Mutagenetix > Incidental Mutation

Incidental Mutation 'R1831:Or11g1'

207362

Institutional Source

Beutler Lab

Gene Symbol

Or11g1

Ensembl Gene

ENSMUSG00000094692

Gene Name

olfactory receptor family 11 subfamily G member 1

Synonyms

GA_x6K02T2PMLR-6110726-6111661, Olfr738, MOR106-3

MMRRC Submission

039858-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.088) question?

Stock #

R1831 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

50651003-50651938 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 50651658 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000150559 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000058972] [ENSMUST00000214320] [ENSMUST00000214853] [ENSMUST00000216949]

AlphaFold

L7N1X7

Predicted Effect

probably benign
Transcript: ENSMUST00000058972
AA Change: M219K

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000059540
Gene: ENSMUSG00000094692
AA Change: M219K

Domain	Start	End	E-Value	Type
Pfam:7tm_4	35	311	2.5e-50	PFAM
Pfam:7TM_GPCR_Srsx	39	309	1.3e-5	PFAM
Pfam:7tm_1	45	294	6.9e-22	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000205382

Predicted Effect

probably benign
Transcript: ENSMUST00000214320
AA Change: M219K

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)

Predicted Effect

probably benign
Transcript: ENSMUST00000214853
AA Change: M219K

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)

Predicted Effect

probably null
Transcript: ENSMUST00000216949

Coding Region Coverage

1x: 97.5%
3x: 96.9%
10x: 95.2%
20x: 92.2%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 79 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700109H08Rik	A	G	5: 3,627,255 (GRCm39)	D77G	probably damaging	Het
Adam1b	A	G	5: 121,641,000 (GRCm39)	I15T	possibly damaging	Het
Arfgef1	G	C	1: 10,275,115 (GRCm39)	I312M	probably benign	Het
Capn8	G	A	1: 182,438,666 (GRCm39)		probably null	Het
Carmil1	A	T	13: 24,348,862 (GRCm39)	V15E	probably benign	Het
Ccdc42	T	A	11: 68,481,805 (GRCm39)	M133K	probably benign	Het
Cd5	T	C	19: 10,696,933 (GRCm39)	D485G	probably damaging	Het
Cdhr18	A	G	14: 13,899,619 (GRCm38)	I101T	probably damaging	Het
Cep104	T	A	4: 154,087,003 (GRCm39)	V842E	probably benign	Het
Cep162	T	A	9: 87,088,985 (GRCm39)	I966L	probably damaging	Het
Cklf	T	C	8: 104,977,687 (GRCm39)	F13S	probably damaging	Het
Csf2rb	C	T	15: 78,232,453 (GRCm39)	P587S	probably benign	Het
Cyp21a1	A	T	17: 35,023,009 (GRCm39)		probably benign	Het
Cyp26a1	A	T	19: 37,689,071 (GRCm39)	L335F	probably damaging	Het
Dcst1	A	G	3: 89,260,057 (GRCm39)	F596L	probably damaging	Het
Dennd6a	T	A	14: 26,328,109 (GRCm39)	L44H	probably damaging	Het
Dnah6	G	A	6: 73,158,780 (GRCm39)	R608C	possibly damaging	Het
Dnajb5	A	T	4: 42,957,333 (GRCm39)	T311S	probably benign	Het
Dthd1	A	G	5: 62,984,572 (GRCm39)	T426A	probably benign	Het
Dync1h1	A	G	12: 110,580,493 (GRCm39)	K118R	probably damaging	Het
Efemp1	A	T	11: 28,871,442 (GRCm39)	D347V	possibly damaging	Het
Ephb4	T	A	5: 137,352,677 (GRCm39)	Y87N	probably damaging	Het
Ern1	A	T	11: 106,290,668 (GRCm39)		probably null	Het
Fam184a	A	T	10: 53,523,180 (GRCm39)	D164E	probably damaging	Het
Fkbp10	A	G	11: 100,314,045 (GRCm39)	E351G	probably damaging	Het
Fmn2	A	G	1: 174,437,511 (GRCm39)	S1161G	probably benign	Het
Frem1	A	G	4: 82,939,074 (GRCm39)	S3P	possibly damaging	Het
Gpr3	C	T	4: 132,938,454 (GRCm39)	A73T	possibly damaging	Het
Gprc6a	T	C	10: 51,491,902 (GRCm39)	T616A	probably benign	Het
Gtf3c2	G	T	5: 31,325,713 (GRCm39)	Q452K	probably damaging	Het
H2-Q7	C	A	17: 35,658,675 (GRCm39)	S104R	probably benign	Het
Hacd2	T	C	16: 34,922,434 (GRCm39)	Y208H	probably damaging	Het
Hid1	C	T	11: 115,239,729 (GRCm39)	G734R	probably damaging	Het
Ifi207	A	G	1: 173,559,992 (GRCm39)	I160T	unknown	Het
Itga11	T	A	9: 62,689,300 (GRCm39)	L1155Q	probably damaging	Het
Kmt2d	A	G	15: 98,753,224 (GRCm39)	S157P	probably damaging	Het
Lamb3	A	G	1: 193,017,187 (GRCm39)	T793A	probably damaging	Het
Lonrf2	G	A	1: 38,852,357 (GRCm39)	P165S	probably benign	Het
Lrrc66	G	A	5: 73,764,769 (GRCm39)	S758L	possibly damaging	Het
Ltn1	C	T	16: 87,197,034 (GRCm39)	S1213N	possibly damaging	Het
Meak7	T	C	8: 120,497,992 (GRCm39)	M171V	probably null	Het
Med1	T	C	11: 98,047,437 (GRCm39)		probably benign	Het
Megf6	C	T	4: 154,355,134 (GRCm39)	T1483M	probably benign	Het
Micall2	A	G	5: 139,702,508 (GRCm39)	V245A	probably benign	Het
Mipep	T	G	14: 61,109,512 (GRCm39)	Y630D	probably damaging	Het
Ndst3	T	A	3: 123,395,127 (GRCm39)	H501L	probably benign	Het
Nek10	A	T	14: 14,842,789 (GRCm38)	M165L	probably benign	Het
Nmbr	C	A	10: 14,642,609 (GRCm39)	T56K	probably benign	Het
Nxpe2	T	A	9: 48,237,452 (GRCm39)	M268L	probably benign	Het
Oasl2	A	G	5: 115,039,367 (GRCm39)	Y185C	probably benign	Het
Ogdhl	T	A	14: 32,059,484 (GRCm39)	V377E	probably damaging	Het
Or14j4	G	A	17: 37,920,730 (GRCm39)	S304L	possibly damaging	Het
Ovgp1	A	G	3: 105,892,384 (GRCm39)	R346G	probably benign	Het
Parp14	T	A	16: 35,678,958 (GRCm39)	N337Y	possibly damaging	Het
Pask	A	C	1: 93,248,491 (GRCm39)		probably null	Het
Pax3	G	T	1: 78,108,977 (GRCm39)	T227K	probably damaging	Het
Pik3r6	T	A	11: 68,434,860 (GRCm39)	M594K	probably benign	Het
Pms1	A	G	1: 53,246,370 (GRCm39)	F390L	probably benign	Het
Polg	G	A	7: 79,109,518 (GRCm39)	T433I	probably benign	Het
Prex1	T	C	2: 166,427,021 (GRCm39)	Y898C	probably damaging	Het
Ranbp2	T	A	10: 58,315,044 (GRCm39)	C1921*	probably null	Het
Rif1	T	A	2: 51,968,507 (GRCm39)	L230*	probably null	Het
Rnf148	A	G	6: 23,654,772 (GRCm39)	F75L	probably damaging	Het
Rps18-ps6	A	G	13: 97,897,053 (GRCm39)	V15A	probably benign	Het
Sclt1	A	G	3: 41,681,546 (GRCm39)	V91A	probably damaging	Het
Sirt1	T	C	10: 63,156,425 (GRCm39)	D735G	probably benign	Het
Spag5	T	A	11: 78,205,082 (GRCm39)	N622K	probably benign	Het
Sspo	T	G	6: 48,466,720 (GRCm39)	C3935W	probably damaging	Het
Strbp	A	G	2: 37,515,277 (GRCm39)	S250P	possibly damaging	Het
Tgfbr2	T	C	9: 115,919,604 (GRCm39)	T541A	possibly damaging	Het
Thada	A	C	17: 84,538,542 (GRCm39)	S1489A	probably damaging	Het
Tiam1	A	T	16: 89,657,182 (GRCm39)	S685T	probably benign	Het
Tpsb2	T	A	17: 25,585,494 (GRCm39)		probably null	Het
Trip4	C	A	9: 65,765,622 (GRCm39)	G359V	probably damaging	Het
Tsr1	T	C	11: 74,791,182 (GRCm39)	F254L	probably benign	Het
Vmn1r120	T	C	7: 20,787,556 (GRCm39)	K52E	probably benign	Het
Vmn1r29	C	A	6: 58,284,692 (GRCm39)	Y137*	probably null	Het
Vmn2r52	T	C	7: 9,893,415 (GRCm39)	K575E	probably damaging	Het
Wdr95	A	G	5: 149,475,891 (GRCm39)	Y63C	probably damaging	Het

Other mutations in Or11g1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01608:Or11g1	APN	14	50,651,910 (GRCm39)	missense	probably benign
IGL01935:Or11g1	APN	14	50,651,012 (GRCm39)	missense	probably benign
IGL02431:Or11g1	APN	14	50,651,226 (GRCm39)	missense	probably damaging	1.00
BB008:Or11g1	UTSW	14	50,651,786 (GRCm39)	missense	probably damaging	0.96
BB018:Or11g1	UTSW	14	50,651,786 (GRCm39)	missense	probably damaging	0.96
PIT4480001:Or11g1	UTSW	14	50,651,372 (GRCm39)	missense	probably benign	0.14
R0620:Or11g1	UTSW	14	50,651,154 (GRCm39)	missense	probably benign	0.20
R1445:Or11g1	UTSW	14	50,651,858 (GRCm39)	missense	probably damaging	1.00
R1915:Or11g1	UTSW	14	50,651,798 (GRCm39)	missense	probably damaging	1.00
R4748:Or11g1	UTSW	14	50,651,333 (GRCm39)	missense	possibly damaging	0.77
R5301:Or11g1	UTSW	14	50,651,030 (GRCm39)	missense	probably benign	0.09
R5767:Or11g1	UTSW	14	50,651,235 (GRCm39)	missense	possibly damaging	0.55
R5831:Or11g1	UTSW	14	50,651,439 (GRCm39)	splice site	probably null
R6173:Or11g1	UTSW	14	50,651,654 (GRCm39)	missense	possibly damaging	0.70
R6176:Or11g1	UTSW	14	50,651,847 (GRCm39)	missense	probably damaging	1.00
R7356:Or11g1	UTSW	14	50,651,159 (GRCm39)	missense	probably damaging	1.00
R7678:Or11g1	UTSW	14	50,651,471 (GRCm39)	missense	probably damaging	0.98
R7931:Or11g1	UTSW	14	50,651,786 (GRCm39)	missense	probably damaging	0.96
R8508:Or11g1	UTSW	14	50,651,132 (GRCm39)	missense	probably benign	0.00
R8696:Or11g1	UTSW	14	50,651,420 (GRCm39)	missense	possibly damaging	0.95
R9374:Or11g1	UTSW	14	50,651,625 (GRCm39)	missense	probably benign	0.38
R9470:Or11g1	UTSW	14	50,651,235 (GRCm39)	missense	possibly damaging	0.55
R9551:Or11g1	UTSW	14	50,651,625 (GRCm39)	missense	probably benign	0.38

Predicted Primers

PCR Primer
(F):5'- ATCCTTCTCTCATGACTGGGCG -3'
(R):5'- CACTCCAGCTGCATGTTCAG -3'

Sequencing Primer
(F):5'- GCAACATCCTTGTGATCAGTTG -3'
(R):5'- GATGTTGGGCTCACATACATGACC -3'

Posted On

2014-06-23