: Y1548*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:An_peroxidase
|
29 |
557 |
2.1e-134 |
PFAM |
|
transmembrane domain
|
594 |
616 |
N/A |
INTRINSIC |
|
EFh
|
819 |
847 |
1.82e-4 |
SMART |
|
EFh
|
855 |
883 |
3.45e-5 |
SMART |
|
transmembrane domain
|
1044 |
1066 |
N/A |
INTRINSIC |
|
Pfam:Ferric_reduct
|
1087 |
1236 |
5.3e-21 |
PFAM |
|
Pfam:FAD_binding_8
|
1272 |
1374 |
8.5e-21 |
PFAM |
|
Pfam:NAD_binding_6
|
1380 |
1534 |
3.5e-33 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110530
|
| SMART Domains |
Protein: ENSMUSP00000106159
Gene: ENSMUSG00000033256
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
61 |
N/A |
INTRINSIC |
|
SH2
|
130 |
214 |
9.16e-27 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110531
|
| SMART Domains |
Protein: ENSMUSP00000106160
Gene: ENSMUSG00000033256
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
48 |
67 |
N/A |
INTRINSIC |
|
SH2
|
136 |
220 |
9.16e-27 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110532
|
| SMART Domains |
Protein: ENSMUSP00000106161
Gene: ENSMUSG00000033256
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
19 |
38 |
N/A |
INTRINSIC |
|
low complexity region
|
45 |
61 |
N/A |
INTRINSIC |
|
low complexity region
|
77 |
87 |
N/A |
INTRINSIC |
|
low complexity region
|
146 |
165 |
N/A |
INTRINSIC |
|
Blast:SH2
|
225 |
278 |
2e-22 |
BLAST |
|
SCOP:d1ayaa_
|
237 |
291 |
1e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000121237
|
| SMART Domains |
Protein: ENSMUSP00000113923
Gene: ENSMUSG00000033256
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
61 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000125826
|
| SMART Domains |
Protein: ENSMUSP00000117099
Gene: ENSMUSG00000033256
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
14 |
56 |
N/A |
INTRINSIC |
|
low complexity region
|
76 |
105 |
N/A |
INTRINSIC |
|
low complexity region
|
129 |
148 |
N/A |
INTRINSIC |
|
low complexity region
|
155 |
171 |
N/A |
INTRINSIC |
|
low complexity region
|
187 |
197 |
N/A |
INTRINSIC |
|
low complexity region
|
256 |
275 |
N/A |
INTRINSIC |
|
SH2
|
344 |
428 |
9.16e-27 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000135848
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000143484
|
| SMART Domains |
Protein: ENSMUSP00000120732
Gene: ENSMUSG00000033256
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
14 |
33 |
N/A |
INTRINSIC |
|
SH2
|
71 |
155 |
3.19e-26 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000151130
|
| SMART Domains |
Protein: ENSMUSP00000114524
Gene: ENSMUSG00000033256
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
6 |
48 |
N/A |
INTRINSIC |
|
low complexity region
|
68 |
97 |
N/A |
INTRINSIC |
|
low complexity region
|
121 |
140 |
N/A |
INTRINSIC |
|
low complexity region
|
147 |
163 |
N/A |
INTRINSIC |
|
low complexity region
|
179 |
189 |
N/A |
INTRINSIC |
|
low complexity region
|
248 |
267 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000139819
|
| SMART Domains |
Protein: ENSMUSP00000119980
Gene: ENSMUSG00000033256
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
14 |
24 |
N/A |
INTRINSIC |
|
low complexity region
|
83 |
102 |
N/A |
INTRINSIC |
|
low complexity region
|
149 |
163 |
N/A |
INTRINSIC |
|
SH2
|
218 |
302 |
9.16e-27 |
SMART |
|
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.0%
- 20x: 91.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]
|
| Allele List at MGI |
All alleles(6) : Targeted, other(3) Gene trapped(3)
|
| Other mutations in this stock |
Total: 87 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acadsb |
G |
C |
7: 131,043,004 (GRCm39) |
R355T |
probably damaging |
Het |
| Ackr2 |
C |
T |
9: 121,738,581 (GRCm39) |
R319C |
probably benign |
Het |
| Acot4 |
G |
A |
12: 84,088,712 (GRCm39) |
A187T |
probably damaging |
Het |
| Adgrb2 |
A |
C |
4: 129,906,350 (GRCm39) |
Q926P |
probably damaging |
Het |
| Adgrb3 |
T |
C |
1: 25,571,658 (GRCm39) |
T420A |
probably damaging |
Het |
| Adra1b |
A |
T |
11: 43,726,476 (GRCm39) |
V147E |
probably damaging |
Het |
| Bco1 |
A |
G |
8: 117,832,498 (GRCm39) |
Y98C |
probably damaging |
Het |
| Car5a |
C |
T |
8: 122,650,547 (GRCm39) |
V166M |
probably benign |
Het |
| Cdh5 |
T |
C |
8: 104,839,541 (GRCm39) |
L4P |
possibly damaging |
Het |
| Clec12a |
A |
G |
6: 129,330,762 (GRCm39) |
T115A |
probably damaging |
Het |
| Cmya5 |
G |
A |
13: 93,210,956 (GRCm39) |
T3279I |
possibly damaging |
Het |
| Col4a4 |
C |
T |
1: 82,517,709 (GRCm39) |
G105D |
unknown |
Het |
| Cyp2d34 |
A |
T |
15: 82,500,295 (GRCm39) |
H481Q |
probably benign |
Het |
| Dhx15 |
A |
T |
5: 52,327,422 (GRCm39) |
C307* |
probably null |
Het |
| Dnah9 |
A |
G |
11: 65,740,887 (GRCm39) |
Y4100H |
probably damaging |
Het |
| Dock10 |
T |
C |
1: 80,508,009 (GRCm39) |
N1647S |
probably benign |
Het |
| Esyt1 |
T |
C |
10: 128,352,238 (GRCm39) |
E763G |
probably benign |
Het |
| Fbh1 |
G |
T |
2: 11,768,699 (GRCm39) |
D332E |
possibly damaging |
Het |
| Fndc8 |
G |
A |
11: 82,790,355 (GRCm39) |
V275M |
probably damaging |
Het |
| Focad |
T |
G |
4: 88,147,620 (GRCm39) |
Y420D |
probably benign |
Het |
| Gml |
A |
T |
15: 74,688,280 (GRCm39) |
H62Q |
probably benign |
Het |
| Gpr158 |
A |
T |
2: 21,832,129 (GRCm39) |
L1076F |
probably benign |
Het |
| Gpr161 |
A |
G |
1: 165,134,136 (GRCm39) |
T133A |
possibly damaging |
Het |
| Gpr83 |
G |
T |
9: 14,779,629 (GRCm39) |
C269F |
possibly damaging |
Het |
| Gsg1l |
A |
T |
7: 125,509,369 (GRCm39) |
I256K |
possibly damaging |
Het |
| Hao1 |
T |
A |
2: 134,372,584 (GRCm39) |
R141S |
probably benign |
Het |
| Hnf1a |
G |
A |
5: 115,098,254 (GRCm39) |
A116V |
probably damaging |
Het |
| Hrh4 |
A |
T |
18: 13,155,261 (GRCm39) |
T267S |
probably damaging |
Het |
| Igfals |
A |
T |
17: 25,099,278 (GRCm39) |
N123I |
probably benign |
Het |
| Iglon5 |
T |
A |
7: 43,128,545 (GRCm39) |
T91S |
probably benign |
Het |
| Impg2 |
A |
T |
16: 56,087,583 (GRCm39) |
N1134I |
possibly damaging |
Het |
| Incenp |
A |
G |
19: 9,850,093 (GRCm39) |
V860A |
possibly damaging |
Het |
| Irf5 |
A |
T |
6: 29,536,672 (GRCm39) |
H461L |
possibly damaging |
Het |
| Itpr2 |
A |
G |
6: 146,229,830 (GRCm39) |
L1255P |
probably damaging |
Het |
| Kank2 |
A |
G |
9: 21,706,761 (GRCm39) |
S86P |
probably damaging |
Het |
| Kcnma1 |
C |
A |
14: 23,380,997 (GRCm39) |
D903Y |
probably damaging |
Het |
| Kcnn3 |
A |
T |
3: 89,428,301 (GRCm39) |
M176L |
possibly damaging |
Het |
| Mccc1 |
A |
T |
3: 36,039,150 (GRCm39) |
I281N |
probably damaging |
Het |
| Mms19 |
G |
A |
19: 41,942,116 (GRCm39) |
A584V |
probably benign |
Het |
| Mon2 |
A |
T |
10: 122,882,216 (GRCm39) |
D184E |
probably damaging |
Het |
| Mrpl1 |
T |
C |
5: 96,374,202 (GRCm39) |
V159A |
possibly damaging |
Het |
| Mtrex |
C |
A |
13: 113,049,633 (GRCm39) |
|
probably null |
Het |
| Myo18a |
C |
T |
11: 77,709,597 (GRCm39) |
T190I |
probably benign |
Het |
| Myo7a |
A |
T |
7: 97,725,938 (GRCm39) |
M1038K |
probably damaging |
Het |
| Myrfl |
T |
A |
10: 116,668,852 (GRCm39) |
I304F |
probably damaging |
Het |
| Neo1 |
G |
A |
9: 58,824,314 (GRCm39) |
R705* |
probably null |
Het |
| Nfat5 |
T |
C |
8: 108,093,966 (GRCm39) |
S736P |
probably benign |
Het |
| Nlrp4c |
C |
T |
7: 6,068,765 (GRCm39) |
P222L |
probably damaging |
Het |
| Nmt1 |
T |
A |
11: 102,955,664 (GRCm39) |
W481R |
probably damaging |
Het |
| Ntrk3 |
T |
A |
7: 77,897,049 (GRCm39) |
I663L |
probably damaging |
Het |
| Nup210l |
A |
T |
3: 90,061,864 (GRCm39) |
E681V |
probably damaging |
Het |
| Nxpe2 |
T |
C |
9: 48,237,914 (GRCm39) |
T114A |
probably damaging |
Het |
| Or4c105 |
A |
T |
2: 88,648,402 (GRCm39) |
I296F |
probably benign |
Het |
| Or55b3 |
A |
G |
7: 102,126,720 (GRCm39) |
L119P |
probably damaging |
Het |
| Or56b1b |
A |
T |
7: 108,164,282 (GRCm39) |
V240D |
probably benign |
Het |
| Pald1 |
ATGCTGCTGCTGCTGC |
ATGCTGCTGCTGC |
10: 61,191,701 (GRCm39) |
|
probably benign |
Het |
| Ppm1e |
T |
C |
11: 87,122,521 (GRCm39) |
T479A |
probably damaging |
Het |
| Ppp1r7 |
A |
G |
1: 93,288,518 (GRCm39) |
E298G |
probably benign |
Het |
| Pramel29 |
G |
A |
4: 143,936,180 (GRCm39) |
P27S |
probably damaging |
Het |
| Prkaca |
T |
C |
8: 84,717,616 (GRCm39) |
|
probably null |
Het |
| Prss36 |
A |
G |
7: 127,532,664 (GRCm39) |
V718A |
probably damaging |
Het |
| Pxk |
C |
T |
14: 8,151,507 (GRCm38) |
R441* |
probably null |
Het |
| Rnf182 |
G |
A |
13: 43,822,010 (GRCm39) |
W187* |
probably null |
Het |
| Rrp12 |
G |
C |
19: 41,868,920 (GRCm39) |
D519E |
possibly damaging |
Het |
| Rufy4 |
T |
C |
1: 74,173,279 (GRCm39) |
L415P |
probably damaging |
Het |
| Ryk |
T |
A |
9: 102,765,706 (GRCm39) |
D335E |
probably benign |
Het |
| S100a11 |
A |
T |
3: 93,433,428 (GRCm39) |
I91F |
probably benign |
Het |
| Scin |
T |
C |
12: 40,118,922 (GRCm39) |
R625G |
possibly damaging |
Het |
| Simc1 |
T |
A |
13: 54,672,452 (GRCm39) |
C267S |
probably benign |
Het |
| Slc28a1 |
T |
C |
7: 80,787,950 (GRCm39) |
V279A |
possibly damaging |
Het |
| Slc30a8 |
T |
A |
15: 52,194,953 (GRCm39) |
|
probably null |
Het |
| Slco6d1 |
A |
G |
1: 98,348,941 (GRCm39) |
D4G |
probably damaging |
Het |
| Tmem127 |
G |
A |
2: 127,098,094 (GRCm39) |
|
probably null |
Het |
| Trpm1 |
G |
A |
7: 63,884,755 (GRCm39) |
R812H |
probably damaging |
Het |
| Tsga10 |
T |
A |
1: 37,874,661 (GRCm39) |
I75F |
probably damaging |
Het |
| Tyms |
C |
T |
5: 30,267,014 (GRCm39) |
|
probably null |
Het |
| Ubr4 |
A |
G |
4: 139,153,008 (GRCm39) |
|
probably null |
Het |
| Unc45a |
A |
G |
7: 79,981,488 (GRCm39) |
V438A |
possibly damaging |
Het |
| Usf2 |
T |
C |
7: 30,654,765 (GRCm39) |
D110G |
probably damaging |
Het |
| Vit |
T |
C |
17: 78,853,875 (GRCm39) |
|
probably null |
Het |
| Vmn2r104 |
A |
T |
17: 20,262,497 (GRCm39) |
M211K |
probably damaging |
Het |
| Vmn2r11 |
T |
C |
5: 109,199,938 (GRCm39) |
H505R |
probably benign |
Het |
| Vmn2r77 |
G |
A |
7: 86,450,821 (GRCm39) |
A236T |
probably damaging |
Het |
| Xpo1 |
T |
C |
11: 23,235,155 (GRCm39) |
M608T |
probably benign |
Het |
| Zfp112 |
T |
C |
7: 23,824,385 (GRCm39) |
F116L |
probably damaging |
Het |
| Zfp84 |
A |
G |
7: 29,476,768 (GRCm39) |
T487A |
possibly damaging |
Het |
| Zfpl1 |
A |
C |
19: 6,131,901 (GRCm39) |
L241R |
probably benign |
Het |
|
| Other mutations in Duox1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00650:Duox1
|
APN |
2 |
122,163,622 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL00956:Duox1
|
APN |
2 |
122,153,787 (GRCm39) |
missense |
probably benign |
0.42 |
|
IGL01413:Duox1
|
APN |
2 |
122,151,191 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01444:Duox1
|
APN |
2 |
122,170,571 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01633:Duox1
|
APN |
2 |
122,164,279 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01814:Duox1
|
APN |
2 |
122,176,753 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01868:Duox1
|
APN |
2 |
122,168,888 (GRCm39) |
missense |
probably benign |
|
|
IGL02096:Duox1
|
APN |
2 |
122,174,655 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02126:Duox1
|
APN |
2 |
122,176,817 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL02342:Duox1
|
APN |
2 |
122,177,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02687:Duox1
|
APN |
2 |
122,166,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02708:Duox1
|
APN |
2 |
122,156,498 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02935:Duox1
|
APN |
2 |
122,155,000 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
antiquity
|
UTSW |
2 |
122,170,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Dejavous
|
UTSW |
2 |
122,151,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1706_Duox1_051
|
UTSW |
2 |
122,149,953 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5032_duox1_732
|
UTSW |
2 |
122,167,798 (GRCm39) |
missense |
probably benign |
|
|
Vaguely
|
UTSW |
2 |
122,156,616 (GRCm39) |
nonsense |
probably null |
|
|
D4043:Duox1
|
UTSW |
2 |
122,175,276 (GRCm39) |
missense |
probably benign |
|
|
R0047:Duox1
|
UTSW |
2 |
122,177,122 (GRCm39) |
unclassified |
probably benign |
|
|
R0047:Duox1
|
UTSW |
2 |
122,177,122 (GRCm39) |
unclassified |
probably benign |
|
|
R0241:Duox1
|
UTSW |
2 |
122,163,878 (GRCm39) |
splice site |
probably benign |
|
|
R0479:Duox1
|
UTSW |
2 |
122,176,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0834:Duox1
|
UTSW |
2 |
122,176,982 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1105:Duox1
|
UTSW |
2 |
122,168,183 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1205:Duox1
|
UTSW |
2 |
122,158,406 (GRCm39) |
nonsense |
probably null |
|
|
R1281:Duox1
|
UTSW |
2 |
122,157,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1302:Duox1
|
UTSW |
2 |
122,177,760 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1532:Duox1
|
UTSW |
2 |
122,175,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1706:Duox1
|
UTSW |
2 |
122,149,953 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1719:Duox1
|
UTSW |
2 |
122,169,125 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1753:Duox1
|
UTSW |
2 |
122,163,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1828:Duox1
|
UTSW |
2 |
122,177,861 (GRCm39) |
nonsense |
probably null |
|
|
R1940:Duox1
|
UTSW |
2 |
122,156,465 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1944:Duox1
|
UTSW |
2 |
122,177,001 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2069:Duox1
|
UTSW |
2 |
122,163,543 (GRCm39) |
missense |
probably benign |
|
|
R2113:Duox1
|
UTSW |
2 |
122,167,735 (GRCm39) |
missense |
probably benign |
|
|
R2202:Duox1
|
UTSW |
2 |
122,175,194 (GRCm39) |
missense |
probably benign |
0.19 |
|
R2314:Duox1
|
UTSW |
2 |
122,164,211 (GRCm39) |
nonsense |
probably null |
|
|
R2507:Duox1
|
UTSW |
2 |
122,163,619 (GRCm39) |
missense |
probably benign |
0.34 |
|
R2508:Duox1
|
UTSW |
2 |
122,163,619 (GRCm39) |
missense |
probably benign |
0.34 |
|
R3177:Duox1
|
UTSW |
2 |
122,170,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3277:Duox1
|
UTSW |
2 |
122,170,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4124:Duox1
|
UTSW |
2 |
122,167,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4271:Duox1
|
UTSW |
2 |
122,154,856 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4411:Duox1
|
UTSW |
2 |
122,168,115 (GRCm39) |
missense |
probably benign |
0.30 |
|
R4419:Duox1
|
UTSW |
2 |
122,157,607 (GRCm39) |
missense |
probably benign |
|
|
R4420:Duox1
|
UTSW |
2 |
122,157,607 (GRCm39) |
missense |
probably benign |
|
|
R4578:Duox1
|
UTSW |
2 |
122,164,258 (GRCm39) |
missense |
probably benign |
0.15 |
|
R4628:Duox1
|
UTSW |
2 |
122,176,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4665:Duox1
|
UTSW |
2 |
122,149,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4666:Duox1
|
UTSW |
2 |
122,149,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4730:Duox1
|
UTSW |
2 |
122,164,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4767:Duox1
|
UTSW |
2 |
122,163,922 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4857:Duox1
|
UTSW |
2 |
122,146,212 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4904:Duox1
|
UTSW |
2 |
122,151,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5032:Duox1
|
UTSW |
2 |
122,167,798 (GRCm39) |
missense |
probably benign |
|
|
R5201:Duox1
|
UTSW |
2 |
122,158,403 (GRCm39) |
missense |
probably benign |
|
|
R5474:Duox1
|
UTSW |
2 |
122,177,106 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5835:Duox1
|
UTSW |
2 |
122,158,341 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5939:Duox1
|
UTSW |
2 |
122,176,832 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5941:Duox1
|
UTSW |
2 |
122,174,637 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5943:Duox1
|
UTSW |
2 |
122,163,916 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5970:Duox1
|
UTSW |
2 |
122,170,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6023:Duox1
|
UTSW |
2 |
122,168,165 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6050:Duox1
|
UTSW |
2 |
122,149,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6064:Duox1
|
UTSW |
2 |
122,151,243 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6093:Duox1
|
UTSW |
2 |
122,177,755 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6188:Duox1
|
UTSW |
2 |
122,150,275 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6246:Duox1
|
UTSW |
2 |
122,157,655 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6259:Duox1
|
UTSW |
2 |
122,175,264 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6290:Duox1
|
UTSW |
2 |
122,164,288 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6300:Duox1
|
UTSW |
2 |
122,168,181 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6341:Duox1
|
UTSW |
2 |
122,168,202 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6498:Duox1
|
UTSW |
2 |
122,150,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6883:Duox1
|
UTSW |
2 |
122,155,065 (GRCm39) |
splice site |
probably null |
|
|
R7002:Duox1
|
UTSW |
2 |
122,150,358 (GRCm39) |
nonsense |
probably null |
|
|
R7410:Duox1
|
UTSW |
2 |
122,176,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7421:Duox1
|
UTSW |
2 |
122,153,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7608:Duox1
|
UTSW |
2 |
122,156,616 (GRCm39) |
nonsense |
probably null |
|
|
R7702:Duox1
|
UTSW |
2 |
122,160,120 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7766:Duox1
|
UTSW |
2 |
122,167,782 (GRCm39) |
missense |
probably benign |
|
|
R7833:Duox1
|
UTSW |
2 |
122,154,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7980:Duox1
|
UTSW |
2 |
122,177,801 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8275:Duox1
|
UTSW |
2 |
122,175,249 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8717:Duox1
|
UTSW |
2 |
122,168,152 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8992:Duox1
|
UTSW |
2 |
122,175,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9196:Duox1
|
UTSW |
2 |
122,150,689 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9344:Duox1
|
UTSW |
2 |
122,168,163 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9397:Duox1
|
UTSW |
2 |
122,150,783 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R9491:Duox1
|
UTSW |
2 |
122,156,907 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9510:Duox1
|
UTSW |
2 |
122,160,023 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9521:Duox1
|
UTSW |
2 |
122,159,216 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R9562:Duox1
|
UTSW |
2 |
122,151,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9565:Duox1
|
UTSW |
2 |
122,151,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9569:Duox1
|
UTSW |
2 |
122,148,971 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Duox1
|
UTSW |
2 |
122,163,519 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAGGAACATGAACCTGGCTAC -3'
(R):5'- AGACACATTCTGGCCCTAGAG -3'
Sequencing Primer
(F):5'- GAACATGAACCTGGCTACTGTTTTG -3'
(R):5'- GAGATCTCTGAGCCTACACATGATG -3'
|
| Posted On |
2014-06-23 |
Incidental Mutation