|Institutional Source||Beutler Lab|
|Gene Name||CD5 antigen|
|Synonyms||Lyt-1, Ly-1, Ly-A, Ly-12|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R1831 (G1)|
|Chromosomal Location||10718143-10738974 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 10719569 bp|
|Amino Acid Change||Aspartic acid to Glycine at position 485 (D485G)|
|Ref Sequence||ENSEMBL: ENSMUSP00000025571 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000025571]|
|Predicted Effect||probably damaging
AA Change: D485G
PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
AA Change: D485G
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. This protein is a type-I transmembrane glycoprotein found on the surface of thymocytes, T lymphocytes and a subset of B lymphocytes. The encoded protein contains three SRCR domains and may act as a receptor to regulate T-cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]
PHENOTYPE: Homozygous mutation of this gene does not result in a phenotype. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Cd5||
(F):5'- GCTCAGGTGGCTCCATTATG -3'
(R):5'- GATACAGGCCTGTCACCATC -3'
(F):5'- CCTGGAACTAGCTATGTGGAC -3'
(R):5'- GGCCTGTCACCATCTCAGAAAAC -3'