Incidental Mutation 'R1828:Nrip3'
ID 207017
Institutional Source Beutler Lab
Gene Symbol Nrip3
Ensembl Gene ENSMUSG00000034825
Gene Name nuclear receptor interacting protein 3
Synonyms A330103B05Rik, D7H11orf14, ICRFP703N2430Q5.2, ICRFP703B1614Q5.2
MMRRC Submission 039855-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R1828 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 109357263-109380752 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 109365763 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 85 (S85P)
Ref Sequence ENSEMBL: ENSMUSP00000033331 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033331] [ENSMUST00000041460] [ENSMUST00000207400]
AlphaFold Q9JJR9
Predicted Effect probably benign
Transcript: ENSMUST00000033331
AA Change: S85P

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000033331
Gene: ENSMUSG00000034825
AA Change: S85P

DomainStartEndE-ValueType
low complexity region 42 57 N/A INTRINSIC
Pfam:Asp_protease 86 208 6e-16 PFAM
Pfam:Asp_protease_2 109 201 3.4e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000041460
AA Change: S96P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000044116
Gene: ENSMUSG00000034825
AA Change: S96P

DomainStartEndE-ValueType
low complexity region 53 68 N/A INTRINSIC
Pfam:Asp_protease 97 219 9.7e-16 PFAM
Pfam:Asp_protease_2 120 214 1e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207400
AA Change: S78P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 97.4%
  • 3x: 96.9%
  • 10x: 95.2%
  • 20x: 92.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130008F23Rik T C 17: 41,190,962 (GRCm39) T156A probably benign Het
9230106D20Rik A T 10: 19,536,065 (GRCm39) noncoding transcript Het
Abca3 A G 17: 24,585,171 (GRCm39) D144G probably benign Het
Anxa2 T A 9: 69,390,260 (GRCm39) L121Q probably damaging Het
Anxa7 A T 14: 20,512,732 (GRCm39) I267N probably damaging Het
Asb14 A T 14: 26,633,797 (GRCm39) D334V possibly damaging Het
Batf3 A G 1: 190,830,714 (GRCm39) N20S probably benign Het
Bub1b A G 2: 118,468,920 (GRCm39) H895R probably benign Het
C1qtnf12 G A 4: 156,050,160 (GRCm39) probably null Het
Cars1 T C 7: 143,130,385 (GRCm39) I294V probably damaging Het
Ccdc142 G A 6: 83,084,462 (GRCm39) A527T probably damaging Het
Ccdc168 A T 1: 44,096,234 (GRCm39) N1621K possibly damaging Het
Ccdc92 T C 5: 124,913,242 (GRCm39) N96D probably benign Het
Ceacam18 T A 7: 43,288,880 (GRCm39) D210E probably benign Het
Cenpe A G 3: 134,952,257 (GRCm39) T1373A probably damaging Het
Cfap161 T G 7: 83,440,932 (GRCm39) probably null Het
Cimip4 T C 15: 78,270,588 (GRCm39) Y60C possibly damaging Het
Cldn19 A G 4: 119,112,990 (GRCm39) D74G probably benign Het
Clec12a A G 6: 129,330,762 (GRCm39) T115A probably damaging Het
Cox7a2l T A 17: 83,811,397 (GRCm39) Q78L probably benign Het
Crot T C 5: 9,019,080 (GRCm39) N491S probably benign Het
Cspg4b T A 13: 113,505,342 (GRCm39) L2157Q probably damaging Het
Ctr9 A G 7: 110,643,165 (GRCm39) probably null Het
Cyp4f14 T G 17: 33,130,209 (GRCm39) D190A probably damaging Het
D630039A03Rik C T 4: 57,910,240 (GRCm39) V191I probably benign Het
Dnah10 A T 5: 124,838,343 (GRCm39) N1124I probably benign Het
Duox1 T A 2: 122,177,861 (GRCm39) Y1548* probably null Het
Epdr1 G A 13: 19,778,773 (GRCm39) Q6* probably null Het
Erbin A G 13: 103,996,577 (GRCm39) probably null Het
Ero1a A T 14: 45,525,217 (GRCm39) I436K probably damaging Het
Exph5 A T 9: 53,287,941 (GRCm39) Q1674L possibly damaging Het
Fat4 A T 3: 39,037,607 (GRCm39) Y3753F probably damaging Het
Gaa T C 11: 119,174,098 (GRCm39) V763A probably damaging Het
Golim4 G A 3: 75,809,745 (GRCm39) T216I probably damaging Het
Gpr83 G T 9: 14,779,629 (GRCm39) C269F possibly damaging Het
Gtf2f2 A G 14: 76,245,143 (GRCm39) probably null Het
Gtf3c5 T C 2: 28,469,694 (GRCm39) Y70C probably damaging Het
Hao1 T A 2: 134,372,584 (GRCm39) R141S probably benign Het
Hecw2 T C 1: 53,965,182 (GRCm39) D548G probably benign Het
Hr G A 14: 70,809,477 (GRCm39) probably null Het
Hrg A C 16: 22,774,853 (GRCm39) E161A probably damaging Het
Hydin A T 8: 111,237,526 (GRCm39) N1933I probably benign Het
Itpr2 A G 6: 146,229,830 (GRCm39) L1255P probably damaging Het
Kcnma1 C A 14: 23,380,997 (GRCm39) D903Y probably damaging Het
Kif5c T C 2: 49,570,252 (GRCm39) probably null Het
Mgat5b C A 11: 116,868,614 (GRCm39) H512Q probably damaging Het
Mtmr4 T C 11: 87,502,943 (GRCm39) V999A probably benign Het
Mttp G T 3: 137,813,041 (GRCm39) Q545K probably damaging Het
Ncstn CAGCTCCACGAAG CAG 1: 171,899,038 (GRCm39) probably null Het
Nexn A G 3: 151,948,405 (GRCm39) I386T probably damaging Het
Nxpe2 T C 9: 48,237,914 (GRCm39) T114A probably damaging Het
Olr1 T C 6: 129,465,895 (GRCm39) N37S possibly damaging Het
Or14j5 C T 17: 38,161,966 (GRCm39) A161V probably benign Het
Or4b1d A G 2: 89,968,931 (GRCm39) L184S probably damaging Het
Or4c105 A T 2: 88,648,402 (GRCm39) I296F probably benign Het
Or55b3 A G 7: 102,126,720 (GRCm39) L119P probably damaging Het
Or5p80 G T 7: 108,229,855 (GRCm39) V219F possibly damaging Het
Pax4 T C 6: 28,443,446 (GRCm39) Y290C probably benign Het
Pcdhb2 T A 18: 37,429,038 (GRCm39) V337D probably damaging Het
Pglyrp4 T C 3: 90,640,310 (GRCm39) Y187H probably damaging Het
Pi4ka A G 16: 17,098,614 (GRCm39) M2017T probably benign Het
Pkdrej T C 15: 85,703,483 (GRCm39) T818A possibly damaging Het
Pxk C T 14: 8,151,507 (GRCm38) R441* probably null Het
Pygm T C 19: 6,447,637 (GRCm39) I648T possibly damaging Het
Rab4a A T 8: 124,550,565 (GRCm39) K15I probably damaging Het
Rasa3 T C 8: 13,635,035 (GRCm39) E428G probably benign Het
Rnf182 G A 13: 43,822,010 (GRCm39) W187* probably null Het
Rpl3 C T 15: 79,964,591 (GRCm39) V222M possibly damaging Het
Rtl9 C T X: 141,886,011 (GRCm39) S1141F possibly damaging Het
S100a11 A T 3: 93,433,428 (GRCm39) I91F probably benign Het
Sfswap C T 5: 129,590,148 (GRCm39) T215I probably damaging Het
Slit2 A G 5: 48,461,372 (GRCm39) D1456G probably damaging Het
Tex19.2 C T 11: 121,008,317 (GRCm39) V44I probably benign Het
Tmem127 G A 2: 127,098,094 (GRCm39) probably null Het
Tpd52 G T 3: 9,012,579 (GRCm39) N59K probably damaging Het
Trpc3 G A 3: 36,692,695 (GRCm39) P766S possibly damaging Het
Usp17la T A 7: 104,510,331 (GRCm39) V312D probably damaging Het
Xirp2 A G 2: 67,345,582 (GRCm39) N2608D possibly damaging Het
Zfp764l1 T A 7: 126,991,081 (GRCm39) H302L probably damaging Het
Zscan25 C A 5: 145,227,858 (GRCm39) H507Q possibly damaging Het
Other mutations in Nrip3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01700:Nrip3 APN 7 109,361,074 (GRCm39) missense possibly damaging 0.95
IGL02253:Nrip3 APN 7 109,360,951 (GRCm39) splice site probably null
PIT4696001:Nrip3 UTSW 7 109,364,714 (GRCm39) nonsense probably null
R0140:Nrip3 UTSW 7 109,361,022 (GRCm39) unclassified probably benign
R1179:Nrip3 UTSW 7 109,362,762 (GRCm39) missense probably damaging 1.00
R5488:Nrip3 UTSW 7 109,361,045 (GRCm39) missense probably damaging 1.00
R5489:Nrip3 UTSW 7 109,361,045 (GRCm39) missense probably damaging 1.00
R6282:Nrip3 UTSW 7 109,362,686 (GRCm39) splice site probably null
R7134:Nrip3 UTSW 7 109,364,695 (GRCm39) missense probably damaging 0.99
R8414:Nrip3 UTSW 7 109,362,735 (GRCm39) missense possibly damaging 0.72
R9161:Nrip3 UTSW 7 109,365,777 (GRCm39) missense probably damaging 1.00
R9201:Nrip3 UTSW 7 109,360,906 (GRCm39) missense probably benign 0.05
R9641:Nrip3 UTSW 7 109,362,793 (GRCm39) missense probably damaging 1.00
Z1177:Nrip3 UTSW 7 109,365,782 (GRCm39) missense probably benign 0.34
Predicted Primers PCR Primer
(F):5'- TGAGGAGAGGGCCTACTATTGG -3'
(R):5'- TGACAATACCAACGCTTTCCTC -3'

Sequencing Primer
(F):5'- CTATTGGGATCATAAAGGGCCCTC -3'
(R):5'- GAGCTGCTCTGTGAAGTCC -3'
Posted On 2014-06-23