Incidental Mutation 'R1827:Vmn2r77'
ID |
206911 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r77
|
Ensembl Gene |
ENSMUSG00000090949 |
Gene Name |
vomeronasal 2, receptor 77 |
Synonyms |
EG546983 |
MMRRC Submission |
039854-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.079)
|
Stock # |
R1827 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
7 |
Chromosomal Location |
86444349-86461240 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to A
at 86450821 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Alanine to Threonine
at position 236
(A236T)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000129540
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164996]
|
AlphaFold |
L7N2B7 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000164996
AA Change: A236T
PolyPhen 2
Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000129540 Gene: ENSMUSG00000090949 AA Change: A236T
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
78 |
467 |
1.4e-30 |
PFAM |
Pfam:NCD3G
|
510 |
562 |
1e-20 |
PFAM |
Pfam:7tm_3
|
594 |
830 |
2.6e-52 |
PFAM |
|
Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.0%
- 20x: 91.6%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 87 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Acadsb |
G |
C |
7: 131,043,004 (GRCm39) |
R355T |
probably damaging |
Het |
Ackr2 |
C |
T |
9: 121,738,581 (GRCm39) |
R319C |
probably benign |
Het |
Acot4 |
G |
A |
12: 84,088,712 (GRCm39) |
A187T |
probably damaging |
Het |
Adgrb2 |
A |
C |
4: 129,906,350 (GRCm39) |
Q926P |
probably damaging |
Het |
Adgrb3 |
T |
C |
1: 25,571,658 (GRCm39) |
T420A |
probably damaging |
Het |
Adra1b |
A |
T |
11: 43,726,476 (GRCm39) |
V147E |
probably damaging |
Het |
Bco1 |
A |
G |
8: 117,832,498 (GRCm39) |
Y98C |
probably damaging |
Het |
Car5a |
C |
T |
8: 122,650,547 (GRCm39) |
V166M |
probably benign |
Het |
Cdh5 |
T |
C |
8: 104,839,541 (GRCm39) |
L4P |
possibly damaging |
Het |
Clec12a |
A |
G |
6: 129,330,762 (GRCm39) |
T115A |
probably damaging |
Het |
Cmya5 |
G |
A |
13: 93,210,956 (GRCm39) |
T3279I |
possibly damaging |
Het |
Col4a4 |
C |
T |
1: 82,517,709 (GRCm39) |
G105D |
unknown |
Het |
Cyp2d34 |
A |
T |
15: 82,500,295 (GRCm39) |
H481Q |
probably benign |
Het |
Dhx15 |
A |
T |
5: 52,327,422 (GRCm39) |
C307* |
probably null |
Het |
Dnah9 |
A |
G |
11: 65,740,887 (GRCm39) |
Y4100H |
probably damaging |
Het |
Dock10 |
T |
C |
1: 80,508,009 (GRCm39) |
N1647S |
probably benign |
Het |
Duox1 |
T |
A |
2: 122,177,861 (GRCm39) |
Y1548* |
probably null |
Het |
Esyt1 |
T |
C |
10: 128,352,238 (GRCm39) |
E763G |
probably benign |
Het |
Fbh1 |
G |
T |
2: 11,768,699 (GRCm39) |
D332E |
possibly damaging |
Het |
Fndc8 |
G |
A |
11: 82,790,355 (GRCm39) |
V275M |
probably damaging |
Het |
Focad |
T |
G |
4: 88,147,620 (GRCm39) |
Y420D |
probably benign |
Het |
Gml |
A |
T |
15: 74,688,280 (GRCm39) |
H62Q |
probably benign |
Het |
Gpr158 |
A |
T |
2: 21,832,129 (GRCm39) |
L1076F |
probably benign |
Het |
Gpr161 |
A |
G |
1: 165,134,136 (GRCm39) |
T133A |
possibly damaging |
Het |
Gpr83 |
G |
T |
9: 14,779,629 (GRCm39) |
C269F |
possibly damaging |
Het |
Gsg1l |
A |
T |
7: 125,509,369 (GRCm39) |
I256K |
possibly damaging |
Het |
Hao1 |
T |
A |
2: 134,372,584 (GRCm39) |
R141S |
probably benign |
Het |
Hnf1a |
G |
A |
5: 115,098,254 (GRCm39) |
A116V |
probably damaging |
Het |
Hrh4 |
A |
T |
18: 13,155,261 (GRCm39) |
T267S |
probably damaging |
Het |
Igfals |
A |
T |
17: 25,099,278 (GRCm39) |
N123I |
probably benign |
Het |
Iglon5 |
T |
A |
7: 43,128,545 (GRCm39) |
T91S |
probably benign |
Het |
Impg2 |
A |
T |
16: 56,087,583 (GRCm39) |
N1134I |
possibly damaging |
Het |
Incenp |
A |
G |
19: 9,850,093 (GRCm39) |
V860A |
possibly damaging |
Het |
Irf5 |
A |
T |
6: 29,536,672 (GRCm39) |
H461L |
possibly damaging |
Het |
Itpr2 |
A |
G |
6: 146,229,830 (GRCm39) |
L1255P |
probably damaging |
Het |
Kank2 |
A |
G |
9: 21,706,761 (GRCm39) |
S86P |
probably damaging |
Het |
Kcnma1 |
C |
A |
14: 23,380,997 (GRCm39) |
D903Y |
probably damaging |
Het |
Kcnn3 |
A |
T |
3: 89,428,301 (GRCm39) |
M176L |
possibly damaging |
Het |
Mccc1 |
A |
T |
3: 36,039,150 (GRCm39) |
I281N |
probably damaging |
Het |
Mms19 |
G |
A |
19: 41,942,116 (GRCm39) |
A584V |
probably benign |
Het |
Mon2 |
A |
T |
10: 122,882,216 (GRCm39) |
D184E |
probably damaging |
Het |
Mrpl1 |
T |
C |
5: 96,374,202 (GRCm39) |
V159A |
possibly damaging |
Het |
Mtrex |
C |
A |
13: 113,049,633 (GRCm39) |
|
probably null |
Het |
Myo18a |
C |
T |
11: 77,709,597 (GRCm39) |
T190I |
probably benign |
Het |
Myo7a |
A |
T |
7: 97,725,938 (GRCm39) |
M1038K |
probably damaging |
Het |
Myrfl |
T |
A |
10: 116,668,852 (GRCm39) |
I304F |
probably damaging |
Het |
Neo1 |
G |
A |
9: 58,824,314 (GRCm39) |
R705* |
probably null |
Het |
Nfat5 |
T |
C |
8: 108,093,966 (GRCm39) |
S736P |
probably benign |
Het |
Nlrp4c |
C |
T |
7: 6,068,765 (GRCm39) |
P222L |
probably damaging |
Het |
Nmt1 |
T |
A |
11: 102,955,664 (GRCm39) |
W481R |
probably damaging |
Het |
Ntrk3 |
T |
A |
7: 77,897,049 (GRCm39) |
I663L |
probably damaging |
Het |
Nup210l |
A |
T |
3: 90,061,864 (GRCm39) |
E681V |
probably damaging |
Het |
Nxpe2 |
T |
C |
9: 48,237,914 (GRCm39) |
T114A |
probably damaging |
Het |
Or4c105 |
A |
T |
2: 88,648,402 (GRCm39) |
I296F |
probably benign |
Het |
Or55b3 |
A |
G |
7: 102,126,720 (GRCm39) |
L119P |
probably damaging |
Het |
Or56b1b |
A |
T |
7: 108,164,282 (GRCm39) |
V240D |
probably benign |
Het |
Pald1 |
ATGCTGCTGCTGCTGC |
ATGCTGCTGCTGC |
10: 61,191,701 (GRCm39) |
|
probably benign |
Het |
Ppm1e |
T |
C |
11: 87,122,521 (GRCm39) |
T479A |
probably damaging |
Het |
Ppp1r7 |
A |
G |
1: 93,288,518 (GRCm39) |
E298G |
probably benign |
Het |
Pramel29 |
G |
A |
4: 143,936,180 (GRCm39) |
P27S |
probably damaging |
Het |
Prkaca |
T |
C |
8: 84,717,616 (GRCm39) |
|
probably null |
Het |
Prss36 |
A |
G |
7: 127,532,664 (GRCm39) |
V718A |
probably damaging |
Het |
Pxk |
C |
T |
14: 8,151,507 (GRCm38) |
R441* |
probably null |
Het |
Rnf182 |
G |
A |
13: 43,822,010 (GRCm39) |
W187* |
probably null |
Het |
Rrp12 |
G |
C |
19: 41,868,920 (GRCm39) |
D519E |
possibly damaging |
Het |
Rufy4 |
T |
C |
1: 74,173,279 (GRCm39) |
L415P |
probably damaging |
Het |
Ryk |
T |
A |
9: 102,765,706 (GRCm39) |
D335E |
probably benign |
Het |
S100a11 |
A |
T |
3: 93,433,428 (GRCm39) |
I91F |
probably benign |
Het |
Scin |
T |
C |
12: 40,118,922 (GRCm39) |
R625G |
possibly damaging |
Het |
Simc1 |
T |
A |
13: 54,672,452 (GRCm39) |
C267S |
probably benign |
Het |
Slc28a1 |
T |
C |
7: 80,787,950 (GRCm39) |
V279A |
possibly damaging |
Het |
Slc30a8 |
T |
A |
15: 52,194,953 (GRCm39) |
|
probably null |
Het |
Slco6d1 |
A |
G |
1: 98,348,941 (GRCm39) |
D4G |
probably damaging |
Het |
Tmem127 |
G |
A |
2: 127,098,094 (GRCm39) |
|
probably null |
Het |
Trpm1 |
G |
A |
7: 63,884,755 (GRCm39) |
R812H |
probably damaging |
Het |
Tsga10 |
T |
A |
1: 37,874,661 (GRCm39) |
I75F |
probably damaging |
Het |
Tyms |
C |
T |
5: 30,267,014 (GRCm39) |
|
probably null |
Het |
Ubr4 |
A |
G |
4: 139,153,008 (GRCm39) |
|
probably null |
Het |
Unc45a |
A |
G |
7: 79,981,488 (GRCm39) |
V438A |
possibly damaging |
Het |
Usf2 |
T |
C |
7: 30,654,765 (GRCm39) |
D110G |
probably damaging |
Het |
Vit |
T |
C |
17: 78,853,875 (GRCm39) |
|
probably null |
Het |
Vmn2r104 |
A |
T |
17: 20,262,497 (GRCm39) |
M211K |
probably damaging |
Het |
Vmn2r11 |
T |
C |
5: 109,199,938 (GRCm39) |
H505R |
probably benign |
Het |
Xpo1 |
T |
C |
11: 23,235,155 (GRCm39) |
M608T |
probably benign |
Het |
Zfp112 |
T |
C |
7: 23,824,385 (GRCm39) |
F116L |
probably damaging |
Het |
Zfp84 |
A |
G |
7: 29,476,768 (GRCm39) |
T487A |
possibly damaging |
Het |
Zfpl1 |
A |
C |
19: 6,131,901 (GRCm39) |
L241R |
probably benign |
Het |
|
Other mutations in Vmn2r77 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00954:Vmn2r77
|
APN |
7 |
86,449,975 (GRCm39) |
missense |
probably benign |
0.06 |
IGL01105:Vmn2r77
|
APN |
7 |
86,460,872 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01367:Vmn2r77
|
APN |
7 |
86,461,124 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL01634:Vmn2r77
|
APN |
7 |
86,460,857 (GRCm39) |
missense |
probably benign |
|
IGL01805:Vmn2r77
|
APN |
7 |
86,460,395 (GRCm39) |
missense |
probably benign |
0.18 |
IGL01868:Vmn2r77
|
APN |
7 |
86,452,224 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01980:Vmn2r77
|
APN |
7 |
86,450,678 (GRCm39) |
missense |
probably benign |
0.14 |
IGL02055:Vmn2r77
|
APN |
7 |
86,450,763 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02066:Vmn2r77
|
APN |
7 |
86,452,836 (GRCm39) |
nonsense |
probably null |
|
IGL02185:Vmn2r77
|
APN |
7 |
86,444,360 (GRCm39) |
missense |
unknown |
|
IGL02200:Vmn2r77
|
APN |
7 |
86,451,187 (GRCm39) |
missense |
probably benign |
0.04 |
IGL02336:Vmn2r77
|
APN |
7 |
86,451,224 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02445:Vmn2r77
|
APN |
7 |
86,452,848 (GRCm39) |
nonsense |
probably null |
|
IGL02557:Vmn2r77
|
APN |
7 |
86,444,342 (GRCm39) |
unclassified |
probably benign |
|
IGL02659:Vmn2r77
|
APN |
7 |
86,449,979 (GRCm39) |
missense |
probably benign |
0.32 |
IGL02978:Vmn2r77
|
APN |
7 |
86,460,555 (GRCm39) |
missense |
probably benign |
|
IGL03180:Vmn2r77
|
APN |
7 |
86,450,843 (GRCm39) |
missense |
possibly damaging |
0.85 |
IGL03255:Vmn2r77
|
APN |
7 |
86,461,131 (GRCm39) |
missense |
probably benign |
0.04 |
IGL03273:Vmn2r77
|
APN |
7 |
86,460,494 (GRCm39) |
missense |
probably damaging |
0.99 |
R0046:Vmn2r77
|
UTSW |
7 |
86,451,146 (GRCm39) |
missense |
possibly damaging |
0.73 |
R0047:Vmn2r77
|
UTSW |
7 |
86,460,858 (GRCm39) |
missense |
probably benign |
0.01 |
R0066:Vmn2r77
|
UTSW |
7 |
86,449,964 (GRCm39) |
missense |
probably benign |
0.17 |
R0066:Vmn2r77
|
UTSW |
7 |
86,449,964 (GRCm39) |
missense |
probably benign |
0.17 |
R0389:Vmn2r77
|
UTSW |
7 |
86,450,702 (GRCm39) |
missense |
probably benign |
0.29 |
R0635:Vmn2r77
|
UTSW |
7 |
86,460,383 (GRCm39) |
missense |
probably benign |
|
R0689:Vmn2r77
|
UTSW |
7 |
86,460,872 (GRCm39) |
missense |
probably damaging |
0.99 |
R0827:Vmn2r77
|
UTSW |
7 |
86,451,224 (GRCm39) |
missense |
probably damaging |
1.00 |
R1167:Vmn2r77
|
UTSW |
7 |
86,450,954 (GRCm39) |
missense |
probably benign |
0.02 |
R1228:Vmn2r77
|
UTSW |
7 |
86,450,242 (GRCm39) |
critical splice donor site |
probably null |
|
R1353:Vmn2r77
|
UTSW |
7 |
86,451,394 (GRCm39) |
missense |
probably benign |
0.29 |
R1392:Vmn2r77
|
UTSW |
7 |
86,450,830 (GRCm39) |
missense |
probably benign |
0.00 |
R1392:Vmn2r77
|
UTSW |
7 |
86,450,830 (GRCm39) |
missense |
probably benign |
0.00 |
R1613:Vmn2r77
|
UTSW |
7 |
86,460,356 (GRCm39) |
missense |
probably damaging |
1.00 |
R1654:Vmn2r77
|
UTSW |
7 |
86,461,123 (GRCm39) |
missense |
probably damaging |
1.00 |
R1742:Vmn2r77
|
UTSW |
7 |
86,444,543 (GRCm39) |
missense |
probably benign |
0.35 |
R1911:Vmn2r77
|
UTSW |
7 |
86,461,001 (GRCm39) |
missense |
probably damaging |
1.00 |
R1974:Vmn2r77
|
UTSW |
7 |
86,449,964 (GRCm39) |
missense |
probably benign |
0.17 |
R2008:Vmn2r77
|
UTSW |
7 |
86,450,921 (GRCm39) |
missense |
probably benign |
0.31 |
R2093:Vmn2r77
|
UTSW |
7 |
86,450,702 (GRCm39) |
missense |
probably benign |
0.29 |
R2143:Vmn2r77
|
UTSW |
7 |
86,461,152 (GRCm39) |
missense |
probably damaging |
1.00 |
R2269:Vmn2r77
|
UTSW |
7 |
86,460,897 (GRCm39) |
missense |
probably benign |
0.03 |
R2972:Vmn2r77
|
UTSW |
7 |
86,452,893 (GRCm39) |
missense |
probably benign |
0.01 |
R2974:Vmn2r77
|
UTSW |
7 |
86,452,893 (GRCm39) |
missense |
probably benign |
0.01 |
R3037:Vmn2r77
|
UTSW |
7 |
86,450,191 (GRCm39) |
missense |
probably benign |
|
R3694:Vmn2r77
|
UTSW |
7 |
86,450,044 (GRCm39) |
missense |
probably damaging |
1.00 |
R3695:Vmn2r77
|
UTSW |
7 |
86,450,044 (GRCm39) |
missense |
probably damaging |
1.00 |
R3805:Vmn2r77
|
UTSW |
7 |
86,444,368 (GRCm39) |
nonsense |
probably null |
|
R3870:Vmn2r77
|
UTSW |
7 |
86,461,050 (GRCm39) |
missense |
probably damaging |
1.00 |
R4732:Vmn2r77
|
UTSW |
7 |
86,450,195 (GRCm39) |
missense |
probably benign |
0.00 |
R4733:Vmn2r77
|
UTSW |
7 |
86,450,195 (GRCm39) |
missense |
probably benign |
0.00 |
R5009:Vmn2r77
|
UTSW |
7 |
86,451,015 (GRCm39) |
missense |
possibly damaging |
0.82 |
R5201:Vmn2r77
|
UTSW |
7 |
86,460,846 (GRCm39) |
missense |
probably damaging |
0.98 |
R5218:Vmn2r77
|
UTSW |
7 |
86,451,341 (GRCm39) |
missense |
probably damaging |
0.98 |
R5469:Vmn2r77
|
UTSW |
7 |
86,451,271 (GRCm39) |
missense |
probably benign |
0.01 |
R5673:Vmn2r77
|
UTSW |
7 |
86,461,214 (GRCm39) |
missense |
probably benign |
0.05 |
R5771:Vmn2r77
|
UTSW |
7 |
86,461,235 (GRCm39) |
missense |
probably benign |
0.06 |
R5832:Vmn2r77
|
UTSW |
7 |
86,460,670 (GRCm39) |
nonsense |
probably null |
|
R5899:Vmn2r77
|
UTSW |
7 |
86,460,924 (GRCm39) |
missense |
probably damaging |
1.00 |
R6151:Vmn2r77
|
UTSW |
7 |
86,450,878 (GRCm39) |
missense |
probably benign |
0.00 |
R6182:Vmn2r77
|
UTSW |
7 |
86,460,957 (GRCm39) |
missense |
probably damaging |
1.00 |
R6326:Vmn2r77
|
UTSW |
7 |
86,451,031 (GRCm39) |
missense |
probably benign |
|
R6419:Vmn2r77
|
UTSW |
7 |
86,460,767 (GRCm39) |
missense |
probably damaging |
0.99 |
R6549:Vmn2r77
|
UTSW |
7 |
86,450,065 (GRCm39) |
missense |
probably benign |
0.06 |
R6874:Vmn2r77
|
UTSW |
7 |
86,451,286 (GRCm39) |
missense |
probably benign |
0.00 |
R6972:Vmn2r77
|
UTSW |
7 |
86,452,202 (GRCm39) |
missense |
probably damaging |
1.00 |
R7056:Vmn2r77
|
UTSW |
7 |
86,451,023 (GRCm39) |
missense |
probably benign |
0.06 |
R7185:Vmn2r77
|
UTSW |
7 |
86,451,035 (GRCm39) |
missense |
probably benign |
0.00 |
R7261:Vmn2r77
|
UTSW |
7 |
86,460,518 (GRCm39) |
nonsense |
probably null |
|
R7298:Vmn2r77
|
UTSW |
7 |
86,449,979 (GRCm39) |
missense |
probably benign |
0.00 |
R7662:Vmn2r77
|
UTSW |
7 |
86,460,492 (GRCm39) |
nonsense |
probably null |
|
R8182:Vmn2r77
|
UTSW |
7 |
86,460,801 (GRCm39) |
missense |
probably damaging |
1.00 |
R8327:Vmn2r77
|
UTSW |
7 |
86,450,680 (GRCm39) |
missense |
probably benign |
0.08 |
R8387:Vmn2r77
|
UTSW |
7 |
86,450,947 (GRCm39) |
missense |
probably benign |
0.00 |
R8825:Vmn2r77
|
UTSW |
7 |
86,452,855 (GRCm39) |
missense |
probably benign |
|
R8898:Vmn2r77
|
UTSW |
7 |
86,444,430 (GRCm39) |
missense |
probably damaging |
1.00 |
R8973:Vmn2r77
|
UTSW |
7 |
86,452,150 (GRCm39) |
missense |
possibly damaging |
0.93 |
R9258:Vmn2r77
|
UTSW |
7 |
86,452,302 (GRCm39) |
missense |
possibly damaging |
0.88 |
R9338:Vmn2r77
|
UTSW |
7 |
86,460,994 (GRCm39) |
missense |
probably damaging |
1.00 |
R9358:Vmn2r77
|
UTSW |
7 |
86,452,236 (GRCm39) |
missense |
probably benign |
0.00 |
R9377:Vmn2r77
|
UTSW |
7 |
86,444,442 (GRCm39) |
missense |
probably benign |
0.05 |
R9404:Vmn2r77
|
UTSW |
7 |
86,451,247 (GRCm39) |
missense |
probably benign |
|
R9673:Vmn2r77
|
UTSW |
7 |
86,450,171 (GRCm39) |
missense |
possibly damaging |
0.75 |
R9679:Vmn2r77
|
UTSW |
7 |
86,460,741 (GRCm39) |
missense |
probably benign |
0.07 |
|
Predicted Primers |
PCR Primer
(F):5'- TTCATCTCCTTCTAAGTGACCAGG -3'
(R):5'- CATATCAAATTGTGACACACTGACC -3'
Sequencing Primer
(F):5'- CCTTCTAAGTGACCAGGAACAGTTTC -3'
(R):5'- TTGTGACACACTGACCCAGAGTC -3'
|
Posted On |
2014-06-23 |