Incidental Mutation 'R1843:Arap3'
| ID |
207490 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arap3
|
| Ensembl Gene |
ENSMUSG00000024451 |
| Gene Name |
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 |
| Synonyms |
DRAG1, E030006K04Rik, Centd3 |
| MMRRC Submission |
039868-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.780)
|
| Stock # |
R1843 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
18 |
| Chromosomal Location |
37972624-37997574 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 37975583 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Tryptophan
at position 1265
(R1265W)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000035662
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000042944]
|
| AlphaFold |
Q8R5G7 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000042944
AA Change: R1265W
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000035662
Gene: ENSMUSG00000024451
AA Change: R1265W
| Domain | Start | End | E-Value | Type |
|---|
|
SAM
|
1 |
68 |
1.5e-7 |
SMART |
|
low complexity region
|
81 |
98 |
N/A |
INTRINSIC |
|
low complexity region
|
134 |
142 |
N/A |
INTRINSIC |
|
PH
|
283 |
376 |
3.4e-16 |
SMART |
|
PH
|
390 |
480 |
1.61e-8 |
SMART |
|
ArfGap
|
484 |
606 |
1.44e-25 |
SMART |
|
low complexity region
|
642 |
661 |
N/A |
INTRINSIC |
|
PH
|
671 |
785 |
2.86e1 |
SMART |
|
PH
|
795 |
901 |
6.87e-3 |
SMART |
|
RhoGAP
|
913 |
1089 |
2.11e-47 |
SMART |
|
Pfam:RA
|
1113 |
1206 |
6.2e-16 |
PFAM |
|
PH
|
1220 |
1323 |
3.46e-8 |
SMART |
|
low complexity region
|
1388 |
1407 |
N/A |
INTRINSIC |
|
low complexity region
|
1457 |
1469 |
N/A |
INTRINSIC |
|
low complexity region
|
1475 |
1486 |
N/A |
INTRINSIC |
|
low complexity region
|
1494 |
1529 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000184293
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.9%
- 10x: 95.3%
- 20x: 92.4%
|
| Validation Efficiency |
|
| MGI Phenotype |
Strain: 5428754
Lethality: E10-E11
FUNCTION: This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
PHENOTYPE: Mice homozygous for a knock-out allele die around E11 exhibiting pallor, embryonic growth arrest, yolk sac and placental abnormalities, and an endothelial cell-autonomous defect in sprouting angiogenesis. Knock-in mice homozygous for a point mutation display similar angiogenesis defects. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(5) : Targeted(5)
|
| Other mutations in this stock |
Total: 102 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933405L10Rik |
C |
T |
8: 105,708,974 (GRCm38) |
T88M |
probably damaging |
Het |
| 9430038I01Rik |
A |
G |
7: 137,377,066 (GRCm38) |
|
probably benign |
Het |
| Adgra3 |
A |
C |
5: 49,961,492 (GRCm38) |
S905A |
probably damaging |
Het |
| Adgrv1 |
A |
G |
13: 81,544,533 (GRCm38) |
Y1618H |
probably damaging |
Het |
| Anapc15-ps |
T |
C |
10: 95,673,314 (GRCm38) |
T26A |
probably benign |
Het |
| Ankrd13d |
T |
C |
19: 4,271,595 (GRCm38) |
K360E |
probably damaging |
Het |
| Anks1b |
T |
A |
10: 90,512,889 (GRCm38) |
|
probably null |
Het |
| Apob |
T |
C |
12: 8,007,602 (GRCm38) |
F2028S |
possibly damaging |
Het |
| Arhgef37 |
A |
G |
18: 61,518,050 (GRCm38) |
Y135H |
probably damaging |
Het |
| Armh3 |
A |
C |
19: 45,975,252 (GRCm38) |
S42R |
probably benign |
Het |
| Atp1a1 |
T |
C |
3: 101,582,017 (GRCm38) |
T760A |
probably benign |
Het |
| Cdc42bpb |
T |
A |
12: 111,322,821 (GRCm38) |
M497L |
probably benign |
Het |
| Ces5a |
C |
T |
8: 93,514,231 (GRCm38) |
V413M |
probably damaging |
Het |
| Chd5 |
A |
T |
4: 152,385,806 (GRCm38) |
Y1903F |
probably damaging |
Het |
| Chd9 |
T |
A |
8: 91,010,794 (GRCm38) |
N1500K |
probably benign |
Het |
| Chmp7 |
G |
T |
14: 69,719,799 (GRCm38) |
D303E |
probably benign |
Het |
| Chrnb4 |
A |
T |
9: 55,034,818 (GRCm38) |
Y391N |
possibly damaging |
Het |
| Crtc1 |
T |
C |
8: 70,388,152 (GRCm38) |
T475A |
probably benign |
Het |
| Cyp2c69 |
A |
G |
19: 39,877,528 (GRCm38) |
I207T |
probably benign |
Het |
| Dcp1a |
A |
G |
14: 30,518,983 (GRCm38) |
E250G |
probably damaging |
Het |
| Ddx20 |
T |
C |
3: 105,679,082 (GRCm38) |
Q649R |
probably benign |
Het |
| Defb12 |
T |
A |
8: 19,112,738 (GRCm38) |
K59N |
probably damaging |
Het |
| Dpy19l3 |
A |
T |
7: 35,729,760 (GRCm38) |
I85N |
probably damaging |
Het |
| Duox2 |
C |
T |
2: 122,292,258 (GRCm38) |
|
probably null |
Het |
| Ebi3 |
T |
A |
17: 55,956,679 (GRCm38) |
Y197N |
probably damaging |
Het |
| Emc1 |
G |
A |
4: 139,375,512 (GRCm38) |
R994Q |
probably benign |
Het |
| Ercc6 |
G |
T |
14: 32,546,820 (GRCm38) |
M530I |
probably damaging |
Het |
| Evl |
T |
A |
12: 108,652,996 (GRCm38) |
D70E |
probably damaging |
Het |
| Fbln2 |
A |
G |
6: 91,265,775 (GRCm38) |
N819S |
probably damaging |
Het |
| Foxk2 |
A |
G |
11: 121,285,537 (GRCm38) |
I170V |
probably benign |
Het |
| Gfm1 |
T |
C |
3: 67,435,610 (GRCm38) |
V159A |
probably damaging |
Het |
| Gm10837 |
A |
G |
14: 122,490,765 (GRCm38) |
T18A |
unknown |
Het |
| Gm12887 |
A |
T |
4: 121,622,030 (GRCm38) |
V25E |
probably damaging |
Het |
| Hectd4 |
A |
G |
5: 121,297,180 (GRCm38) |
H985R |
possibly damaging |
Het |
| Hsfy2 |
A |
G |
1: 56,636,632 (GRCm38) |
Y249H |
possibly damaging |
Het |
| Hspg2 |
T |
C |
4: 137,545,567 (GRCm38) |
V2639A |
probably damaging |
Het |
| Igf2r |
A |
G |
17: 12,704,270 (GRCm38) |
|
probably null |
Het |
| Invs |
T |
A |
4: 48,422,035 (GRCm38) |
I889N |
probably damaging |
Het |
| Kcnq1 |
A |
T |
7: 143,183,120 (GRCm38) |
M209L |
probably benign |
Het |
| Klra7 |
A |
G |
6: 130,229,994 (GRCm38) |
I48T |
possibly damaging |
Het |
| Krt26 |
CTAGTA |
CTA |
11: 99,333,526 (GRCm38) |
|
probably benign |
Het |
| Lrif1 |
T |
A |
3: 106,732,811 (GRCm38) |
V404D |
probably damaging |
Het |
| Lrriq1 |
T |
A |
10: 103,227,173 (GRCm38) |
|
probably null |
Het |
| Lypd6 |
T |
A |
2: 50,188,762 (GRCm38) |
I90N |
possibly damaging |
Het |
| Mbp |
A |
G |
18: 82,584,122 (GRCm38) |
D174G |
probably damaging |
Het |
| Megf9 |
G |
T |
4: 70,534,785 (GRCm38) |
P13Q |
probably damaging |
Het |
| Myo15b |
A |
T |
11: 115,869,586 (GRCm38) |
T1155S |
probably benign |
Het |
| Nherf2 |
C |
T |
17: 24,641,719 (GRCm38) |
S150N |
possibly damaging |
Het |
| Nlrp6 |
T |
A |
7: 140,923,093 (GRCm38) |
C371S |
probably damaging |
Het |
| Nosip |
T |
A |
7: 45,077,309 (GRCm38) |
|
probably null |
Het |
| Nox3 |
G |
T |
17: 3,669,878 (GRCm38) |
P344H |
probably damaging |
Het |
| Nup210l |
T |
C |
3: 90,172,086 (GRCm38) |
V959A |
probably damaging |
Het |
| Olfr175-ps1 |
T |
A |
16: 58,824,077 (GRCm38) |
I211F |
probably damaging |
Het |
| Or10d1 |
A |
G |
9: 39,572,735 (GRCm38) |
Y175H |
possibly damaging |
Het |
| Or2b2b |
C |
A |
13: 21,674,672 (GRCm38) |
V91L |
probably benign |
Het |
| Or2k2 |
T |
C |
4: 58,785,384 (GRCm38) |
I113V |
probably benign |
Het |
| Or5b119 |
A |
G |
19: 13,479,931 (GRCm38) |
I89T |
probably benign |
Het |
| Osbpl3 |
A |
C |
6: 50,370,143 (GRCm38) |
S25A |
probably damaging |
Het |
| Otog |
G |
A |
7: 46,246,283 (GRCm38) |
C107Y |
probably damaging |
Het |
| Pax7 |
G |
A |
4: 139,784,491 (GRCm38) |
R260C |
probably damaging |
Het |
| Pbrm1 |
A |
T |
14: 31,038,957 (GRCm38) |
I224F |
probably damaging |
Het |
| Pcdh1 |
T |
A |
18: 38,192,225 (GRCm38) |
|
probably null |
Het |
| Pcnx1 |
T |
C |
12: 81,980,935 (GRCm38) |
L1585P |
probably damaging |
Het |
| Pde4c |
C |
T |
8: 70,747,950 (GRCm38) |
H362Y |
probably damaging |
Het |
| Pdlim2 |
C |
T |
14: 70,164,779 (GRCm38) |
R296H |
probably damaging |
Het |
| Pgm2 |
A |
T |
4: 99,961,478 (GRCm38) |
Q90L |
probably damaging |
Het |
| Phlpp1 |
A |
G |
1: 106,343,505 (GRCm38) |
H814R |
probably benign |
Het |
| Pknox2 |
A |
T |
9: 36,954,831 (GRCm38) |
M5K |
possibly damaging |
Het |
| Pole |
G |
A |
5: 110,330,835 (GRCm38) |
|
probably null |
Het |
| Polr1b |
A |
G |
2: 129,102,966 (GRCm38) |
I61V |
probably benign |
Het |
| Prelp |
T |
C |
1: 133,914,757 (GRCm38) |
K217E |
probably damaging |
Het |
| Prkce |
C |
T |
17: 86,475,546 (GRCm38) |
Q202* |
probably null |
Het |
| Psmd2 |
T |
G |
16: 20,656,582 (GRCm38) |
M370R |
probably benign |
Het |
| Rimklb |
A |
T |
6: 122,464,009 (GRCm38) |
H68Q |
probably damaging |
Het |
| Rnasel |
A |
G |
1: 153,754,674 (GRCm38) |
D312G |
possibly damaging |
Het |
| Rxrg |
A |
T |
1: 167,598,752 (GRCm38) |
M1L |
probably benign |
Het |
| Scrn1 |
A |
G |
6: 54,522,841 (GRCm38) |
F220L |
possibly damaging |
Het |
| Scyl3 |
A |
G |
1: 163,950,675 (GRCm38) |
S461G |
probably benign |
Het |
| Serpina1c |
T |
A |
12: 103,895,023 (GRCm38) |
T411S |
probably benign |
Het |
| Serpinb6d |
C |
T |
13: 33,671,381 (GRCm38) |
P346L |
probably benign |
Het |
| Shld2 |
A |
G |
14: 34,267,803 (GRCm38) |
I382T |
probably benign |
Het |
| Spg21 |
G |
T |
9: 65,465,336 (GRCm38) |
V17F |
probably damaging |
Het |
| Spink5 |
A |
T |
18: 43,999,891 (GRCm38) |
M525L |
probably benign |
Het |
| Sun2 |
T |
C |
15: 79,737,563 (GRCm38) |
T155A |
probably benign |
Het |
| Tchh |
T |
A |
3: 93,446,780 (GRCm38) |
F1176I |
unknown |
Het |
| Tex15 |
T |
A |
8: 33,576,654 (GRCm38) |
D2037E |
probably benign |
Het |
| Tfdp2 |
T |
C |
9: 96,317,804 (GRCm38) |
C392R |
possibly damaging |
Het |
| Tmem30c |
T |
C |
16: 57,276,780 (GRCm38) |
N139S |
probably benign |
Het |
| Tns2 |
C |
T |
15: 102,113,133 (GRCm38) |
|
probably null |
Het |
| Trim66 |
T |
C |
7: 109,475,839 (GRCm38) |
E405G |
probably damaging |
Het |
| Trpc4 |
T |
A |
3: 54,279,994 (GRCm38) |
F456I |
probably benign |
Het |
| Tspo2 |
T |
C |
17: 48,448,790 (GRCm38) |
D108G |
possibly damaging |
Het |
| Tyk2 |
A |
T |
9: 21,121,554 (GRCm38) |
C304* |
probably null |
Het |
| Vgll4 |
A |
T |
6: 114,862,795 (GRCm38) |
S185T |
probably benign |
Het |
| Vmn2r94 |
A |
C |
17: 18,244,470 (GRCm38) |
S519R |
probably benign |
Het |
| Vmn2r96 |
T |
G |
17: 18,597,921 (GRCm38) |
S587A |
probably benign |
Het |
| Vps4b |
C |
A |
1: 106,778,982 (GRCm38) |
A287S |
possibly damaging |
Het |
| Yeats2 |
C |
T |
16: 20,229,564 (GRCm38) |
P1332S |
probably benign |
Het |
| Zfp462 |
T |
G |
4: 55,010,010 (GRCm38) |
S659A |
possibly damaging |
Het |
| Zfp507 |
C |
T |
7: 35,793,725 (GRCm38) |
R631Q |
probably damaging |
Het |
| Zfp764l1 |
A |
C |
7: 127,391,488 (GRCm38) |
D442E |
probably benign |
Het |
| Zswim5 |
G |
T |
4: 116,877,699 (GRCm38) |
E80D |
unknown |
Het |
|
| Other mutations in Arap3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00515:Arap3
|
APN |
18 |
37,975,926 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01145:Arap3
|
APN |
18 |
37,989,179 (GRCm38) |
missense |
probably benign |
|
|
IGL01154:Arap3
|
APN |
18 |
37,996,734 (GRCm38) |
missense |
probably benign |
0.28 |
|
IGL01305:Arap3
|
APN |
18 |
37,991,327 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL01542:Arap3
|
APN |
18 |
37,990,836 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL01543:Arap3
|
APN |
18 |
37,990,836 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL01544:Arap3
|
APN |
18 |
37,990,836 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL01545:Arap3
|
APN |
18 |
37,990,836 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL01677:Arap3
|
APN |
18 |
37,996,647 (GRCm38) |
missense |
probably benign |
|
|
IGL01925:Arap3
|
APN |
18 |
37,984,246 (GRCm38) |
missense |
probably benign |
0.21 |
|
IGL01933:Arap3
|
APN |
18 |
37,978,453 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
IGL02048:Arap3
|
APN |
18 |
37,996,979 (GRCm38) |
missense |
possibly damaging |
0.56 |
|
IGL02064:Arap3
|
APN |
18 |
37,991,701 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02207:Arap3
|
APN |
18 |
37,987,853 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02376:Arap3
|
APN |
18 |
37,978,453 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
IGL02531:Arap3
|
APN |
18 |
37,989,751 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02568:Arap3
|
APN |
18 |
37,996,658 (GRCm38) |
missense |
probably benign |
0.32 |
|
IGL02640:Arap3
|
APN |
18 |
37,987,802 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
IGL02658:Arap3
|
APN |
18 |
37,990,994 (GRCm38) |
missense |
probably benign |
0.09 |
|
IGL03090:Arap3
|
APN |
18 |
37,989,112 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL03352:Arap3
|
APN |
18 |
37,981,302 (GRCm38) |
splice site |
probably benign |
|
|
ANU22:Arap3
|
UTSW |
18 |
37,991,327 (GRCm38) |
critical splice donor site |
probably null |
|
|
P0016:Arap3
|
UTSW |
18 |
37,984,348 (GRCm38) |
missense |
probably benign |
0.00 |
|
PIT4260001:Arap3
|
UTSW |
18 |
37,996,895 (GRCm38) |
missense |
probably benign |
0.08 |
|
R0066:Arap3
|
UTSW |
18 |
37,996,707 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0324:Arap3
|
UTSW |
18 |
37,973,225 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R0562:Arap3
|
UTSW |
18 |
37,975,540 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1289:Arap3
|
UTSW |
18 |
37,981,973 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R1346:Arap3
|
UTSW |
18 |
37,975,918 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1419:Arap3
|
UTSW |
18 |
37,978,432 (GRCm38) |
missense |
possibly damaging |
0.51 |
|
R1470:Arap3
|
UTSW |
18 |
37,989,196 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R1470:Arap3
|
UTSW |
18 |
37,989,196 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R1537:Arap3
|
UTSW |
18 |
37,989,684 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1644:Arap3
|
UTSW |
18 |
37,984,245 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1731:Arap3
|
UTSW |
18 |
37,989,912 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1758:Arap3
|
UTSW |
18 |
37,989,912 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1907:Arap3
|
UTSW |
18 |
37,996,671 (GRCm38) |
missense |
probably benign |
0.28 |
|
R1954:Arap3
|
UTSW |
18 |
37,982,002 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2124:Arap3
|
UTSW |
18 |
37,973,350 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R2135:Arap3
|
UTSW |
18 |
37,974,456 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2172:Arap3
|
UTSW |
18 |
37,990,560 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2418:Arap3
|
UTSW |
18 |
37,989,944 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2419:Arap3
|
UTSW |
18 |
37,989,944 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2907:Arap3
|
UTSW |
18 |
37,990,527 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R4425:Arap3
|
UTSW |
18 |
37,978,600 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4669:Arap3
|
UTSW |
18 |
37,996,254 (GRCm38) |
missense |
probably benign |
0.08 |
|
R4734:Arap3
|
UTSW |
18 |
37,996,275 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4815:Arap3
|
UTSW |
18 |
37,973,243 (GRCm38) |
missense |
probably benign |
|
|
R5328:Arap3
|
UTSW |
18 |
37,991,687 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R5350:Arap3
|
UTSW |
18 |
37,982,035 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5466:Arap3
|
UTSW |
18 |
37,996,736 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5482:Arap3
|
UTSW |
18 |
37,974,674 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R5572:Arap3
|
UTSW |
18 |
37,991,066 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5779:Arap3
|
UTSW |
18 |
37,984,365 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6053:Arap3
|
UTSW |
18 |
37,990,771 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R6144:Arap3
|
UTSW |
18 |
37,985,433 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R6166:Arap3
|
UTSW |
18 |
37,974,370 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6248:Arap3
|
UTSW |
18 |
37,991,354 (GRCm38) |
missense |
probably benign |
0.09 |
|
R6266:Arap3
|
UTSW |
18 |
37,990,791 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R6385:Arap3
|
UTSW |
18 |
37,997,031 (GRCm38) |
nonsense |
probably null |
|
|
R6694:Arap3
|
UTSW |
18 |
37,991,537 (GRCm38) |
critical splice donor site |
probably null |
|
|
R6856:Arap3
|
UTSW |
18 |
37,979,863 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R7073:Arap3
|
UTSW |
18 |
37,974,442 (GRCm38) |
nonsense |
probably null |
|
|
R7297:Arap3
|
UTSW |
18 |
37,973,563 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R7352:Arap3
|
UTSW |
18 |
37,973,278 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7652:Arap3
|
UTSW |
18 |
37,978,452 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7726:Arap3
|
UTSW |
18 |
37,989,467 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7747:Arap3
|
UTSW |
18 |
37,988,888 (GRCm38) |
splice site |
probably null |
|
|
R7944:Arap3
|
UTSW |
18 |
37,989,179 (GRCm38) |
missense |
probably benign |
|
|
R8152:Arap3
|
UTSW |
18 |
37,991,357 (GRCm38) |
missense |
possibly damaging |
0.61 |
|
R8338:Arap3
|
UTSW |
18 |
37,973,630 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8549:Arap3
|
UTSW |
18 |
37,973,312 (GRCm38) |
missense |
probably benign |
0.17 |
|
R8793:Arap3
|
UTSW |
18 |
37,974,439 (GRCm38) |
missense |
probably benign |
0.04 |
|
R8876:Arap3
|
UTSW |
18 |
37,997,024 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R9142:Arap3
|
UTSW |
18 |
37,979,881 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
R9237:Arap3
|
UTSW |
18 |
37,979,881 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
R9583:Arap3
|
UTSW |
18 |
37,976,043 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R9696:Arap3
|
UTSW |
18 |
37,979,852 (GRCm38) |
missense |
probably damaging |
1.00 |
|
X0011:Arap3
|
UTSW |
18 |
37,974,101 (GRCm38) |
critical splice donor site |
probably null |
|
|
X0026:Arap3
|
UTSW |
18 |
37,985,311 (GRCm38) |
critical splice donor site |
probably null |
|
|
X0027:Arap3
|
UTSW |
18 |
37,973,485 (GRCm38) |
splice site |
probably null |
|
|
X0066:Arap3
|
UTSW |
18 |
37,991,646 (GRCm38) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GCTAGAGATACTCACAGGTGC -3'
(R):5'- GTGGCATCAGGAGCCATAAC -3'
Sequencing Primer
(F):5'- GAGATACTCACAGGTGCATCTTTTC -3'
(R):5'- GTGGCATCAGGAGCCATAACTTTAC -3'
|
| Posted On |
2014-06-23 |
Incidental Mutation