Incidental Mutation 'R1845:Or4c108'
ID 207615
Institutional Source Beutler Lab
Gene Symbol Or4c108
Ensembl Gene ENSMUSG00000089751
Gene Name olfactory receptor family 4 subfamily C member 108
Synonyms GA_x6K02T2Q125-50452032-50451097, Olfr1213, MOR233-7, Gm13762
MMRRC Submission 039870-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.116) question?
Stock # R1845 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 88803298-88810611 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 88803482 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 251 (V251A)
Ref Sequence ENSEMBL: ENSMUSP00000126588 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099806] [ENSMUST00000144908] [ENSMUST00000168169]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000099806
AA Change: V251A

PolyPhen 2 Score 0.220 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000097394
Gene: ENSMUSG00000101480
AA Change: V251A

Pfam:7tm_4 29 303 2.5e-47 PFAM
Pfam:7tm_1 39 286 3.2e-17 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131574
Predicted Effect probably benign
Transcript: ENSMUST00000144908
AA Change: V251A

PolyPhen 2 Score 0.220 (Sensitivity: 0.91; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000168169
AA Change: V251A

PolyPhen 2 Score 0.220 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000126588
Gene: ENSMUSG00000075111
AA Change: V251A

Pfam:7tm_1 39 286 1.8e-26 PFAM
Pfam:7tm_4 138 282 3.3e-36 PFAM
Meta Mutation Damage Score 0.4315 question?
Coding Region Coverage
  • 1x: 97.4%
  • 3x: 96.8%
  • 10x: 95.0%
  • 20x: 91.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 82 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110038F14Rik CGGG CGGGGGG 15: 76,833,863 (GRCm39) probably benign Het
Abca17 A T 17: 24,486,690 (GRCm39) C1446S probably damaging Het
Asb16 C A 11: 102,167,582 (GRCm39) A316E possibly damaging Het
Axdnd1 C T 1: 156,204,114 (GRCm39) V384I possibly damaging Het
BC024139 A T 15: 76,009,461 (GRCm39) L207* probably null Het
Bcl3 T G 7: 19,543,552 (GRCm39) S305R probably damaging Het
Cachd1 T C 4: 100,634,555 (GRCm39) V77A probably benign Het
Cd101 C T 3: 100,936,764 (GRCm39) probably null Het
Cela1 T C 15: 100,583,048 (GRCm39) N64S probably benign Het
Cep128 T C 12: 91,256,372 (GRCm39) D366G probably benign Het
Col12a1 A G 9: 79,604,823 (GRCm39) V675A probably benign Het
Copg1 A G 6: 87,870,800 (GRCm39) Y201C probably damaging Het
Cyp24a1 T C 2: 170,329,837 (GRCm39) R372G probably benign Het
Dcaf1 A C 9: 106,729,161 (GRCm39) I567L probably benign Het
Dcn A G 10: 97,342,536 (GRCm39) D164G probably benign Het
Dnase2a T A 8: 85,635,951 (GRCm39) H113Q probably benign Het
Espl1 T C 15: 102,207,448 (GRCm39) V304A probably benign Het
Fam193a A G 5: 34,600,716 (GRCm39) D315G possibly damaging Het
Fkbp8 T A 8: 70,983,685 (GRCm39) probably null Het
Foxp4 T A 17: 48,188,884 (GRCm39) T321S probably null Het
Fut10 A G 8: 31,726,328 (GRCm39) N361S probably damaging Het
Gyg1 A T 3: 20,205,286 (GRCm39) V94D probably damaging Het
Has2 T C 15: 56,531,974 (GRCm39) K247R probably damaging Het
Helz2 G T 2: 180,873,878 (GRCm39) D2205E probably benign Het
Hps6 T A 19: 45,993,409 (GRCm39) S449T probably benign Het
Ints10 T C 8: 69,247,323 (GRCm39) Y64H probably damaging Het
Kalrn T C 16: 34,177,331 (GRCm39) H278R probably damaging Het
Klhdc8a T C 1: 132,231,548 (GRCm39) V280A possibly damaging Het
Klk1b5 A G 7: 43,869,549 (GRCm39) M210V probably benign Het
Kmt2c G A 5: 25,578,434 (GRCm39) A614V probably benign Het
Lck T A 4: 129,451,879 (GRCm39) I45F probably benign Het
Lin7a A C 10: 107,247,920 (GRCm39) E75A probably damaging Het
Lrp1 A T 10: 127,414,542 (GRCm39) C1070S probably damaging Het
Mapk8ip3 G T 17: 25,133,557 (GRCm39) N289K probably benign Het
Mbtps1 T C 8: 120,249,232 (GRCm39) D686G probably benign Het
Mknk1 T A 4: 115,730,428 (GRCm39) C178* probably null Het
Mtmr6 A G 14: 60,534,184 (GRCm39) N474S probably damaging Het
Mvb12b A G 2: 33,730,169 (GRCm39) probably null Het
Myh6 T C 14: 55,182,131 (GRCm39) K1759R probably damaging Het
Nfatc1 T C 18: 80,678,746 (GRCm39) K881E possibly damaging Het
Nlrp10 A G 7: 108,526,248 (GRCm39) F30S probably damaging Het
Nop14 G T 5: 34,807,672 (GRCm39) A430E possibly damaging Het
Ntn4 C T 10: 93,543,215 (GRCm39) R314W probably damaging Het
Or1j18 A T 2: 36,624,854 (GRCm39) I174F probably damaging Het
Or4c107 A G 2: 88,789,211 (GRCm39) I134V probably damaging Het
Or6c205 A G 10: 129,086,463 (GRCm39) E20G probably benign Het
Or6c88 A T 10: 129,407,217 (GRCm39) Q231L probably damaging Het
Or7g17 A T 9: 18,768,782 (GRCm39) Y287F possibly damaging Het
Osbpl7 C A 11: 96,949,954 (GRCm39) S378R probably damaging Het
Otof A T 5: 30,529,067 (GRCm39) Y1775* probably null Het
Parp16 T C 9: 65,122,876 (GRCm39) S46P possibly damaging Het
Pdlim2 C T 14: 70,402,228 (GRCm39) R296H probably damaging Het
Pi16 A T 17: 29,538,361 (GRCm39) Q58L possibly damaging Het
Pld3 C A 7: 27,238,877 (GRCm39) M190I probably benign Het
Plscr4 T G 9: 92,372,099 (GRCm39) I290S probably damaging Het
Ppip5k2 T C 1: 97,651,531 (GRCm39) D928G possibly damaging Het
Ppp1r13l T A 7: 19,102,536 (GRCm39) L15Q probably damaging Het
Prorp T A 12: 55,351,117 (GRCm39) I142N possibly damaging Het
Ptpn14 C A 1: 189,571,699 (GRCm39) S263R possibly damaging Het
Sema7a G A 9: 57,862,182 (GRCm39) V178I possibly damaging Het
Sesn2 A T 4: 132,224,381 (GRCm39) Y342* probably null Het
Shroom3 G T 5: 93,090,945 (GRCm39) V1151F probably damaging Het
Sltm A G 9: 70,450,314 (GRCm39) N38S possibly damaging Het
Smg1 T C 7: 117,753,845 (GRCm39) probably benign Het
Spsb1 A T 4: 149,991,367 (GRCm39) V67E probably damaging Het
Suox A G 10: 128,506,408 (GRCm39) V540A possibly damaging Het
Tbc1d12 T A 19: 38,899,529 (GRCm39) I483N probably damaging Het
Tbcb A T 7: 29,923,924 (GRCm39) D198E possibly damaging Het
Tbce T C 13: 14,194,294 (GRCm39) K122E probably benign Het
Tcap T A 11: 98,275,205 (GRCm39) L113H probably damaging Het
Thsd7a A T 6: 12,321,040 (GRCm39) I1545N probably damaging Het
Tmed10 T C 12: 85,421,277 (GRCm39) T55A possibly damaging Het
Tmem268 T A 4: 63,498,180 (GRCm39) V200D probably damaging Het
Tmem45b A C 9: 31,342,651 (GRCm39) I50M probably damaging Het
Trp53bp2 T C 1: 182,286,468 (GRCm39) W1103R probably damaging Het
Ttn C T 2: 76,594,377 (GRCm39) V20524M probably damaging Het
Ulk2 A T 11: 61,703,564 (GRCm39) N379K probably benign Het
Vmn1r59 A G 7: 5,457,553 (GRCm39) V69A probably benign Het
Vmn2r10 A T 5: 109,149,861 (GRCm39) Y394* probably null Het
Zfp212 T C 6: 47,908,475 (GRCm39) S485P probably benign Het
Zfp512b A T 2: 181,227,528 (GRCm39) C776S probably damaging Het
Zfp518b A G 5: 38,829,084 (GRCm39) Y974H probably damaging Het
Other mutations in Or4c108
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01812:Or4c108 APN 2 88,803,868 (GRCm39) nonsense probably null
IGL02685:Or4c108 APN 2 88,803,365 (GRCm39) missense possibly damaging 0.94
R0240:Or4c108 UTSW 2 88,803,740 (GRCm39) missense probably damaging 1.00
R0240:Or4c108 UTSW 2 88,803,740 (GRCm39) missense probably damaging 1.00
R1446:Or4c108 UTSW 2 88,804,109 (GRCm39) missense probably benign 0.00
R1868:Or4c108 UTSW 2 88,804,128 (GRCm39) missense possibly damaging 0.60
R1953:Or4c108 UTSW 2 88,804,224 (GRCm39) nonsense probably null
R4205:Or4c108 UTSW 2 88,803,482 (GRCm39) missense probably benign 0.22
R4751:Or4c108 UTSW 2 88,803,477 (GRCm39) missense probably damaging 1.00
R4895:Or4c108 UTSW 2 88,804,055 (GRCm39) missense probably benign 0.39
R4937:Or4c108 UTSW 2 88,803,834 (GRCm39) missense probably damaging 1.00
R5621:Or4c108 UTSW 2 88,803,810 (GRCm39) missense probably benign 0.00
R5678:Or4c108 UTSW 2 88,803,317 (GRCm39) nonsense probably null
R5938:Or4c108 UTSW 2 88,803,357 (GRCm39) missense probably benign 0.00
R6021:Or4c108 UTSW 2 88,803,376 (GRCm39) nonsense probably null
R6180:Or4c108 UTSW 2 88,804,226 (GRCm39) missense probably damaging 1.00
R6724:Or4c108 UTSW 2 88,803,612 (GRCm39) missense probably benign 0.02
R6873:Or4c108 UTSW 2 88,803,768 (GRCm39) missense probably benign
R6893:Or4c108 UTSW 2 88,804,143 (GRCm39) missense probably benign 0.00
R7221:Or4c108 UTSW 2 88,803,497 (GRCm39) missense probably damaging 0.99
R7634:Or4c108 UTSW 2 88,804,001 (GRCm39) missense probably damaging 1.00
R8233:Or4c108 UTSW 2 88,804,082 (GRCm39) missense probably benign
R8262:Or4c108 UTSW 2 88,803,552 (GRCm39) missense probably damaging 0.99
R8979:Or4c108 UTSW 2 88,804,173 (GRCm39) missense probably benign 0.00
R9136:Or4c108 UTSW 2 88,804,113 (GRCm39) missense probably benign 0.00
R9696:Or4c108 UTSW 2 88,803,615 (GRCm39) missense probably benign 0.05
R9726:Or4c108 UTSW 2 88,804,221 (GRCm39) missense probably benign
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2014-06-23